PRX1354 / Sawai Pharma - LARVOL DELTA

The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells. (PubMed) - J Cell Mol Med - "This study demonstrates that soluble klotho (1 nM, 24 hrs) significantly induces expression of Nrf2 and the antioxidant enzymes haeme oxygenase (HO-1) and peroxiredoxin-1 (Prx-1) and enhances glutathione levels in human aortic smooth muscle cells (HASMC). Thus, our findings highlight a novel Nrf2-mediated mechanism underlying the protective actions of soluble klotho in HAMSC. Targeting klotho may thus represent a therapeutic strategy against VSMC dysfunction and cardiovascular ageing."

Journal • Atherosclerosis • Biosimilar • Chronic Kidney Disease • Diabetes • Dyslipidemia • Immunology • Renal Disease

The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct. (PubMed) - J Bone Miner Res - "In the former, the prevailing mechanism of the cortical bone loss in both sexes is increased osteoclastogenesis caused by estrogen deficiency; this is likely driven, at least in part, by mesenchymal/stromal cell-derived SDF1. Decreased osteoblastogenesis, due in part to increased H2 O2, combined with increased osteoclastogenesis caused by aging mechanisms independent of estrogen deficiency, are the prevailing mechanisms of the loss of cortical bone with old age."

Journal • Biosimilar

Prx1 promotes the proliferation and migration of vascular smooth muscle cells in a TLR4-dependent manner. (PubMed) - Mol Med Rep - "Silencing of the TLR4 gene attenuated the Prx1‑induced proliferation and migration of the VSMCs. Therefore, the promotion of VSMC proliferation and migration by Prx1 was dependent on TLR4, which may become a novel target in the diagnosis, treatment and prognosis of patients with IH."

Journal • Biosimilar

Evaluation of toxicological biomarkers in secreted proteins of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and their expressions in the plasma of rats and incineration workers. (PubMed) - Biochim Biophys Acta - "Fifteen secreted proteins were identified by a nano-LC-ESI-MS/MS and nano-ESI on a Q-TOF2 MS and the identities of eight secreted proteins including glyoxalase 1 (GLO 1), homogentisate dioxygenase (HGD), peroxiredoxin 1 (PRX 1), proteasome subunit beta type (PSMB) 5 and 6, UDP-glucose 6-dehydrogenase (UDP-GlcDH), hydroxyacyl-coenzyme A dehydrogenase (HADH) and serotransferrin (STF) were confirmed by western blotting. Of these, PSMB 5 and PRX 1 were also found in the plasma of rats exposed to 2,3,7,8-TCDD, whereas GLO 1, HGD, PSMB 6 and PRX 1 were found in the plasma of incineration workers exposed to dioxins."

Biomarker • Journal • Biosimilar

Induction of antioxidant genes by sulforaphane and klotho in human aortic smooth muscle cells. (PubMed) - "Interestingly preliminary data suggest that treatment of SMC with SFN for 12 or 24h enhances the expression of klotho. Taken together, these findings demonstrate that both SFN and klotho can enhance antioxidant defences which may protect against vascular SMC dysfunction in age-related cardiovascular diseases.Supported by the British Heart Foundation, Heart Research UK and the 'Marco Polo' Program, University of Bologna."

Journal • Atherosclerosis • Biosimilar • Dyslipidemia • Immunology • Inflammation