recombinant exendin-4 (Uni-E4) / Uni-Bio Sci - LARVOL DELTA

Accessible Type 2 diabetes medication through stable expression of Exendin-4 in Saccharomyces cerevisiae. (PubMed, Front Syst Biol) - "In this study, experimental models for recombinant Exendin-4 protein production were designed in both Escherichia coli and Saccharomyces cerevisiae. Protein expression in the chromosomally integrated S. cerevisiae strain was observed at the expected size of Exendin-4 and confirmed by immunoassay. This provides a foundation for the use of this Generally Regarded as Safe organism as an affordable treatment for Type 2 diabetes that can be propagated, prepared, and distributed locally."

Journal • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Candidate anti-tuberculosis medicines and regimens under clinical evaluation. (PubMed, Clin Microbiol Infect) - "A large number of potential anti-TB candidate medicines and innovations in clinical trial design for the evaluation of regimens, rather than single medicines, provide hope for improvements in the treatment of TB."

Journal • Review • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

415: UNITE4TB: tuberculosis renewed European Union project (ERS 2023) - "Aims: to explain how to use and discuss the methods used to diagnose tuberculosis (TB) and identify resistance; to describe the different drugs and regimens being studied for TB treatment; to explain the advances and challenges in the development of biomarkers; to explain the importance of treatment adherence and the different interventions in use."

Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

"@IgorStojkov_ @DerryMercer @GeraldineJoanny @YojanaGadiya @FernowJosepine @RaquelAFDuarte @SwissButcher74 @IHIEurope @EFPIA @AllianceBEAM @EuropeVaccine @TRIC_TB @UNITE4TB @AMR_Combine @UU_University @lygature @GSK @Evotec @JanssenGlobal @LMU_Muenchen @Bioversys" (@AMRAccelerator)

Clinical

"Deep empathy @fabian_theis quoting @EricTopol at the #UNITE4TB #ERS webnar on AI and Tuberculosis" (@otavio_ranzani)

Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

"Presenting Work Package Biomarkers at the @UNITE4TB Project Steering Committee in Tres Cantos, Madrid, Spain. Thank you @GSK for hosting us! #tuberculosis #biomarkers" (@biosquirrel_)

Biomarker • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

"UNITE4TB partners, please help spread the word: @ISPUP, @LaStatale, @lygature, @EuroRespSoc, @TBAlliance, @TBnet_EU, @LMU_Uniklinikum, @DZIF_, @GSK, @JNJNews, @EFPIA, @radboudumc, @OUCRU_Programme, @taskapplied, @FINDdx, @EuropeanLung, @CPathInstitute, @kncvtbc, @UCSF_CTB" (@UNITE4TB)

Production of active Exendin-4 in Nicotiana benthamiana and its application in treatment of type-2 diabetics. (PubMed, Front Plant Sci) - "In this study, we report that the GLP-1 analogue recombinant Exendin-4 (Exdn-4) can be produced at a high level in Nicotiana benthamiana, with an estimated yield of 50.0 µg/g fresh biomass. Moreover, Exdn-4 without any extra residues was produced from BGC : Exdn-4 bound onto MCC beads by treating with enterokinase. Plant-produced Exdn-4 (Exendin-4) was as effective as chemically synthesized Exendin-4 in glucose-induced insulin secretion (GIIS) from mouse MIN6m9 cells a pancreatic beta cell line."

Journal • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

"#StrongerTogether ! We're proud @IHIEurope @AMRAccelerator project @UNITE4TB is fighting to #ENDTB 💪💊" (@AMR_Combine)

"Unite4Truth deep dive: Bill Gates and the use of "Insecticide Cures" for fake diseases: https://t.co/AoS6IxbXe3" (@PodcastBill)

"Hello @UNITE4TB, welcome to Twitter! 👋🏻" (@JensJot)

"El Dr Barros (@GSK) presenta l’estudi #UNITE4 que compta amb finançament de la @EU_Commission a través del #IMI2 #TallerTB21 @TB_UITB" (@tbexperimental)

UNITE4TB: a new consortium for clinical drug and regimen development for TB. (PubMed, Int J Tuberc Lung Dis) - No abstract available

Clinical • Journal

"Intriguing during these tumultuous times... @Roche @DrRomie @purviparwani @pjain @MattSakumoto @Karthik28930366 #unite4india" (@MamtaSwa)