OM-85-IN / Optimus Holding, OM Pharma - LARVOL DELTA

Intranasal OM-85 Attenuates Allergen- and Virus-Induced Airway Inflammation by Restoring Epithelial–Macrophage Homeostasis (ERS 2026) - "Intranasal OM-85 mitigates allergen-induced airway inflammation by enhancing epithelial–macrophage interactions and promoting resolution. Its antiviral activity supports its potential as a mucosal immunotherapy for preventing allergic airway disease exacerbations."

Eosinophilia • Infectious Disease • Inflammation • Influenza • Respiratory Diseases • PTPRC

Safety and Tolerability of Intranasal OM-85 (OM-85-IN) in Healthy Volunteers and Patients With Mild Allergic Asthma: A Phase 1a/1b Randomized, Double-Blind, Placebo-Controlled Study (ATS 2025) - "These findings indicate that the direct application of OM-85-IN to the nasal mucosa is safe and well tolerated. Upcoming Phase 1b in patients with mild asthma will study safety and tolerability in diseased conditions including potential protection from nasal allergen challenge."

Clinical • P1 data • Asthma • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Respiratory Diseases

A Clinical Study Investigating OM-85-IN Safety and Tolerability in Healthy Volunteers and Mild Allergic Asthma Patients (clinicaltrials.gov) - P1 | N=41 | Completed | Sponsor: OM Pharma SA | Active, not recruiting ➔ Completed

Trial completion • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

A Clinical Study Investigating OM-85-IN Safety and Tolerability in Healthy Volunteers and Mild Allergic Asthma Patients (clinicaltrials.gov) - P1 | N=41 | Active, not recruiting | Sponsor: OM Pharma SA | Recruiting ➔ Active, not recruiting

Enrollment closed • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

A Clinical Study Investigating OM-85-IN Safety and Tolerability in Healthy Volunteers and Mild Allergic Asthma Patients (clinicaltrials.gov) - P1 | N=41 | Recruiting | Sponsor: OM Pharma SA

New P1 trial • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases