Restylane / Bausch Health - LARVOL DELTA

Pan-Facial Layering of Hyaluronic Acid Filler (clinicaltrials.gov) - P=N/A | N=30 | Completed | Sponsor: Erevna Innovations Inc. | Active, not recruiting ➔ Completed

Trial completion • Aesthetic Medicine

A Study to Evaluate the Effectiveness and Safety of Restylane Shaype in the Improvement of Jawline Definition (clinicaltrials.gov) - P=N/A | N=162 | Not yet recruiting | Sponsor: Galderma R&D

New trial

Efficacy and safety of injectable sodium hyaluronate gel in correcting moderate to severe nasolabial folds: a single-center, randomized, double-blind, controlled trial (PubMed, Zhejiang Da Xue Xue Bao Yi Xue Ban) - "DKL is equivalent to Restylane® 2 in 12-month efficacy and exhibits a favorable safety profile for correcting moderate to severe nasolabial folds, offering a new option for minimally invasive filling correction in clinical practice."

Clinical • Journal

Characterizing Major In Vitro Rheologic and Physicochemical Properties of Thermally Altered Hyaluronic Acid Fillers. (PubMed, Dermatol Surg) - "Overall, in vitro heat exposure of tested HA fillers does not alter rheologic and physicochemical properties. These findings suggest that EBDs over preinjected HA fillers are unlikely to compromise filler integrity. Further in vivo validation is necessary."

Journal • Preclinical

Laryngeal Electromyography-Guided Injection Laryngoplasty: A Prospective Series. (PubMed, J Voice) - "LEMG-guided injection laryngoplasty can be performed with low morbidity. It is an alternative to fiber-optic-guided injection. Use this method when two-operator injections are unavailable, patient tolerance to fiberscope examination is poor, or LEMG expertise is available. Use temporary substances, as extrusion and inadvertent lamina propria injection are possible complications."

Journal • Mood Disorders • Psychiatry

Association of AbobotulinumtoxinA and Skinbooster for Periorbital Wrinkles: A Randomized, Controlled, Double-Blind, Split-Face Study. (PubMed, Aesthetic Plast Surg) - "The association of abobotulinumtoxinA with Restylane® Skinbooster Vital provides enhanced and lasting improvements in severe canthal wrinkles."

Clinical • Journal • Aesthetic Medicine

Hyaluronic Acid Filler Migration (clinicaltrials.gov) - P=N/A | N=10 | Active, not recruiting | Sponsor: Erevna Innovations Inc. | Recruiting ➔ Active, not recruiting | Trial primary completion date: Dec 2027 ➔ Dec 2026

Enrollment closed • Trial primary completion date

Pan-Facial Layering of Hyaluronic Acid Filler (clinicaltrials.gov) - P=N/A | N=30 | Active, not recruiting | Sponsor: Erevna Innovations Inc. | Recruiting ➔ Active, not recruiting

Enrollment closed • Aesthetic Medicine

A Study to Evaluate the Effectiveness and Safety of Restylane Skinboosters Vital Lidocaine (clinicaltrials.gov) - P=N/A | N=171 | Recruiting | Sponsor: Galderma R&D | Active, not recruiting ➔ Recruiting

Enrollment open

Modifying Upper Eyelid Crease Using Hyaluronic Acid Fillers: A Clinical Case Series. (PubMed, J Craniofac Surg) - "Hyaluronic acid (HA) filler injection is a safe, minimally invasive, and reversible technique for refining the upper eyelid crease. Beyond asymmetry correction, this approach allows controlled adjustment of crease thickness, offering a personalized alternative or adjunct to surgical blepharoplasty in carefully selected patients."

Journal • Aesthetic Medicine

Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies (clinicaltrials.gov) - P=N/A | N=41 | Completed | Sponsor: Galderma R&D | Active, not recruiting ➔ Completed

Trial completion • Aesthetic Medicine

A Study to Evaluate the Effectiveness and Safety of Restylane Skinboosters Vital Lidocaine (clinicaltrials.gov) - P=N/A | N=171 | Active, not recruiting | Sponsor: Galderma R&D | Recruiting ➔ Active, not recruiting

Enrollment closed

Randomized Masked Trial of Injectable Cross-Linked Hyaluronic Acid for Moderate-to-Severe Nasolabial Folds (clinicaltrials.gov) - P=N/A | N=356 | Active, not recruiting | Sponsor: Chongqing Jinsaixing Medical Technology Co., Ltd

Head-to-Head • New trial

Post-Menopause Skin Rejuvenation Study (clinicaltrials.gov) - P4 | N=50 | Active, not recruiting | Sponsor: Erevna Innovations Inc. | Recruiting ➔ Active, not recruiting

Enrollment closed

Hyaluronic Acid Filler Migration (clinicaltrials.gov) - P=N/A | N=10 | Recruiting | Sponsor: Erevna Innovations Inc. | Trial completion date: Jan 2026 ➔ Dec 2027 | Initiation date: Jul 2025 ➔ Dec 2025 | Trial primary completion date: Dec 2025 ➔ Dec 2027

Trial completion date • Trial initiation date • Trial primary completion date

Long-Term Effects of Tear Trough Hyaluronic Acid Filler: A Retrospective Study. (PubMed, J Clin Aesthet Dermatol) - "This study challenges conventional beliefs by demonstrating the extended efficacy of TT-HA fillers, providing evidence of significant improvement in infraorbital hollowing up to 18 months posttreatment. These findings offer valuable insights for clinicians and patients, guiding expectations, and treatment planning in cosmetic dermatology practice. Further research is warranted to elucidate factors contributing to the prolonged longevity of TT-HA fillers to optimize treatment outcomes."

Journal • Retrospective data • Aesthetic Medicine • Dermatology

Safety and Effectiveness of Restylane® Kysse for Lip Augmentation in Chinese Subjects (clinicaltrials.gov) - P=N/A | N=22 | Completed | Sponsor: Galderma R&D | N=50 ➔ 22

Enrollment change

P037 Efficacy and safety of injectable bio-revitalizers and rejuvenate therapies, including platelet-rich plasma and exosome-based treatments: a systematic review of licensed products in the UK. (PubMed, Br J Dermatol) - "Inclusion criteria focused on licensed products approved in the UK under MHRA and NICE regulations, such as Profhilo®, Restylane® Skinboosters, Sunekos®, Nucleofill®, Juvelook®, PRP and exosome-based therapies...This review offers a comprehensive evaluation of licensed bio-revitalizers and rejuvenate therapies, providing colleagues with evidence-based insights for improving patient care and advancing practice in aesthetic and therapeutic dermatology. The findings serve as a valuable teaching tool, fostering reflection on current practices and encouraging innovation within the field."

Journal • Review • Dermatology

A Prospective, Randomized, Active-Controlled, Evaluator-Blinded, Noninferiority Clinical Trial Examining a Non-Cross-Linked Bovine-Derived Type I/III Collagen Filler Combined with Hyaluronic Acid for Periocular Rejuvenation. (PubMed, Aesthetic Plast Surg) - "The combination of collagen and HA offers a comprehensive approach for periocular rejuvenation. This method combines the volumizing benefits of HA with the tissue-regenerative properties of collagen. Furthermore, this approach minimizes complications while enhancing treatment longevity, thus establishing a new standard for minimally invasive periocular rejuvenation."

Head-to-Head • Journal • Aesthetic Medicine

Clinical Durability of Hyaluronic Acid-Based Dermal Fillers for Facial Application: A Systematic Review. (PubMed, Aesthetic Plast Surg) - "HA filler longevity is influenced by manufacturing technology, tissue mobility, and anatomical factors. All technologies demonstrated good durability, though Vycross was associated with more long-term adverse events. Subjective satisfaction mirrored objective persistence, emphasizing the clinical relevance of both assessments. Individualized product selection remains essential to achieve safe, predictable, and satisfactory outcomes."

Journal • Review • Aesthetic Medicine

Safety and Effectiveness of 2 High-G Prime Soft Tissue Filler for Chin Augmentation: A Prospective, Randomized, Comparator-Controlled, Evaluator-Blinded Trial. (PubMed, Aesthet Surg J) - "With no statistically significant difference in overall volume utilized between HASHA and HAVLX, HASHA injections required 15.27% less volume in the menton/pognion to achieve visual correction. Additionally, HASHA demonstrated a significantly higher efficiency score for correction of nasomental angle. Secondary endpoints were not significantly different and demonstrate both products as being safe and effective."

Journal

An Expert Opinion on Hyaluronic Acid Fillers for Indian Facial Aesthetics: Insights From a Pre-meeting Questionnaire and Ad-Board Discussion. (PubMed, Cureus) - "Considering both anatomical changes and patient expectations, an individualized approach to facial aesthetic treatments is necessary. There is a need for Indian-specific aesthetic guidelines owing to limited published literature that respects cultural facial characteristics and evolving beauty standards across age groups."

Journal • Review • Aesthetic Medicine

Filler Up! Key Quality and Safety Considerations in Non-Cosmetic Applications of Soft-Tissue Fillers in Otolaryngology (AAO-HNSF 2025) - "Starting in 2003 with Restylane, hyaluronic acid (HA) fillers led the way, sparking a wave of innovation that now includes over 20 FDA-approved formulations for aesthetic use. Beyond hyaluronic acid, the filler market also includes calcium hydroxylapatite, poly-L-lactic acid, and polymethylmethacrylate microspheres, each with distinct properties tailored for specific applications.While fillers are well-established in cosmetic practices, their non-cosmetic applications are recently gaining more prominence in otolaryngology...Additionally, autologous fat grafting, as a potentially more permanent alternative, will be addressed. Panelists will also examine the potential risks associated with these products and discuss best practices for complication management.Learning Objectives: Review the development, properties, and regulatory approval of various soft-tissue fillers and their implications for clinical use.Examine the non-aesthetic applications of soft-tissue fillers in..."

Clinical • Aesthetic Medicine • Otorhinolaryngology

Post-Menopause Skin Rejuvenation Study (clinicaltrials.gov) - P4 | N=50 | Recruiting | Sponsor: Erevna Innovations Inc.

New P4 trial

Effectiveness and Safety of a Cross-Linked Hyaluronic Acid Plus Mannitol Filler for the Correction of Nasolabial Folds in Chinese Subjects: A Randomized, Blinded, Controlled Study. (PubMed, Aesthet Surg J) - "Non-inferiority of the investigational device versus the comparator in correcting NLFs in Chinese subjects was demonstrated. Results up to 12 months suggest comparable safety and effectiveness profiles."

Journal • Aesthetic Medicine