lidocaine injection / Generic mfg. - LARVOL DELTA

[PREPRINT] Effect of intravenous lidocaine dose on pain upon awakening in pediatric tonsillectomy: A randomized trial (medRxiv) - P=NA | N=200 | "The primary outcome was pain on awakening, while secondary outcomes included pain scores at 1, 4, 12, and 24 h after awakening; incidences of laryngospasm, bronchospasm, or perioperative stridor; and time to extubation. Intraoperative cardiac events were classified as safety events. Our findings indicated that intravenous lidocaine dose-dependently reduced pain on awakening, with the median effective dose being 1.75 mg/kg. Significant differences were observed between groups A and D (P ≤ 0.001). No incidents of laryngospasm, bronchospasm, or perioperative stridor were observed. Furthermore, there were significant between-group differences in time to extubation (P ≤ 0.05)."

Clinical data • Preprint • CNS Disorders • Pain

[PREPRINT] A randomised controlled trial of the effect of intra-articular lidocaine on pain scores in inflammatory arthritis (medRxiv) - P=NA | N=80 | NCT05302232 | "The placebo effect of intra-articular injection was low. Post lidocaine injection, those in the high painDETECT group had an NRS score 2.2 points higher than those in the low painDETECT group (p=0.03). In the replication sample, post lidocaine NRS scores were significantly higher in those with a high painDETECT score, fibromyalgia, and low-pressure pain threshold at the trapezius (p=0.002, p=0.001, p=0.005 respectively)."

Clinical data • Preprint • Anesthesia • Pain