deferoxamine / Generic mfg. - LARVOL DELTA

A programmed oxidized alginate/chitosan sandwich-layered dressing for sequential regulation of diabetic wound healing. (PubMed, Int J Biol Macromol) - "Meanwhile, the inner electrospun PLGA nanofiber membrane provides sustained deferoxamine (DFO) release, which was associated with increased HIF-1α expression and enhanced angiogenesis during the proliferative phase...In diabetic wound models, DFOPLGA@CGel reduced intracellular oxidative stress, increased angiogenesis-related signals and vessel density, and accelerated wound-area reduction. Overall, this work highlights the importance of temporal regulation in biomaterial design and presents a promising platform for precise microenvironment modulation and chronic wound therapy."

Journal • Inflammation • HIF1A

Neodymium Nitrate Suppresses Malignant Phenotypes in Hep-G2 Cells by Targeting Nrf2 to Inhibit EMT and Induce Ferroptosis. (PubMed, Toxics) - "Nrf2 overexpression reversed the suppression of migration, invasion, EMT-associated markers, and ferroptotic phenotypes, while the ferroptosis inhibitor deferoxamine rescued migration and invasion. These findings suggest that Nd(NO3)3 exerts anti-malignant effects in Hep-G2 cells by targeting Nrf2 to coordinately suppress EMT and promote ferroptosis, identifying the Nrf2-ferroptosis axis as a potential therapeutic target in HCC cells. However, these findings are based on in vitro experiments in a single Hep-G2 cell line with n = 3 biological replicates, which limits statistical power and generalizability; the results should therefore be interpreted as preliminary evidence requiring further validation in additional cell lines and in vivo models."

Journal • Hepatocellular Cancer • Oncology • Solid Tumor • CDH1 • GPX4 • NFE2L2 • VIM

Polyphenols-functionalized hydroxyapatite nanocomposites/carbohydrazide grafted gelatin/oxidized dextran adhesive hydrogel with osteogenic and angiogenic activity for bone defect repair. (PubMed, Biomater Adv) - "To address these challenges, we report an injectable adhesive hydrogel synergizing tannic acid-functionalized hydroxyapatite nanocomposites and deferoxamine to remodel microenvironment for bone defect repair...Immunohistochemical evaluation confirmed enhanced neovascularization in vivo. Hence, this work developed an injectable adhesive hydrogel as a promising bone adhesive for bone defect repair through material-mediated microenvironment with synergistic multifunctionality in osteogenesis and angiogenesis."

Journal

Samm50 Downregulation-Driven Mitochondrial Dysfunction Triggers Ferroptosis and Contributes to Ketamine-Induced Neurotoxicity and Cognitive Impairment. (PubMed, Neuropharmacology) - "In vitro, ferroptosis inhibitors Fer-1 and deferoxamine (DFO) reversed ketamine-induced cell death, Fe2+ overload, LPO, and MMP loss, but Fer-1 failed to restore ATP or Samm50 expression. MitoQ rescued ATP, MMP, and ROS...Collectively, ketamine induces hippocampal neurotoxicity and cognitive impairment via a two-step mechanism: it first downregulates Samm50, leading to primary mitochondrial dysfunction (energy failure and oxidative stress); this mitochondrial impairment then triggers ferroptosis through iron accumulation and suppression of GPX4/SLC7A11. Samm50 downregulation serves as a critical upstream event linking mitochondrial dysfunction to ferroptosis, representing a novel therapeutic target for ketamine-induced neuropsychiatric toxicity."

Journal • Alzheimer's Disease • Cognitive Disorders • Metabolic Disorders • Psychiatry • GPX4 • SLC7A11 • TFRC

PINK1-Associated Mitophagy Protects Against Cisplatin-Induced Ototoxicity by Regulating the Subcellular Distribution of ACSL4. (PubMed, Cells) - "Pharmacological activation of mitophagy or PINK1 overexpression alleviated ferroptosis in vitro, while deferoxamine treatment reduced cisplatin-induced hearing loss and blood-labyrinth barrier damage in vivo. These findings support a model in which impaired PINK1-associated mitophagy contributes to cytosolic ACSL4 accumulation and ferroptotic injury. Modulating mitophagy and ACSL4 subcellular distribution may represent a potential strategy for mitigating cisplatin-induced ototoxicity."

Journal • Hematological Disorders • Otorhinolaryngology • ACSL4 • GPX4 • PINK1

A transferrin receptor-targeted liposome for iron metabolism regulation-augmented photodynamic therapy in glioblastoma. (PubMed, Bioact Mater) - "Here, we developed a transferrin receptor (TfR)-targeted liposome (AD@LST) that co-delivers 5-ALA and the iron chelator deferoxamine (DFO) for tumor-targeted PpIX biosynthesis and augmented PDT in GBM...Furthermore, iron deprivation by AD@LST counteracts heme-mediated antioxidant defenses and reduces mitochondrial oxygen consumption, markedly further improving PDT efficacy. In subcutaneous GBM models, AD@LST enables fluorescence imaging-guided repeated PDT with efficient tumor suppression. This liposome demonstrates great potential in clinical translational applicability."

Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • CPOX

Hyaluronic Acid-Deferoxamine Improves Mandibular Bone Repair in an Irradiated Murine Fracture Model (ACS-CLINCON 2026) - "Abstract is embargoed at this time."

Preclinical • Musculoskeletal Diseases • Orthopedics

Hyaluronic Acid-Deferoxamine Improves Vascularity and Healing in a Murine Model of Femoral Fracture Repair (ACS-CLINCON 2026) - "Abstract is embargoed at this time."

Preclinical • Musculoskeletal Diseases • Orthopedics

Realgar Transforming Solution Triggers Ferroptosis-Associated Death in NB4 Leukemia Cells through Disruption of Iron Homeostasis and Suppression of the SLC7A11/GPX4 Axis. (PubMed, Biol Pharm Bull) - "NB4 cells were treated with RTS, arsenic trioxide (ATO), or realgar, and cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Moreover, ferrostatin-1 and deferoxamine mesylate partially rescued RTS-induced cytotoxicity and alleviated oxidative damage and iron overload. These results indicate that RTS induces ferroptosis-associated cell death in NB4 cells by disrupting iron homeostasis and inhibiting the SLC7A11/GPX4 axis, supporting further investigation of RTS as a modernized arsenic-based anti-leukemic formulation."

Journal • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • GPX4 • HMOX1 • IREB2 • NCOA4 • SLC7A11 • TFRC

Induction of transferrin receptor 1-mediated ferroptosis by ultrasound-triggered microbubble destruction sensitizes glioblastoma to radiotherapy. (PubMed, Mol Biomed) - "Suppression of ferroptosis by ferrostatin-1 or deferoxamine abolished UTMD-induced radiosensitization in GBM cells, whereas blockade of apoptosis, autophagy, or necroptosis showed no significant effect...In GBM-bearing C57BL/6J and NOD-SCID mouse models, UTMD similarly upregulated TFR1 expression, triggered ferroptosis, and sensitized tumors to IR, and these effects were reversed by TFR1 knockdown. In conclusion, UTMD promoted the radiosensitivity of GBM partially by induction of TFR1-mediated ferroptosis, providing novel insights into the mechanism underlying UTMD-mediated radiosensitization."

Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • ACSL4 • GPX4 • TFRC

Pulsed electromagnetic fields induce ferroptosis in osteosarcoma cells and promote osteogenic differentiation. (PubMed, J Bone Oncol) - "The above-mentioned phenotypes could be partially reversed by the ferroptosis inhibitor deferoxamine (DFO)...The adopted electromagnetic-field parameters and frequency range are relatively limited. Further multi-parameter optimization and validation in larger-scale animal models are required."

Journal • Oncology • Osteosarcoma • Sarcoma • Solid Tumor • GPX4 • SLC7A11

Comparative and Subtractive Genomics Analysis of Multidrug-Resistant Klebsiella pneumoniae Strains for Novel Target Identification and Drug Repurposing Strategies. (PubMed, Int J Microbiol) - "Subsequent molecular dynamics simulations, including root mean square deviation (RMSD), root mean square fluctuation (RMSF), radius of gyration (Rg), hydrogen-bond occupancy, principal component analysis (PCA), and PCA-based free energy landscape (FEL) analyses, consistently identified tenapanor, micafungin, deferoxamine, and cobicistat as the most stable protein-ligand complexes, with tenapanor exhibiting the most favorable overall structural and thermodynamic stability profile. These findings identify accD as a promising therapeutic target in MDR K. pneumoniae and suggest several FDA-approved compounds as potential candidates for drug repurposing. Although experimental validation is needed to confirm their biological activity and therapeutic potential, this study demonstrates the potential of integrating comparative genomics with molecular dynamics analyses to support antimicrobial target identification and drug repurposing against MDR bacterial pathogens."

Journal • Infectious Disease • Pneumonia

Inhibiting ferroptosis alleviates cold-induced injury in porcine lung tissue slices (TTS 2026) - " To evaluate the role of ferroptosis in lung tissue viability during SCS, PCLS were incubated with LPD or LPD supplemented with either Liproxstatin-1 (LIP-1), a ferroptosis inhibitor, or Deferoxamine (DFO), an iron chelator... Inhibiting ferroptosis during SCS significantly protects PCLS viability and cellular activity. Future studies will examine additional markers of ferroptosis to investigate the underlying mechanisms of cold-induced injury, which could aid the development of optimized preservation solutions to expand the donor pool of transplantable lungs."

Preclinical • Cardiovascular • Reperfusion Injury • ANXA2 • CXCL8 • HMGB1

β-Amyloid and Glutathione Dysregulation Cooperatively Drive Lipid Peroxidation and Ferroptosis in Neuron-Like Cells. (PubMed, Free Radic Biol Med) - "Cell death was prevented by ferrostatin-1, liproxstatin-1, and the iron chelator deferoxamine, but not by the pan-caspase inhibitor Z-VAD-FMK, confirming an iron-dependent ferroptotic mechanism...Pharmacological inhibition of lysosomal function with bafilomycin A1 or treatment with the CMA inhibitor polyphyllin D rescued cell viability under these conditions. Collectively, these findings suggest a potential association among CMA activation, reduced GPX4 abundance, and increased susceptibility to ferroptotic cell death, providing new insight into how age-related redox imbalance may contribute to neuronal vulnerability in AD."

Journal • Alzheimer's Disease • CNS Disorders • GPX4

Design, synthesis and mechanism study of fluorine-containing bulbocapnine derivatives inducing ferroptosis for anti-colon Cancer therapy. (PubMed, Int Immunopharmacol) - "Ferrostatin-1 (Fer-1) and Deferoxamine (DFO) could antagonize this process by inhibiting oxidative stress and iron homeostasis imbalance...They also further elucidate the mechanism by which the drug molecule inhibits colorectal cancer through ferrocide. Taken together, the novel drug based on bulbocapnine exhibited potent inhibitory effects on colon cancer cells, which may provide a proof-of-concept basis for B1 and B6 as ferroptosis inducers specifically in the HT-29 colorectal cancer model, warranting further evaluation in broader preclinical models to assess their translational potential."

Journal • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • GPX4

Ebselen sensitizes multidrug-resistant cancer cells to doxorubicin by disrupting cellular redox homeostasis and inducing ferroptosis. (PubMed, Life Sci) - "Ebselen sensitizes MDR cancer cells to doxorubicin by targeting the TrxR-NRF2/Keap1 axis, disrupting redox homeostasis, inducing iron-dependent ferroptosis and suppressing drug efflux. These findings identify TrxR as a promising therapeutic target for overcoming chemoresistance."

Journal • Oncology • ABCB1 • ACO1 • GPX4 • NQO1 • TFRC

Prodrug-like Quinone Containing Two Redox-Active Centers Induces Ferroptosis in Prostate Cancer Cells with Cytotoxic Action Partially Depending on NAD(P)H Quinone Dehydrogenase 1 (NQO1). (PubMed, ACS Omega) - "Evidence of membrane damage, ROS generation, lipid peroxidation, and reversal by deferoxamine indicated ferroptosis induction by 4, whereas 1 triggered caspase-3-dependent apoptosis...Docking and enzymatic assays confirmed partial dependence on NQO1, with 4 showing greater ROS production despite lower enzymatic activity. Overall, compound 4 highlights the potential of dual-redox quinone platforms to induce ferroptosis, providing a viable lead candidate for novel antineoplastic drug discovery in prostate cancer and other malignancies."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • CASP3 • NQO1

Cell Surface Expression and PET Imaging Establish DLL3 as a Clinically Actionable Target in Neuroblastoma. (PubMed, J Nucl Med) - "To assess in vivo tumor accessibility, DLL3-targeted PET imaging with [89Zr]Zr-deferoxamine-SC16.56 was performed in patient-derived xenograft (PDX) models and in 4 patients with neuroblastoma...DLL3-targeted PET imaging demonstrated tumor-specific uptake in PDX models and in 4 patients with relapsed neuroblastoma, confirming in vivo accessibility of DLL3. DLL3 overexpression in neuroblastoma is associated with targetable cell surface localization, supporting DLL3 as a clinically actionable target for imaging and therapeutic strategies."

Journal • Lung Cancer • Neuroblastoma • Oncology • Pediatrics • Solid Tumor • DLL3

INOVA-2023-159: Early Screening and Treatment of Heart Complication in Sickle Cell Disease (clinicaltrials.gov) - P2 | N=100 | Recruiting | Sponsor: Inova Health Care Services | Trial completion date: Jun 2027 ➔ Dec 2027 | Trial primary completion date: Jun 2026 ➔ Jun 2027

Trial completion date • Trial primary completion date • Genetic Disorders • Hematological Disorders • Sickle Cell Disease

Iron-Deprivation Liposomes for Cancer Therapy. (PubMed, Angew Chem Int Ed Engl) - "Although deferoxamine can effectively chelate iron, its clinical application is limited by poor membrane permeability, short half-life, and lack of targeting capability. In addition, the iron-deprivation liposomes can encapsulate anticancer drugs such as doxorubicin, leading to an enhanced antitumor effect through the combination of iron deprivation and chemotherapy for osteosarcoma treatment. In summary, the "iron-deprivation" liposomes integrate iron chelation, imaging functionality, and chain-length-dependent cellular uptake into a versatile nanoplatform for regulating tumor iron homeostasis and achieving enhanced antitumor efficacy through multimodal therapeutic strategies."

Journal • Oncology • Osteosarcoma • Sarcoma • Solid Tumor

Preclinical evaluation of 68Ga-labelled Pt(IV)-DFO complexes as PET-imaging agents for osteosarcoma. (PubMed, Eur J Med Chem) - "In this study, four Pt(IV)-deferoxamine (DFO) complexes (A-D) were evaluated as gallium-68 radiolabelled imaging agents in healthy mice and in a murine osteosarcoma model using positron emission tomography (PET)...Among the investigated complexes, [68Ga]Ga-D provided the highest tumour-to-background contrast with the most desirable pharmacokinetic profile and in vivo stability, making it the most promising candidate for future studies. Overall, these results demonstrate that Pt(IV)-DFO complexes retain their in vivo tumour-targeting capabilities, supporting their potential use as PET-based imaging agents for osteosarcoma."

Journal • Preclinical • Oncology • Osteosarcoma • Sarcoma • Solid Tumor

Sanguinarine chloride inducing ferroptosis and downregulating GPX4 expression in liver cancer: An integrated in silico, in vitro and in vivo study. (PubMed, Exp Ther Med) - "SC-induced cell death was partially rescued by the ferroptosis inhibitors ferrostatin-1 and deferoxamine, further supporting the involvement of ferroptosis. Consistently, in a xenograft model, SC suppressed GPX4 expression, promoted ferroptosis and significantly inhibited tumor growth. Collectively, these findings indicate that SC exerts antitumor effects in liver cancer, at least in part, by inducing ferroptosis through GPX4 downregulation, supporting further investigation of SC as a potential therapeutic candidate."

Journal • Preclinical • Liver Cancer • Oncology • Solid Tumor • GPX4

Acute hyperglycemia after intracerebral hemorrhage is associated with 90-day cognitive impairment. (PubMed, Cerebrovasc Dis) - "The association between admission hyperglycemia and cognition indicates that acute hyperglycemia may identify patients at heightened risk of cognitive decline, underscoring the need for further studies to determine whether aggressive glycemic control mitigates post-ICH cognitive impairment."

Journal • Alzheimer's Disease • Cardiovascular • Cerebral Hemorrhage • Cognitive Disorders • Coronary Artery Disease • Diabetes • Hematological Disorders • Ischemic stroke

Mitophagy-mediated ferroptosis involved in 2,5-hexanedione-induced neurotoxicity in rats. (PubMed, J Environ Sci (China)) - "Ferroptosis involvement was assessed using the iron chelator deferoxamine (DFO) and the ferroptosis inhibitor Ferrostatin-1. The potential role of mitophagy in HD-induced ferroptosis was evaluated by monitoring mitophagy markers and by autophagy inhibition with chloroquine (CQ)...These findings demonstrate that HD induces neuronal ferroptosis via mitophagy activation. Inhibition of ferroptosis or mitophagy effectively attenuates HD-induced neurotoxicity, suggesting potential therapeutic strategies to reduce neural damage from environmental n-hexane exposure."

Journal • CNS Disorders • Pain • BECN1 • GPX4

An Adaptive, Time-Informed, Phenotype-Guided Pharmacological Framework for Severe Traumatic Brain Injury : A Hypothesis-Driven Narrative Review. (PubMed, J Korean Neurosurg Soc) - "Glibenclamide/glyburide and hypertonic sodium lactate produced preliminary imaging or physiological signals without demonstrated functional benefit. Riluzole was neutral in an adult randomized trial, whereas a small study in chronic TBI found that minocycline reduced a neuroinflammatory imaging signal but increased plasma neurofilament light. Metformin and N-acetylcysteine plus probenecid provided exploratory pharmacokinetic, biomarker, or safety data. Amantadine provided phenotype-specific clinical proof of principle in traumatic disorders of consciousness. Cerebrolysin showed mixed human evidence, including a favorable day-90 multidimensional ensemble signal that requires independent replication. Deferoxamine and clemastine remain preclinical...Module activation should require optimized foundational care, a matching phenotype, measurable target activation or engagement, and acceptable systemic safety. This framework prioritizes phenotype-enriched, single-module..."

Journal • CNS Disorders • Vascular Neurology • Plasma NfL