Sanvar (vapreotide) / PharmGKB, Debiopharm, Bausch Health, Eisai - LARVOL DELTA

The influence of somatostatin analogues on the incidence of pancreatic fistulas and postoperative morbidity in patients undergoing pancreatic resection: A Bayesian network meta-analysis. (PubMed, PLoS One) - "While robust evidence confirms the efficacy of octreotide in preventing POPF, a critical concern regarding its inconsistent efficacy within the PD subgroup persists. This variability indicates that the overall clinical benefit of octreotide may be predominantly attributable to its utility in non-PD pancreatic resections."

Clinical • Journal • Retrospective data • Review • Oncology • Pancreatic Cancer • Pancreatitis • Solid Tumor

Investigation into in silico and in vitro approaches for inhibitors targeting MCM10 in Leishmania donovani: a comprehensive study. (PubMed, Mol Divers) - "In vitro experiments also demonstrated a dose-dependent reduction in L. donovani viability for suramin, vapreotide, and pasireotide, with computed IC50 values providing quantitative metrics of their anti-leishmanial efficacy. The research offers a comprehensive understanding of LdMcm10 as a drug target and provides a foundation for further investigations and clinical exploration, ultimately advancing drug discovery strategies for leishmaniasis treatment."

Journal • Preclinical • Infectious Disease • MCM10

Targeting of essential mycobacterial replication enzyme DnaG primase revealed Mitoxantrone and Vapreotide as novel mycobacterial growth inhibitors. (PubMed, Mol Inform) - "Reduced solvent exposure and confined motions of the active centre of DnaG upon complexation with drugs indicated that both drugs led to the closure of the active site of DnaG. From this study's findings, we propose Mitoxantrone and Vapreotide as potential anti-mycobacterial agents, with their novel mechanism of action against mycobacterial DnaG."

Journal • Infectious Disease • Novel Coronavirus Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Octreotide and postoperative pancreatic fistula after pancreaticoduodenectomy: What we know so far? A narrative review. (PubMed, Indian J Cancer) - "Most of the earlier studies used different definitions of POPF and other complications; included patients with varied pancreatic pathologies such as cancer, chronic pancreatitis, and benign lesions; surgical techniques such as pancreaticoduodenectomy, distal pancreatectomy, and other procedures; use of somatostatin and its analogs such as octreotide, lanreotide, pasireotide, and vapreotide; varied surgeon and institutional volume; and so on. Data indicate favorable role of newer somatostatin analogs, and further studies are urgently needed. The question about the efficacy of prophylactic octreotide to reduce POPF after pancreaticoduodenectomy remains open to debate."

Journal • Review • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Pancreatitis • Solid Tumor

"Shuddhi ki utpatti ko sanvar kahte hai,shuddhi ki vradhhi ko nirjara kahte hai&shudhhi ki purta ko moksha kahte hai(starting of pure utilization is sanvar,continuously increasing purity of utilization is K/A Nirzara&comple pure utilization is salvation).Mai dhyaya ho,shradheya ho" (@singhv2003)

Neuroprotective Effects of Vapreotide on Tau Transfection-Induced Neurodegeneration. (PubMed, Neurotox Res) - "In viability experiments using 10 µM Memantine as a positive control, it was observed that Vapreotide at 50 µM (p < 0.0001) and 100 µM (p < 0.05) had a protective effect on cell viability, 100 µM CYN154806 was found to decrease (p < 0.05) cell viability. With the qRT-PCR method, it was found that Vapreotide, decreased the BAX/BCL2 (50 µM-p < 0.001; 100 µM-p < 0.01; 200 µM-p < 0.001) expression level and decreased the expression level (50 µM-p < 0.01; 100 µM-p < 0.01; 200 µM-p < 0.001) of the APOE4 gene, which constitutes a genetic risk for AD. This study demonstrates a potential therapeutic role for a somatostatin analogue Vapreotide in Alzheimer's disease."

IO biomarker • Journal • Alzheimer's Disease • CNS Disorders • BAX • BCL2 • MAPT

"View this paper via: https://t.co/gp4VAQkmtK😋 @sanvarmamd @Sunny_PatelMD @RKaragozian @ReshamRamMD @DonaldJensenMD @TienDongMD @DaveHarman13 @augustoNYC @NDP1001 @jlouissaint89 @hevargasmd @Dr_AlRubaiy" (@MetabolismAnd)

"Fachseminar #BAHAkademie am 09.11.: #Pharmakovigilanz und #Digitalisierung. Mit: Anika Buschmann, Sanvartis; Sheila Elz @Bayer; Imke Simmchen-Wittekopf @EArzneimittel; @NicoleTappee, MCG Medical Consulting Group und @ProfThun, @berlinnovation. Mehr Infos: https://t.co/p1EgjyL2zV" (@BAH_digital)

Do somatostatin-analogues have the same impact on postoperative morbidity and pancreatic fistula in patients after pancreaticoduodenectomy and distal pancreatectomy? - A systematic review with meta-analysis of randomized-controlled trials. (PubMed, Pancreatology) - "Somatostatin analogues did not affect POPF and clinically relevant POPF after PD, but seemed to be associated with less POPF after DP. As no sufficiently powered RCT could be identified by the systematic review, further RCTs are urgently needed to investigate the effect of somatostatin analogues after DP."

Journal • Retrospective data • Review

"Don’t play. You didn’t date @Casanvar" (@BrowofJustice)

State-of-the-art tools unveil potent drug targets amongst clinically approved drugs to inhibit helicase in SARS-CoV-2. (PubMed, Arch Med Sci) - "The functional binding pockets of the clinically approved drugs on SARS-CoV-2 helicase protein molecule suggest that vapreotide and atazanavir may interrupt the activities of the SARS-CoV-2 helicase. The study suggests that vapreotide may be a choice of drug for wet lab studies to inhibit the infection of SARS-CoV-2."

Clinical • Journal • Immunology • Infectious Disease • Novel Coronavirus Disease

A plausible Way for Excretion of Metal Nanoparticles via Active Targeting. (PubMed, Drug Dev Ind Pharm) - "To reach this goal, PEGylated quantum dots (QDs) were coated with vapreotide (VAP) for selectively reaching somatostatin receptors (sstrs) expressed in the podocyte...This study confirms that QDs-VAP can target the podocytès sstrs then can be cleared via podocyte cells. Moreover, these results are considered a highly promising approach for future therapy, targeting, clearance, and diagnosis of podocyte-associated diseases."

Journal

The Use of  Prophylactic Somatostatin Therapy Following Pancreaticoduodenectomy: A Meta-analysis of Randomised Controlled Trials. (PubMed, World J Surg) - "SA did not improve the post-operative outcomes following PD, including reducing the incidence of POPF. The routine administration of SA cannot be recommended following PD."

Journal • Retrospective data • Review

Green Dual-template Synthesis of AgPd Core-shell Nanoparticles with Enhanced Electrocatalytic Activity. (PubMed, Nanotechnology) - "The main reasons are that the AgPd-5 possessed excellent specific surface area due to their rough structure, and Ag can remove more CO-like species. Based on Vapreotide acetate/Ag-template method to synthesize AgPd core-shell structure is the first time, which would have broad application prospects for the direct ethanol fuel cells."

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