TGN-1062
/ TGen
- LARVOL DELTA
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February 05, 2025
Targeting RNA Modification and Mitochondrial Metabolism Crosstalk in Leukemic Stem Cells with CDK7 Inhibitor TGN-1062.
(PubMed, Blood Adv)
- No abstract available
Journal
March 06, 2024
TGN-1062, a dual CDK7 and FLT3 Inhibitor, shows potent anti-AML activity and synergizes with Venetoclax
(AACR 2024)
- "Since its approval venetoclax, a BCL2 inhibitor, has been the standard treatment for older patients in combination with a hypomethylating agent (HMA), such as azacitidine or decitabine, with a 76% complete response (CR). Targeting CDK7 with TGN-1062 in combination with venetoclax or an HMA is a promising therapeutic approach for treatment of AML and needs further investigation."
IO biomarker • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • CDK7 • MYC
March 14, 2023
Inhibition of CDK7 using small molecule inhibitor, TGN-1062, augments the effect of cisplatin treatment in head and neck PDX models
(AACR 2023)
- "While there are some successful treatments, like use of cetuximab in patients with EGFR expressing tumors, there is still a major unmet need in this area. Targeting CDK7 with TGN-1062 in combination with SOC therapy is a promising approach for treatment of HNSCC. TGN-1062 is a potent CDK7 inhibitor with potential for clinical development."
IO biomarker • Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • BCL2 • CDK7 • EGFR
March 09, 2022
TGN-1062 inhibits CDK7 and augments the effects of gemcitabine and nab-paclitaxel in pancreatic cancer models
(AACR 2022)
- "Our potent and selective small molecule inhibitor of CDK7, TGN-1062, shows promise in pancreatic cancer models as a single or in combination with SOC . Preliminary data suggests that TGN-1062 can be developed further in multiple cancer indications."
IO biomarker • Preclinical • Acute Myelogenous Leukemia • Gastrointestinal Cancer • Lung Cancer • Oncology • Pancreatic Cancer • Solid Tumor • BCL2 • CASP3 • CDK7 • MYC
March 11, 2021
[VIRTUAL] Preclinical studies with TGN-1062, a selective and reversible small molecule inhibitor of CDK7
(AACR 2021)
- "TGN-1062 is a novel, selective, and reversible inhibitor of CDK7 and has significant antitumor activity in vivo. TGN-1062 is a potent CDK7 inhibitor with potential for clinical development."
IO biomarker • Preclinical • Acute Myelogenous Leukemia • Lung Cancer • Neuroendocrine Tumor • Oncology • Ovarian Cancer • Small Cell Lung Cancer • Solid Tumor • BAX • BCL2 • CDK7 • MCL1 • MYC
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