Repretin (epoetin alfa biosimilar) / SEDICO, Rotapharm - LARVOL DELTA

Benign Keratoses With Inverted Follicular Keratosis-Like Features in a Patient Receiving Ripretinib: A Case Report. (PubMed, J Cutan Pathol) - "Inverted follicular keratosis (IFK) is a rare benign neoplasm of the follicular infundibulum and typically presents as a solitary, nonpigmented verrucous papule on the head and neck of older males and can mimic viral warts, basal cell carcinoma (BCC), or squamous cell carcinoma (SCC). To the best of our knowledge, this represents the first reported association between repretinib treatment and benign keratoses with IFK-like features. Further studies are needed to clarify the clinical significance and biological implications of this observation."

Journal • Actinic Keratosis • Basal Cell Carcinoma • Dermatology • Gastrointestinal Stromal Tumor • Melanoma • Non-melanoma Skin Cancer • Oncology • Sarcoma • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma • PDGFRA

IDENTIFICATION OF NEW POTENTIAL DRUGGABLE TARGETS IN GASTROINTESTINAL STROMAL TUMOR (GIST) THROUGH RNA SEQUENCING ANALYSIS (AIOM 2022) - "Imatinib, a tyrosinekinase inhibitor is the standard treatment for GISTs; however, many patients develop resistance to this drug and to sunitinib, regorafenib and repretinib (used as second, third and fourth lines of treatment) and so identification of new potential pharmacological targets remains an unmet clinical need. TOP2A may represent a novel druggable target in GIST; further studies will be needed to better understand its role in the carcinogenesis process."

Gastrointestinal Cancer • Gastrointestinal Disorder • Gastrointestinal Stromal Tumor • Oncology • Sarcoma • TOP2A