SN-2000 / Stream Neuroscience - LARVOL DELTA

Genetic dissection of seedling resistance to septoria nodorum blotch resistance in a nested association mapping panel derived from synthetic hexaploid wheat lines and bread wheat. (PubMed, Plant Dis) - "We screened the population using two P. nodorum isolates (Sn4 and Sn2000) and three necrotrophic effectors (SnToxA, SnTox1, and SnTox3)...The SHW lines SW91 and SW93, as well as HRSW cultivars 'Bolles' and 'Linkert', and their progenies consistently showed increased resistance compared to other backgrounds. These lines, carrying novel SNB resistance loci derived from cultivated emmer and Aegilops tauschii, provide valuable germplasm for improving SNB resistance in wheat breeding programs."

Journal

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development. (PubMed, Epilepsia) - "These include AUT00206, a positive allosteric modulator of Kv3.1 and Kv3.2 voltage-gated potassium channels in development for the treatment of rare epilepsy syndromes as well as neurodevelopmental and neuropsychiatric disorders; ION283, an antisense oligonucleotide designed to suppress the expression of glycogen synthase 1, under investigation for the treatment of Lafora disease; MSCA-7136, a selective allosteric RAS/mitogen-activated protein kinase-extracellular signal regulated kinase (MEK) inhibitor being developed for the treatment of focal seizures associated with mesial temporal lobe epilepsy and seizures associated with tuberous sclerosis complex; OV329, a selective inhibitor of γ-aminobutyric acid (GABA) aminotransferase, in development for the treatment of drug-resistant focal seizures; PTI5803 (probenecid), an uricosuric agent and a blocker of pannexin 1 channels, repurposed as a treatment for seizures associated with focal cortical dysplasia; simufilam, a..."

Journal • Preclinical • CNS Disorders • Developmental Disorders • Epilepsy • Mental Retardation • Psychiatry