pasylated uricase (HZN-007) / XL-protein, Amgen - LARVOL DELTA

Computational Approach for Rational Design of Fusion Uricase with PAS Sequences. (PubMed, Int J Mol Cell Med) - "In this study, several variants of PASylated uricase from the Aspergillus flavus species were analyzed computationally to find the appropriate fusions to solve short half-life and stability concern...Molecular docking results showed that the highest binding affinity to uric acid belonged to uricase-PAS1-100 by the formation of six hydrogen and four non-hydrogen bonds. Altogether, the results indicated that the PASylation process would be promising upon the production of urate oxidase with improved solubility and stability."

Journal • Oncology