GRT-R910
/ Gritstone bio, The University of Manchester
- LARVOL DELTA
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October 23, 2023
Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy Adults
(clinicaltrials.gov)
- P1 | N=81 | Completed | Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) | Active, not recruiting ➔ Completed
Trial completion • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • CD4 • CD8 • IL10 • TNFA
September 06, 2023
Preliminary results of durable immune response induced by a self-amplifying mRNA (samRNA) SARS-CoV-2 vaccine candidate, GRT-R910, in adults previously vaccinated with mRNA or AZD1222 primary series
(IDWeek 2023)
- No abstract available
Clinical • Infectious Disease • Novel Coronavirus Disease
September 06, 2023
An Interim Report of the Safety, Reactogenicity, and Immunogenicity of a Self-amplifying mRNA (samRNA) COVID-19 Vaccine GRT-R910 as a Booster in Healthy Adults
(IDWeek 2023)
- No abstract available
Clinical • Infectious Disease • Novel Coronavirus Disease
June 07, 2023
GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults.
(PubMed, Nat Commun)
- P1 | "GRT-R910 increased and/or broadened functional Spike-specific T cell responses and primed functional T cell responses to conserved non-Spike epitopes. This study is limited due to small sample size, and additional data from ongoing studies will be required to corroborate these interim findings."
Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • IFNG
June 08, 2023
Study of GRT-R910 COVID-19 Boost Vaccine in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=40 | Completed | Sponsor: Gritstone bio, Inc. | Active, not recruiting ➔ Completed
Trial completion • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • IFNG
May 19, 2023
Study of GRT-R910 COVID-19 Boost Vaccine in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=40 | Active, not recruiting | Sponsor: Gritstone bio, Inc. | Trial completion date: Jan 2024 ➔ May 2023 | Trial primary completion date: Jan 2024 ➔ May 2023
Trial completion date • Trial primary completion date • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • IFNG
February 04, 2023
First study of a self-amplifying mRNA (samRNA) vaccine, GRT-R910, as a COVID-19 boost in healthy volunteers ≥60 years of age: preliminary evidence of sustained immunogenicity
(ECCMID 2023)
- No abstract available
Clinical • Infectious Disease • Novel Coronavirus Disease
December 16, 2022
Study of GRT-R910 COVID-19 Boost Vaccine in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=40 | Active, not recruiting | Sponsor: Gritstone bio, Inc. | Recruiting ➔ Active, not recruiting | N=120 ➔ 40
Enrollment change • Enrollment closed • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • IFNG
October 17, 2022
Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy Adults
(clinicaltrials.gov)
- P1 | N=81 | Active, not recruiting | Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) | Recruiting ➔ Active, not recruiting | N=135 ➔ 81
Enrollment change • Enrollment closed • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • CD4 • CD8 • IL10 • TNFA
September 08, 2022
Title: A novel low-dose self-amplifying mRNA vaccine (GRT-R910) induces strong and broad boost in cellular and humoral immune response following primary series with a chimpanzee adenovirus SARS-CoV-2 vaccination
(IDWeek 2022)
- No abstract available
Preclinical • Infectious Disease • Novel Coronavirus Disease
September 27, 2022
Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy Adults
(clinicaltrials.gov)
- P1 | N=135 | Recruiting | Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) | Trial completion date: Sep 2022 ➔ Oct 2023 | Trial primary completion date: Sep 2022 ➔ Oct 2023
Trial completion date • Trial primary completion date • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • CD4 • CD8 • IL10 • TNFA
August 08, 2022
Study of GRT-R910 COVID-19 Boost Vaccine in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=120 | Recruiting | Sponsor: Gritstone bio, Inc. | N=20 ➔ 120 | Trial completion date: Jan 2023 ➔ Jan 2024 | Trial primary completion date: Jan 2023 ➔ Jan 2024
Enrollment change • Trial completion date • Trial primary completion date • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • IFNG
January 11, 2022
Study of GRT-R910 COVID-19 Boost Vaccine in Healthy Volunteers
(clinicaltrials.gov)
- P1; N=20; Recruiting; Sponsor: Gritstone Bio, Inc.; N=120 ➔ 20
Clinical • Enrollment change • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • IFNG
December 08, 2021
Study of GRT-R910 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Boost Vaccine in Healthy Volunteers
(clinicaltrials.gov)
- P1; N=120; Recruiting; Sponsor: Gritstone Oncology, Inc.
Clinical • New P1 trial • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • IFNG
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