sumatriptan succinate transdermal (KC5010) / Kimberly-Clark, Sorrento - LARVOL DELTA

Evaluation of Gum Arabic Double-layer Microneedle Patch Containing Sumatriptan for Loading and Transdermal Delivery. (PubMed, Curr Drug Deliv) - "The release amount of drug from 12 patches made of the prepared microneedles was comparable to that of subcutaneous injection, providing a new possibility for migraine treatment."

Journal • CNS Disorders • Migraine • Pain

Sofusa System With Sumatriptan (KC5010) Phase 1 Dose Escalation Safety and PK Study (KCC-SMT-002) (clinicaltrials.gov) - P1 | N=19 | Completed | Sponsor: Sorrento Therapeutics, Inc. | Unknown status ➔ Completed

Trial completion • CNS Disorders • Migraine

Sorrento Announces Clinical Research Agreement With Mayo Clinic and FDA Clearance for the First Phase 1b Pilot Study Using Sofusa Lymphatic Drug Delivery Technology to Deliver Ipilimumab in Patients With Melanoma (GlobeNewswire) - "Sorrento Therapeutics, Inc...announced a research collaboration agreement with Mayo Clinic to conduct human clinical proof of concept studies using the Sofusa Lymphatic Drug Delivery System (S-LDDS) technology across multiple products and indications...The first study resulting in this agreement is MC20711, a Phase 1b study of the administration of Ipilimumab Intra-Lymphatically using the Sofusa® DoseConnect™ in Patients with Metastatic Melanoma....This is an investigator-initiated study developed by Svetomir Markovic..."

Licensing / partnership • Melanoma • Oncology

Study to Assess the Safety and Efficacy of Enbrel Administered by Sofusa DoseConnect for Rheumatoid Arthritis (clinicaltrials.gov) - P1b; N=10; Recruiting; Sponsor: Sorrento Therapeutics, Inc.; Trial completion date: Apr 2021 ➔ Apr 2022; Trial primary completion date: Apr 2021 ➔ Apr 2022

Clinical • Trial completion date • Trial primary completion date • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Study to Assess the Safety and Efficacy of Enbrel Administered by Sofusa DoseConnect for Rheumatoid Arthritis (clinicaltrials.gov) - P1b; N=10; Recruiting; Sponsor: Sorrento Therapeutics, Inc.; Not yet recruiting ➔ Recruiting

Clinical • Enrollment open • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Study to Assess the Safety and Efficacy of Enbrel Administered by Sofusa DoseConnect for Rheumatoid Arthritis (clinicaltrials.gov) - P1b; N=10; Not yet recruiting; Sponsor: Sorrento Therapeutics, Inc.

Clinical • New P1 trial • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • CRP

Transdermal Delivery of Sumatriptan Succinate Using Iontophoresis and Dissolving Microneedles. (PubMed, J Pharm Sci) - "Tests, carried out with Franz diffusion cells and skin of Göttingen minipigs, showed that small decreases in the polymer concentration led to negligible lag times and marked increases in the cumulative amount of drug permeated in 6 hours (Q) and in the flux (J). At 500 μA/cm, Q and J nearly doubled for a microneedle loaded with 5% (w/w) sumatriptan and 20% (w/w) PVP (Lag Time = 0 min; Q = 2888 μg/cm; J = 490 μg/cm/h) relative to a system loaded with 5% (w/w) drug and 30% (w/w) PVP (Lag Time = 36 min; Q = 1437 μg/cm; J = 266 μg/cm/h)."

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Experimental and Mathematical Study of the Transdermal Delivery of Sumatriptan Succinate from Polyvinylpyrrolidone-based Microneedles. (PubMed, Eur J Pharm Biopharm) - "The calculated diffusion coefficients were one order of magnitude greater than the value estimated when the drug was directly applied to the skin surface. The dissolution rate constant was affected by the concentration of the polymer matrix."

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