Epoyet (epoetin alfa biosimilar) / Procaps, Biogalenic, Delta Farma, Biosidus, Pentafarma - LARVOL DELTA

Treating complex PTSD with Schema Therapy, ImRs and EMDR: a review and case study. (PubMed, Eur J Psychotraumatol) - "The final phase (41-50) emphasized relapse prevention and was used as follow-up. Results showed notable reductions in maladaptive schemas, such as Unrelenting Standards/Hypercriticism and Detached Self-Soother and a decrease in the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) score from severe to below the clinical cut-off for PTSD. While the patient's case demonstrates promising outcomes, further research is needed to establish the efficacy of integrating ST, EMDR and ImRs for CPTSD. A randomized controlled trial is essential to compare this combined approach with each treatment separately and to explore the impact of treatment sequencing. Ultimately, optimizing therapy for CPTSD will require a personalized approach based on individual needs and responses."

Journal • Review • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

The Impact of Childhood Abuse on the Development of Early Maladaptive Schemas and the Expression of Violence in Adolescents. (PubMed, Behav Sci (Basel)) - "The schemas that proved to be the most relevant for the violence factor were those of Punitiveness (PU: 0.89) and Mistrust/Abuse (MA: 0.77), followed by the schemas of Emotional Inhibition (EI: 0.68), Unrelenting Standards/Hypercriticalness (US: 0.63), and Entitlement/Grandiosity (ET: 0.58). The mediation that the Punitiveness schema achieves between victimization in the family and subsequent aggressive behavior is based on the internalization of the punitive parental figure and the victim's development of the belief that violence is the only answer when others do not meet their expectations."

Journal • Mood Disorders

Study of HEMAX PFS Versus EPREX/ ERYPO® in Predialysis Chronic Kidney Disease (clinicaltrials.gov) - P3 | N=43 | Completed | Sponsor: Bio Sidus SA | Active, not recruiting ➔ Completed | N=120 ➔ 43

Enrollment change • Trial completion • Anemia • Chronic Kidney Disease • Hematological Disorders • Nephrology • Renal Disease

Seasonal variations in the phenolic profile, antioxidant activity, and mineral content of south Indian black tea (Camellia sinensis (L.) O. Kuntze). (PubMed, Sci Rep) - "On the other hand, the employed cultivars differed noticeably in terms of seasonal change of minerals. These results appear to indicate that the harvest period is hypercritical in deciding the antioxidant potency of tea crop shoots."

Journal

Pharmacokinetic and pharmacodynamic study of 3 products of epoetin alfa as single subcutaneous dose in healthy volunteers. (PubMed, Fundam Clin Pharmacol) - "The comparison between Hemax® PFS and Eprex® resulted in similar 90%CI for C , AUC and AUC ratios, all of them within the 80-125% interval, with a power above 95% for each ratio. These findings suggest biosimilar patterns for absorption velocity (with Tmax close to 15 h), absorption extent and elimination (with an elimination half-life close to 25-30 h for each formulation)."

Journal • PK/PD data

"You've lost the plot, dude. You have become a bad actor. A hypercritical, obsessive, highly biased hack. The contrarian who NEEDS attention. I am appalled by your obsession and your theses." (@grumpy_NP)

"Academic bullying includes Sharp words Overwork Unfounded hypercriticism Mobbing Threats Withholding information Impossible deadlines Humiliation Isolation @Lotus_STEMM #AcademicTwitter #AcademicChatter #PhdChat #scicomm #ResearchIntegrity #ECRchat #scipol https://t.co/4PZtkqDCIU" (@BRAINCURES)

"symmetrical hyperextension. elevated beighton score. if asymmetrical exam then hypercritical of collaterals and PCL" (@ryvesmooreMD)

Hypercritical stenosis of the right external iliac treated with endovascular lithotripsy without using peripheral stenting (LINC 2022) - No abstract available

Diagnosis of hypercritical chronic pulmonary disorders using dense convolutional network through chest radiography. (PubMed, Multimed Tools Appl) - "The proposed framework shows effective results in classifying lung images into Normal, COVID-pneumonia, pneumonia, and other chronic pulmonary disorders (OCPD). This framework can be effectively utilized in this current pandemic scenario to help the radiologist in substantiating their diagnosis and in starting well in time treatment of these deadly lung diseases."

Journal • Asthma • Chronic Obstructive Pulmonary Disease • Cough • Fibrosis • Immunology • Infectious Disease • Novel Coronavirus Disease • Oncology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Tuberculosis

"No thanks also stop being hypercritical." (@1689Berean)

"Yes! And I can’t watch my recorded talk because I’m hypercritical of myself" (@geetamehta0)

Impact of native and external factors on exosome release: understanding reactive exosome secretion and its biogenesis. (PubMed, Mol Biol Rep) - "The trading of exosomes between tumor and yonder cells plays a hypercritical role in tumor growth and progression...In this review, we will discuss how the non-native physiological factors influence the release of exosomes and how these reactive exosomes orchestrate a unique patterning of a cargo sorting mechanism. We will also discuss the role of reactively secreted exosomes in mediating tumor metastasis, angiogenesis, and tumor progression."

Journal • Review • Oncology

Distinguishing online academic bullying: identifying new forms of harassment in a dissenting Emeritus Professor's case. (PubMed, Heliyon) - "Such scholars may face an asymmetrical challenge in confronting cyber harassment from hypercritical academics and cybermobs on poorly moderated platforms. Universities should therefor consider appropriate countermeasures to protect both the public and their employees against victimisation by academic cyberbullies."

Clinical • Journal

Study of HEMAX PFS Versus EPREX/ ERYPO® in Predialysis Chronic Kidney Disease (clinicaltrials.gov) - P3; N=120; Active, not recruiting; Sponsor: Bio Sidus SA; Recruiting ➔ Active, not recruiting; Trial completion date: Jan 2021 ➔ Jan 2022; Trial primary completion date: Sep 2020 ➔ Jul 2021

Clinical • Enrollment closed • Trial completion date • Trial primary completion date • Anemia • Chronic Kidney Disease • Hematological Disorders • Nephrology • Renal Disease

Evaluation of erythropoietin biosimilars Epotin™, Hemax® and Jimaixin™ by electrophoretic methods used for doping control analysis and specific N-glycan analysis revealed structural differences from original epoetin alfa drug Eprex®. (PubMed, J Pharm Biomed Anal) - "Jimaixin™ and Epotin™ presented also a lower amount of fully sialylated forms. HILIC method also showed that O-acetylation level of sialic acid residues might vary from one rEPO to the other."

Journal • EPO

[VIRTUAL] ANALYSIS OF THE USE OF COMMERCIAL NAMES IN THE MEDICAL REQUIREMENTS OF A UNIVERSITY HOSPITAL COMPARED TO THESE PERFORMED IN THE ONCOLOGY SERVICE (HEMO 2020) - "The following medications were more prescribed: Clexane® (179), Tramal® (123), Hemax® (48) and AAS® (25). Legislation guidelines and recommendations provided, both in national and international literature, are not being complied with, except in the Oncology Service, which constitutes a sanitary infraction at the University Hospital itself. This result points, therefore, a non-conformity when analyzed according to the specific legislation."

Clinical • Hematological Disorders • Oncology

Communication of Critical Laboratory Values: Optimization of the Process through Secure Messaging. (PubMed, Lab Med) - "Secure messaging has facilitated the reporting of critical laboratory values, making it more efficient and providing a reliable record of the process. This process meets or exceeds the standards of the accrediting agencies. The method is suitable for activating rapid-response teams in case of hypercritical values."

Journal

Study of HEMAX PFS Versus EPREX/ ERYPO® in Predialysis Chronic Kidney Disease (clinicaltrials.gov) - P3; N=120; Recruiting; Sponsor: Bio Sidus SA

Clinical • New P3 trial