amikacin sulfate / Generic mfg. - LARVOL DELTA

Less is more: Improving outcomes in haemato-oncology with optimal antibiotic use for febrile neutropenia (ASH 2025) - "Management of FN: Rapid administration of piperacillin-tazobactam and amikacin (Piptaz/Ami) for fever (≥38°C) with neutropenia (≤0.5x10 9 /L or expected neutropenia) after taking BCs...Two patients had relapsed AML, 2 newly diagnosed AML (on Venetoclax/Azacytidine and one on palliative Hydroxycarbamide), and 1 post-haploidentical HSCT for lymphoma... Patient population: 49% had AML/MDS; 66% had active disease (presentation or relapse). Treatment modalities: intensive chemotherapy (37%) autologous (37%) or allogeneic HSCT (13%). Median age was 57 years (23-85)."

Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Cerebral Hemorrhage • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Lymphoma • Myelodysplastic Syndrome • Neutropenia • Pneumonia • Renal Disease

Prevalence, Antibiotic Resistance Pattern, and Molecular Characteristics of Staphylococcus epidermidis Isolated From Milk of Pure Breeds of Dairy Cattle With Subclinical Mastitis. (PubMed, J Trop Med) - "Our antibiogram results underscored a high resistance of S. epidermidis isolates, particularly against cefoxitin (56.25%) and penicillin (43.75%), while demonstrating remarkable susceptibility to amikacin (2.08%), clindamycin (0%), ciprofloxacin (0%), and chloramphenicol (0%). Further research is needed to examine geographic and farm-specific factors affecting S. epidermidis prevalence, and genetic techniques like multilocus sequence typing should be employed to study clonal spread and horizontal gene transfer. Routine antimicrobial sensitivity assessments and continuous monitoring of medication use are essential to develop sustainable strategies against antibiotic resistance in the dairy industry."

Journal • Gene Therapies • Inflammation

Genomic landscape of Mycobacterium tuberculosis: Identifying mutation hotspots and stable regions for implications for drug development. (PubMed, New Microbes New Infect) - "These regions show mostly involved rrs mutations (amikacin, kanamycin, and capreomycin resistance), and rpoA has a compensatory role in rifampicin resistance. The most common nucleotide substitution was G to A (G→A) (16 %), followed by A to G (A→G) and T to C (T→C) (15 %). These findings collectively highlight novel genomic regions of stability and hypervariability, offering insights for refining WGS-based surveillance, resistance prediction, and future drug target prioritization."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Amikacin liposomal inhalation suspension versus injectable streptomycin in patients with refractory pulmonary Mycobacterium avium complex disease: A single-center, retrospective cohort study. (PubMed, Medicine (Baltimore)) - "ALIS and injectable SM had similar sputum culture conversion rates. However, the former had a higher continuation probability than the latter."

Clinical • Journal • Retrospective data • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases

Impact of Plant Growth Promoting Rhizobacteria Exiguobacterium Acetylicum RGK and Enterobacter Mori RGK1 on Growth Parameters and Phytochemicals of Asparagus Racemosus. (PubMed, Curr Microbiol) - "Additionally, has shown antibiotic susceptibility to antibiotics such as Amikacin, Netilin, Co-trimaxazole, Streptomycin, Furazolidone, Kanamycin, Nalidixic acid, Nitrofurantoin, Tobramycin, Oxytetracyclin, Chloramphenicol, Gentamycin and their ability to withstand salt concentration (NaCl) up to 5-6%. As compared to the untreated plants, PGPR-treated plantlets showed higher amounts of secondary metabolites, primarily Diosgenin. The main focus is on the use of multiple microbial strains in a single formulation, an emerging trend in sustainable agriculture."

Journal

Clinical characteristics, antimicrobial susceptibility patterns, and treatment outcomes of nontuberculous mycobacterial diseases in eastern China: a retrospective cohort study (2019-2022). (PubMed, Microbiol Spectr) - "Antimicrobial susceptibility testing revealed that Mycobacterium avium complex exhibited relatively favorable sensitivity to clarithromycin, amikacin, ethambutol, rifapentine, rifampicin, and moxifloxacin, while the Mycobacterium chelonae/Mycobacterium abscessus complex showed sensitivity only to amikacin (66.7%). By linking pathogen types, drug resistance, and treatment duration to outcomes, this work equips doctors in Eastern China to diagnose faster, choose effective therapies, and improve patient survival. These findings also urge policymakers to prioritize localized data collection and standardized protocols for NTM management globally."

Journal • Retrospective data • Bronchiectasis • Chronic Cough • Cough • Infectious Disease • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Deciphering the emergence of mutations in Pseudomonas aeruginosa after ceftolozane/tazobactam treatment and evaluating therapeutic alternatives. (PubMed, BMC Microbiol) - "Ceftolozane/tazobactam resistance development was associated mainly with chromosomal mutations in the ampC gene but also with mutations in its regulatory genes. Knowledge about these mutations and gene polymorphisms is essential for interpreting resistance phenotypes from genomic data."

Journal

Microevolutionary models and multi-omics analysis uncover the cross-drug resistance characteristics of capreomycin-selected Mycobacterium tuberculosis. (PubMed, Curr Res Microb Sci) - "Although Cm and amikacin (Am) are historically grouped as second-line injectable drugs (SLIDs) with shared resistance mechanisms (e.g., rrs mutations), recent clinical and genetic data suggests divergent evolutionary pathways...In addition, the transcriptome-proteome-lipid metabolome analysis of representative strains were performed. Our findings reveal that Cm resistance is a combinatory effect of both genetic and non-genetic changes, providing potential optimization strategies to the molecular drug sensitivity testing used in clinical practice."

Journal • Infectious Disease • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Revisiting predictors of high-dose methotrexate related severe nephrotoxicity in children with acute lymphoblastic leukemia. (PubMed, J Oncol Pharm Pract) - "All nephrotoxic events resolved completely.ConclusionsConcurrent amikacin use and low baseline urine pH are significant predictors of HDMTX-related severe nephrotoxicity in children with ALL. Identification of these factors is crucial for preventing nephrotoxicity."

Journal • Acute Kidney Injury • Acute Lymphocytic Leukemia • Hematological Malignancies • Leukemia • Nephrology • Oncology • Pediatrics • Renal Disease

Polydopamine-Antibiotic Composite Coating for Antibiofilm Applications. (PubMed, Macromol Biosci) - "To address this challenge, we developed a polymer-based antimicrobial coating using polydopamine (PD) embedded with gentamicin (Gent)...The approach was further extended to incorporate other antibiotics (tobramycin, amikacin), demonstrating adaptability to multiple antimicrobial agents. Finally, artificial urine inoculated with PAO1 was deployed through PD-Gent-coated silicone Foley catheters under continuous flow for 24 h. Despite this continuous introduction of PAO1, the coated catheters inhibited biofilm formation by three-fold compared to the uncoated control catheters. These findings underscore the promise of PD-Gent as a robust, versatile coating with strong potential to significantly reduce the incidence of catheter-associated infections in clinical settings."

Journal • Infectious Disease

Study of fullerene C60 effect on Escherichia coli in presence of antibiotics. (PubMed, Sci Rep) - "A statistically significant enhancement in the diameter of zones of inhibition was observed with tetracycline and co-trimoxazole, whereas amikacin and gentamicin evidenced only slight increases. The findings indicate that fullerene C60 could disrupt bacterial membrane integrity or metabolic activity, thereby potentiating the antibiotics. This paves the way for introducing nanomaterials like fullerene C60 into treatment strategies to target antibiotic resistance and bring about better therapeutic outcomes in bacterial infections."

Journal • Infectious Disease

A Persistent Problem: Mycobacterium abscessus Infection of an Orthopedic Device after Trauma. (PubMed, Mil Med) - "After a multitude of surgeries, including orthopedic hardware removal from the forearm, and concurrent antibiotic therapy of amikacin, imipenem, tedizolid, and omadacycline, the patient was deemed medically cleared of her infection. This has implications for both civilian and military battlefield-related trauma infections. This case serves as an example of successful multi-disciplinary management through appropriately aggressive surgery and tailored antibiotic therapy."

Journal • Infectious Disease • Musculoskeletal Diseases • Nontuberculous Mycobacterial Disease • Orthopedics

Therapeutic drug monitoring of amikacin in Chinese premature infant: a population pharmacokinetic analysis and dosage optimization. (PubMed, BMC Infect Dis) - "Weight, postmenstrual age and renal function have significant influence on the PK of amikacin in Chinese premature infants. The optimal dosage regimens might provide an alternative choice for premature infants in China in the therapy of amikacin."

Journal • PK/PD data • Acute Kidney Injury • Nephrology • Renal Disease

Global epidemiological and genetic characteristics of carbapenem-resistant Escherichia coli carrying blaIMP. (PubMed, Microbiol Spectr) - "The nine isolates were multidrug-resistant but susceptible to colistin, tigecycline, and amikacin. Additionally, the study elucidated the global epidemiological status, transmission features, and potential threats of blaIMP-positive CRECs through a large-scale analysis of publicly available genomic data. These findings not only facilitate a better understanding of the genetic dynamics and transmission pathways of blaIMP but also help develop effective regulatory measures and antibiotic stewardship programs to alleviate the increasingly severe burden of antimicrobial resistance."

Journal

Molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae ST15-KL19 isolates from ICU patients in a Chinese tertiary hospital. (PubMed, Front Microbiol) - "The isolates exhibited complete resistance to β-lactams and carbapenems but remained susceptible to tigecycline and amikacin. Clinically, infections were associated with prolonged ICU stays and poor outcomes, with only 17.6% of patients achieving full recovery and 5.9% experiencing in-hospital mortality. These findings indicate that ST15-KL19 CRKP constitutes a regionally endemic clone with high resistance and virulence potential, underscoring the urgent need for strengthened molecular surveillance and stringent infection control measures."

Journal • Critical care • Infectious Disease • Pneumonia

Prevalence, Antimicrobial Resistance, and Risk Factors of Enteric Bacterial Infections Among Children Under Five in Nairobi County, Kenya. (PubMed, Int J Microbiol) - "High resistance to ampicillin and amoxicillin-clavulanic acid was common, exceeding 70% in key pathogens like E. coli and E. cloacae. In contrast, meropenem, amikacin, gentamicin, and ciprofloxacin retained near-complete efficacy...Urgent integrated interventions are needed, including strengthening WASH infrastructure, promoting rational antibiotic use, and enhancing AMR surveillance. These findings provide a critical baseline for public health action and underscore the need to safeguard last-line antibiotics."

Journal • Infectious Disease

Single - molecule, real - time sequencing of ceftazidime - avibactam - resistant Pseudomonas aeruginosa and the mechanism of resistance to ceftazidime - avibactam (PubMed, Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi) - "Mutation or downregulation of oprD gene may lead to CAZ-AVI resistance in P. aeruginosa."

Journal • VIM

Five-year surveillance of antimicrobial resistance patterns among blood culture isolates at the University Teaching Hospital, Kigali, Rwanda. (PubMed, Ann Clin Microbiol Antimicrob) - "This study reveals a substantial burden of AMR in blood culture isolates, particularly affecting hospitalized and pediatric patients. The high resistance rates to commonly used antibiotics highlight an urgent need for strengthened antimicrobial stewardship programs, improved infection prevention measures, and enhanced diagnostic laboratory capacity to guide therapy."

Journal • Infectious Disease • Pediatrics • Pneumonia

Morganella morganii Urinary Tract Infection in Jordanian Children: Case series from a Tertiary Hospital. (PubMed, Infect Chemother) - "M. morganii should be considered in pediatric UTIs, especially among children with urinary tract anomalies or catheter use. Awareness of its distinct resistance profile is critical for selecting appropriate empiric therapy."

Journal • Infectious Disease • Nephrology • Pediatrics

Phenotypic and Molecular Analysis of Fosfomycin Resistance Among P. aeruginosa Isolates from Cystic Fibrosis Patients. (PubMed, Infect Drug Resist) - "Based on AST, significant antibiotic resistance was observed, particularly against fosfomycin (77.2%), imipenem, and amikacin (53.5%). The presence of resistance genes suggests a genetic basis for these patterns, emphasizing the importance of developing new strategies to manage P. aeruginosa infections effectively. Future studies should focus on targeted inhibitors for these genes to overcome resistance and improve clinical outcomes."

Biomarker • Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Mycobacterium avium Infection in a Domestic Shorthair Cat Following Subdermal Hyaluronic Acid Filler Injection. (PubMed, Vet Ophthalmol) - "Non-tuberculous mycobacterial (NTM) infections are a known and documented complication of subdermal filler injections in human patients. This is the first described case of NTM infection associated with HA injection in a cat. Treatment success with conventional oral antibiotics may be limited, necessitating extended therapeutic courses and alternative drug delivery routes like intralesional injection."

Journal • Aesthetic Medicine • Infectious Disease • Nontuberculous Mycobacterial Disease • Respiratory Diseases

Genomic and Phenotypic Characterization of Extensively Drug-Resistant Clinical Klebsiella quasipneumoniae subsp. similipneumoniae ST1929 Isolates. (PubMed, Infect Drug Resist) - "All four isolates belonged to the novel ST1929-KL159 clonotype and exhibited an extensively drug-resistant phenotype, with resistance to β-lactams, carbapenems, fluoroquinolones, tigecycline, and trimethoprim-sulfamethoxazole. Amikacin was the only consistently active agent; one isolate showed high-level resistance to polymyxin B due to a premature stop mutation in mgrB (Gln30*)...similipneumoniae ST1929, an extensively drug-resistant lineage harboring bla NDM-1 and the tigecycline resistance cluster tmexC2D2-toprJ2 on a transferable IncU plasmid. The findings underscore the need for accurate detection and surveillance of this rare lineage."

Journal • Infectious Disease • Pneumonia

Incidence and Antibiotic Susceptibility of Gram-Negative Bacteria Associated With Chest Infections in Intensive Care Unit Patients From a Selected Hospital in the Kingdom of Saudi Arabia. (PubMed, Biomed Res Int) - "exhibited high resistance to third-generation cephalosporins (86%-93%) and carbapenems (70%-77%) while maintaining moderate susceptibility to amikacin (45%) and tigecycline (36%). These findings demonstrate a substantial burden of MDR among ICU GNB isolates, with colistin emerging as the only consistently effective therapeutic option. ICU cohort is dominated by a limited number of highly resistant GNB led by K. pneumoniae, P. aeruginosa, and A. baumannii. The cohort predominantly affects older adults (> 60 years), and the breadth of MDR/XDR/PDR underscores the urgency of rigorous antimicrobial stewardship, infection prevention, and rapid diagnostics to optimize empiric therapy."

Journal • Retrospective data • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Antimicrobial Resistance of Acinetobacter Species and Pseudomonas Species in a Tertiary Care Center in Gandaki Province, Nepal. (PubMed, J Nepal Health Res Counc) - "The study underscores alarming levels of antimicrobial resistance in Acinetobacter species and Pseudomonas species. Acinetobacter species demonstrated higher resistance to most antibiotics compared to Pseudomonas species. The variation in resistance patterns across sample types highlights the need of infection site and pathogen-specific antibiotic stewardship strategies."

Journal • Retrospective data • Infectious Disease

Asymptomatic Bacteriuria, their Related Risk Factors and Antibiotic Susceptibility Pattern of Isolates Among Hemodialysis Patients. (PubMed, J Nepal Health Res Counc) - "This study demonstrates high prevalence of asymptomatic bacteriuria among hemodialysis patients. Routine screening of asymptomatic bacteriuria aids in early detection and management of complications along with optimization of antibiotic use."

Journal • Cardiovascular • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease