diltiazem / Generic mfg. - LARVOL DELTA

SG12 A rare case of perianal granular cell tumour in a patient with localized recessive dystrophic epidermolysis bullosa. (PubMed, Br J Dermatol) - "The wound site was left open to promote healing; however, this was complicated by concomitant RDEB resulting in persisting well-demarcated ulceration unresponsive to topical Oleogel-S10, mupirocin 2% and Trimovate®. Botulinum toxin injections, topical glyceryl trinitrate and diltiazem are now being considered as the next step for this patient, with the aim of encouraging skin healing by relaxing the anal sphincter muscle...Additionally, this case presents the importance of tailored examinations under anaesthesia to facilitate perianal diagnoses in patients with EB, where skin fragility and pain limit the feasibility of routine examination methods. This case joins the existing literature that reports the challenges of wound healing in EB postoperatively, but importantly suggests that future management of other, nonsurgical perianal wounds in EB could also utilize similar techniques involving therapeutic anal sphincter muscle relaxation."

Journal • Anesthesia • Oncology • Pain • CD68

The Paradoxical Pro-Arrhythmic Effect of Ginseng: A Case of Atrial Fibrillation in A Healthy Adult. (PubMed, Eur J Case Rep Intern Med) - "Herbal supplements -especially ginseng-may trigger atrial fibrillation, even in young patients without structural heart disease.Ginseng consumption has paradoxical cardiovascular effects, ranging from proarrhythmic to antiarrhythmic.Always investigate the use of over-the counter and supplemental medications when evaluating palpitations or new-onset atrial fibrillation in the emergency department or internal medicine department."

Journal • Atrial Fibrillation • Cardiovascular • Fatigue • Heart Failure • Musculoskeletal Pain • Pain

A Case of Right-Sided Heart Failure and Severe Pulmonary Hypertension Secondary to Partial Anomalous Pulmonary Venous Connection. (PubMed, Respirol Case Rep) - "She was successfully managed medically with diltiazem and diuretics, showing sustained clinical improvement. This case highlights isolated PAPVC as a critical, under-recognised cause of severe pulmonary hypertension in adults."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases

Atrial Fibrillation in a Young Healthy Adult: A Case Report From Anaphylaxis to Arrhythmia. (PubMed, Cureus) - "The arrhythmia occurred within five minutes of intramuscular epinephrine administration and resolved following rate control with intravenous diltiazem. He remained in sinus rhythm during telemetry monitoring and was discharged with outpatient follow-up. This case highlights the potential for transient AF in the setting of allergic reactions and raises diagnostic and therapeutic questions regarding the role of venom-induced autonomic effects versus sympathomimetic drug administration."

Journal • Allergy • Atrial Fibrillation • Cardiovascular

Supraventricular Tachycardia as an Uncommon Presentation of Dengue Myocarditis. (PubMed, JACC Case Rep) - "Despite normal echocardiography, SVT in dengue-endemic areas should arouse suspicion for myocarditis, requiring early electrocardiography and guideline-based therapy."

Journal • Cardiovascular • Dengue Fever • Hematological Disorders • Inflammation • Thrombocytopenia • Ventricular Tachycardia

Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study (clinicaltrials.gov) - P=N/A | N=13656 | Not yet recruiting | Sponsor: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

New trial • Real-world evidence • Cardiovascular • Infectious Disease • Pneumonia • Respiratory Diseases

Employing intrinsic fluorone-dye fluorescence in a quenching-based ("on-off") strategy for diltiazem determination in tablets and capsules. (PubMed, BMC Chem) - "It was successfully applied to analyze DLZ in pharmaceutical formulations (tablets/capsules) with no matrix interference, and the statistical comparison (t- and F-tests) showed no significant difference from the reference method. Critically, the procedure uses distilled water as the sole solvent, aligning with green chemistry principles while offering simplicity, cost-efficiency, and high-throughput potential."

Journal

Comment on "Adenosine versus Fixed-Dose Intravenous Bolus Diltiazem on Reversing Supraventricular Tachycardia in the Emergency Department: A Multi-Center Cohort Study". (PubMed, J Emerg Med) - No abstract available

Journal • Cardiovascular • Ventricular Tachycardia

From heart to brain: cognitive potential of propranolol and diltiazem through cholinergic enhancement via butyrylcholinesterase inhibition. (PubMed, Front Pharmacol) - "Given their established safety profiles and CNS activity, these compounds represent promising candidates for repurposing in the treatment of AD and other cognitive disorders. Further in vivo studies are warranted to explore their therapeutic potential."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Developmental Disorders • Pain

Magnesium in Aconitine-Induced Electrical Storm-Mechanism Yes, Mandate No. (PubMed, Ann Noninvasive Electrocardiol) - "We propose a practical, evidence-based algorithm emphasizing: (1) first-line flecainide 2 mg/kg IV, (2) magnesium sulfate adjunct targeting serum levels of 1.5-2.0 mmol/L, (3) aggressive calcium repletion to > 1.00 mmol/L, (4) early high-flux hemoperfusion within 6 h, and (5) VA-ECMO for refractory cases. Verapamil, diltiazem, and β-blockers as sole agents should be explicitly avoided."

Journal • Review • Cardiovascular • Hypotension

Controlled Release Technologies for Diltiazem Hydrochloride: A Comprehensive Review of Solid Dosage Innovations. (PubMed, Pharmaceutics) - " This review not only synthesizes current formulation strategies but also explores reverse engineering of ideal release profiles and the integration of advanced modeling tools such as physiologically based pharmacokinetic (PBPK) modeling and in vitro-in vivo correlation (IVIVC). These approaches support the rational design of personalized, regulatory-compliant DH therapies."

Journal • Review • Cardiovascular • Hypertension

A Case of Atrial Fibrillation and Rapid Ventricular Response in a 22-Year-Old Athlete With Sickle Cell Trait. (PubMed, Cureus) - "The patient was administered intravenous (IV) diltiazem for rate control, and synchronized cardioversion was successfully performed to restore sinus rhythm. Short-term anticoagulation therapy with apixaban was prescribed, along with flecainide on an as-needed basis for rhythm management...Preventive measures for athletes with SCT should include adequate hydration, heat acclimatization, and education of players and coaching staff. This case highlights the importance of heightened awareness, adherence to guideline-based management, and the necessity for further research into the association between SCT and AF in young athletes."

Journal • Atrial Fibrillation • Cardiovascular • Genetic Disorders • Hematological Disorders • Metabolic Disorders • Sickle Cell Disease • Ventricular Tachycardia

Integrating drug effects on individual cardiac ionic currents and cardiac action potentials to understand nonclinical translation to clinical ECG changes. (PubMed, Front Pharmacol) - "The results showed that hERG block-mediated QTC prolongation with dofetilide was shortened by co-administration of lidocaine or mexiletine-drugs that inhibit INaL...Consistent with this interpretation, nifedipine, which preferentially inhibits ICaL over hERG (ICaL: 13.2 nM; hERG: 35 μM; ratio = 2,651) caused APD shortening without AP triangulation. Results from this study thus support the following: 1) diltiazem failed to reduce moxifloxacin-induced QTC prolongation due to its concomitant hERG block at clinical exposure levels; and 2) the importance of using physiologically relevant protocols to generate ion channel pharmacology and obtaining functional recordings from myocytes to provide a better understanding of nonclinical data translation to clinical ECG signals. Data used in this manuscript, including the original electrophysiology records, may be found at: https://osf.io/69ght/."

Journal

Rapid carbamazepine detection by means of a disposable electrochemical sensor based on a molecularly imprinted polymer. (PubMed, Talanta) - "The prepared sensor showed high selectivity towards CBZ over pharmaceuticals with similar chemical structures (CBZ 10,11-epoxide, diclofenac and diltiazem), with a response under 5.5 % of that for CBZ. Additionally, its performance in real water samples was assessed, yielding good recoveries. Hence, an easy-to-use MIP-based sensor was successfully developed with potential applications for on-site monitoring of CBZ in the environment."

Journal

Safety and efficacy of diltiazem for the treatment of atrial fibrillation with rapid ventricular response in obese patients. (PubMed, Am J Emerg Med) - "Diltiazem was effective and well tolerated in patients with obesity, even at lower actual-body-weight-based doses. Higher initial doses increased the likelihood of early rate control without increasing adverse events, suggesting modestly higher, individualized dosing may be safe and effective. Ideal-body-weight-based dosing better aligned with guideline targets, supporting its use in obese patients. Prospective studies are needed to determine optimal dosing strategies to maximize the efficacy and safety of diltiazem."

Journal • Atrial Fibrillation • Cardiovascular • Genetic Disorders • Obesity

Hidden in Plain Sight: Low Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality. (PubMed, Transpl Int) - "The normalization of tacrolimus CDR through co-medication with diltiazem and reductions in steroid dosing may improve graft survival. Our findings support personalized tacrolimus management based on metabolic profiling and genetic testing."

Journal • Infectious Disease • Transplantation • CYP3A5

A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022) (clinicaltrials.gov) - P1 | N=24 | Not yet recruiting | Sponsor: Merck Sharp & Dohme LLC

New P1 trial

Alembic Pharmaceuticals informed the exchanges that it has received final approval from the USFDA for its Abbreviated New Drug Application (ANDA) for Diltiazem Hydrochloride Tablets USP in 30 mg, 60 mg, 90 mg, and 120 mg strengths. (The Economic Times)

ANDA • Hypertension

Intra-Arterial Vasodilators for Radial Artery Spasm and Occlusion Prevention in Trans-radial Coronary Procedures: A Network Meta-Analysis of Randomized Control Trials (AHA 2025) - "A random-effects model was used for outcomes with high heterogeneity. In the network meta-analysis, 21 clinical trials with 11010 patients comparing 10 treatments for the prevention of spasm (Placebo, Verapamil, Diltiazem, Molsidomine, Nitroglycerin, Nicorandil, ISDN, Labetalol, Magnesium, and Phentolamine) were included, forming a network centered on Verapamil and Placebo with multiple direct connections. Patients undergoing radial artery catheterization for coronary interventions, verapamil and molsidomine significantly reduced the risk of RAS relative to placebo."

Retrospective data

A QSPR study of coronary artery disease drugs using eccentricity-based indices. (PubMed, Sci Rep) - "This study advances QSPR modeling by using eccentricity-based graphical invariants, specifically designed to enhance the predictive accuracy for physicochemical properties of drugs used to treat coronary artery disease, including atorvastatin, simvastatin, rosuvastatin, aspirin, clopidogrel, metoprolol, atenolol, enalapril, lisinopril, amlodipine, diltiazem, nitroglycerin, isosorbide dinitrate, ranolazine, gemfibrozil, and fenofibrate. The experimental values were compared with forecasted data, revealing a strong correlation between them. This demonstrates the reliability of our regression models in assessing these vital physicochemical parameters."

Journal • Cardiovascular • Coronary Artery Disease

Evaluation of diltiazem dosing strategies in the management of atrial fibrillation in the emergency department. (PubMed, Am J Emerg Med) - "Initiating immediate-release oral diltiazem after an initial IV bolus does not result in more treatment failures than initiating a continuous infusion."

Journal • Atrial Fibrillation • Cardiovascular • Hypotension

Alembic Pharma gets US FDA approval for angina treatment drug Diltiazem (Business Standard) - "The approved ANDA is therapeutically equivalent to the reference listed drug (RLD), Cardizem Tablets of Bausch Health US, LLC."

ANDA • Cardiovascular

Metoprolol vs. Diltiazem in Patients with Angina and Non-Obstructive Coronary Artery Disease with or Without Evidence of Coronary Microvascular Spasm on Acetylcholine Testing. (PubMed, J Clin Med) - "In particular, the SAQ summary score was 63.1 ± 24 and 66.0 ± 25 (p = 0.59) for metoprolol and diltiazem, respectively, in the CMVS group, and 70.9 ± 17 and 74.3 ± 16 (p = 0.37) with the two drugs, respectively, in the NEG group. Our small open-label study shows that patients with ANOCA with negative Ach test or Ach-induced CMVS show largely comparable short-term symptomatic outcomes and ECG-EST results when treated with either metoprolol or diltiazem."

Journal • Cardiovascular • Coronary Artery Disease

Not Just One Answer: A Case of Resistant Hypertension with Overlapping Etiologies (KIDNEY WEEK 2025) - "Despite adherence to a low sodium diet, CPAP and a six-drug regimen including amlodipine 10mg, metoprolol 150mg, lisinopril 40mg, terazosin 20mg, chlorthalidone 25mg, and spironolactone 25mg daily, BP remained elevated at 160-180/80-90 mm Hg...He remained on metoprolol ER 50mg, diltiazem 240mg, furosemide 20mg daily for his hypertrophic cardiomyopathy...A concurrent renal artery stenosis was managed with angioplasty that helped bring his BP to goal. With this case, we highlight the importance of identifying and understanding the pathophysiology of secondary causes of resistant hypertension."

Clinical • Cardiomyopathy • Cardiovascular • Endocrine Disorders • Hypertension • Hypertrophic Cardiomyopathy • Nephrology • Renal Calculi

Stevens-Johnson syndrome or toxic epidermal necrolysis from antihypertensive medications: A systematic review of cases. (PubMed, Medicine (Baltimore)) - "Early recognition by clinicians is vital to achieving a favorable outcome, but identification of culprit medications can be difficult. Future studies should seek larger sample sizes and try to prove causation by further understanding the underlying pathophysiology."

Journal • Review • Cardiovascular • Hypertension • Infectious Disease • Renal Disease • Septic Shock • Steven-Johnson Syndrome