diltiazem / Generic mfg. - LARVOL DELTA

ReCAST AF: Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation (clinicaltrials.gov) - P4 | N=988 | Not yet recruiting | Sponsor: Universitaire Ziekenhuizen KU Leuven

New P4 trial • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease

Topical Diltiazem in the Management of Cutaneous Leiomyoma-Associated Pain: Evaluation With a Cold-Provocation Test. (PubMed, Australas J Dermatol) - "We report a patient with genetically confirmed hereditary leiomyomatosis and renal cell cancer (HLRCC) in whom topical diltiazem 2% was associated with reduced pain, assessed using a controlled cold-provocation test and validated pain scores. This brief report suggests that topical diltiazem may be a useful symptomatic option and supports further evaluation."

Journal • Genito-urinary Cancer • Oncology • Pain • Renal Cell Carcinoma • Solid Tumor

Comparative Efficacy and Safety of Vasodilators Used to Prevent Internal Thoracic Artery Spasm in Coronary Artery Bypass Grafting: A Systematic Review. (PubMed, Cureus) - "This review systematically evaluates the comparative efficacy and safety of vasodilators used to prevent ITA spasm, including papaverine, glyceryl trinitrate-verapamil (GV) solution, systemic diltiazem, and efonidipine. Delivery method influenced efficacy, with topical or intraluminal administration providing rapid, direct vasodilation. Overall, combination therapy (GV solution) offers a practical and safe approach for intraoperative ITA spasm prevention."

Journal • Review

Hypotensive Agents for Controlled Hypotension in Endoscopic Sinus Surgery: A Systematic Review and Network Meta-Analysis. (PubMed, JAMA Otolaryngol Head Neck Surg) - "Randomized clinical trials of patients undergoing ESS and receiving dexmedetomidine, clonidine, esmolol, labetalol, bisoprolol, metoprolol, diltiazem, nifedipine, or verapamil vs placebo. In this systematic review and network meta-analysis, controlled hypotension improved surgical field quality in ESS with comparable safety. Diltiazem, esmolol, dexmedetomidine, labetalol, and clonidine were effective; dexmedetomidine was associated with reduced MAP the most, and esmolol favored recovery."

Clinical • Journal • Retrospective data • Hypotension • Otorhinolaryngology

APIXABAN VERSUS RIVAROXABAN IN ATRIAL FIBRILLATION PATIENTS RECEIVING CONCOMITANT DILTIAZEM (ACC 2026) - "Abstract is embargoed at this time."

Clinical • Atrial Fibrillation • Cardiovascular

A prolonged diagnostic examination of anal fissure with complicating contact dermatitis (PubMed, Ugeskr Laeger) - "This case report presents a 44-year-old woman, who was assessed by several different specialities, due to persistent perianal symptoms, while treated intermittently with diltiazem gel for an anal fissure. After 18 months, the patient was diagnosed with complicating allergic contact dermatitis caused by diltiazem gel."

Journal • Contact Dermatitis • Dermatitis • Dermatology • Gastrointestinal Disorder • Immunology

Na+ Uptake Triggered in Adrenal Chromaffin Cells by a 5-ns Electric Pulse is Facilitated by Ca2+ Influx Via an L-Type-Like Ca2+ Channel Independent of Changes in Membrane Potential. (PubMed, J Membr Biol) - "A 5-ns, 5 MV pulse elicited a tetrodotoxin-insensitive rise in ING-2 fluorescence that exhibited a similar electric field dependency and response to pulse-pair stimulation as the inward current...Full inhibition was achieved with the selective L-type voltage-gated Ca2+ channel (VGCC) inhibitors nitrendipine, verapamil, or diltiazem but not the broad-spectrum inhibitor Cd2+...These results provide evidence that nanoelectropulse-induced Na+ influx into chromaffin cells involves several Na+ influx pathways that are facilitated by Ca2+ influx via an L-type-like Ca2+ channel associated with cholesterol-rich membrane domains. Investigating such membrane effects is essential for developing nanosecond electric pulse technologies for stimulating and/or modulating excitable cells."

Journal • CD2 • NALCN

Sudden Death With Vasospastic Angina That Could Not Be Medically Managed. (PubMed, Cureus) - "During admission, telemetry captured a prolonged ventricular pause (~10 seconds) secondary to diltiazem...This case illustrates a rare but severe form of vasospastic angina that remained constrained and refractory to escalating medical therapy and ultimately resulted in a fatal ventricular arrhythmia. Early recognition, optimization of vasodilator therapy, and careful rhythm surveillance are essential, but even with appropriate management, some patients remain at risk for sudden cardiac death."

Journal • Cardiovascular • Critical care • Heart Failure • Myocardial Ischemia • Pain

Author's Response to Letter to the Editor "Critical insights on Safety of Diltiazem for Acute Management of Atrial Fibrillation (AF) in Patients with Heart Failure and Reduced Ejection Fraction in the Emergency Department". (PubMed, J Emerg Med) - No abstract available

Journal • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Heart Failure

RaP-AF: Rate Control in Patients With Atrial Fibrillation (clinicaltrials.gov) - P=N/A | N=13 | Completed | Sponsor: National Taiwan University Hospital | Active, not recruiting ➔ Completed | N=50 ➔ 13

Enrollment change • Trial completion • Atrial Fibrillation • Cardiovascular

Misdiagnosis of Supraventricular Tachycardia as Panic Attacks: A Case Report Highlighting the Importance of Accurate Cardiovascular Evaluation. (PubMed, Cureus) - "The patient was successfully treated with intravenous diltiazem, and her symptoms resolved promptly...Timely and accurate diagnosis is crucial to avoid delays in appropriate treatment and prevent unnecessary psychiatric interventions. The case highlights the value of thorough cardiovascular evaluation, particularly in patients with recurrent or unexplained episodes of palpitations, as well as the role of advanced diagnostic techniques in improving diagnostic accuracy."

Journal • Cardiovascular • CNS Disorders • Mental Retardation • Mood Disorders • Psychiatry • Ventricular Tachycardia

Comparison of topical diltiazem, diclofenac suppository and periprostatic nerve block with periprostatic nerve block alone for pain control during transrectal ultrasonography-guided prostate biopsy: An RCT (EAU 2026) - No abstract available

Biopsy • Pain

A Comparative Study of Topical 2% Diltiazem Versus Lateral Internal Sphincterotomy in the Treatment of Fissure-in-Ano. (PubMed, Cureus) - "Study concludes that lateral internal sphincterotomy remains the gold standard treatment for chronic anal fissure. Diltiazem therapy is a good alternative for patients who refused surgery or prefer medical line of treatment and can be used as a first choice in management of chronic fissures."

Journal • Gastrointestinal Disorder • Pain

Using Physiologically Based Pharmacokinetic Modeling and Simulations to Predict Antihypertensive Drug Doses in Cirrhotic Patients. (PubMed, J Clin Pharmacol) - "The model predicted that the healthy doses of nifedipine 20 mg three times daily (TID), verapamil 80 mg TID, nebivolol 10 mg once daily, and diltiazem 60 mg TID should be adjusted to 44%, 41%, 49.8%, and 51% of these doses, respectively, in the mild cirrhosis population. Among the studied drugs, nifedipine was the most affected and diltiazem was the least affected by cirrhosis, highlighting variability in hepatic impact across antihypertensive drugs. In the absence of dedicated clinical trials in cirrhosis for these drugs, validated PBPK models offer evidence-based insights to support clinicians in evaluating antihypertensive dosing options."

Journal • PK/PD data • Cardiovascular • Fibrosis • Gastroenterology • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis

Evaluation of Surgical and Conservative Approaches in the Treatment of Anal Fissure: A Systematic Review. (PubMed, Acta Gastroenterol Belg) - "Conservative methods - particularly topical diltiazem and nifedipine, botulinum toxin injections, and pelvic floor therapy - were effective in pain reduction and healing for many patients and had mostly mild adverse effects. Both surgical and conservative approaches serve as complementary strategies in the management of anal fissures. Surgical methods, particularly LIS, provide an effective treatment option with high success rates, while conservative approaches are beneficial in the early stages and for specific patient populations."

Journal • Review • Gastrointestinal Disorder • Pain

Pre-ablation rate control therapy and direct-to-catheter ablation in patients with persistent atrial fibrillation: A DECAAF II subanalysis. (PubMed, J Interv Card Electrophysiol) - "Prior treatment with diltiazem or metoprolol before ablation of PersAF did not show additional benefits in reducing patient outcomes such as AF recurrence, fibrosis, or improving QoL."

Journal • Atrial Fibrillation • Cardiovascular • Fibrosis • Immunology

Hydrophobic hydration of analgesics and diltiazem complexes explored by electrochemical impedance spectroscopy and diffusion-ordered spectroscopy. (PubMed, Phys Chem Chem Phys) - "Analgesics and DTZ were dispersed as free entities in deuterated dimethyl sulfoxide (an aprotic solvent), whereas oligomeric clathrates were observed in heavy water (a protic solvent). These findings suggest that the hydrophobic hydration of the complex formed by acidic and basic drugs may involve intermolecular electrostatic interactions embedded within the hydrogen-bonding network in water."

Journal • Pain

Capillary blood microsampling and LC-Orbitrap analysis for adherence monitoring of cardiovascular drugs: method development, cross-validation, and patient proof-of-concept using VAMS and Capitainer-B. (PubMed, Talanta) - "Amlodipine, atenolol, atorvastatin, bisoprolol, carvedilol, clopidogrel, diltiazem, lercanidipine, metoprolol, nebivolol, prasugrel, rosuvastatin, salicylic acid, simvastatin hydroxy acid, and verapamil were included. In a proof-of-concept involving 30 patients, finger-prick concentrations from VAMS and Capitainer-B were interchangeable, supporting the suitability of these adherence workflows but reference ranges for capillary blood remain necessary to enable routine clinical interpretation. In summary, this work established a reliable, LC-Orbitrap-based microsampling platform for monitoring adherence and identified stability issued amongst others that guide future method selection and development."

Journal • Cardiovascular

Postpartum management of the hypertensive disorders of pregnancy: systematic review and meta-analysis. (PubMed, Am J Obstet Gynecol) - "While diuretics may aid in BP control, they cannot be recommended as monotherapy. Evidence guiding the optimal choice of antihypertensive agents remains limited. Of greatest relevance to practice is the effectiveness of: enalapril or amlodipine (vs. nifedipine) in controlling BP; and BP self-measurement/management or lifestyle change (vs. usual care) in preventing longer-term cardiovascular outcomes."

Journal • Retrospective data • Review • Cardiovascular • Hypertension

A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022) (clinicaltrials.gov) - P1 | N=24 | Recruiting | Sponsor: Merck Sharp & Dohme LLC | Not yet recruiting ➔ Recruiting

Enrollment open

Ventricular Fibrillation Arrest Due to Coronary Endothelial Dysfunction-Vasospasm After Myocardial Bridge Unroofing: Perioperative Management of Double-Trouble. (PubMed, JACC Case Rep) - "Perioperative intravenous diltiazem/verapamil or nitroglycerin drips when undergoing surgical unroofing should be considered to mitigate the risk of spasm-induced ventricular fibrillation arrest concomitant to endothelial dysfunction within or outside the bridged segment."

Journal • Acute Coronary Syndrome • Cardiovascular • Myocardial Ischemia • Pain • Ventricular Tachycardia

Incidence of Cardiogenic Shock Following Administration of Intravenous Diltiazem for Acute Management of Atrial Fibrillation/Flutter with Rapid Ventricular Response in a Community Hospital Setting (ASHP 2025) - No abstract available

Clinical • Atrial Fibrillation • Cardiovascular

Comparing Oral and Intravenous Diltiazem for Rate Control in Emergency Department Patients with Atrial Fibrillation and Rapid Ventricular Response (ASHP 2025) - No abstract available

Clinical • Atrial Fibrillation • Cardiovascular

Impact of Suboptimal Weight-Based IV Diltiazem Dosing on the Need for Second Agents for Rate Control Therapies in the Emergency Department (ASHP 2025) - No abstract available

Diltiazem and Low Ejection Fraction (ASHP 2025) - No abstract available