TCR discovery for stem to T-cell program / University of Maryland, EOM Pharma - LARVOL DELTA

Identification of a Highly Functional Effector CD8+ T Cell Program after Transplantation in Mice and Humans. (PubMed, Am J Transplant) - "In healthy human donors and transplant candidates, the CD43 1D4 mAb clone defined antigen-experienced cytokine-producing CD8+ T cells. In sum, these data support an important role for activated CD43+ CD8+ T cells as potent effectors, and point to a potential role for CD43 1B11 signaling in augmenting effector functions in the context of sub-threshold antigen or costimulation."

IO biomarker • Journal • Preclinical • Transplant Rejection • Transplantation • CD8 • ICOS • IFNG • PRF1 • SPN

Long-Term Follow-up and T Cell Characteristics of Patients with ASXL1-Mutated Relapsed or Refractory MDS or CMML Treated with Guadecitabine and Atezolizumab (ASH 2023) - "Herein we report long-term follow-up of this cohort of patients, along with T cell programmed death-1 (PD-1) expression analyzed based on mutational status. Significant upregulation of PD-1 was noted in T lymphocytes from both wild-type and co-mutated patients. The effect of mutant ASXL1 on T cell responsiveness to ICI deserves further investigation; patients with ASXL1-mutated HMA-refractory myeloid malignancies may benefit from ICI."

Clinical • IO biomarker • Chronic Myelomonocytic Leukemia • Hematological Malignancies • Leukemia • Myelodysplastic Syndrome • Oncology • ASXL1 • CD8 • PD-1 • TP53

Using Adjuvants to Drive T Cell Responses for Next-Generation Infectious Disease Vaccines. (PubMed, Vaccines (Basel)) - "Directly manipulating specific immune activation or antigen delivery pathways with adjuvants may selectively augment desired T cell responses in vaccination and may improve the effectiveness and durability of vaccine responses in humans. In this review we outline recently studied adjuvants in their potential for antigen presenting cell and T cell programming during vaccination, with an emphasis on what has been observed in studies in humans as available."

Clinical • Journal • Review • Infectious Disease