Primaxin (cilastatin/imipenem) / Abbott - LARVOL DELTA

A Trial of HRS-8427 in the Treatment of Adults With Complicated Urinary Tract Infection, Including Acute Pyelonephritis (clinicaltrials.gov) - P3 | N=579 | Active, not recruiting | Sponsor: Jiangsu HengRui Medicine Co., Ltd. | Recruiting ➔ Active, not recruiting | Trial completion date: Nov 2025 ➔ Nov 2026 | Trial primary completion date: Nov 2025 ➔ Nov 2026

Enrollment closed • Trial completion date • Trial primary completion date • Infectious Disease • Nephrology

Timing of surgery for a melioidosis-associated abdominal aortic pseudoaneurysm: a case report. (PubMed, Trop Med Health) - "In melioidosis-endemic regions, aortic infection should be considered in diabetic patients with fever and abdominal or back pain. For carefully selected patients with suspected contained rupture, hemodynamic stability, and good response to targeted antimicrobial therapy, delayed elective open reconstruction under strict surveillance and with emergency intervention capability may be a feasible strategy. However, this single case cannot establish the superiority of delayed surgery or define the optimal timing of intervention."

Journal • Back Pain • Cardiovascular • Diabetes • Infectious Disease • Inflammation • Lumbar Back Pain • Metabolic Disorders • Musculoskeletal Pain • Pain • Type 2 Diabetes Mellitus

Severe Polymicrobial Pneumonia With Septicemia After Interruption of Immunoglobulin Replacement in X-Linked Agammaglobulinemia: A Case Report. (PubMed, Case Reports Immunol) - "Intravenous imipenem-cilastatin and levofloxacin were administered according to antimicrobial susceptibility results. This case highlights the consequences of interrupted immunoglobulin replacement in XLA and the importance of combining pathogen-directed antimicrobial therapy with restoration of humoral protection in severe infection. It also illustrates how financial barriers may compromise continuity of lifelong treatment."

Journal • Bronchiectasis • Cough • Hematological Disorders • Immunology • Infectious Disease • Pain • Pneumococcal Infections • Pneumonia • Primary Immunodeficiency • Pulmonary Disease • Respiratory Diseases • BTK

Safety Profile of Imipenem/Cilastatin as an Embolic Agent for Intestinal Embolization: Preclinical Evaluation in a Swine Model. (PubMed, J Vasc Interv Radiol) - "Regardless of systemic heparin administration, transcatheter arterial embolization using IPM/CS causes heterogeneous intestinal ischemia in a swine model."

Journal • Preclinical • Cardiovascular

Guidelines for off-label use of anti-tuberculosis drugs (PubMed, Zhonghua Jie He He Hu Xi Za Zhi) - "NAT2 genotype-inferred acetylator phenotype may support individualized dose adjustment together with TDM, efficacy, and safety assessments (2, B).Recommendation 7: Off-label rifampicin use includes a 3-month regimen of isoniazid and rifampicin (3HR) (1, B) or a 4-month regimen of rifampicin (4R) (2, B) for tuberculosis preventive treatment; individualized high-dose use in TBM or investigational use in drug-susceptible pulmonary tuberculosis (2, C); local administration as adjunct therapy only (2, D); and use during pregnancy, including early pregnancy, after individualized benefit-risk assessment (2, C).Recommendation 8: Based on pharmacokinetic and safety data from Chinese populations, the 3H₂P₂ regimen-isoniazid 500-600 mg, plus rifapentine, 450-600 mg, twice weekly for 3 months-is recommended for tuberculosis preventive treatment (1, B).Recommendation 9: Levofloxacin is a key drug for fluoroquinolone-susceptible MDR/RR-TB (1, B); it may also be used for..."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Heart Failure • Hepatology • Infectious Disease • Liver Failure • Metabolic Disorders • Pain • Pulmonary Disease • Renal Disease • Respiratory Diseases • Tuberculosis • NAT2

A CASE OF PYOGENIC SPONDYLITIS CAUSED BY MESH INFECTION AFTER LAPAROSCOPIC SACROCOLPOPEXY (PubMed, Hinyokika Kiyo) - "We report a case involving an 81-year-old woman who developed pyogenic spondylitis following laparoscopic sacrocolpopexy (LSC) for a cystocele in November year X. During concomitant uterine resection, purulent discharge was observed, and oral levofloxacin was administered for 5 days postoperatively...She was admitted and treated with intravenous sulbactam/ampicillin for 1 week, but her symptoms did not improve...After surgery, the antibiotic regimen was switched to intravenous imipenem/cilastatin, resulting in good infection control...Oral minocycline was initiated on postoperative day 69 and continued until day 133...Although pyogenic spondylitis is recognized as a serious complication of LSC, this represents postoperative case encountered at our institution. On the basis of a review of the literature, we discuss this case and its clinical implications."

Journal • Endometriosis • Infectious Disease • Inflammatory Arthritis • Musculoskeletal Pain • Orthopedics • Pain • Seronegative Spondyloarthropathies

Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Infection with Sulbactam-Durlobactam: A Two-Case Report. (PubMed, Infect Drug Resist) - "Current guidelines recommend SUL-DUR in combination with imipenem-cilastatin or meropenem for the treatment of CRAB pneumonia. Considering the absence of concurrent bacterial pathogens and concerns regarding additional broad-spectrum antimicrobial exposure, SUL-DUR monotherapy was selected as an individualized treatment strategy and resulted in resolution of fever, improvement of pulmonary lesions, and successful ventilator liberation. These two cases expand the clinical experience of SUL-DUR in severe CRAB infections, demonstrating successful treatment of CRAB bloodstream infection with SUL-DUR-based combination therapy and favorable outcomes of individualized SUL-DUR monotherapy for selected monomicrobial CRAB pneumonia."

Journal • Infectious Disease • Mood Disorders • Pneumonia • Respiratory Diseases

In reply to Letter to Editor regarding "A multicenter, randomized, double-blind, imipenem/cilastatin-controlled clinical study of cefiderocol for the treatment of complicated urinary tract infections caused by Gram-negative pathogens in Chinese adults". (PubMed, Int J Antimicrob Agents) - No abstract available

Clinical • Journal • Infectious Disease • Nephrology

Impact of renal impairment on pharmacokinetics, safety, and tolerability of funobactam, combined with imipenem and cilastatin. (PubMed, Antimicrob Agents Chemother) - P1 | "The treatment was well tolerated, with no deaths, severe adverse events, or discontinuation due to adverse events. Dosage adjustments of funobactam, imipenem, and cilastatin will be needed in patients with renal impairment or ESRD requiring HD.CLINICAL TRIALSThis study is registered with ClinicalTrials.gov as NCT04787562."

Journal • PK/PD data • Chronic Kidney Disease • Nephrology • Renal Disease

Transarterial periarticular embolisation in inflammatory rheumatic monoarthritis: a proof-of-concept study. (PubMed, Rheumatology (Oxford)) - "TAPE is a feasible, safe, and well-tolerated treatment associated with clinically meaningful pain reduction in therapy-refractory inflammatory rheumatic monoarthritis. Larger prospective studies are warranted."

Journal • Ankylosing Spondylitis • Immunology • Musculoskeletal Pain • Osteoarthritis • Pain • Psoriatic Arthritis • Rheumatoid Arthritis • Rheumatology • Seronegative Spondyloarthropathies • Spondylarthritis

From diagnostic dilemma to successful management: Early prosthetic mitral valve endocarditis complicated by splenic infarction caused by Klebsiella pneumoniae. (PubMed, Radiol Case Rep) - "Despite initial colistin therapy, clinical and biological improvement was only achieved after escalation to rifampicin combined with imipenem/cilastatin, with complete disappearance of the vegetation on follow-up transesophageal echocardiography. This case highlights the pivotal role of multimodality imaging in diagnosing prosthetic valve endocarditis and detecting embolic complications, particularly in initially inconclusive transthoracic echocardiography, as well as the therapeutic challenges associated with prosthetic valve infective endocarditis caused by multidrug-resistant organisms."

Journal • Cardiovascular • Infectious Disease • Pneumonia

Artificial intelligence-assisted multidisciplinary therapy for a complex case of cholangitis with septic shock: a case report and simulated decision-making analysis. (PubMed, AME Case Rep) - "Concurrently, antibiotic therapy was escalated to imipenem-cilastatin...AI demonstrates potential to replicate core diagnostic and therapeutic logic, but current models lack deep perception of "clinical reality feasibility". AI is a promising decision support tool, particularly in resource-limited settings, but human contextual adaptation remains irreplaceable."

Journal • Septic Shock

Imipenem/Cilastatin Sodium as Reabsorbable Embolic Agent in Acute Lower Gastrointestinal Bleeding: A Multicentric Prospective Study. (PubMed, Diagnostics (Basel)) - " In this study IPM/CS was a safe and feasible embolic agent in selected patients with acute LGIB; no bowel ischemia occurred during the 30 day follow-up. Future studies with larger samples are required to confirm these findings to include IPM/CS as an off-label alternative embolic agent in LGIB."

Journal • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Oncology • Solid Tumor

Genicular Artery Embolization (GAE) for the Treatment of Advanced Knee Osteoarthritis in Selected Nonoperative Patients: A Pilot Study at 6 Months Follow-Up. (PubMed, J Clin Med) - "All patients underwent GAE with selective embolization of hypervascular genicular branches using an imipenem/cilastatin suspension as a temporary embolic agent... GAE with a temporary embolic agent appeared to be a safe and effective procedure in improving pain and function in patients with advanced knee OA who are not candidates for joint replacement surgery. The clinical benefit was progressive and sustained up to 6 months, supporting the role of synovitis modulation as a therapeutic target."

Journal • Immunology • Musculoskeletal Pain • Orthopedics • Osteoarthritis • Pain • Rheumatology

Development of the MCA/PTA Diameter Ratio as a Predictor of Response After Superselective Embolization for Plantar Fasciitis: A Preliminary Derivation Study. (PubMed, J Vasc Interv Radiol) - "The MCA/PTA diameter ratio is associated with early and durable pain relief after superselective MCA embolization. A cutoff of 0.48 shows promise as an angiographic predictor but requires prospective multicenter validation."

Journal • Musculoskeletal Diseases • Pain

Imipenem/Cilastatin Versus Imipenem/Cilastatin Plus Lipiodol in Genicular Artery Embolization: Safety and Clinical Success in a Comparative Cohort Study. (PubMed, J Vasc Interv Radiol) - "GAE performed with either IPM/CS alone or a combined IPM/CS+L regimen is safe and provides significant symptomatic relief for knee OA. While Lipiodol offers technical advantages, it does not confer superior long-term clinical efficacy compared to IPM/CS alone."

Journal • Immunology • Osteoarthritis • Pain • Rheumatology

Genicular artery embolization for refractory pain after knee arthroplasty: clinical outcomes from a retrospective pilot study. (PubMed, CVIR Endovasc) - "In this small retrospective pilot cohort, GAE using IPM/CLS appeared technically feasible and safe and was associated with early pain reduction. Sustained clinically meaningful benefit at 12 months was limited to a subset of patients, indicating variable durability. These findings should be interpreted with caution and require confirmation in larger prospective studies."

Clinical data • Journal • Retrospective data • Dermatology • Immunology • Infectious Disease • Musculoskeletal Pain • Orthopedics • Osteoarthritis • Pain • Rheumatology

Severe fever with thrombocytopenia syndrome complicated by invasive pulmonary aspergillosis and septic shock: a case report highlighting the role of mNGS. (PubMed, Front Med (Lausanne)) - "Treatment consisted of imipenem/cilastatin, isavuconazonium sulfate, continuous renal replacement therapy, and mechanical ventilation. Clinicians in endemic areas should maintain a high index of suspicion for SFTS and IPA in patients presenting with unexplained fever, thrombocytopenia, and organ dysfunction. However, the favorable outcome cannot be attributed solely to mNGS, as multiple supportive interventions were administered concurrently; the clinical improvement likely reflects a synergistic effect of timely targeted therapy and comprehensive intensive care."

Journal • Acute Kidney Injury • Critical care • Hematological Disorders • Hepatology • Infectious Disease • Leukopenia • Liver Failure • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases • Septic Shock • Thrombocytopenia

Disseminated Nocardia farcinica with multiple cerebral abscesses in a patient receiving induction immunosuppression for autoimmune hepatitis: case report. (PubMed, Front Med (Lausanne)) - "Two months earlier, he had been treated with high-dose corticosteroids and azathioprine and prescribed trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis, which had been interrupted for an estimated 2-4 weeks before presentation during ongoing corticosteroid therapy...Antimicrobial therapy was transitioned to imipenem-cilastatin and TMP-SMX based on susceptibility testing. During infection management, azathioprine was paused, and prednisone was continued at a dose of 25 mg/day, followed by a biochemical autoimmune hepatitis flare requiring hepatology-guided monitoring...Disseminated nocardiosis should be considered for immunosuppressed patients with autoimmune hepatitis presenting with subacute neurological decline and ring-enhancing brain lesions, particularly during outpatient immunosuppression transitions when antimicrobial prophylaxis may be interrupted or incompletely reconciled. The patient demonstrated progressive neurological improvement and radiographic abscess..."

Journal • Alzheimer's Disease • Autoimmune Hepatitis • CNS Disorders • Cognitive Disorders • Hematological Disorders • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammation

Enterococcus faecium pneumonia diagnosed by metagenomic next-generation sequencing in a patient with chronic obstructive pulmonary disease. (PubMed, IDCases) - "Despite empirical broad-spectrum antibiotics (piperacillin-tazobactam followed by imipenem-cilastatin), his condition deteriorated into acute respiratory distress syndrome (ARDS) requiring invasive mechanical ventilation. The patient gradually improved on imipenem-cilastatin plus moxifloxacin and was successfully extubated and discharged. This case suggests that E. faecium can cause severe CAP in COPD patients, and mNGS is a valuable diagnostic tool when conventional cultures are negative; herpesviruses with classification C detected by mNGS should not be overinterpreted."

Biomarker • Journal • Next-generation sequencing • Acute Respiratory Distress Syndrome • Chronic Obstructive Pulmonary Disease • Cough • Epstein-Barr Virus Infections • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Transarterial Microembolization in Refractory Plantar Fasciitis: Functional and Patient-Reported Early- to Midterm Outcomes from a Single-Center Pilot Study. (PubMed, Diagnostics (Basel)) - " In this single-center observational pilot study with ambispective data collection, 16 procedures in 13 patients were treated using imipenem/cilastatin... Transarterial microembolization was associated with rapid functional and patient-reported improvement and a favorable safety profile. These exploratory, hypothesis-generating findings warrant confirmation in controlled prospective studies."

Journal • Musculoskeletal Diseases • Pain

Time-Dependent Degradation of Imipenem in Aqueous Solution and Its Impact on Antibacterial Activity. (PubMed, Antibiotics (Basel)) - "However, Imipenem solution after 24 h with chemical degradation exhibited significantly decreased effects against E. coli and P. aeruginosa. Accordingly, the patterns of metabolite changes in Imipenem and Cilastatin were characterized according to concentration and dissolution time, and the corresponding antibacterial activities against different bacterial strains were compared."

Journal • Infectious Disease

Commentary: Genicular Artery Embolization using Imipenem/Cilastatin vs. Microsphere for Knee Osteoarthritis (GAUCHO): 12-Month Clinical Results of a Single-blind Randomized Controlled Trial. (PubMed, Cardiovasc Intervent Radiol) - No abstract available

Journal • Immunology • Osteoarthritis • Pain • Rheumatology

Successful treatment of inducible macrolide-resistant Mycobacterium abscessus subspecies abscessus surgical site infection after cosmetic surgery. (PubMed, IDCases) - "Treatment was initiated with combination antimicrobial therapy, including imipenem/cilastatin, amikacin, and tigecycline for 4 weeks, followed by clofazimine and sitafloxacin for 11 months as maintenance therapy. After 12 months of treatment, the fistula closed, and no recurrence occurred during follow-up. This case highlights the importance of considering MAA in surgical site infections following cosmetic surgery and suggests that individualized combination antimicrobial therapy based on susceptibility testing may lead to successful outcomes in macrolide-resistant extrapulmonary MAA."

Journal • Aesthetic Medicine • Dermatology • Infectious Disease • Nontuberculous Mycobacterial Disease • Respiratory Diseases

Successful treatment of Mycobacterium abscessus pulmonary disease with limited resection and perioperative chemotherapy containing clofazimine: a case report. (PubMed, Respir Med Case Rep) - "Clarithromycin susceptibility shifted from susceptible on Day 3 to resistant on Day 14. Combination antimicrobial therapy was initiated with imipenem/cilastatin, amikacin, azithromycin, clofazimine, and sitafloxacin...The patient completed a 12-month course of antimicrobial therapy and remains recurrence-free at 30 months based on CT follow-up. The only notable side effect of chemotherapy was grade 2 skin hyperpigmentation, which was attributed to clofazimine."

Journal • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases