Primaxin (cilastatin/imipenem) / Abbott - LARVOL DELTA

Bu Zhong Yi Qi Tang targets key monocyte-associated genes to enhance sepsis therapy. (PubMed, J Ethnopharmacol) - "BZYQT enhances sepsis therapy by targeting critical monocyte-associated genes, thereby modulating immune responses and reducing inflammation."

Journal • Infectious Disease • Inflammation • Septic Shock • SAT1

Pharmacokinetics, Safety, and Tolerability of Funobactam in Combination with Imipenem/Cilastatin in Healthy Adult Elderly Male and Female Subjects (IDWeek 2025) - No abstract available

Clinical • Combination therapy • PK/PD data • Infectious Disease

Pharmacokinetics, Safety, and Tolerability of Funobactam in Combination with Imipenem/Cilastatin in Subjects with Various Degrees of Renal Function (IDWeek 2025) - No abstract available

Clinical • Combination therapy • PK/PD data • Infectious Disease

Breaking Down the Abscess: Nocardia farcinica Behind an Abdominal Mystery (ACG 2025) - "This case presents a 39-year-old male with a complex medical history who developed nocardiosis identified in an intrabdominal wall abscess.Case Description/ A 39-year-old incarcerated male with large-vessel arteritis (inconsistently on prednisone and methotrexate leading to a complicated vascular history now on rivaroxaban), multiple DVT's requiring an IVC filter, pyoderma gangrenosum and chronic mesenteric ischemia presented to the ED for two months of hematochezia, 70-lb weight loss, hand rashes with abdominal and leg pain...He was started on vancomycin and piperacillin/tazobactam...He was then changed to imipenem-cilastatin and trimethoprim/sulfamethoxazole; however, resistances returned to imipenem-cilastatin and switched to linezolid...A) Colonial characteristics of N. farcinica on blood agar plates include pale yellow pigmentation, elevated growth, a rough surface, and opacity. B) Gram staining of N. farcinica revealed Gram-positive bacteria characterized by..."

Cardiovascular • Gastrointestinal Disorder • Infectious Disease • Pyoderma Gangrenosum • Respiratory Diseases

Treatment of liver abscess caused by Klebsiella pneumoniae with multi-site infection: a case report. (PubMed, J Med Case Rep) - "This medical case report describes a patient with a pyogenic liver abscess caused by Klebsiella pneumoniae who was eventually diagnosed with invasive Klebsiella pneumoniae liver abscess syndrome. Invasive Klebsiella pneumoniae liver abscess syndrome has permanent morbidity, poor quality of life, and lacks warning signs. Despite the complexity of the condition, the patient received effective treatment and the abscess was successfully managed. Through this case, we propose that invasive Klebsiella pneumoniae liver abscess syndrome caused by hypervirulent Klebsiella pneumoniae should be considered for patients with diabetes and fever in the emergency department. Targeted intravenous antibiotics and percutaneous drainage of the abscess are key to the treatment of invasive Klebsiella pneumoniae liver abscess syndrome."

Journal • Anorexia • Back Pain • CNS Disorders • Diabetes • Hepatology • Infectious Disease • Inflammatory Arthritis • Metabolic Disorders • Musculoskeletal Pain • Ocular Infections • Ocular Inflammation • Oncology • Ophthalmology • Pain • Pneumonia • Renal Disease • Respiratory Diseases • Seronegative Spondyloarthropathies • Solid Organ Transplantation • Solid Tumor • Transplantation • Type 2 Diabetes Mellitus

Transarterial Embolization for Chronic Postsurgical or Posttraumatic Pain of Musculoskeletal Origin: Clinical Outcomes and Imaging Correlates. (PubMed, Life (Basel)) - "TAE was performed using imipenem/cilastatin particles to selectively target pathological vasculature...No major adverse events occurred, and follow-up imaging demonstrated resolution of inflammation in selected cases. These results support the role of TAE as a minimally invasive treatment option for intervention-related CPSP involving the musculoskeletal system, and further prospective studies are warranted."

Clinical data • Journal • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Tophaceous gout of the knee: successful treatment with transarterial microembolization. (PubMed, Skeletal Radiol) - "Transarterial microembolization (TAME) using imipenem/cilastatin (IPM/CS) was performed, targeting abnormal vascular blushes identified on angiography...Subsequently, febuxostat with prophylactic colchicine was initiated as urate-lowering therapy. This case illustrates the feasibility of TAME as a potential adjunctive treatment in selected patients with refractory tophaceous gout. Additionally, pre-procedural imaging, such as contrast-enhanced magnetic resonance imaging (MRI), may help identify patients who are more likely to benefit from TAME."

Journal • Gout • Immunology • Inflammation • Inflammatory Arthritis • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Rheumatology

Assessing antibiotics consumption, use and outcomes in a Yemeni tertiary hospital: A prospective cross-sectional study. (PubMed, PLoS One) - "The study found an alarmingly high prevalence of antibiotic use and excessive consumption, with both overuse and underuse patterns observed, underscoring the need for effective regulatory interventions and improved antibiotic stewardship in Yemen."

Journal • Observational data • Infectious Disease

Trends in carbapenem antibiotics utilization, costs, and market dynamics in Medicaid: a retrospective analysis from 1991 to 2023. (PubMed, Front Med (Lausanne)) - "Four carbapenems; imipenem/cilastatin, meropenem, ertapenem, and doripenem were examined. Continuous monitoring of antibiotic use is essential to balance effective infection management with the containment of antimicrobial resistance and healthcare costs. Further research is needed to evaluate the long-term effects of stewardship programs and the introduction of novel therapeutic options on carbapenem utilization."

Journal • Reimbursement • Retrospective data • US reimbursement • Infectious Disease • Novel Coronavirus Disease

Disseminated Mycobacterium abscessus Infection in a Three-Year-Old Girl With CHARGE Syndrome: A Case Report and Literature Review. (PubMed, Cureus) - "Following microbiologic diagnosis, treatment was started with azithromycin and imipenem/cilastatin, along with exchanges of the intravenous device. However, subsequent deterioration of her condition required the admission to the intensive care unit and finally led to the introduction of a four-agent regimen with azithromycin, amikacin, linezolid, and tigecycline, whose sensitivity was confirmed later. After the initiation of sensitive antimicrobial therapy, she gradually recovered and was discharged with oral azithromycin and sitafloxacin...Although her immune function showed no abnormalities, we identified several predisposing factors related to her post-septic condition and her congenital medical history through an investigation of her clinical features with a literature review. While some previous cases of disseminated rapid-growing mycobacterial infections were successfully managed by intravascular device removal alone, this case underscores the need for tailored..."

Journal • Critical care • Infectious Disease • Nontuberculous Mycobacterial Disease • Otorhinolaryngology • Pediatrics • Respiratory Diseases

Incidence of and risk factors for side effects associated with antibiotic treatment for pneumonia. (PubMed, J Infect Chemother) - "Broad-spectrum antibiotics tended to cause diarrhea more frequently. The use of cefotiam and meropenem was associated with increased liver enzyme levels."

Adverse events • Journal • Dermatology • Hepatology • Infectious Disease • Liver Failure • Pneumonia • Respiratory Diseases

A Retrospective, Multicentric Evaluation of the Safety and Efficacy of Transcatheter Arterial Micro Embolization for Refractory Achilles Tendinopathy. (PubMed, Cardiovasc Intervent Radiol) - "TAME for chronic AT is a safe and effective treatment that improves long-term functional outcomes and can be offered to patients resistant to conservative management."

Journal • Retrospective data • Pain

BlaGES-6 producing Pseudomonas aeruginosa ST235 is involved in resistance to different β-lactams. (PubMed, Microb Pathog) - "Minimum inhibitory concentration assays demonstrated HU63's resistance to all β-lactams tested (meropenem, imipenem-cilastatin, ceftazidime, piperacillin-tazobactam), while HU141 remained susceptible except to cefoxitin and cloxacillin. These findings underscore the multifactorial nature of resistance in Carbapenem-resistant Pseudomonas aeruginosa (CRPA), combining enzymatic inactivation, efflux, and genetic adaptability. The study emphasizes the urgent need for genomic surveillance to track high-risk clones and develop therapies targeting tolerance mechanisms alongside traditional resistance."

Journal

Severe complications following transarterial microembolization for a micro arterio-venous fistula in a patient with chronic venous ulcer: a case report. (PubMed, Front Radiol) - "The patient developed significant complications, including extensive leg swelling, skin changes, and cellulitis requiring prolonged inpatient care. These findings highlight the importance of patient selection and embolic agent considerations to mitigate potential risks associated with TAME."

Journal • Cardiovascular • Dermatology • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Venous Ulcer

Combined Percutaneous Sclerotherapy Plus Transarterial Embolization for Refractory Sports Injuries in Young Athletes: A Feasibility Study. (PubMed, Cardiovasc Intervent Radiol) - "The combined sclerotherapy plus embolization technique is feasible and safe for treating refractory lower-extremity tendinopathies in young athletes. Comparative studies are needed to assess potential added benefits."

Journal • Pain

PIVOT-PO: A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) (clinicaltrials.gov) - P3 | N=1690 | Completed | Sponsor: Spero Therapeutics | Recruiting ➔ Completed | N=2648 ➔ 1690 | Trial completion date: Nov 2025 ➔ Feb 2025 | Trial primary completion date: Nov 2025 ➔ Jan 2025

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Infectious Disease • Nephrology

Successful management of Nocardia farcinica brain abscess in an immunocompetent adult with trimethoprim/sulfamethoxazole hypersensitivity: A case report and review. (PubMed, Diagn Microbiol Infect Dis) - "N. farcinica brain abscess can occur in immunocompetent adults, posing therapeutic challenges with TMP/SMX intolerance. This case demonstrates that alternative regimens-imipenem/cilastatin, amikacin, amoxicillin, and minocycline-can achieve sustained remission. Individualized therapy based on drug susceptibility and patient factors is critical."

Journal • CNS Disorders • Epilepsy • Immunology • Infectious Disease

Impact of Antibiotic Post-Prescription Authorization in Resource-Limited Emergency Rooms and Acute Care Units (ASM Microbe 2025) - "In August 2020, a PPA was implemented for piperacillin/tazobactam, meropenem, imipenem/cilastatin and ertapenem. This study demonstrates the positive impact of PPA on antibiotic consumption and clinical outcomes in emergency settings. Future studies should evaluate PPA early in the course of treatment to identify the most effective interventions for improving the quality of care."

Infectious Disease

Impact of Antimicrobial Stewardship Program Suspension on Antibiotic Use during a Healthcare System Crisis: A Single-Center Experience in South Korea (ASM Microbe 2025) - "Preauthorization antibiotics included carbapenems (meropenem, imipenem/cilastatin, and ertapenem), ceftazidime/avibactam, and ceftolozane/tazobactam. PAF antibiotics included colistin, daptomycin, glycopeptides (vancomycin and teicoplanin), linezolid, and tigecycline... The suspension of antimicrobial stewardship interventions resulted in a significant increase in the use of restricted antibiotics, particularly those requiring preauthorization, highlighting the essential role of ASP in controlling antibiotic overuse and misuse."

Clinical

A case report of peritoneal dialysis-associated peritonitis caused by Mycobacterium mageritense. (PubMed, IJID Reg) - "Based on susceptibility testing, treatment was initiated with trimethoprim/sulfamethoxazole (TMP/SMX) (80 mg/400 mg) 5 mg/kg every 24 hours in combination with minocycline 100 mg every 12 hours, which was subsequently changed to TMP/SMX plus faropenem 200 mg every 8 hours due to nausea caused by minocycline...We switched to TMP/SMX, imipenem/cilastatin 500 mg every 12 hours, and used linezolid 600 mg every 12 hours, which was later replaced with amikacin, guided by therapeutic drug monitoring...We treated the patient with TMP/SMX and sitafloxacin 100 mg every 24 hours, which was well-tolerated...Our findings underscore the importance of suspecting non-tuberculous mycobacteria in PD catheter-related infection and considering the early inclusion of acid-fast bacillus culture. Given the diagnostic challenges and the complexity of managing multi-drug antimicrobial therapy in patients with renal dysfunction, we recommend early catheter removal."

Journal • Chronic Kidney Disease • Diabetic Nephropathy • Infectious Disease • Nephrology • Nontuberculous Mycobacterial Disease • Renal Disease • Respiratory Diseases

Wound dehiscence rates decreased in reconstructive surgery of anorectal malformations after introduction of a standardized postoperative treatment program. (PubMed, World J Pediatr Surg) - "The standardized post-PSARP program comprised a minimum of 3 days of: intravenous antibiotics imipenem+cilastatin (with optional subsequent oral amoxicillin+clavulanic acid+metronidazole), fasting after primary PSARP (no stoma), urinary catheter and regular wound cleansing...In primary PSARPs (no stoma, 59% males), wound dehiscence developed in 6 of 33 patients (18%) in the standardized post-PSARP program group versus 17 of 40 patients (43%) in the control group (p=0.026). Wound dehiscence rates may be reduced using a standardized post-PSARP treatment program."

Journal • Pediatrics

TARGETING PAIN IN THE FIRST METATARSOPHALANGEAL JOINT: A NEW COMPLEMENTARY APPROACH IN RHEUMATOLOGY AND INTERVENTIONAL RADIOLOGY COLLABORATION USING EMBOLIZATION (EULAR 2025) - "Imipenem/cilastatin-based embolization offers a minimally invasive, effective alternative for managing refractory MTPJ pain of various etiologies. The technique demonstrates significant improvements in pain relief and functional outcomes, with a favorable safety profile compared to surgical interventions. Future studies involving larger cohorts, multi-center settings, and long-term follow-up are needed to validate its safety, efficacy, and sustained clinical benefits."

Anesthesia • Ankylosing Spondylitis • Gout • Immunology • Inflammation • Musculoskeletal Pain • Osteoarthritis • Pain • Rheumatoid Arthritis • Rheumatology • Seronegative Spondyloarthropathies • Spondylarthritis

A new treatment alternative for patients with painful hand osteoarthritis: Early results of the efficacy and safety of intraarterial imipenem-silastatin therapy (EULAR 2025) - "All patients (100%) had previously used NSAIDs, seven patients (77.8%) had low-dose glucocorticoids, five patients (55.6%) had colchicine, four patients (44.4%) had hydroxychloroquine and two patients (22.2%) had a history of biologic disease-modifying anti-rheumatic drug (DMARD) use due to misdiagnosis. In clinical practice, treatment options for patients with painful hand OA are very limited. A study by Kubo T et al. from Japan demonstrated the efficacy and safety of intra-arterial imipenem-cilastatin+iodinated contrast embolisation in 92 patients with hand OA in 2023 [1]."

Clinical • Dermatology • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Osteoarthritis • Pain • Rheumatology • Urticaria

A case of portal venous gas caused by the use of a nasojejunal nutrition tube. (PubMed, J Int Med Res) - "This patient was discharged after 1 week of treatment with imipenem/cilastatin sodium for anti-infection, gastrointestinal decompression, fluid replacement, and pain relief, and the patient's abdominal pain was significantly relieved...The successful treatment of this patient highlights that addressing physical factors, providing gastrointestinal decompression, and administering anti-infection therapy can aid in the management of such cases. Bacterial culture of gastric juice and drug sensitivity testing can guide effective anti-infection treatment."

Journal • Infectious Disease • Nephrology • Pain • Pulmonary Disease • Respiratory Diseases

Clinical study of polymyxin E sodium mesylate in the treatment of carbapenem-resistant gram-negative bacteria (CRO) infection in critically ill patients (ChiCTR) - P4 | N=40 | Recruiting | Sponsor: Hangzhou Linping Hospital of Traditional Chinese Medicine; Hangzhou Linping Hospital of Traditional Chinese Medicine

New P4 trial • Infectious Disease