Stayban Pap (flurbiprofen transdermal) / GC-Rise Pharma, Taisho - LARVOL DELTA

Enhanced transdermal delivery of flurbiprofen via eutectic mixtures and novel terpene ester derivatives of L-amino acids. (PubMed, Int J Pharm) - "These findings underscore the effectiveness of chemical modifications in improving flurbiprofen's transdermal delivery potential, especially via eutectic mixtures, which appear to play a critical role in enhancing skin permeability. Consequently, this study supports the potential of tailored chemical modifications in developing more effective and controlled transdermal therapies."

Journal

Optimization of Chitosan-Decorated Solid Lipid Nanoparticles for Improved Flurbiprofen Transdermal Delivery. (PubMed, ACS Omega) - "Also, the total permeation of chitosan-coated SLNs (F7-F9) was significantly higher than that of the noncoated formulation (F5). Overall, this study has successfully designed a suitable carrier system of chitosan-coated SLNs that provide insight into the current conventional therapeutic approaches and suggest new directions for the advancements in transdermal drug delivery systems for improved permeation of flurbiprofen."

Journal

Flurbiprofen-loaded ethanolic liposome particles for biomedical applications. (PubMed, J Microbiol Methods) - "In stability study, optimized formulation showed maximum stability at 4 °C. These results suggest that transdermal system mediated application of flurbiprofen loaded ethanolic liposome can be considered as an effective way to afford consistent and predictable release of flurbiprofen which could provide beneficial effects in the management of various inflammatory diseases."

Journal • Pain

Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model. (PubMed, Lipids Health Dis) - "The overall study concluded that this ethosomal approach offers a new delivery system for sustained and targeted delivery for flurbiprofen."

Journal • Preclinical