gemifloxacin mesylate / Generic mfg. - LARVOL DELTA

The puzzle of early deception: Lying before belief representation. (PubMed, Cognition) - "The resulting pattern is asymmetric: young children show flexible sensitivity to witness access, audience knowledge, and opportunities for concealment, yet remain brittle under follow-up questioning, semantic leakage, and evidence-coordinated cover-story demands. This pattern is best understood as evidence for a factive, access-based form of epistemic mindreading that precedes robust belief-based deception."

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In vitro antibacterial activity of gepotidacin in combination with other antimicrobial agents against Neisseria gonorrhoeae isolates. (PubMed, Antimicrob Agents Chemother) - "Synergy and antagonism were evaluated using fractional inhibitory concentration (FIC) and FIC index (FICI) results for gepotidacin and comparator agents (azithromycin, cefixime, ceftriaxone, gemifloxacin, sitafloxacin, gentamicin, spectinomycin, doxycycline, and lefamulin). The evaluation of FICI showed no antagonistic or synergistic interactions, while the evaluation of individual FIC values revealed strain- and agent-specific synergistic or additive effects."

Journal • Preclinical • Infectious Disease

Gemifloxacin resistance in Mycobacterium tuberculosis without QRDR mutations in gyrA or gyrB: evidence for non-canonical resistance mechanisms. (PubMed, Microbiol Spectr) - "Although gemifloxacin is no longer used clinically due to toxicity, its unique structure reveals hidden, non-target-based resistance mechanisms (e.g., efflux, permeability changes) that likely also compromise current fluoroquinolones like levofloxacin and moxifloxacin. This exposes a critical blind spot: current molecular diagnostics (e.g., Xpert MTB/XDR, GenoType) may falsely label resistant strains as susceptible, risking treatment failure. We argue that phenotypic drug susceptibility testing (DST) must be mandatory-not optional-in multidrug-resistant tuberculosis (MDR-TB) programs to safeguard against this silent, undetected resistance."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Factive mindreading reflects the optimal use of limited cognitive resources. (PubMed, Proc Biol Sci) - "Even agents that use more sophisticated strategies avoid representing beliefs unless necessary. Our results elucidate the computational principles underlying efficient social prediction and explain many of the successes and failures of human and non-human mindreading from first principles."

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Disproportionality Analysis of Fluoroquinolone-Associated Peripheral Neuropathy in the FAERS Database (2007-2024). (PubMed, Clin Transl Sci) - "Positive disproportionality signals were observed for the commonly prescribed FQs (ciprofloxacin, levofloxacin, moxifloxacin, and ofloxacin), with seven distinct PN manifestations generating signals. Notably, we detected PN-related signals for gemifloxacin, a relatively new FQ with limited prior evaluation of neurotoxicity...Strengthened clinical monitoring for early signs of PN is advisable when FQ treatment becomes unavoidable. Further controlled epidemiological studies are needed to validate these signals and define at-risk groups, alongside mechanistic research aimed at supporting the development of neuroprotective strategies."

Journal • Infectious Disease • Pain

Self-Stabilizing Covalent Ligand Targets Bacterial Phosphatidylethanolamine and Enhances Antibiotic Efficacy. (PubMed, Pharmaceutics) - "Conjugation of DMAX to Gemifloxacin (Gem) significantly enhanced antibiotic efficacy by 10-fold compared with free Gem, even after rapid drug clearance, while maintaining safety in mammalian cells. These results identify DMAX as an efficient and versatile PE-targeting platform, enabling selective membrane anchoring to advance precision antibiotic strategies."

Journal • Infectious Disease

Chiral separation of fluoroquinolones by capillary electrophoresis using glucosamine-functionalized carbon quantum dots as a Pseudostationary phase. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "Compared to the CE system using free glucosamine solely as the chiral selector, the CE system employing GA-CQDs as a pseudostationary phase demonstrated a substantial improvement in chiral resolution (Rs) for all six model analytes (Ofloxacin: 1.56 → 9.21; Pazufloxacin: 0 → 8.53; Prulifloxacin: 1.38 → 7.58; Lomefloxacin: 1.01 → 2.84; Gemifloxacin: 0 → 1.25; Balofloxacin: 0 → 0.88). This study represents the first report on employing GA-CQDs as a chiral selective medium to construct a capillary electrophoresis system, which achieved satisfactory enantioselectivity. Furthermore, the chiral recognition mechanism of glucosamine was preliminarily investigated through molecular modeling simulations, with the binding energy providing insights into the separation process."

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A long way to long-distance movement: A study on the acquisition of factive islands. (PubMed, J Child Lang) - "Seventy monolingual Romanian-speaking children (split into two age groups: 5-year-old and 7-year-old children) and 15 adults took part in a comprehension task, which tested the (un)availability of adjunct extraction from the clausal complements of both cognitive and emotive factive verbs. The results show that only at age 7 do children begin to observe the restrictions imposed by factive islands, regardless of the sub-type of factive verb, even though they do not reach full mastery of the phenomenon at this age."

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In-vitro microbiological evaluation of gemifloxacin derivatives: Synthesis, vibrational spectroscopy, molecular docking and DFT studies. (PubMed, Pak J Pharm Sci) - "Energy gaps (HOMO-LUMO) of derivative G-D09 and G-D10 is 1.72 eV determinant as cognizant. Molecular docking approach was also applied through MOE software against K. pneumonia (PDB ID: 6k63), C. freundii (PDB ID: 3JWB) and C. albicans (PDB ID: 1AI9) ranging between -6.05 and -7.79 kcal/ mol, authenticating their higher antibacterial response towards Klebsiella pneumoniae among all compounds and G-D10 as potent antifungal agent."

Journal • Preclinical • Infectious Disease • Pneumonia • Respiratory Diseases

Gemifloxacin ameliorates acetic acid-induced ulcerative colitis via modulation of inflammatory, oxidative, and adhesive biomarkers and histopathological changes in rats. (PubMed, J Mol Histol) - "Gemifloxacin demonstrated remarkable anti-inflammatory, antioxidant, and tissue-protective impacts in a rat prototype of ulcerative colitis with therapeutic outcomes comparable to those of sulfasalazine. These findings support its promise as an adjuvant medication in controlling and managing inflammatory bowel diseases."

Biomarker • Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Oncology • Ulcerative Colitis • ICAM1 • IL1B • MPO • NFKB1 • TNFA

High-efficiency photocatalytic degradation of multiple quinolone antibiotics using a hybrid heterojunction with synergistic doping of boron and bismuth. (PubMed, J Colloid Interface Sci) - "This configuration exhibited exceptional reduction capacity and optimized photogenerated carrier separation and migration efficiency, leading to excellent degradation performance for gatifloxacin ((26.89 ± 1.94) × 10-2 min-1), sparfloxacin ((10.48 ± 2.03) × 10-2 min-1), moxifloxacin ((8.43 ± 1.02) × 10-2 min-1), and gemifloxacin ((4.13 ± 0.13) × 10-2 min-1). The degradation disparities among these quinolone antibiotics were systematically elucidated through analyses of steric hindrance, frontier molecular orbital energies, Mulliken charge distribution, reaction sites, and active species contribution rates. This study offers guidance for the systematic development of heterojunction photocatalysts to address fluoroquinolone pharmaceutical pollutants in aquatic ecosystems."

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Radionuclide-Aided Improvement of the Therapeutic Efficacy of Novel Antibody-Drug Conjugates against HER2-Expressing Cancers. (PubMed, Mol Pharm) - "New trastuzumab-based ADCs utilizing fendiline or gemifloxacin as drug moieties were developed, and they were decorated with therapeutic radionuclide 177Lu or 225Ac. Radiolabeled versions of newly synthesized ADCs showed significantly improved anticancer efficacy compared to unlabeled ADCs, especially when they were armed with 225Ac, demonstrating the great potential of radiolabeled ADCs in cancer therapy. This study offers an effective strategy for improving the therapeutic efficacy of ADCs by fortifying them with radionuclides."

Journal • Oncology • HER-2

Theory of Mind Abilities and Comprehension of Mental Terms in Subgroups of Children With Autism Spectrum Disorder and Developmental Language Disorder. (PubMed, J Speech Lang Hear Res) - "Comprehension of mental terms, including the factive verb know, the nonfactive verbs think and guess, and the adjective sure, was evaluated contrasting these terms by using 12 paired stimuli organized into three sets...This study underscores differences in ToM and FNFT comprehension across subgroups and highlights similarities between ASD-LI and DLD. These findings emphasize the strong link between language skills and ToM abilities, with FNFT comprehension playing a crucial role in ToM development."

Journal • Autism Spectrum Disorder • Developmental Disorders • Genetic Disorders • Psychiatry

Evaluation of Quinoline-Related Carboxylic Acid Derivatives as Prospective Differentially Antiproliferative, Antioxidative, and Anti-Inflammatory Agents. (PubMed, Chem Biol Drug Des) - "Gemifloxacin, considerably unlike markets FQs, indomethacin and quinoline derivatives, exerted exceptional and differential antiproliferation propensities in colorectum SW480, HCT116, and CACO2, pancreatic PANC1, prostate PC3, mammary T47D, lung A375, and melanoma A549 adherent monolayers using the sulforhodamine B colorimetric method versus antineoplastic cisplatin. All quinoline derivatives and gemifloxacin alike, but not levofloxacin, ciprofloxacin, or indomethacin, displayed substantially selective viability reduction affinities in prolonged tumor incubations of cervical HELA and mammary MCF7 cells...Conclusively, this study revealed the considerably profound repurposed duality of cytotoxicity and anti-inflammation pharmacologies of quinoline derivatives. Activity-guided structural modifications of the present nuclear scaffolds can be inherently linked to the betterment and enhancement of their repurposed pharmacologies."

Journal • Cervical Cancer • Colorectal Cancer • Inflammation • Melanoma • Oncology • Solid Tumor

Antimicrobial Resistance and Public Health Risks Associated with Staphylococci Isolated from Raw and Processed Meat Products. (PubMed, Foodborne Pathog Dis) - "The antibiotic resistance and susceptibility behavior showed that 82% of the Staphylococcus isolates were resistant to β-lactam antibiotics such as aztreonam, followed by methicillin (68%), oxacillin (54%), cefepime (36%), ceftazidime (34%), cefaclor (24%), cefotaxime (22%), ertapenem (4%), meropenem and imipenem (2%). Among non-β-lactam antibiotics, the most widespread resistance was observed against nalidixic acid (80%), sulfadiazine (76%), vancomycin (24%), erythromycin (10%), chloramphenicol (6%), and kanamycin and gatifloxacin (4%). One hundred percent of the isolates were susceptible to ciprofloxacin, tetracycline, gemifloxacin, and cefotaxime/clavulanic acid...Current findings show widespread occurrence of MDR Staphylococcus strains in raw meat and street meat products, which is a potential risk to public health. Therefore, the study suggests strict monitoring of hygiene through the whole food chain and judicious use of antibiotics."

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Comparison of Mutant Prevention Concentrations of Fluoroquinolones Against ESBL-Positive and ESBL-Negative Klebsiella pneumoniae Isolates from Orthopedic Patients. (PubMed, Microb Drug Resist) - "The MPC90 values of 55 isolates of ESBL-positive K. pneumoniae against 4 fluoroquinolones were 32 µg/mL for levofloxacin and gatifloxacin, 16 µg/mL for ciprofloxacin, and 4 µg/mL for gemifloxacin. The mutant-preventing ability of gatifloxacin and gemifloxacin was the strongest among the 4 fluoroquinolones. So gemifloxacin may be the first choice of drug to treat K. pneumoniae infection."

Journal • Infectious Disease • Orthopedics • Pneumonia • Respiratory Diseases

Multiplex PCR-based genotyping of Salmonella Enteritidis and Salmonella Typhimurium from food sources and assessment of their antimicrobial resistance profiles in Egypt. (PubMed, Mol Biol Rep) - "Stakeholders must implement strict control measures and rationalize antibiotic use in veterinary and human medicine due to the rise of antibiotic-resistant strains."

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Quantum Reconstructions as Stepping Stones Toward ψ-Doxastic Interpretations? (PubMed, Found Phys) - "In this paper, I discuss whether ψ-doxastic interpretations constitute a reasonable alternative. My thesis is that if we want to engage QRP with ψ-doxastic interpretations, then we should aim at a reconstruction that is spelled out in non-factive experiential terms."

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Epistemic language in news headlines shapes readers' perceptions of objectivity. (PubMed, Proc Natl Acad Sci U S A) - "Specifically, we ask whether factive verb framing (e.g., "Scientists know climate change is happening") increases perceived objectivity compared to nonfactive framing (e.g., "Scientists believe [...]")...Surprisingly, verb framing had relatively little, inconsistent influence over participants' judgments of the truth of claims. These results demonstrate how, apart from shaping whether we believe a claim is true or false, epistemic language in media can influence whether we believe a claim has an objective answer at all."

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Amoxicillin, gemifloxacin and rabeprazole, as first-line Helicobacter pylori therapy in clinical practice: A pilot study. (PubMed, Medicine (Baltimore)) - "Diarrhea, bloating, abdominal pain, and nausea-vomiting were seen in some patients, but no reflux, constipation, skin rash, listlessness-fatigue, headache, dizziness, palpitations, dry mouth, or weight loss was seen in any patient. In regions with high resistance to clarithromycin and metronidazole in particular, the combination of gemifloxacin with amoxicillin and rabeprazole can be considered for use in first-stage treatment as both the efficacy and tolerability are high."

Journal • Constipation • Dermatology • Fatigue • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pain • Xerostomia

Luminescent and time-resolved determination of gemifloxacin mesylate in pharmaceutical formulations and spiked blood plasma samples using a lanthanide complex as a probe. (PubMed, Anal Methods) - "The proposed method showed good accuracy with an average recovery of 99% with relative standard deviations of less than 5% in spiking experiments, even in complex pharmaceutical dosage forms such as tablets and in human blood plasma. Herein, the ability of the suppression of the luminescence background by using the long lag times of the lanthanide probe in a time-resolved detection scheme provided reliable and precise results, which suggests its potential for use in further real or patient samples."

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Prevalence and antimicrobial resistance of Enterobacteriaceae in the north of Kazakhstan. (PubMed, Open Vet J) - "In all isolates identified, antibiotic resistance/sensitivity was determined by disc-diffusion method to ampicillin, cefoxitin, gentamicin, levomycetin, tetracycline, ciprofloxacin, norfloxacin, ofloxacin, cefoperazone, cefpodoxime, streptomycin, kanamycin, doxycycline, gemifloxacin, nalidixic acid, furazolidone, furadonine, amoxicillin, and enrofloxacin. The study has demonstrated that the greatest number of Enterobacteriaceae were sensitive to the action of meropenem, which belongs to the group of beta-lactam antibiotics; resistance was demonstrated against tetracycline, doxycycline, ampicillin, amoxicillin, ofloxacin, and cefpodoxime. The most common genes encoding antimicrobial resistance were as follows: BlaTEM and OXA in 41 and 28 isolates, respectively, encoding resistance to beta-lactams; StrA and StrB in 45 and 48 isolates encoding aminoglycosides; and tetA and tetB in 43 and 28 isolates encoding tetracyclines. Obtained data demonstrate that uncontrolled and..."

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Antiurease Activity of Antibiotics: In Vitro, In Silico, Structure Activity Relationship, and MD Simulations of Cephalosporins and Fluoroquinolones. (PubMed, ACS Omega) - "Levofloxacin-based, or clarithromycin-based, triple therapy is frequently used to inhibit the bacterial urease enzyme for the eradication of H. pylori...The results demonstrate the jack bean urease inhibitory activity of cephalosporins, wherein cefadroxil, cefpodoxime, cefotaxime, and cefaclor displayed inhibitions (IC50 21.35 ± 0.64 to 62.86 ± 0.78 μM) compared with the standard thiourea (IC50 21.25 ± 0.15 μM). Among fluoroquinolones, levofloxacin, ofloxacin, and gemifloxacin (IC50 7.24 ± 0.29 to 16.53 ± 0.85 μM) unveiled remarkable inhibitory profiles...Ciprofloxacin and moxifloxacin displayed weak urease inhibitions...MD simulations and MMPBSA results demonstrated the existence of significant protein-ligand binding. Overall, these results warrant further investigations into the significance of these active molecules in relation to their inhibitory potential against the targeted urease enzyme."

Journal • Preclinical • Gastric Cancer • Gastrointestinal Cancer • Infectious Disease • Oncology • Peptic Ulcer • Solid Tumor

EFFICACY AND SAFETY OF GEMIFLOXACIN CONTAINING TREATMENT REGIMEN IN FIRST-LINE TREATMENT OF HELICOBACTER PYLORI. (PubMed, Arq Gastroenterol) - "First group patients were treated with amoxicillin, gemifloxacin and pantoprazole and second group patients were treated with amoxicillin, metronidazole, bismuth subcitrate and pantoprazole for seven days. Conclusion - Gemifloxacin containing treatment regimen is as effective as bismuth containing quadruple treatment regimen for H. pylori infection and patient compliance is better in this group. Gemifloxacin containing treatment regimens may be novel and effective alternatives for eradication of H. pylori infection."

Journal • Gastrointestinal Disorder • Infectious Disease

Wastewater purification from Rhodamine B and Gemifeloxacine (GEM) by GOPF nanocomposite: A novel MD simulation for experimental contaminants removing. (PubMed, Water Environ Res) - "In this study, the synthesized nanocomposite was evaluated novel graphene oxide/pectin/ferrite (GOPF) adsorbent to the adsorption of Rhodamine B (RhB) and Gemifloxacin (GEM) from wastewater...Also, the anti-cancer test of nanocomposite was done with 75% viability in high concentrations of nanocomposite. Thus, GOPF application results not only are suitable for dyes but only satisfying for drugs."

Journal • Oncology