GH56 / Genhouse Bio - LARVOL DELTA

Targeting MTAP-deleted tumor via synthetic lethality with a combination of a PRMT5i and an MAT2Ai (AACR 2024) - "In summary, we discovered potent, selective and brain penetrant PRMT5 inhibitor GH56 and MAT2A inhibitor GH31. Both compounds are currently under evaluation in IND-enabling studies and will provide more options for MTAP-deleted cancers."

Synthetic lethality • Brain Cancer • CNS Tumor • Gastrointestinal Cancer • Glioblastoma • Lung Cancer • Mesothelioma • Non Small Cell Lung Cancer • Oncology • Pancreatic Cancer • Solid Tumor • CDKN2A • MAT2A • MTAP