clonazepam / Generic mfg. - LARVOL DELTA

Survival Following a Tricyclic Antidepressant Overdose Presenting With Serotonin Syndrome-Like Symptoms and Critical Illness Polyneuropathy: A Case Report. (PubMed, Cureus) - "We report the case of a patient who ingested a lethal dose of amitriptyline, presented with serotonin syndrome-like neurological symptoms on arrival, and subsequently developed suspected critical illness polyneuropathy (CIP) during the clinical course...Clonazepam, levetiracetam, and cyproheptadine were administered, along with alkalinization therapy...Subsequently, limb weakness and nerve conduction study findings raised suspicion for CIP. This case highlights that tricyclic antidepressant intoxication can manifest with diverse neurological and neuromuscular complications, necessitating comprehensive management from the acute through chronic phases."

Journal • Acute Respiratory Distress Syndrome • Anesthesia • CNS Disorders • Depression • Infectious Disease • Metabolic Disorders • Movement Disorders • Pain • Pneumonia • Psychiatry • Pulmonary Disease • Respiratory Diseases

Minocycline attenuates panicogenic responses in a CO2-induced panic attack model: a translational approach. (PubMed, Transl Psychiatry) - "Treatment with minocycline, similar to the clinically effective panicolytic clonazepam, attenuates CO2-induced panic-like responses in both mice and humans. These results support the potential of minocycline as a therapeutic strategy for PD."

Journal • CNS Disorders • Inflammation • Mood Disorders • Psychiatry • IL10

Management strategies for burning mouth syndrome: a comprehensive review. (PubMed, J Oral Facial Pain Headache) - "Key pharmacological treatments such as clonazepam and capsaicin are explored in detail, alongside the potential of newer agents like various classes of antidepressants (including tricyclic antidepressants, selective serotonin reuptake inhibitors, and serotonin and noradrenaline reuptake inhibitors, vortioxetine) and antiepileptics showing promise in addressing the multifactorial nature of BMS. The integration of telemedicine and digital health resources is proposed to enhance patient management and accessibility to multidisciplinary care. This review provides a comprehensive update on all available therapeutic approaches for BMS, encompassing pharmacological treatments, non-pharmacotherapeutic interventions, and lifestyle optimization strategies, offering a holistic perspective on managing this condition."

Journal • Review • Pain

Infantile Epsilon-Sarcoglycan (SGCE) Myoclonus-Dystonia: Diagnostic Pitfalls and Poor Response to Pharmacologic Treatment. (PubMed, Cureus) - "Trials with zonisamide, carbamazepine, sodium valproate, and clonazepam were ineffective; however, motor and cognitive development remained within the average range. Genetic testing was essential for diagnosis, pharmacologic response was limited, and functional outcome remained favorable. The later emergence of behavioral symptoms underscores the need for long-term multidisciplinary follow-up."

Journal • CNS Disorders • Dystonia • Epilepsy • Mental Retardation • Movement Disorders • Psychiatry

Early life exposure to clonazepam has both short- and long-term effects on seizures induced with pentylenetetrazol (PTZ). (PubMed, Front Pharmacol) - "Abruptly ceasing clonazepam administration in infant rats results in the development of withdrawal phenomena, represented by a striking increase in seizure propensity. Interestingly, transient augmentation of GABAergic inhibition during critical periods of synaptogenesis and neural network formation and maturation permanently modifies susceptibility to PTZ-induced epileptiform activity."

Journal • CNS Disorders • Epilepsy

Orthostatic tremor and its subtypes: a single centre cohort of 74 patients. (PubMed, J Neurol) - "We provide further insight into the clinical phenotypes of the OT subgroups and encourage future studies to validate these findings with larger sample sizes and establish reliable tools to measure OT severity to better assess disease progression and treatment response."

Journal • Retrospective data • Movement Disorders

Risk of miscarriage after benzodiazepine use during pregnancy: updated systematic review and meta-analysis. (PubMed, BMC Pregnancy Childbirth) - "This updated meta-analysis indicates that early pregnancy exposure to benzodiazepines is associated with an increased risk of miscarriage. The consistency across analyses and evidence of dose-response strengthen confidence in this association. Clinicians should carefully weigh risks and benefits, consider non-pharmacological alternatives, and ensure close monitoring when prescribing benzodiazepines to women of childbearing potential."

Journal • Retrospective data • Review • CNS Disorders • Epilepsy • Mood Disorders • Psychiatry

A case of childhood hyperekplexia due to a novel nonsense variant in the GLRA1 gene. (PubMed, Medicine (Baltimore)) - "This case expands the phenotypic spectrum of GLRA1-related hyperekplexia to include mild phenotypes with a negative nose-tap test. It underscores the critical role of whole-exome sequencing in distinguishing hyperekplexia from epilepsy, thereby avoiding inappropriate antiepileptic therapy."

Journal • CNS Disorders • Epilepsy • Immunology

Epidemiological Assessment of Benzodiazepine Dependence via Pharmacist-Led EMR Review in Pain and Palliative Care Institution. (PubMed, Pharmacy (Basel)) - "In this outpatient pain and palliative-care population, benzodiazepine-related dependence phenomena were common: 59.7% of patients met the criteria for dependence based on the pharmacist-led EMR review. The involvement of the pharmacist was essential, as this systematic evaluation would have been difficult to perform within routine medical consultations. The pharmacist's contribution enabled a detailed epidemiological characterization, revealing that the exposure duration-more than daily dose-was the principal, modifiable correlate of dependence, and that alprazolam was disproportionately represented in the higher-dependence categories. These findings underscore the value of pharmacist-supported surveillance to identify and measure BZD dependance."

Journal • Anesthesia • CNS Disorders • Insomnia • Mood Disorders • Pain • Palliative care • Psychiatry • Sleep Disorder

Intracerebral Hemorrhage With Superimposed Psychiatric Illness: Navigating the Evaluation of Altered Mental Status. (PubMed, Cureus) - "This report describes a 70-year-old woman with schizophrenia and bipolar disorder on haloperidol, lithium, and clonazepam who presented with confusion, rigidity, and agitation...This case underscores the diagnostic complexity of AMS in patients with coexisting psychiatric and neurologic disease. Overlapping symptoms can obscure acute intracerebral pathology, emphasizing the need for interdisciplinary collaboration, serial neuroimaging, and prompt EEG when indicated."

Journal • Bipolar Disorder • Cerebral Hemorrhage • CNS Disorders • Epilepsy • Hematological Disorders • Mental Retardation • Psychiatry • Schizophrenia

A diagnostic odyssey leading to the AIFM1-related disorder (ACMG 2026) - "Treatment and Management The patient is currently treated with Valproic acid, Ethosuxamide and Clonazepam...This variant occurred de novo in the unaffected mother. Whole blood RNA-seq identified aberrant splice products with the inclusion of an extra exon, leading to a frameshift in 10% of the reads."

CNS Disorders • Developmental Disorders • Epilepsy • Myositis • Otorhinolaryngology • AIF1 • NBEA

Response to bilateral globus pallidus interna (GPi) deep brain stimulation in a woman with dystonia due to ATP1A3 p.Arg756Cys (ACMG 2026) - "Treatment and Management After earlier treatment with botulinum toxin and baclofen and unsuccessful trials of carbidopa-levodopa, the patient underwent bilateral GPi DBS placement at age 17...She remains on clonazepam, which has shown efficacy for her dystonia...Her epilepsy is responsive to levetiracetam monotherapy...Diagnostic Workup In childhood, she underwent extensive genetic and metabolic workup for neurodegenerative diseases, including muscle biopsy and CSF studies. ATP1A3 was tested in a research lab with negative results before ATP1A3 p.Arg756Cys was found via gene panel at age 28."

Clinical • Ataxia • CNS Disorders • Depression • Dystonia • Epilepsy • Infectious Disease • Movement Disorders • Parkinson's Disease • Postpartum Depression

AN UNUSUAL CASE OF CEREBELLAR ISCHEMIC STROKE INITIALLY PRESENTING AS ISOLATED HEMIFACIAL SPASM WITHOUT OTHER NEUROLOGICAL SYMPTOMS AND SIGNS (ADPD 2026) - "Her symptoms were improved by atorvastatin, antiplatelet medication and symptomatic medications including baclofen and clonazepam. For now, we report for the first time a rare manifestation of cerebellar ischemic stroke initially presenting isolated hemifacial spasm without other neurological symptoms and signs. As like this case, if there are abrupt-onset isolated hemifacial spasm, it should be considered diagnosis of cerebellar ischemic stroke."

Clinical • Cardiovascular • Ischemic stroke

Nocturnal sleep-related scratching disorder as a possible variant of NREM arousal disorder: Clinical features and polysomnographic study of four newly reported cases. (PubMed, Sleep Med X) - "Paroxetine, 20 mg with clonazepam as (0.5-1.0 mg) at bedtime induced 50 % efficacy. MSLT: no objective sleepiness. These cases of sleep-related scratching disorder represent a heterogeneous presumed variant of NREM arousal disorder with various comorbidities, and with full/partial control from diverse therapies."

Journal • CNS Disorders • Dental Disorders • Depression • Fibrosis • Major Depressive Disorder • Psychiatry • Sexual Disorders • Sleep Disorder

Prehospital rescue treatment of cluster epileptic seizures and status epilepticus. (PubMed, Neurol Sci) - "Benzodiazepines, such as diazepam, lorazepam, and midazolam, are first-line treatments for SE due to their rapid onset of action, which facilitates seizure control...Additionally, challenges such as the availability of medications, training of emergency medical personnel, and development of standardized protocols are discussed. Ultimately, ensuring timely, effective treatment before hospital arrival by prehospital benzodiazepines use may improve outcomes for patients experiencing cluster epileptic seizures and SE."

Journal • Review • Anesthesia • CNS Disorders • Depression • Epilepsy • Hypotension • Psychiatry

When the face twitches: An atypical neurological presentation of spontaneous intracranial hypotension (EHF-EHC 2025) - "He was initially treated with clonazepam without improvement, followed by botulinum toxin type A injections, which resulted in a partial reduction of the spasms... This case underscores the importance of integrating focal neurological deficits with headache syndromes, including rare manifestations of SIH. Considering the long-term complications of venous congestion, an alternative treatment was proposed for both headache and hemifacial spasm."

Alzheimer's Disease • Cardiovascular • CNS Disorders • Hypotension • Otorhinolaryngology • Vascular Neurology

Efficacy of Clonidine in Reducing Craving in Inpatients With Cocaine/Crack Use Disorder (clinicaltrials.gov) - P4 | N=36 | Not yet recruiting | Sponsor: University of Sao Paulo General Hospital

New P4 trial

Surgical Management of Dentin Hypersensitivity Associated With Noncarious Cervical Lesions in a Patient With a Psychiatric History: A Case Report. (PubMed, Cureus) - "Although no change in psychotropic medication dosage was made - specifically, brexpiprazole (1 mg daily), quetiapine (25 mg daily), and clonazepam (0.5 mg daily, with an additional as-needed dose permitted, maximum once daily) - her psychiatrist noted stable affect with less focus on somatic distress. While anecdotal and based on patient self-report, these observations suggest that alleviating persistent orofacial symptoms may contribute to improved psychological well-being in medically complex patients. This case illustrates that with interdisciplinary communication and medical stabilization, psychiatric disorders need not preclude periodontal plastic surgery and that individualized, coordinated management can extend the indications of root coverage procedures to include the treatment of therapy-resistant hypersensitivity."

Journal • CNS Disorders • Immunology • Mental Retardation • Pain • Psychiatry

Effects of topically applied liquid N-acetylcysteine for the management of burning mouth syndrome. (PubMed, Sci Rep) - "Topically administered liquid NAC demonstrates potential as an effective and well-tolerated therapeutic strategy for managing BMS, offering symptom relief with minimal systemic burden. Although the combination with clonazepam did not demonstrate sustained superiority at 8 weeks, its principal advantage is a faster onset of improvement in OHIP‑14 K, evident by week 4."

Clinical • Journal • Neuralgia • Pain

Clinical and EEG characterization of late-onset de novo absence nonconvulsive status epilepticus secondary to benzodiazepine withdrawal. (PubMed, Epileptic Disord) - "NCSE secondary to BDZ withdrawal has distinctive clinical and EEG features but is misdiagnosed without an EEG. Reintroduction of BDZ stops seizures, but long-term management requires gradual BDZ discontinuation to prevent recurrences."

Journal • Absence Seizure Disorder • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Epilepsy • Infectious Disease • Mental Retardation • Movement Disorders • Psychiatry

Effect of Treatments on Pain and Quality of Life in Individual With Burning Mouth Syndrome (clinicaltrials.gov) - P4 | N=150 | Recruiting | Sponsor: Federal University of Minas Gerais | Trial completion date: Oct 2025 ➔ Mar 2026 | Trial primary completion date: Jul 2025 ➔ Feb 2026

HEOR • Trial completion date • Trial primary completion date • Pain

Cannabis-Induced Catatonia Complicated by Rhabdomyolysis, Acute Kidney Injury, and Sympathetic Overactivity: A Case Report. (PubMed, Cureus) - "Psychotic symptoms emerged concurrently with catatonic features, with recent cannabis use preceding symptom onset and a prolonged symptom-free interval prior to presentation, supporting a diagnosis of cannabis-induced catatonia in a patient with a history of cannabis-related psychosis. The patient was managed with intravenous fluids, lorazepam, aripiprazole, and clonazepam. Residual mild psychomotor slowing and psychotic ideation persisted.  This case report presents an instance of catatonia associated with cannabis use in a young adult with a prior history of cannabis-related psychosis. It explores the clinical reasoning used to distinguish this presentation from other potential causes, including mood disorders, antipsychotic-related effects, and medical or organic conditions, and discusses evidence-based management approaches aimed at minimizing medical complications and optimizing patient outcomes. It also highlights the need for patient education on..."

Journal • Acute Kidney Injury • Cardiovascular • CNS Disorders • Hematological Disorders • Mental Retardation • Nephrology • Psychiatry • Renal Disease • Venous Thromboembolism

Severe Neurocognitive Manifestations in Healthy Young Individuals With COVID-19: A Case Series. (PubMed, Clin Med Insights Case Rep) - "Clomipramine, Zolpidem and Clonazepam were effective in treating these patients. Even in healthy young individuals with COVID-19, severe neurocognitive manifestations could appear with possible long-term consequences. Further research is needed to expand the knowledge on mechanisms, targeted therapeutic strategies and predictors identifying at-risk groups."

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Depression • Fatigue • Infectious Disease • Mental Retardation • Mood Disorders • Novel Coronavirus Disease • Psychiatry • Sleep Disorder

Psychotic major depressive disorder and rapid eye movement sleep behavior disorder cooccurring with a pineal cyst: a case report with neuroimaging insights in a 15-year-old female. (PubMed, BMC Psychiatry) - "This case highlights the value of structural neuroimaging in adolescents with psychotic major depressive disorder and underscores the importance of individualized, multimodal treatment planning. Further research is warranted to clarify the clinical significance of pineal abnormalities and their association with mood and sleep disorders."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry • REM Sleep Behavior Disorder • Sleep Disorder

Retrospective analysis of clinical toxicology results from 2017 to 2023: exploring the characteristics and prevalence trends of detected drugs and poisons. (PubMed, J Forensic Leg Med) - "Estazolam (n = 347), midazolam (n = 272), bromadiolone (n = 265), clonazepam (n = 228), and quetiapine (n = 199) were the top five most frequently detected substances in clinical toxicological cases. Additionally, a decline in certain toxicants, such as paraquat, suggests the effectiveness of policy interventions. The findings also emphasize the risks of polypharmacy and the need for enhanced poisoning prevention and emergency response systems."

Journal • Retrospective data • CNS Disorders