clonazepam / Generic mfg. - LARVOL DELTA

Charles bonnet syndrome with subsequent depression in acute angle-closure glaucoma: a case report. (PubMed, Oxf Med Case Reports) - "CBS was diagnosed, and hallucinations resolved with reassurance and low-dose clonazepam. Several weeks later, the patient developed moderate depression (HAM-D = 18), successfully treated with mirtazapine. At three months, he remained asymptomatic. This case is unusual for its association of CBS with angle-closure glaucoma and subsequent depression, underscoring the need for proactive inquiry, de-stigmatization, and integrated ophthalmic-psychiatric care."

Journal • Age-related Macular Degeneration • CNS Disorders • Depression • Glaucoma • Macular Degeneration • Mood Disorders • Ophthalmology • Psychiatry • Retinal Disorders

Multidimensional Phenotyping of Orthostatic Tremor and Orthostatic Myoclonus: Baseline Findings from a Longitudinal Clinical Study. (PubMed, Tremor Other Hyperkinet Mov (N Y)) - "Clonazepam was most prescribed; other agents showed inconsistent associations...This study presents the first structured multidimensional phenotyping of orthostatic tremor and orthostatic myoclonus, integrating clinical, electrophysiological, comorbidity, functional, and treatment domains. Findings demonstrate diagnostic overlap and support multidimensional approaches for refining classification and guiding individualized management across orthostatic hyperkinetic syndromes."

Journal • ADHD (Impulsive Aggression) • Alzheimer's Disease • CNS Disorders • Dementia • Diabetes • Diabetic Neuropathy • Metabolic Disorders • Movement Disorders • Pain

AN UNUSUAL CASE OF CEREBELLAR ISCHEMIC STROKE INITIALLY PRESENTING AS ISOLATED HEMIFACIAL SPASM WITHOUT OTHER NEUROLOGICAL SYMPTOMS AND SIGNS (ADPD 2026) - "For now, we report for the first time a rare manifestation of cerebellar ischemic stroke initially presenting isolated hemifacial spasm without other neurological symptoms and signs. As like this case, if there are abrupt-onset isolated hemifacial spasm, it should be considered diagnosis of cerebellar ischemic stroke."

Clinical • Cardiovascular • Ischemic stroke

First report of malignant hyperthermia syndrome in an American Guinea hog. (PubMed, Can Vet J) - "Premedication with clonazepam, tiletamine-zolazepam, and xylazine; anesthetic induction with propofol and maintenance with isoflurane with oxygen on spontaneous ventilation; a ketamine infusion; and morphine for analgesia were provided. Key clinical message: This is the first report of MHS in a subject from a porcine companion breed and of an atypical, delayed onset. As MHS is life-threatening, preanesthetic genetic testing and/or preemptive treatment with oral dantrolene should be considered for pigs undergoing inhalant-based anesthesia."

Journal • Anesthesia • Cardiovascular • Gynecology • Metabolic Disorders • Ventricular Tachycardia • RYR1

Intentional Naproxen Overdose Causing Metabolic Acidosis: A Case Report. (PubMed, Cureus) - "We describe the case of a 24-year-old female who presented to the Emergency Department after an intentional multidrug overdose involving naproxen, hydroxyzine, and clonazepam. This case report aims to illustrate that large doses of naproxen may contribute to metabolic acidosis in overdose situations. In cases of intentional ingestions involving multiple substances, clinicians should consider NSAIDs as potential contributors to acid-base abnormalities, particularly when more common causes are excluded."

Journal • Metabolic Disorders

Seizure Clusters: Current Concepts in Definition and Treatment. (PubMed, J Clin Med) - "Consequently, the off-label use of oral benzodiazepines, including clobazam, clonazepam, and lorazepam, remains common when oral therapy is feasible, despite limited evidence. These include prompt intravenous benzodiazepine administration, followed by the intravenous loading of antiseizure medications such as brivaracetam or lacosamide in cases of seizure recurrence. In ED settings, "empirical" definitions of SCs (i.e., more than three seizures within 24 h) may facilitate timely intervention."

Journal • Review • CNS Disorders • Epilepsy

A Retrospective Study of Mood and Anxiety Disorders Management Profile (MooD-MaP) of Patients Admitted at the Makati Medical Center from 2014-2017. (PubMed, Psychopharmacol Bull) - "In MDD, clonazepam, escitalopram, quetiapine, and aripiprazole predominated, while clonazepam and selective serotonin reuptake inhibitors were most commonly used in AD. Psychopharmacologic management of hospitalized patients with mood and anxiety disorders in this Philippine tertiary center largely aligns with international practice. High rates of polypharmacy and suicidality underscore the need for optimized, evidence-based prescribing and longitudinal outcome studies."

Journal • Retrospective data • Bipolar Disorder • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Case Report: Four cases for cariprazine and alcohol use disorder. (PubMed, Front Psychiatry) - "All four patients were treated during the years with many different pharmacologic protocols, involving antipsychotics (olanzapine, quetiapine), mood stabilizers (carbamazepine, lamotrigine), anxiolytics (clonazepam, bromazepam), SSRI antidepressants (fluoxetine, paroxetine, escitalopram), but without achieving of the alcohol abstinence. The consistent achievement of full abstinence across all four patients suggests that it may have potential relevance in the management of alcohol use disorder (AUD). However, in the future, well conducted and highly controlled studies are needed to explore a potential cariprazine's role and its place in the management of alcohol dependence."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders

The efficacy of psychotherapeutic and pharmacological interventions for trichotillomania: A review and meta-analysis. (PubMed, J Psychiatr Res) - "When considering both the magnitude of effect sizes and replication, strong support was found for the efficacy of three interventions: behavioral therapy with habit reversal, Acceptance and Commitment Therapy-enhanced habit reversal therapy, and N-acetylcysteine. Finally, in contrast to previous reviews, the current study did not find consistent support for the efficacy of clonazepam. Limitations and directions for future research are discussed."

Clinical • Journal • Retrospective data • Review

Grinding Truths: Cocaine-associated Oromandibular Dystonia and the Hidden Role of Adulterants (AAN 2026) - "Trials of valbenazine and trihexyphenidyl worsened dystonic movements. While clonazepam provided relief, it was short lived... This case illustrates how cocaine and potential adulterants can interact to disturb dopaminergic pathways and trigger dystonia. Clinicians should consider stimulant-induced and adulterant-related causes in new-onset movement disorders. Broader toxicology testing, increased clinical awareness, and the use of botulinum toxin for refractory cases may improve patient outcomes and diagnostic accuracy."

Clinical • Cardiovascular • CNS Disorders • Dystonia • Immunology • Mental Retardation • Movement Disorders

A Case of Wilson's Disease With Initial Unilateral Chorea and Contralateral MRI Changes (AAN 2026) - "She had been on trientine and zinc for several years, but treatment had lapsed before presentation...Trials of clonazepam, deutetrabenazine, and valbenazine produced no significant benefit... This case represents one of the first reported instances of initial unilateral neurological manifestations of Wilson's disease accompanied by contralateral MRI changes. It underscores the importance of recognizing atypical neurological presentations of Wilson's disease."

Clinical • Diabetes • Genetic Disorders • Hepatology • Immunology • Metabolic Disorders • Movement Disorders

Prevalence, Treatment Patterns, and Healthcare Resource Utilization Among Patients with CDKL5 Deficiency Disorder: Retrospective Analysis of US Claims Data (AAN 2026) - "Levetiracetam (34%), clobazam (33%), and clonazepam (30%) were the most common seizure-related drugs utilized. Increase in uptake post diagnosis was seen for ganaxolone (23%), fenfluramine (5%), and cenobamate (4%)... This real-world retrospective analysis reports prevalence for patients with CDD for the first time in a large, claims-based population. Comorbidities and HCRU burden are significant for patients with CDD."

HEOR • Retrospective data • Cerebral Palsy • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Movement Disorders • CDKL5

Benzodiazepine prescribing patterns among Medicare providers, 2017 to 2023. (PubMed, Front Med (Lausanne)) - "The top three most prescribed BZD medications were alprazolam, lorazepam, and clonazepam, totaling around 88% of all the BZD prescriptions being written to Part D beneficiaries. Despite repeated warnings about the harms of their use in this population, BZDs are being increasingly prescribed to Medicare Part D recipients. Some states and prescriber classes prescribe BZDs significantly over 30 days per beneficiary to older adults."

Journal • Medicare • Reimbursement • US reimbursement • Psychiatry

Benzodiazepines Prescribed to Hospitalized Patients with Major Depressive Disorder: A 3-year Retrospective Observational Study. (PubMed, Neuropsychiatr Dis Treat) - "For non-selective benzodiazepines at baseline, the most commonly prescribed were lorazepam (39.6%, n=110), oxazepam (23.7%, n=66), and clonazepam (16.2%, n=45)...However, the use of clonazepam, estazolam, and alprazolam remained comparable (P > 0.05)...While its use varied significantly over time (P 0.05)...It is advisable to limit benzodiazepine prescriptions for MDD patients to within 12 months. Discontinuing benzodiazepines becomes more challenging after prolonged use beyond this period."

Journal • Observational data • Retrospective data • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

The association between psychotropic medications and cognitive functioning in bipolar disorder. (PubMed, Int J Bipolar Disord) - "Prescribers may consider limiting the administration of the medications which can affect cognitive functioning. Interventions should be further developed for people with bipolar disorder to improve their cognitive functioning and quality of life."

Journal • Bipolar Disorder • CNS Disorders • Cognitive Disorders • Mood Disorders • Psychiatry

A Case of Malignant Catatonia Complicated by Seizures and Respiratory Failure Mimicking Autoimmune Encephalitis: A Diagnostic Challenge (AAN 2026) - "Despite treatment with benzodiazepines and dantrolene, the patient developed recurrent fevers, autonomic instability, and seizure-like activity...Over several weeks, her rigidity and autonomic symptoms improved with clonazepam titration...After excluding infectious, autoimmune, and structural causes, abrupt cessation of olanzapine was identified as the most likely precipitant, leading to dopaminergic and GABAergic imbalance... Malignant catatonia can mimic several medical and neurological conditions, complicating diagnosis. This case illustrates that, even in the absence of ECT, timely recognition, sustained benzodiazepine therapy, and comprehensive supportive care can achieve full recovery and prevent life-threatening complications."

Clinical • Bipolar Disorder • CNS Disorders • Epilepsy • Immunology • Infectious Disease • Mood Disorders • Respiratory Diseases

Efficacy of Melatonin for Sleep Disturbances in Parkinson's Disease: Systematic Review and Meta-analysis. (AAN 2026) - "No significant differences was found between melatonin and clonazepam in ESS (MD=−2.65 [−5.36 to 0.06]; p=0.06)... Melatonin is a well-tolerated treatment that improves sleep quality, sleep onset latency, and total sleep time in PD. However, improvements in subjective sleep quality assessments did not meet minimal clinically important difference, which limits the clinical significance of these findings. Additional research is required to determine whether these benefits translate to other objective sleep parameters."

Retrospective data • Review • CNS Disorders • Insomnia • Mental Retardation • Movement Disorders • Parkinson's Disease • REM Sleep Behavior Disorder • Sleep Disorder

Longitudinal Cognitive Assessment in Stiff Person Syndrome: A Case Report (AAN 2026) - "Medications – immunoglobulin, clonazepam, and pregabalin – remained stable between assessments. Findings indicate some areas of cognitive decline may be associated with SPS, including when symptoms co-occur with persistent psychological symptoms. Results underscore the importance of longitudinal cognitive assessment in SPS to inform potential cognitive rehabilitation and mental health interventions."

Case report • Clinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Depression • Mood Disorders

A Rare Case of Disseminated Coccidioidomycosis Complicated by Bilateral Pulmonary Embolism (AAN 2026) - "Interval brain imaging revealed progression of basal, nodular, leptomeningeal enhancement, prompting resumption of amphotericin B and replacement of fluconazole with posaconazole...He developed episodes of paroxysmal sympathetic hyperactivity with multifocal segmental myoclonus, treated with clonazepam and baclofen... This case highlights a complicated course of disseminated coccidioidomycosis, refractory to the first-generation triazole, leading to massive pulmonary emboli. Appropriate antifungal treatment under multidisciplinary evaluations and early recognition of complications can aid in optimal patient management."

Clinical • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Cognitive Disorders • Cough • Movement Disorders • Pulmonary Embolism • Respiratory Diseases • Ventriculomegaly

Patterns of Antiseizure Medication Use and Therapeutic Load in Adults with Developmental and Epileptic Encephalopathies: A Single-center Study (AAN 2026) - "The most frequent seizure type was generalized, 52 (63.4%).The most frequent ASM combination was lamotrigine-topiramate-valproate in 7 (8.5%), followed by clobazam-lamotrigine-levetiracetam-valproate in 4 (4.9%), clobazam-levetiracetam-valproate in 4 (4.9%), and clonazepam-lamotrigine-valproate in 4 (4.9%). In this cohort of adults with DEEs, therapeutic load was not associated with disease duration or etiology. Valproate-based polytherapy remains the cornerstone of treatment despite the availability of newer ASMs. These findings highlight stable prescribing patterns and the need for individualized long-term strategies in the management of adult patients with DEEs."

Clinical • CNS Disorders • Developmental Disorders • Epilepsy

Autoimmune Encephalitis Associated with Anti-BR Serine/Threonine Kinase 2 Antibodies: A Case Report (AAN 2026) - "Intravenous steroids followed by oral taper, combined with IVIG, together with sodium valproate and clonazepam for psychiatric symptoms, produced gradual clinical improvement...Oral prednisone was continued and later switched to mycophenolate mofetil... Anti-BRSK2 AE can follow viral encephalitis, not only SCLC, and responds well to conventional immunotherapy when tumor-free."

Case report • Clinical • CNS Disorders • Depression • Immunology • Infectious Disease • Lung Cancer • Mood Disorders • Small Cell Lung Cancer • Solid Tumor • BRSK2

Belly Dancer Dyskinesia in Pregnancy: A case report and literature review on a rare hyperkinetic disorder. (AAN 2026) - "The dyskinesia resolved within two days on clonazepam 0.5 mg three times daily. She was discharged on levetiracetam to avoid long-term benzodiazepines, with no further recurrence, and had an uncomplicated vaginal-delivery... Our case demonstrates a rare movement disorder, raising awareness about BDD associated with pregnancy, with a benign outcome, which can cause intense stress and functional limitation. The underlying pathophysiology is elusive warranting further investigation. Clinician awareness is crucial to rule-out central etiology and recognize this rare entity early, ensuring the proper diagnosis to prevent misclassification as a functional neurological disorder and guide management."

Case report • Clinical • Review • ADHD (Impulsive Aggression) • CNS Disorders • Hematological Disorders • Migraine • Movement Disorders • Obstetrics • Rare Diseases

Healthcare Resource Utilization (HCRU) in Patients with Epilepsy (PWE): A Comparison of Diazepam Nasal Spray (DNS) vs No Use (AAN 2026) - "Concomitant benzodiazepines (eg, clonazepam, clobazam) and cannabidiol were more common among patients with DNS (P<0.001)...Midazolam and gabapentin were more common in patients without DNS (P<0.001)... In this real-world database, PWE with DNS were more likely to receive concomitant medications indicative of refractory epilepsy. However, they had significantly fewer inpatient and outpatient visits and lower readmission rate vs a matched cohort, supporting the role of DNS in improved health outcomes that reduce patient, caregiver, and provider burden. Ongoing analyses will further analyze HCRU of PWE with DNS compared with other ISMs or no ISM."

Clinical • HEOR • CNS Disorders • Epilepsy

Consensus Molecules Associated with Parkinson's Disease. (PubMed, Neurol Int) - "Drugs include L-dopa (49%), carbidopa (63%), benserazide (50%), entacapone (74%), tolcapone (56%), rasagiline (76%), selegiline (46%), pargyline (4%), ropinirole (61%), pramipexole (56%), lisuride (27%), cabergoline (16%), bromocriptine (12%), and zonisamide (9%). Adjunctive therapies include droxidopa (33%), trihexyphenidyl (28%), biperiden (17%), amantadine (24%), memantine (7%), rivastigmine (13%), donepezil (6%), galantamine (4%), domperidone (6%), clonazepam (4%), tetrabenazine (16%), mazindol (13%), quetiapine (6%), and clozapine (4%). Contraindicated drugs include haloperidol (4%), sulpiride (3%), and methyldopa (6%)...Chemical inducers of PD include 6-hydroxydopamine (40%), N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 78%), tetrahydropyridine (77%), probenecid (4%), quinolinic acid (4%), 1,2,3,4-tetrahydroisoquinoline (TIQ, 16%), salsolinol (32%), rotenone (25%), and β-Methylamino-L-alanine (BMAA, 29%). Notably, our study highlights conditional essential..."

Journal • Review • CNS Disorders • Movement Disorders • Parkinson's Disease

Tremor in multiple system atrophy: a systematic literature review. (PubMed, J Neural Transm (Vienna)) - "Preliminary reports suggest potential benefit of clonazepam and botulinum toxin, while a pilot high intensity focused ultrasound therapy showed no improvement. This first systematic review demonstrates that tremor in MSA is common and phenotypically diverse. Rest tremor is generally less frequent than action tremor and a 3-Hz pseudo-orthostatic tremor is characteristic of MSA-C."

Journal • Review • CNS Disorders • Movement Disorders • Multiple System Atrophy • Parkinson's Disease