frovatriptan / Generic mfg. - LARVOL DELTA

Drugs for prevention of migraine. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

Plasma versus Whole Blood Tacrolimus Concentration and Outcomes After Kidney Transplantation: Post Hoc Analysis of the ALLEGRO Trial. (PubMed, Clin J Am Soc Nephrol) - "Larger studies are needed to determine whether late PTC is a better marker than WBTC to detect potential tacrolimus-related nephrotoxicity in KTR."

Journal • Retrospective data • Infectious Disease • Transplantation

Drugs for acute treatment of migraine. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

Comparison table: Triptans. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

Impact of single-use bioreactor bag materials on Spodoptera frugiperda cell expansion for recombinant adeno-associated virus manufacturing. (PubMed, Biotechnol Prog) - "While growth kinetics in shake flasks and the Pall Allegro XRS system were comparable, reduced growth rates and delayed proliferation were observed in Cytiva Cellbags...Analytical extractables and leachables profiling was not performed; therefore, leachable-mediated contributions cannot be fully excluded. These findings highlight the importance of single-use bag selection and occupancy optimization for robust and scalable Sf9 cell expansion processes."

Journal • Gene Therapies • Infectious Disease

Ischemic Colitis Reporting Across the Triptan Class: A Cross-Database Analysis With FDA Label Review (ACG 2026) - " We queried the FDA Adverse Event Reporting System (FAERS) and WHO VigiBase on 5/1/2026 for IC reports associated with sumatriptan, naratriptan, rizatriptan, zolmitriptan, almotriptan, eletriptan, and frovatriptan... Sumatriptan had the highest absolute IC case volume (FAERS: 87 cases; VigiBase: 114 cases) consistent with its dominant overall reporting volume. Rizatriptan was the only agent with significantly elevated IC reporting proportions in both FAERS (1.76% vs 0.79%, p=0.0007) and VigiBase (0.55% vs 0.31%, p=0.009). Frovatriptan was elevated in FAERS only (4.48% vs 0.85%, p=0.020)."

Review • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Migraine

Efficacy and patient characteristics of ritlecitinib in non-responders (SALT score >20) and responders (SALT score ≤20) at Month 36 in patients with alopecia areata from the ALLEGRO clinical trial program (EADV 2026) - No abstract available

Clinical • Alopecia • Immunology

Exploring fingernail involvement in alopecia areata and efficacy of ritlecitinib: a post-hoc analysis in patients from the ALLEGRO trials (EADV 2026) - No abstract available

Clinical • Retrospective data • Alopecia • Immunology

Updated Integrated Safety Analysis of Ritlecitinib up to ~ 5 Years in Patients with Alopecia Areata from the ALLEGRO Clinical Trial Program. (PubMed, Am J Clin Dermatol) - P2, P2a, P2b, P3 | "In this updated integrated safety analysis of the ALLEGRO clinical trials, long-term ritlecitinib treatment was generally well tolerated up to ~ 5 years in patients aged ≥ 12 years with AA. The overall safety profile was consistent with previously reported data."

Journal • Alopecia • Cardiovascular • Genetic Disorders • Hepatocellular Cancer • Herpes Zoster • Immunology • Infectious Disease • Novel Coronavirus Disease • Pain • Respiratory Diseases • Skin Cancer • Solid Tumor • Varicella Zoster

Exploring charge density waves in two-dimensional NbSe2 with machine learning. (PubMed, NPJ Comput Mater) - "Here, we develop a physically informed workflow for training machine-learning interatomic potentials (MLIPs) based on the E(3)-equivariant Allegro architecture, tailored to capture the subtle structural and dynamical signatures of CDWs in mono- and bilayer NbSe2...Our MLIPs enable reliable simulations of commensurate and incommensurate CDW phases, including their sensitivity to dimensionality and stacking, as well as CDW dynamics, phonons, and transition temperatures estimated via the stochastic self-consistent harmonic approximation. This work opens new possibilities for studying and tuning CDWs in NbSe2 and other two-dimensional systems, with implications for electron-phonon coupling, superconductivity, and advanced materials design."

Journal

Chemical intuition on bond-dissociation energies as an emergent ability of universal machine-learning interatomic potentials. (PubMed, Nat Commun) - "To expose this information, we develop an edge-wise emergent energy-decomposition framework and apply it to an Allegro neural-network potential trained on SPICE2, a dataset composed of stable molecular structures...We further examine a hybrid training set and find that combining complementary chemical data improves transition-state energy-prediction accuracy while reshaping the learned bond representations. These results indicate that scalable interatomic potentials can acquire transferable bond concepts without explicit bond-energy labels, providing a way to analyze the transition-state energy-prediction problem."

Journal

A Multi-Centre Real-World Evaluation of Ritlecitinib in Severe Alopecia Areata: Patient Reported Outcome Measures (BAD 2026) - "Ritlecitinib has shown clinically meaningful efficacy in trials for alopecia areata (AA). Interpretation of our findings should consider differences in case mix, prior or concomitant therapies, adherence and follow-up between trial and real-world settings. Larger, prospective studies using trial-aligned endpoints and validated PROMs (as used in ALLEGRO) are needed to refine real-world effectiveness estimates."

Clinical • HEOR • Patient reported outcomes • Real-world • Real-world evidence • Alopecia • Immunology

Risk-Prioritized Experience Replay for Stable In-Hand Manipulation. (PubMed, Sensors (Basel)) - "Risk-PER is integrated with Deep Deterministic Policy Gradient (DDPG) and evaluated in MuJoCo simulation on two Allegro Hand in-hand manipulation tasks involving a block and an egg. Across the evaluated settings, Risk-PER achieves higher success rates, lower manipulation risk, and more stable learning behavior than HER and reward-penalty-based risk-averse baselines. These results suggest that incorporating task-specific risk awareness into replay prioritization can improve both learning efficiency and manipulation stability in dexterous in-hand manipulation."

Journal

Analysis of brain network temporal reconfiguration and frequency-domain features during dynamic orchestral segmentation transition based on electroencephalography. (PubMed, PLoS One) - "In a passive listening task, we used Mozart's Serenade in G major for Strings, K.525 (Allegro) as the auditory stimulus...Furthermore, θ power increased with greater structural complexity and a higher spectral centroid (FDR-corrected p < 0.05), indicating a specific mapping between these acoustic features and oscillatory activity. Our study provides evidence for the deep interactive relationship that persists between changes in musical acoustic structure and internal neural oscillations of the brain."

Journal • CNS Disorders

Evaluation of novel materials for front-of-neck access simulations. (PubMed, Anaesth Intensive Care) - "We undertook a study to compare the fidelity of a 3D-printed airway model and SCOBY skin model with a commercially available plastic and foam model (Crico-Trainer 'Frova', VBM-Medizintechnik GmbH, Sulz am Neckar, Germany) trialled by 27 volunteer anaesthesia specialists and trainees...Model fidelity, environmental impact, and ethical considerations were rated as important or very important by participants. Further studies are needed to confirm these findings in other hospital settings."

Journal • Anesthesia

Plasma versus Whole Blood Tacrolimus Concentration and Outcomes After Kidney Transplantation: Post Hoc Analysis of the ALLEGRO Trial (ERA 2026) - No abstract available

Retrospective data • Transplantation

The impact of ubrogepant on the use of other migraine acute treatments, opioid discontinuation, and healthcare utilization: Results from a pre-post opioid subcohort analysis (AHS 2026) - "Acute medications other than ubrogepant included acetaminophen, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan, dihydroergotamine, ergotamine, amobarbital, aprobarbital, butabarbital, butalbital, mephobarbital, metharbital, pentobarbital, phenobarbital, secobarbital, talbutal, barbital, codeine, hydrocodone, meperidine, morphine, oxycodone, propoxyphene, tramadol, aspirin, bromfenac, celecoxib, diclofenac, diflunisal, esomeprazole, etodolac, famotidine, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, oxaprozin, piroxicam, sulindac, tolmetin, lasmiditan, Zavegepant, and Rimegepant (<15 pills). Opioid use included acetaminophen/tramadol, oxymorphone, levorphanol, buprenorphine/naloxone, meperidine, morphine, oxycodone, codeine, methadone, oxycodone, hydromorphone, butorphanol, and tapentadol... In patients with a history of opioid use,..."

HEOR • CNS Disorders • Migraine • Pain

Complete Scalp Hair Regrowth and Predictors of Response in Patients With Alopecia Areata Receiving Ritlecitinib 50 mg up to 3 Years in the ALLEGRO Clinical Trial Program (EADV-Sp 2026) - P2b, P3 | "Conclusions Among patients aged ≥12 years with AA and ≥50% scalp hair loss receiving ritlecitinib 50 mg, almost one-third achieved complete scalp hair regrowth (SALT score of 0 during at least 1 visit) up to Month 36-38, with the majority sustaining that response at later visits or remaining at SALT score ≤5. Patients who were female, had shorter duration of significant (≥50%) scalp hair loss, shorter disease duration, or less extensive scalp hair loss at baseline were more likely to achieve complete scalp hair regrowth with ritlecitinib treatment."

Clinical • Alopecia • Immunology • JAK3

Therapy: A Transdisciplinary Healthy Equity Relationship: Allegro Pediatrics + Youth Eastside Services (YES) —A Collaborative Mental Health Care Intervention for Adolescents (PAS 2026) - "The mean patient age was 14 years (+/- 2 SD), two-thirds are minority youth, and gender was equally distributed. All youth in Therapy are Medicaid-insured, and most have experienced adverse childhood events placing them at increased risk for mental health adversity, including abuse (73%) and housing insecurity (20%). Nearly half of the youth enrolled in this pilot reported suicidal ideation (47%) and/or self-harming behaviors (43%)."

Clinical • CNS Disorders • Depression • General Anxiety Disorder • Mood Disorders • Pediatrics • Suicidal Ideation

Characterizing Defect Dynamics in Silicon Carbide Using Symmetry-Adapted Collective Variables and Machine Learning Interatomic Potentials. (PubMed, J Chem Theory Comput) - "We employ an active learning strategy comprising symmetry-adapted collective variable discovery and enhanced sampling to compile configurationally diverse training data, calculation of energies and forces using density functional theory (DFT), and training of an E(3)-equivariant MLIP based on the Allegro model. The trained MLIP reproduces DFT-level accuracy in defect transition activation free energy barriers, enables the efficient and stable simulation of multidefect 216-atom supercells, and permits an analysis of the temperature dependence of defect thermodynamic stability and formation/annihilation kinetics to propose an optimal annealing temperature to maximally stabilize VV divacancies."

Journal

Machine learned potential for defected single layer hexagonal boron nitride. (PubMed, J Chem Phys) - "We present here a MLIP suitable for simulations of the temperature dependent structure and dynamics of single layer hexagonal boron nitride (h-BN) with defects and grain boundaries, developed using a strictly local equivariant deep neural network, Allegro...Molecular dynamics simulations of the grain boundary yield a scaled mobility of 1.739 × 10-11 m3/Js at 1500 K which, given the different setups without continuous e-beam irradiation, is not too far from the experimental value of 1.36 × 10-9 m3/Js. The ability to predict grain boundary mobility within reasonable agreement with experiment demonstrates the robustness of the MLIP and its suitability for reliable simulations of defect structures and dynamics in single layer h-BN."

Journal

Learning potential energy surfaces of hydrogen atom transfer reactions in peptides. (PubMed, Digit Discov) - "We benchmark three atomistic machine-learned potential architectures, SchNet, Allegro, and MACE, on their ability to learn HAT potential energy surfaces and indirectly predict reaction barriers through direct energy predictions...We analyze scaling laws, model transferability, and cost-performance trade-offs, and outline strategies for improvement through the combination of machine-learned potentials with transition state search algorithms and active learning. The presented approach is generalizable to other biomolecular systems, offering a method toward quantum-accurate barrier predictions of chemical reactivity in complex biological environments."

Journal

Long-Term Efficacy and Safety of Ritlecitinib in Adults and Adolescents with Alopecia Areata: 3-Year Results from the ALLEGRO Phase 2b/3 and ALLEGRO-LT Phase 3 Clinical Studies. (PubMed, Am J Clin Dermatol) - P2, P2a, P2b, P3 | "Ritlecitinib 50 mg demonstrated clinically meaningful clinician- and patient-reported efficacy up to 3 years, with no new safety signals observed. These data support the long-term use of ritlecitinib in patients aged ≥ 12 years with severe AA. [Graphical abstract and video abstract available online.]."

Journal • P2/3 data • P2b data • P3 data • Alopecia • Immunology • JAK3

Long-term efficacy, complete scalp hair regrowth and normal body hair/nails in adolescents with severe alopecia areata (AA) receiving ritlecitinib up to 3 years in the ALLEGRO clinical trials (AAD 2026) - P2b, P3 | "Through 3 years, 44.4% (12/27) of adolescents had SALT score 0 at ≥1 time point (complete scalp hair regrowth). Most cases of complete scalp hair regrowth also showed normal EBA and ELA scores (83.3%), body hair (83.3%), or fingernails (100%) at any occurrence of when SALT score 0 was reached."

Clinical • Alopecia • Immunology

Long-term efficacy, complete scalp hair regrowth, and normal body hair and nails in patients with alopecia areata (AA) receiving ritlecitinib 50 mg once daily up to 3 years in the ALLEGRO clinical trial program (AAD 2026) - P2b, P3 | "The majority (61.4%, 35/57) did not have a subsequent increase in SALT score at later visits, and most (84.2%, 48/57) remained at SALT score ≤5 at subsequent visits. Most cases of complete scalp hair regrowth also showed normal EBA and ELA scores (78.9%), body hair (71.9%), or fingernails (89.5%) at any occurrence of when SALT score 0 was reached."

Clinical • Alopecia • Immunology