primidone / Generic mfg. - LARVOL DELTA

EPIPOP: Population Pharmacokinetics of Antiepileptic in Pediatrics (clinicaltrials.gov) - P=N/A | N=753 | Completed | Sponsor: Assistance Publique - Hôpitaux de Paris | Recruiting ➔ Completed

Trial completion • CNS Disorders • Epilepsy • Pediatrics

Modeling the fate of organic micropollutants in agricultural soils: Laboratory parameterization and field-scale implications. (PubMed, J Contam Hydrol) - "Four OMP (adamantan-1-amine, carbamazepine, diclofenac, and sulfamethoxazole) exhibited biphasic sorption behavior, which was best described by a two-site kinetic model. Three OMP (acesulfame, saccharin, and valsartanate) showed negligible sorption but, following lag phases between 4 and 9 days, indicated microbial adaptation...The remaining compounds (diatrizoate, trifluoromethanesulfonate, primidone) showed neither sorption nor degradation...The results suggest that simplified equilibrium and immediate-degradation assumptions may be sufficient for risk assessment regarding to OMP in homogeneous soils with predominantly uniform flow conditions. Overall, this study presents a comprehensive framework for bridging laboratory observations with field-scale modeling, offering new insights into OMP fate and guiding efficient parameterization strategies for environmental risk assessment for the management of reclaimed water."

Journal

Dissect cerebellar mechanism and therapeutics of tremor subtypes by spatio-temporal neural dynamics (Neuroscience 2025) - "Harmaline-induced tremors responded to both propranolol and primidone, whereas Grid2dupE3 mice exhibited resistance to both drugs. These predictions were validated in a preclinical drug trial, where a T-type calcium channel blocker alleviated tremor in harmaline mice but had no effect in Grid2dupE3 mice. Together, these findings provide a mechanistic explanation for pharmacological failures in ET and offer guidance for the development of more targeted therapeutic strategies."

CNS Disorders • Essential Tremor • Movement Disorders

Study on the efficacy and safety of primidone in adult subjects with amyotrophic lateral sclerosis (ChiCTR) - P2 | N=71 | Not yet recruiting | Sponsor: Yichang Central People’s Hospital; Yichang Central People’s Hospital

New P2 trial • Amyotrophic Lateral Sclerosis • CNS Disorders

Structural basis for agonist and heat activation of nociceptor TRPM3. (PubMed, Nat Struct Mol Biol) - "We also show that the antagonist primidone binds the same site as CIM0216 in the S1-S4 domain but inhibits channel activation. This study provides a structural framework for a mechanistic understanding of thermal and chemical gating of TRPM3 and for guiding the rational design of TRPM3-targeted analgesics and neurotherapeutics."

Journal • CNS Disorders • Pain • TRPM3

Spatiotemporal Neural Dynamics of the Cerebellum Underlie Differential Therapeutic Outcomes in Essential Tremor Subtypes (MDS Congress 2025) - "Harmaline-treated and Grid2dupE3 mice represent distinct ET subtypes, one responsive and the other refractory to propranolol and primidone. Our neural dynamics approach demonstrated that drug responses correlate with distinct PC synchrony patterns, confirmed via two-photon imaging and computational modeling. The model also predicted differential efficacy of T-type calcium channel blockers, underscoring the potential for precision medicine in ET treatment."

CNS Disorders • Essential Tremor • Movement Disorders

A Case of Mitochondrial Membraine Protein-Associated Neurodegeneration with Progressive Parkinsonism in a Young Male (MDS Congress 2025) - "Several medications were tried, including propranolol, primidone, gabapentin, topiramate, carbidopa/levodopa with no symptomatic improvement. N/a"

Clinical • CNS Disorders • Depression • Dystonia • Mental Retardation • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry • FTL

Autosomal Dominant DHDDS-Related Movement Disorder Treated with Primidone (MDS Congress 2025) - "The patient's seizures were well-controlled on carbamazepine currently, but had previously been on ethosuximide and topiramate. We describe a patient with DHDDS heterozygous pathogenic variant and movement phenotype consistent with prior case series reported in the literature.[1][2][3][4] To our knowledge, this is the first report to demonstrate clinical benefit of DHDDS-associated cortical myoclonus with primidone. We suggest that primidone may improve cortical myoclonus through modulation of GABA-related circuitries, as shown in other forms of cortical myoclonus.[5][6][7] Given limited therapies for myoclonus in this patient population, we propose consideration of primidone for symptomatic benefit, though larger studies are needed to validate our case report. [figure1] [figure2]"

Ataxia • CNS Disorders • Epilepsy • Essential Tremor • Mental Retardation • Movement Disorders • Parkinson's Disease • Psychiatry

Can alprazolam alleviate troublesome features beyond the symptoms common to anxiety disorders? A systematic literature review (ECNP 2025) - "39 reports met the search criteria, of which five were more compelling. Three studies reported the beneficial effect of alprazolam in reducing tremor severity, tremor amplitude; and tremor intensity [1-3] (See table below). The GEMA project (Gador Study of Stress Modulation by Alprazolam) reported improvements in semantic verbal fluency in patients who had generalized anxiety disorder treated with low-dose alprazolam [4]."

Review • CNS Disorders • Essential Tremor • General Anxiety Disorder • Mental Retardation • Mood Disorders • Movement Disorders • Psychiatry

A case of neonatal essential tongue tremor diagnosed due to poor feeding. (PubMed, SAGE Open Med Case Rep) - "Treatment resulted in marked improvement in feeding ability, and the primidone was tapered off and discontinued without any side effects after weaning was introduced. We plan to carefully follow up on growth and developmental assessment (especially language development) and continue to provide support to patients and their families."

Journal • Essential Tremor • Movement Disorders • Pediatrics

Drug reaction with eosinophilia and systemic symptoms triggered bycarbamazepine : Cross-reactivity to lamotrigine confirmed by rechallenge (EADV 2025) - "The frequency of cross- reactivity among anticonvulsants (carbamazepine, phenytoin, phenobarbital, and primidone) is as high as 40%—80% among aromatic AEDs explained by their common aromatic ring. Nevertheless, cross- reactivity between aromatic and non-aromatic AEDs (valproic acid, lamotrigine, and levetiracetam.) is less commonly reported...With a score of 7 points, DRESS syndrome is considered to be « definite », according to the RegiSCAR group and CMZ, risperidone and biperiden were withdrawn... According to the Naranjo Causality Scale, the accountability of both drugs was found to be probable (score of '6'). Through this report, we add to the medical literature a new case of DRESS syndrome induced by CMZ, cross-reacting to lamotrigine, anon aromatic AED. This was confirmed by a positive rechallenge to lamotrigine, with a negative result on PT."

Bipolar Disorder • CNS Disorders • Eosinophilia • Hepatology • Infectious Disease • Inflammation • Mood Disorders • Pruritus • Psychiatry

Essential Tremor. (PubMed, Continuum (Minneap Minn)) - "Oral pharmacotherapies, including propranolol and primidone, are mainstays of treatment, whereas DBS and focused ultrasound thalamotomy can be offered to alleviate disabling, medication-refractory tremor. Novel oral pharmacologic agents, noninvasive stimulation for tremor, and botulinum toxin injections for hand and head tremor need further study but may serve as potential future treatment options."

Journal • Review • CNS Disorders • Dystonia • Essential Tremor • Metabolic Disorders • Movement Disorders • Pain

Complex Regional Pain Syndrome and Palmar Fibromatosis Secondary to Treatment with Primidone. (PubMed, Neurologia (Engl Ed)) - No abstract available

Journal • Fibrosis • Musculoskeletal Pain • Pain • Solid Tumor

Primidone: a clinically promising candidate for the treatment of psoriasis. (PubMed, Cell Death Discov) - "Based on these findings, we now reveal both a preventive and, more importantly, a therapeutic effect of primidone in the imiquimod (IMQ)-induced psoriasis-like inflammation model. This allows us to unequivocally identify RIPK1 as a therapeutic target in the treatment of inflammatory disorders, including psoriasis. Given that newly developed RIPK1 inhibitors have shown very limited success in clinical trials for inflammatory and neurological diseases in recent years, and that none of these inhibitors has yet reached clinical utilization, our data strongly recommend a clinical study to evaluate the already approved drug primidone for the treatment of patients suffering from psoriasis within the context of drug repurposing."

Journal • Review • CNS Disorders • Dermatology • Epilepsy • Immunology • Inflammation • Psoriasis • RIPK1

Modified QuEChERS for antiepileptic drugs detection in forensic toxicology. (PubMed, MethodsX) - "This study aims to concurrently assess the blood concentrations of antiepileptic drugs including phenobarbital, carbamazepine, primidone, phenytoin in post-mortem samples through the application modified QuEChERS extraction. The equation of linear calibration curve was obtained with regression coefficient > 0.99. Detection limits were in the range of 0.21-0.38 ng/mL.•This method is inexpensive and fast for determination of antiepileptic drugs in serum•This method has high thought of sample determination.•This method is green chemistry method."

Journal

Trends in prescription of new antiseizure medications in a single center in Latin America: evidence of clinical practice. (PubMed, Front Neurol) - "Of 1,192 prescriptions, third-generation ASMs accounted for the majority (53.7%), led by levetiracetam (24.1%), lamotrigine (14%), and lacosamide (6%). Second-generation ASMs comprised 42.4%, including valproate (21.5%), carbamazepine (11.3%), and clonazepam (5.5%). First-generation ASMs were less frequently prescribed (3.9%), primarily phenytoin (2.3%), primidone (1.0%), and phenobarbital (0.3%)...First-generation ASMs are still prescribed but at lower rates. These results provide insights into changing prescription practices and access to newer medications, informing future research and hospital policies."

Journal • CNS Disorders • Epilepsy

Inhibition of TRPM3 by Primidone Provides a Potential Therapeutic Method for Adenomyosis Management (WCE 2025) - "Our study is to reveal the expression profile of transient receptor potential channels (TRPs) in adenomyosis patients and evaluate the effects of TRPM3 inhibitor, primidone on tamoxifen-induced adenomyosis mice Materials and Methods Eutopic endometrium from adenomyosis patients (n=20) was collected and subjected to mRNA analysis of TRPs. Further verification was conducted on the expression of CHIL1, COL9A2, PSMC3IP, NEIL3, and SPC24, which play an important role in multiple pathological mechanisms, including inflammation, tissue remodeling, injury, DNA repair and cell mitosis. Conclusion The expression profile of TRPs varies significantly in adenomyosis patients, and the TRPM3 inhibitor primidone may provide a potential therapeutic method for adenomyosis management."

Endometriosis • Inflammation • Pain • Women's Health • NEIL3 • PSMC3IP • TRPA1 • TRPM3 • TRPV1

Optimization and development of a green high performance liquid chromatography method for determination of 8 anti-epileptic drugs and 2 active metabolites in human serum assessed using AGREE, AGREEprep, GAPI and BAGI. (PubMed, Anal Methods) - "The aim of this study was to optimize and develop a green high-performance liquid chromatography (HPLC) method suitable for simultaneous detection of 8 AEDs and 2 active metabolites including primidone (PRM), lamotrigine (LTG), carbamazepine (CBZ) and its active metabolite 10,11-epoxide (CBZE), oxcarbazepine (OXC) and its active metabolite 10,11-dihydro-10-hydroxyl carbamazepine (MHD), phenobarbital (PHB), eslicarbazepine acetate (ESLA), clonazepam (CZP) and diazepam (DZP) in human serum. The results of greenness assessment showed that the proposed method was ecofriendly. Finally, the validated method was successfully applied in the analysis of real serum samples."

Journal • CNS Disorders • Epilepsy

A magnetic poly (methacrylic acid-co-ethylene glycol dimethacrylate) copolymer for extraction of anticonvulsants from saliva followed by high performance liquid chromatography analysis. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "Therefore, this study describes the synthesis of a magnetic poly (methacrylic acid-co-ethylene glycol dimethacrylate) copolymer (M-CP) and its use in magnetic dispersive solid phase extraction of primidone (PMR), phenobarbital (PB), phenytoin (PHT), and carbamazepine (CB) from saliva, followed by their determination by high performance liquid-chromatography. The limits of detection ranged from 0.48 to 1.30 mg L-1, while the limits of quantification were lower than the therapeutic levels of each drug, being suitable for the method application. The developed method is simple, fast, and requires few amounts of saliva, sorbent, and solvents, being a good alternative for the therapeutic biomonitoring of anticonvulsants in saliva samples."

Journal • CNS Disorders • Epilepsy

Investigating potential molecular mechanisms of antiepileptic drug-induced depression through network toxicology and molecular docking. (PubMed, Neuroscience) - "After identifying eight AEDs (Topiramate, Zonisamide, Phenobarbital, Primidone, Levetiracetam, Gabapentin, Tiagabine, and Perampanel) potentially associated with depression via a literature review, further analysis integrating drug and disease target databases revealed 25 targets relevant to AED-induced depression. In vitro experiments demonstrated that Zonisamide treatment elevated the expression and activity of MAOA protein in the prefrontal cortex of mice, which may influence monoaminergic neurotransmission through MAO pathway regulation, potentially leading to depression. Collectively, this integrated approach elucidates the mechanisms underlying AED-induced depression, thereby establishing a foundation for future therapeutic strategies."

Journal • CNS Disorders • Depression • Epilepsy • Mood Disorders • Psychiatry

Does pre-treatment with phenobarbital prevent the acute intolerance to primidone in patients with essential tremor? (PubMed, Neurol Sci) - "Pre-treatment with PB minimizes the occurrence of acute intolerance to PMD, most likely due to functional cross-tolerance. The option of receiving low-dose PB for a short period before starting on PMD should be offered to ET patients in whom PMD therapy is indicated. PB-pre-treatment should also be considered whenever occurrence of acute intolerance prevented continuation of PMD therapy."

Journal • Ataxia • Essential Tremor • Movement Disorders

Approach to childhood tremors: Insights from a pediatric neurologist. (PubMed, Eur J Paediatr Neurol) - "Childhood tremor is a common clinical condition with diverse etiologies, where treatable causes, especially vitamin deficiencies, play a significant role. Functional impairments, such as difficulty in drinking water, using a spoon, and writing, may serve as key predictors for initiating first-line anti-tremor therapy. Propranolol remains an effective therapeutic option for essential tremor in children."

Journal • Endocrine Disorders • Essential Tremor • Movement Disorders • Pediatrics

Severe tremors induced by tiletamine e-cigarette and alcohol use: a case report. (PubMed, Front Psychiatry) - "Therefore, primidone was added and gradually titrated to 50 mg/day...As we gradually replaced diazepam with lorazepam, the patient insisted on discharge...The successful management of tremors with a combination of neuroinhibitory therapies suggested an effective strategy for complex cases. Further studies are needed to better understand the long-term impacts and risks of tiletamine dependence."

Journal • Addiction (Opioid and Alcohol) • Anesthesia • CNS Disorders • Movement Disorders • Psychiatry

Opsoclonus-Myoclonus Syndrome with Prominent Tremor: A Unique Presentation of West Nile Virus (P2-10.001). (PubMed, Neurology) - "His tremor greatly improved with primidone and he was discharged to acute rehab...An immediate family member of Dr. Thon has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Genentech."

Journal • Ataxia • CNS Disorders • Critical care • Gastrointestinal Disorder • Immunology • Infectious Disease • Movement Disorders • Oncology • Pain • Pulmonary Disease

Inhibition of TRPM3 by Primidone Provides a Potential Therapeutic Method for Adenomyosis Management. (PubMed, Drug Des Devel Ther) - "To test the expression profile of transient receptor potential channels (TRPs) in adenomyosis patients and evaluate the effects of primidone on tamoxifen-induced adenomyosis mice...From 10 weeks after birth, primidone (2 mg/kg/d) and atosiban (1 mg/kg/d) were given separately to adenomyotic mice by intraperitoneal injection for 3 weeks...Forty-seven DEGSSs were identifieSd after primidone treatment, and bioinformatics analysis predicted that they were enriched in the cell cycle and cell division. The expression profile of TRP channels varies significantly in adenomyosis patients, and primidone may provide a potential therapeutic method for adenomyosis management."

Journal • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health • TRPA1 • TRPM3 • TRPV1