Interleukin 22 subunit alpha receptor / Merck (MSD), Novo Nordisk, BMS - LARVOL DELTA

Thymosin β4 released by mast cells under stress conditions impairs intestinal epithelial barrier via IL22RA1/JAK1/STAT3 signaling in irritable bowel syndrome. (PubMed, World J Gastroenterol) - "Collectively, these results suggest that Tβ4, which is abundant in IBS mucus and the secretome of MCs, plays a crucial role in the pathogenesis of IBS via IL22RA1/JAK1/STAT3 signaling, with potential implications for diagnostic and therapeutic targeting."

Journal • Gastrointestinal Disorder • IL22 • JAK1 • MYLK • TMSB4X

Dupilumab-associated head and neck dermatitis is associated with an overexpression of Interleukin 22 (PubMed, Med Sci (Paris)) - No abstract available

Journal • Dermatitis • Dermatology • Immunology • IL22

THE INTERLEUKIN 22–ONCOSTATIN M AXIS PROMOTES INTESTINAL INFLAMMATION AND TUMORIGENESIS (UEGW 2025) - "We uncover a previously unrecognized pathogenic feedback loop between IL-22 and OSM that sustains epithelial inflammation and promotes tumorigenesis. Targeting the IL-22–OSM axis represents a promising therapeutic approach in IBD and colitis-associated cancer."

Colorectal Cancer • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Inflammatory Bowel Disease • Oncology • Solid Tumor • Ulcerative Colitis • IL22 • OSMR

Interleukin-22 functions to alleviate hypoxia-induced intestinal inflammation by modulating pro- and anti-inflammatory factors in Pelteobagrus fulvidraco. (PubMed, Zool Res) - "While interleukin 22 (IL-22) is recognized as a critical regulator of cellular homeostasis during inflammation in higher vertebrates, its roles in fish are not well understood...Silencing Pf_IL-22 significantly suppressed Th17 cell differentiation pathways, demonstrating its role in shaping downstream immune responses. These findings establish the HIF-1α/IL-22 axis as a key regulatory pathway modulating immune responses and alleviating intestinal inflammation, providing a basis for developing IL-22-targeted immunotherapies and selective breeding strategies in aquaculture."

IO biomarker • Journal • Inflammation • Inflammatory Bowel Disease • Oncology • HIF1A • IL1B • IL22 • TNFA

Fusobacterium nucleatum promotes bladder cancer progression and immune escape by activating the IL22/STAT3/PD-L1 signaling cascade. (PubMed, Tissue Cell) - "Fn promotes the IL22/STAT3/PD-L1 cascade signaling, thereby facilitating in vivo progression and immune evasion of BC."

IO biomarker • Journal • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor • CD8 • GZMB • IFNG • IL22 • PD-L1 • TNFA

Computational analysis of IL-6/IL-22 signaling in liver disease. (PubMed, Biosystems) - "The cytokines interleukin 6 (IL-6) and interleukin 22 (IL-22) are involved in multiple signaling pathways in a variety of cells, e.g. the activation of the acute-phase response, cell homeostasis and tissue repair...We used our model to perform asynchronous simulations, which led us to the hypothesis that the higher levels of IL-6 in comparison to IL-22 in some pathologies may compensate for the slower assembly of the IL-6 receptor complex due to its higher structural complexity. We performed stochastic simulations of partial cytokine agonists confirming prior experimental results showing biased phosphorylation of STAT1/3 for lower cytokine receptor-binding dwell times."

Journal • Fibrosis • Hepatology • Immunology • Liver Failure • IL22 • IL6

Evaluation of the IL-22/IL-22 binding protein axis in macrophage phagocytosis during acute lung injury (IMMUNOLOGY 2025) - "Description Interleukin 22 binding protein (IL-22BP) is a monomeric protein that is produced by myeloid and epithelial cells...Our published work has demonstrated that IL-22BP knockout (IL22BPKO) have significantly exacerbated inflammation and macrophage influx compared to wild type controls in a bleomycin model of injury. We hypothesized that macrophages are critical to the exuberant inflammation observed in IL22BPKO mice and we tested this by administering clodronate...Further, lipid profiling revealed selective lipid metabolism in IL-22BPKO mice. These data suggest lipid uptake is compromised in IL-22BPKO-derived macrophages and demonstrates that IL-22BP may have a novel role in lipid recognition and macrophage function.Keywords: Animals Rodent; Cells Monocytes/Macrophages; Molecules Lipid Mediators; Processes Phagocytosis; Tissues Lung"

Acute Lung Injury • Inflammation • Metabolic Disorders • Respiratory Diseases • IL22 • PPARG

IFN-γ SIGNALING MEDIATES THE EFFECT OF SEPSIS ON INHIBITION OF INTESTINAL EPITHELIAL CELLS PROLIFERATION (DDW 2025) - "In contrast, our previous work demonstrated that interleukin 22 (IL-22) induced H19 lncRNA which plays a role in rescuing IEC proliferation during sepsis by inhibiting the p53-p21 cascade...In contrast, IL22 activates H19 which antagonizing p53 and promoting IEC regeneration, thereby restoring IEC homeostasis in sepsis. This work is supported by grants from NIH and VA."

Infectious Disease • Inflammation • Inflammatory Bowel Disease • Septic Shock • CASP3 • CDKN1A • IFNG • IL22

Quercetin ameliorates obesity and inflammation via microbial metabolite indole-3-propionic acid in high fat diet-induced obese mice. (PubMed, Front Nutr) - "Our results revealed that quercetin supplementation significantly mitigated obesity and chronic inflammation, and improved the disrupted gut barrier function through the actvation of AhR/interleukin 22 (IL-22) pathway...The findings were further corroborated by Caco-2 cell experiment, which indicated that the modulation of the dysregulated gut microbiota to change microbial metabolite IPA coordinated the improvement effect of quercetin on gut barrier disruption. Quercetin supplementation alleviates obesity by restoring high-fat diet induced gut microbiota disorder, which elevates IPA level to activate AhR/IL-22 pathway, thereby enhancing intestinal barrier integrity and suppressing chronic inflammation."

Journal • Preclinical • Genetic Disorders • Inflammation • Metabolic Disorders • Obesity • AHR • IL22

A subset of Natural Killer T cells utilizes Interleukin-22 to mitigate inflammation induced by Francisella tularensis. (IMMUNOLOGY 2025) - "Through multiplex analysis and functional inhibition, we identified interleukin 22 (IL-22) as playing an important role in NKT-mediated regulation of inflammation. Future studies will leverage these properties of NKT cells for therapeutic use."

Infectious Disease • Inflammation • IL22

Fluxapyroxad induces chronic colonic inflammation via inhibiting intestinal aryl hydrocarbon receptors in mice. (PubMed, Sci Total Environ) - "Furthermore, fluxapyroxad decreased interleukin 22 levels and antibacterial peptide secretion by inhibiting Aryl hydrocarbon receptors (AhR) activation, which was confirmed in vitro experiments...These results indicated that AhR inhibition may represent one of the primary mechanisms for chronic colonic inflammation induced by fluxapyroxad exposure. This study shed light on the association between low acute pesticide exposure to fluxapyroxad and chronic colonic inflammation development while contributing to pesticide safety assessment."

Journal • Preclinical • Inflammation • IL1B • IL22 • IL6 • TNFA

The gut microbiota-independent virulence of noninvasive bacterial pathogen Citrobacter rodentium. (PubMed, PLoS Pathog) - "Here we report that CR infection causes severe colitis and mortality in interleukin 22 knockout (Il22-/-) and Rag1 knockout (Rag1-/-) mice under germ-free (GF) conditions...Pretreatment with cefoxitin, a broad-spectrum antibiotic, exacerbates CR-induced colitis and lethality in specific-pathogen-free (SPF) Il22-/- and Rag1-/- mice. Together our results reveal that CR possesses a gut microbiota-independent virulence, which is better illustrated during infections in immunocompromised hosts associated with severe outcomes."

Journal • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • IL22 • RAG1

Production of functional bovine IL-22 in a mammalian episomal expression system. (PubMed, Vet Immunol Immunopathol) - "Interleukin 22 is a member of the interleukin-10 superfamily of cytokines...We showed that this recombinant IL-22 possesses biological activity in bovine macrophages infected with Mycobacterium bovis and is easy to produce in large quantities. Given its role in the defence against infections, the IL-22 produced in this work has potential applications in scientific research as well as in immunotherapy to treat diseases in cattle."

IO biomarker • Journal • Infectious Disease • IL10 • IL22

Multi-locus high-risk alleles association from interleukin's genes with female infertility and certain comorbidities. (PubMed, BMC Res Notes) - "Current findings provided evidence that in the presence of Interleukin33 Ap-value rs1048274 = 0.002 and Cp-value rs16924243 < 0.0001, Interleukin 22Tp-value rs1397852121 < 0.0001 and Tp-value rs2227483 = 0.000, Interleukin17A Ap-value rs2275913 = 0.003 and Interleukin17F Cp-value rs763780 = 0.000 and Interleukin13 Cp-value 1512 = 0.000 and Ap-value 2044 = 0.003, Interleukin4 Tp-value rs2243250 = 0.001 and Tp-value rs2070874 = 0.009 risk alleles, risk genotype also were significantly associated with increased chances of developing infertility. The relationship between risk genotypes and several well-established infertility risk factors including, polycystic ovary syndrome, premature ovarian failure, oophorectomy, diminished ovarian reserve, endometriosis, uterine fibroids, ovarian cysts, uterine polyps, fallopian tube blockage and thyroid dysfunction, also exhibited...."

Journal • Endocrine Disorders • Endometriosis • Gynecology • Infertility • Polycystic Ovary Syndrome • Sexual Disorders • Solid Tumor • Uterine Leiomyoma • Women's Health • IL13 • IL17A • IL2 • IL22 • IL33 • IL4 • IL7

Tryptophan Metabolites Improve Intestinal Mucosal Barrier via the Aryl Hydrocarbon Receptor-Interleukin-22 Pathway in Murine Dextran Sulfate Sodium-Induced Pouchitis. (PubMed, Dis Colon Rectum) - "A high-tryptophan diet and aryl hydrocarbon receptor ligand alleviated dextran sulfate sodium-induced pouchitis in murine ileal pouch-anal anastomosis model, which might be through regulating epithelial tight junctions and promoting goblet-cell differentiation, as well as maintaining the integrity and function of the mucosal barrier. This study provides a rationale for the clinical application of Aryl hydrocarbon receptor ligands in the treatment of pouchitis. See Video Abstract."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • IL22

MICROBIAL-DERIVED METABOLITES PROMOTE NKT22 RESPONSES IN COLITIS ASSOCIATED COLORECTAL CANCER PATIENTS (UEGW 2024) - "Interleukin 22 (IL22) is a cytokine involved in the proliferation and survival of epithelial cells... iNKT cells in CAC patients are the major IL22 producing cells and are induced by the recognition of microbiota-derived metabolites implicated in tryptophan metabolism and Aryl hydrocarbon receptor (AhR) stimulation. NKT22-microbiota interaction in CAC patients plays a potential crucial role in tumor development."

Clinical • Colon Cancer • Colorectal Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Oncology • Solid Tumor • IL22

Role of HIF-1α-Activated IL-22/IL-22R1/Bmi1 Signaling Modulates the Self-Renewal of Cardiac Stem Cells in Acute Myocardial Ischemia. (PubMed, Stem Cell Rev Rep) - "The interleukin 22 (IL-22)/IL-22 receptor 1 (IL-22R1) pathway has emerged as an important regulator of several cellular processes, including the self-renewal and proliferation of stem cells...Therefore, the HIF-1α-induced IL-22/IL-22R1/Bmi1 cascade can modulate the proliferation and activation of eCSCs in vitro and in vivo. Collectively, investigating the HIF-1α-activated IL-22/IL-22R1/Bmi1 signaling pathway might offer a new therapeutic strategy for AMI via eCSC-induced cardiac repair."

Journal • Cardiovascular • Inflammation • Myocardial Infarction • Myocardial Ischemia • BMI1 • HIF1A • IL22

IL-22: A key inflammatory mediator as a biomarker and potential therapeutic target for lung cancer. (PubMed, Heliyon) - "Interleukin 22 (IL-22) is a member of the IL-10 cytokine family...IL-22 has been identified as a pro-cancer factor since dysregulation of the IL-22-IL-22R system has been implicated in the development of different cancers, including lung, breast, gastric, pancreatic, and colon cancers. In this review, we discuss the differential expression, regulatory role, and potential clinical significance of IL-22 in lung cancer, while shedding light on innovative approaches for the future."

Biomarker • Journal • Review • Colon Cancer • Colorectal Cancer • Gastrointestinal Cancer • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pancreatic Cancer • Solid Tumor • IL10 • IL22

Choline-based ionic liquids enhance the dermal delivery of cyclosporine a for potential treatment of psoriasis. (PubMed, Drug Deliv Transl Res) - "Moreover, CyA-loaded ILs (0.5%, w/w) significantly relieved the symptoms of psoriasis in an imiquimod (IMQ)-induced mouse model, and the levels of inflammatory factors, including tumor necrosis factor α, interleukin 22 and interleukin 17, in the affected area were reduced by 71.7%, 75.6%, and 89.3%, respectively. After 7 days of consecutive application, [Ch][So] did not cause significant irritation. In conclusion, ILs demonstrate promising potential for the dermal delivery of CyA for the treatment of psoriasis."

Journal • Dermatology • Immunology • Oncology • Psoriasis • IL17A • IL22 • TNFA

Elucidation of the Reversible Self-Association Interface of a Diabody-Interleukin Fusion Protein Using Hydrogen-Exchange Mass Spectrometry and In Silico Modeling. (PubMed, Mol Pharm) - "In this study, the RSA interface of a diabody-interleukin 22 fusion protein (FP-1) was studied using hydrogen-deuterium exchange coupled with mass spectrometry (HDX-MS) in combination with in silico modeling. Taken together, the results show that a complex solution behavior underlies the self-association of FP-1 and that the interface thereof can be attributed to a specific segment in the variable light chain of the diabody. These findings also demonstrate that the combination of HDX-MS with in silico modeling is a powerful tool to guide the design and candidate selection of novel biotherapeutic modalities."

Journal • IL22

TRYPTOPHAN-DERIVED MICROBIAL METABOLITES PROMOTE NKT22 PRO-TUMORIGENIC FUNCTIONS IN COLTIS ASSOCIATED COLORECTAL CANCER PATIENTS (DDW 2024) - "Interleukin 22 (IL22) palys an important function in restoring IBD status...These data suggest that iNKT cells are induced by the recognition of microbiota-derived metabolites implicated in tryptophan metabolism and Aryl hydrocarbon receptor (AhR) stimulation. NKT22-microbiota interaction in CAC patients plays a potential crucial role in tumor development."

Clinical • Colon Cancer • Colorectal Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Oncology • Solid Tumor • IL22

Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens. (PubMed, Proc Natl Acad Sci U S A) - "Interleukin 22 (IL-22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides...Manipulation of dietary fiber content, measurements of intestinal short-chain fatty acids and oral treatment with acetate disclosed that resistance to C. difficile infection is related to increased production of acetate by Il22ra2-/--associated microbiota. Together, these findings suggest that IL-22BP represents a potential therapeutic target for those at risk for or with already manifest infection with this and perhaps other enteropathogens."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Transplantation • IL22

IL-22 binding protein promotes macrophage phagocytosis during lung injury. (IMMUNOLOGY 2024) - "Interleukin 22 binding protein (IL-22BP) is a soluble receptor predominantly produced by myeloid and epithelial cells. While the only documented function of IL-22BP is regulation of IL-22 activity, our new data suggests IL-22BP is involved in macrophage function and phagocytosis independent of IL-22.We found that IL-22BP knock out (IL-22BPKO) mice had greater pulmonary injury and elevated inflammatory macrophages compared to wildtype mice in a bleomycin injury model. Clodronate ablation of macrophages demonstrate limited ablation in IL-22BPKO mice...We assessed expression of lipid recognition receptors using RT-qPCR. Our data shows reduced expression of macrophage scavenger receptor 1, scavenger receptor 1, lectin type oxidized LDL receptor and transcription factor peroxisome proliferator-activated receptor gamma in IL22BPKO mice.Taken together, these data suggest lipid uptake is compromised in IL-22BPKO-derived macrophages and demonstrates that IL-22BP may have a novel..."

Respiratory Diseases • IL22 • PPARG

Distal colonocytes targeted by C. rodentium recruit T-cell help for barrier defence. (PubMed, Nature) - "Interleukin 22 (IL-22) has a non-redundant role in immune defence of the intestinal barrier1-3...Major histocompatibility complex class II (MHCII) expression by these colonocytes was required to elicit sustained IL-22 signalling from Cr-specific T cells, which was required to restrain Cr invasion. Our findings explain the basis for the regionalization of the host response to Cr and demonstrate that epithelial cells must elicit MHCII-dependent help from IL-22-producing T cells to orchestrate immune protection in the intestine."

Journal • Infectious Disease • HLA-DRB1 • IL22

Anti-inflammatory and anti-rheumatic effects of Phoenix dactylifera L. (date palm) seed by controlling cytokines and inhibiting JAK1/STAT3 pathway on CFA-induced arthritis rat and its phytochemical profiling. (PubMed, J Ethnopharmacol) - "The PDS extracts especially the non-polar extract showed significant anti-inflammatory and anti-oxidative properties in the CFA-induced arthritis rat model. PDS might be used to produce RA medicines."

Journal • Preclinical • Immunology • Inflammatory Arthritis • Oncology • Rheumatoid Arthritis • Rheumatology • IL17A • IL1B • IL22 • IL6 • JAK1 • STAT3 • TNFA