heparin sodium injection / Generic mfg. - LARVOL DELTA

This is hitting the heparin sweet spot: Here is a retrospective analysis of investigating and optimizing aPTT monitoring for safety and efficacy during intravenous heparin infusion (ASH 2025) - "Despite a well established protocol, poor compliance, particularly with timely aPTT draws, remained a key barrier. Addressing workflow inefficiencies through interdisciplinary collaboration, better nursing documentation, and EMR optimization may improve adherence and enhance patient safety."

Retrospective data • Acute Coronary Syndrome • Cardiovascular • Hematological Disorders • Pulmonary Embolism • Renal Disease • Respiratory Diseases

Protamine Overdose–Associated coagulopathy in the setting of post-PCI RCA dissection and cardiac tamponade: A hematologic management dilemma (ASH 2025) - "She received 9000 units of IV heparin and was mistakenly administered 250 mg of protamine instead of 50 mg...Antiplatelet therapy (aspirin and clopidogrel), initially held due to bleeding concerns, was successfully re-initiated 24 hours post-intervention... This case underscores the importance of hematologic vigilance in the setting of protamine overdose during cardiac intervention. Accurate dosing, point-of-care coagulation assessment, and delayed—but timely—re-initiation of antiplatelet therapy can mitigate both bleeding and thrombotic risks. Hematologists should be familiar with protamine pharmacodynamics and emerging reversal strategies, as interdisciplinary collaboration is essential in navigating such high-stakes, dual-risk scenarios."

Cardiovascular • Coronary Artery Disease • Hematological Disorders • Hypotension • Thrombosis

Delayed pulmonary embolism following oocyte retrieval in invitro fertilization: A neglected risk factor for thromboembolic events? (ASH 2025) - "Treatment: The patient was managed with intravenous heparin with a subsequent transition to apixaban after stabilization. This case highlights the diagnostic dilemma and management of delayed PE in ART patients. It emphasizes the importance of early recognition and the need for a high index of suspicion for PE, even in the absence of classic risk factors. Prophylactic anticoagulation may be beneficial in ART patients who are at high risk to prevent thromboembolic events, particularly in those with additional risk factors."

Preclinical • Cardiovascular • Genetic Disorders • Gynecology • Hematological Disorders • Obesity • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Venous Thromboembolism

Labile heparin response in a pre-operative cardiac surgery patient: Unmasking predisposition for post-operative coagulopathy (ASH 2025) - "High-risk patients undergoing cardiac surgery will require IV heparin prior to the procedure...The blood bank can be notified to prepare blood products such as FFP, cryoglobulin or desmopressin which can take longer to obtain in large quantities. This should lead to further evaluation into medications, toxins or biologic causes for the labile response to heparin which may mitigate adverse outcomes. Although the incidence of heparin resistance is rare, performing a clinical study in the future may determine if some of these interventions would be beneficial to patient care."

Clinical • Surgery • Addiction (Opioid and Alcohol) • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Genito-urinary Cancer • Hepatology • Hypotension • Liver Failure • Solid Tumor • Testicular Cancer • Thrombocytopenia • Thrombocytopenic Purpura

Elevated aPTT in the setting of prophylactic unfractionated subcutaneous heparin administration (ASH 2025) - "Therefore, the patient was given intravenous protamine sulfate 50 mg once and received intravenous 0.6 mcg of desmopressin for concerns of uremic bleeding. Critically ill patients are predisposed to a higher baseline bleeding risk due to factors such as platelet dysfunction, coagulation factor deficiencies, more invasive procedures, and mechanical ventilation. Understanding all these factors is a crucial part of decision-making when administering anticoagulation."

Cardiovascular • Chronic Kidney Disease • CNS Disorders • Diabetes • Diabetic Nephropathy • Dyslipidemia • Heart Failure • Hematological Disorders • Hypertension • Hypotension • Metabolic Disorders • Nephrology • Renal Disease • Type 1 Diabetes Mellitus • Venous Thromboembolism

Steroid-sparing use of anakinra for secondary hemophagocytic lymphohistiocytosis in sickle cell disease with multiorgan failure – a case report (ASH 2025) - "Management included intubation and ventilation, vasopressor support, and intravenous heparin. This therapeutic choice is supported by emerging evidence favoring IL-1 blockade as a safer immunomodulatory strategy in selected ICU patients with features suggestive of HLH. Our case adds to the growing body of literature advocating for early identification of HLH in SCD patients with unremitting systemic inflammation and organ dysfunction."

Case report • Clinical • Acute Kidney Injury • Cardiovascular • Dyslipidemia • Genetic Disorders • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Hepatology • Hypertriglyceridemia • Hypotension • Immunology • Inflammation • Liver Failure • Metabolic Disorders • Nephrology • Pulmonary Embolism • Rare Diseases • Renal Disease • Respiratory Diseases • Sickle Cell Disease • IL2RA

Home Intravenous Heparin Therapy via a Central Venous Port for Recurrent Cancer-Associated Stroke Requiring Repeat Mechanical Thrombectomy: A Case Report. (PubMed, Intern Med) - "As an alternative, intravenous heparin was initiated at home via a chemotherapy port, using a portable infusion pump. This individualized approach was implemented without any major complications, and it may represent a practical option for patients with CAS who are either intolerant or refractory to conventional therapies."

Journal • Cardiovascular • Oncology • Pancreatic Cancer • Solid Tumor

Heparin blunts the immunosuppressive effects of glioblastoma derived extracellular vesicles in an vivo mouse model (SNO 2025) - "The mice were then treated with subcutaneous heparin, which has been shown to disrupt the EV-cell binding at the interface preventing uptake... Heparin may decrease the immunosuppressive effects of GBM-EVs by preventing the induction of immunosuppressive cell populations."

Preclinical • Brain Cancer • Glioblastoma • Glioma • Solid Tumor • TIGIT

Procedural eptifibatide administration as an alternative to preprocedural dual antiplatelet therapy for patients undergoing flow diversion procedures: case series and review of the literature. (PubMed, J Neurointerv Surg) - "Intraprocedural eptifibatide may be an acceptable alternative to preprocedural DAPT to achieve platelet inhibition for FD procedures. This protocol did not result in peripheral or neurological hemorrhagic complications and was associated with a very low incidence of post-procedure diffusion lesions."

Journal • Cardiovascular • Hematological Disorders

Heparin decreases serum sphingosine-1-phosphate levels in patients with vascular diseases. (PubMed, Atherosclerosis) - "Circulating S1P concentrations in patients with atherosclerosis are associated to different blood components before and after interventions. Reduced postoperative serum S1P levels in patients are most likely attributed to heparin treatment. The causalities between heparin treatment, reduced serum S1P and reduced intimal hyperplasia deserve further investigations."

Journal • Atherosclerosis • Cardiovascular

Serial Embolic Events From Left Atrial Appendage Thrombus Detected After Mechanical Thrombectomy: A Case Report and Management Considerations. (PubMed, Cureus) - "We report the case of an 82-year-old woman with AF on edoxaban who presented with acute right internal carotid artery (ICA) occlusion...Two days after onset, contrast-enhanced chest CT unexpectedly demonstrated an LAA thrombus, prompting initiation of intravenous heparin...Anticoagulation could not be promptly resumed due to hemorrhagic transformation, and the patient subsequently experienced recurrent embolic events. These findings underscore the need for thorough evaluation of potential embolic sources after thrombectomy, thoughtful consideration of when and how to restart anticoagulation, and the possible role of LAA occlusion as a secondary prevention strategy."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders • Hematological Disorders • Ischemic stroke • Thrombosis

Role of heparin-induced HGF release in the acute phase of STEMI. (PubMed, Front Cardiovasc Med) - "In a subset of four patients, HGF levels were assessed before and 30 min after heparin injection...This study demonstrates that heparin induces a rapid and substantial increase in circulating HGF in STEMI patients, potentially mediating cardioprotection during reperfusion. These findings suggest that comedications like heparin may confound cardioprotective trials and should be considered in future translational strategies."

Journal • Cardiovascular • Myocardial Infarction • Reperfusion Injury • HGF

Protein-Losing Enteropathy Following Fontan Completion: A 30-Year National Cohort Study in Sweden. (PubMed, J Thorac Cardiovasc Surg) - "PLE remains a serious complication following Fontan with notable mortality. Patients with right ventricular morphology of the systemic ventricle had a higher risk of PLE. Previous pulmonary venous congestion was common when PLE was diagnosed early after Fontan. Catheter-based interventions were frequently used to optimize hemodynamics; lymphatic interventions are likely to become more common. In therapy-resistant patients heart transplantation remains an option."

Journal • Transplantation

Heparin blunts the immunosuppressive effects of glioblastoma derived extracellular vesicles in an vivo mouse model (WFNOS 2025) - "The mice were then treated with subcutaneous heparin, which has been shown to disrupt the EV-cell binding at the interface preventing uptake... Heparin may decrease the immunosuppressive effects of GBM-EVs by preventing the induction of immunosuppressive cell populations."

Preclinical • Brain Cancer • Glioblastoma • Glioma • Solid Tumor • TIGIT

Recurrent Leg Deep Vein Thrombosis in a Female with Atypical Right-Sided Variant of May Thurner Syndrome and Factor V Leiden Mutation (ASH 2023) - "She was started on an intravenous heparin drip and subsequently had a thrombectomy procedure. She was subsequently discharged home on apixaban anticoagulation...The patient was then re-initiated on the heparin drip and then bridged to therapeutic warfarin... This is a very atypical presentation of MTS variation affecting the right lower extremity with limited description in the literature. To our knowledge, this is the first case presentation of right sided MTS resulting in a DVT in a patient with factor V Leiden mutation. MTS is a potentially treatable and often-overlooked pathology."

Cardiovascular • Hematological Disorders • Infectious Disease • Novel Coronavirus Disease • Thrombosis • Vasculitis • Venous Thromboembolism

ESRD Following Complete Abdominal Aortic Occlusion (KIDNEY WEEK 2025) - "Vascular surgery was urgently consulted, and a continuous intravenous heparin infusion was initiated...Management often involves anticoagulation and surgical interventions, such as aorto-bifemoral bypass, to restore perfusion. However, the prognosis remains guarded, especially in elderly patients with multiple comorbidities."

Acute Kidney Injury • Atherosclerosis • Cardiovascular • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • Coronary Artery Disease • Genito-urinary Cancer • Hypertension • Immunology • Nephrology • Pulmonary Disease • Renal Cell Carcinoma • Renal Disease • Respiratory Diseases • Solid Tumor

Bloodletting Therapy Using Subcutaneous Heparin and Controlled Scarification for Venous Insufficiency in Free Flap Reconstruction. (PubMed, Microsurgery) - "Subcutaneous heparin combined with controlled scarification represents a safe, practical, and potentially effective method to manage persistent venous congestion when surgical revision is unsuccessful or contraindicated. Future prospective studies are warranted to better define its role and optimize outcomes."

Journal • Cardiovascular

Interaction between Collagen IV and Heparin-Binding Sites in the Activity, Distribution and Clearance of Factor IX(a) (ASH 2024) - "Legacy (linear) numbering was used in the Gla domain and chymotrypsinogen numbering in the protease domain. The collagen site had a dominant effect on protease distribution, while the heparin site had similar effects on both zymogen and protease. Disruption of the heparin site modulated the impact of the K5A variant in the protease, and along with the contradictory effects of K5R, suggest potential interaction between these binding sites in the protease."

Hematological Disorders • Hemophilia • Hemophilia B • Rare Diseases

Effect of vibration on pain during subcutaneous heparin injection: A randomized, single-blind, placebo-controlled trial. (PubMed, Open Med (Wars)) - "It was found that the local vibration technique applied to the site of subcutaneous LMWH injection was effective in reducing the pain developing in relation to the injection. Healthcare professionals can use the vibration technique in the management of the pain relating to subcutaneous heparin injection."

Journal • Pain

Safety of early chemoprophylaxis in traumatic brain injury patients. (PubMed, Surg Neurol Int) - "A 2-year retrospective cohort study was conducted on eligible trauma patients admitted to MyMichigan Medical Center Saginaw who sustained ICH and received subcutaneous heparin (SQH) prophylaxis within 24 h of the first stable head computed tomography (CTH)...On the first imaging post-SQ heparin initiation, 26 of the 63 patients (41%) had improved ICH, 37 patients (59%) had stable ICH, and none had worsening ICH. In TBI patients with ICH, administration of SQH chemoprophylaxis within the first 24 h of stable imaging appears to be safe, without the risk of worsening hemorrhage."

Journal • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Vascular Neurology • Venous Thromboembolism

Alpha-Gal Syndrome as an Underrecognized Cause of Chronic Urticaria: A Diagnostic Challenge in Community Practice (ACAAI 2025) - "Notably, he reported a flare of urticaria after receiving a heparin injection during a recent hospitalization...It illustrates how non-food exposures such as porcine-derived heparin can unmask alpha-gal sensitization. Awareness of this association is critical, particularly in tick-endemic regions (such as the Lone Star tick in the Midwest), to prevent misdiagnosis and facilitate early, effective intervention."

Cardiovascular • Dermatology • Immunology • Urticaria

First Time Diagnosis Of Alpha-Gal Syndrome Presenting With Oropharyngeal Edema Requiring Intubation. (ACAAI 2025) - "Patient was extubated the next day but developed SOB and throat swelling 5-10 minutes after receiving subcutaneous heparin for venous thromboembolism prophylaxis; symptoms improved after epinephrine administration. Discussion This case demonstrates significance of AGS as a differential in atypical anaphylaxis, especially with recent tick bites and dietary triggers. This case also highlights the dose dependent symptom severity seen in alpha gal."

Intubation • Asthma • Cardiovascular • Immunology • Respiratory Diseases • Venous Thromboembolism

The impact of continuous intravenous administration of heparin on coagulation dysfunction and organ failure in patients with sepsis. (PubMed, Sci Rep) - "This retrospective cohort study aimed to evaluate the effects of continuous intravenous heparin on coagulation dysfunction, organ failure, and clinical outcomes in sepsis patients...Despite these benefits, heparin did not reduce 28-day mortality. The study highlights heparin's potential role in managing sepsis-related complications but underscores the need for further research to optimize therapeutic strategies for mortality reduction."

Journal • Retrospective data • Infectious Disease • Septic Shock

Successful thrombolysis of portal vein thrombosis induced by post-liver transplant splenectomy: a case report. (PubMed, Front Transplant) - "One month post-splenectomy, the patient developed PVT, which was initially managed with anticoagulation therapy (aspirin and rivaroxaban). Despite treatment, thrombosis progressed, requiring intravenous heparin and urokinase thrombolysis...Peripheral urokinase infusion may serve as a viable treatment option for patients with contraindications or reluctance toward invasive procedures. Further studies are needed to optimize anticoagulation protocols and long-term management strategies in this patient population."

Journal • Cardiovascular • Fibrosis • Gastroenterology • Hematological Disorders • Hepatitis B • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Cirrhosis • Thrombocytopenia • Thrombosis • Transplantation

The Hypertrophic Heart That Told Two Stories: A Case of Coexisting Hypertrophic Cardiomyopathy and Fabry Disease (AHA 2025) - "Telemetry captured one episode of SVT lasting approximately 24–30 seconds and multiple episodes of NSVT.The patient was started on IV amiodarone, which resolved the SVT and NSVT, though she remained in Afib with RVR. Anticoagulation with IV heparin was initiated...She was referred for endomyocardial biopsy and further evaluation for potential gene-targeted therapy.Discussion This case illustrates the rare coexistence of sarcomeric HCM and Fabry disease in a single patient. It underscores the importance of comprehensive evaluation, including genetic testing, in patients with hypertrophic cardiomyopathy - especially when imaging or family history raises suspicion for an infiltrative or metabolic etiology."

Clinical • Cardiomyopathy • Cardiovascular • Fabry Disease • Genetic Disorders • Hypertrophic Cardiomyopathy • Lysosomal Storage Diseases • Metabolic Disorders • Pulmonary Disease • Rare Diseases