heparin sodium injection / Generic mfg. - LARVOL DELTA

The Clot Thickens: Saddle Pulmonary Embolism as Initial Presentation of Ulcerative Colitis (ACG 2026) - "She was treated with prednisone for induction and discharged on therapeutic enoxaparin...Given the high bleeding risk, intravenous heparin and mechanical thrombectomy were favored over systemic thrombolysis...Figure: Coronal (A) and axial (B) computed tomography angiography images of the chest demonstrating saddle pulmonary embolism. Flexible sigmoidoscopy demonstrating severe continuous circumferential friability and ulceration with spontaneous bleeding extending from rectum (C) to the descending colon (D)."

Cardiovascular • Colon Cancer • Colorectal Cancer • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Inflammation • Inflammatory Bowel Disease • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Ulcerative Colitis • Venous Thromboembolism

Multifocal Ileal Neuroendocrine Tumors Causing Obscure Overt Gastrointestinal Bleeding: A Diagnostic and Management Challenge (ACG 2026) - "Angiography of the superior mesenteric artery with provocative measures, including intra-arterial nitroglycerin, intravenous heparin, and tissue plasminogen activator, did not reveal active extravasation. This case highlights symptomatic grade 1 NETs presenting with obscure overt gastrointestinal bleeding and the diagnostic challenge when advanced endoscopic and imaging modalities are inconclusive. In transfusion-dependent patients, early surgical exploration should be considered, as definitive resection may be both diagnostic and therapeutic."

Endocrine Cancer • Gastroenterology • Nephrology • Neuroendocrine Tumor • Oncology • Renal Disease • Solid Tumor

Intrahepatic Cholangiocarcinoma Presenting as a Hilar Mass With Portal Vein Tumor Thrombus: A Diagnostic and Therapeutic Challenge (ACG 2026) - "IV heparin was started for suspected PVT but discontinued after MDT review favored tumor thrombus over bland thrombosis...The patient was discharged day 4 with plans for gemcitabine, cisplatin, and durvalumab per TOPAZ-1...Figure: Axial contrast-enhanced CT of the abdomen demonstrating a hypodense mass at the hepatic hilum measuring 4.6 cm, with involvement of the portal vasculature. Findings were initially concerning for perihilar (Klatskin) cholangiocarcinoma, prompting multimodal evaluation including EUS-FNA for tissue diagnosis"

Asthma • Atrial Fibrillation • Biliary Cancer • Cardiovascular • Cholangiocarcinoma • Dyslipidemia • Gastroesophageal Reflux Disease • Genetic Disorders • Hepatology • Immunology • Obesity • Oncology • Respiratory Diseases • Solid Tumor • Thrombosis

Ischemic Colitis Secondary to Isolated Splenic Vein Thrombosis: A Rare Case (ACG 2026) - "The patientâs care concluded with a multidisciplinary discussion between the medical and surgical teams to transition the patient from intravenous heparin to apixaban, with outpatient hematology follow-up for a comprehensive hypercoagulability evaluation. 2015;9(6):761-6. Figure: Rectosigmoid Junction Thickening Figure: Sigmoid Colon"

Clinical • Cardiovascular • Chronic Kidney Disease • Diabetes • Gastroenterology • Gastrointestinal Disorder • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Nephrology • Peripheral Arterial Disease • Renal Disease • Thrombosis • Type 2 Diabetes Mellitus

The Clot Thickens: Portal Vein Thrombosis as Presenting Manifestations of Behçet's Disease (ACG 2026) - "Computed tomography (CT) of the abdomen and pelvis revealed a left portal vein thrombosis (Figure 1), and she was started on intravenous (IV) heparin following confirmation with abdominal ultrasound and CT angiography...She was transitioned to apixaban for indefinite anticoagulation, received IV iron, and was discharged with follow-up...Figure: Figure 1. Computed tomography of the abdomen and pelvis demonstrating peripheral left portal vein thrombosis containing a locule of gas."

Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Arthritis • Inflammatory Bowel Disease • Leukopenia • Ocular Inflammation • Ophthalmology • Pulmonary Embolism • Rare Diseases • Respiratory Diseases • Thrombosis • Uveitis • Vasculitis • JAK2

Rare Case of Salmonella Bacteremia Mimicking Severe Sepsis With Pulmonary Embolism in a Traveler (ACG 2026) - "Blood cultures later grew Salmonella species sensitive to ceftriaxone and trimethoprim-sulfamethoxazole. The patient required ICU admission and treatment with intravenous heparin followed by apixaban, along with targeted antimicrobial therapy...This confirms the diagnosis of acute pulmonary embolism Figure: CT scan of the chest in lung window demonstrates wedge-shaped infarction. These findings are compatible with segmental pulmonary emboli"

Clinical • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Inflammation • Malaria • Pulmonary Embolism • Respiratory Diseases • Septic Shock • Thrombocytopenia • Venous Thromboembolism

Sigmoid Diverticulitis With Streptococcus constellatus Bacteremia, Pylephlebitis, and Hepatic Abscesses Mimicking Metastatic Malignancy (ACG 2026) - "Blood cultures were obtained, intravenous heparin was initiated, and ceftriaxone plus metronidazole were started...Antibiotics were narrowed to ampicillin-sulbactam and later transitioned to oral therapy...Figure: MRI Abdomen with and without Contrast: multiple multiloculated, rim-enhancing liver lesions. Figure: MRI Abdomen with and without Contrast: near occlusive thrombus within the left portal vein."

Metastases • Cardiovascular • Gastrointestinal Disorder • Hepatology • Oncology • Thrombosis

Pain Out of Proportion: Cocaine-Induced Mesenteric Ischemia Presenting as Acute Abdomen (ACG 2026) - "The patient was managed with bowel rest, intravenous fluids, heparin infusion, piperacillin-tazobactam, and nasogastric decompression for worsening distention and small bowel obstruction. Figure: CT abdomen demonstrating dilated small bowel loops with mural thickening and hypo enhancement, concerning for ischemic bowel injury. Figure: CT abdomen demonstrating diffusely dilated fluid filled small bowel loops, mesenteric congestion and edema, consistent with small bowel ischemia."

Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Ischemic stroke • Pain • Septic Shock • Thrombosis

Streptococcus Anginous Bacteremia and Splenic Abscess Complicated With Dual Venous Thrombosis: A Rare Trilogy (ACG 2026) - "Given the presence of splanchnic venous thrombosis, Hematology/Oncology recommended systemic anticoagulation with intravenous heparin and transition to oral anticoagulation...This case emphasizes the importance of early imaging and multidisciplinary management in patients with S. anginosus bacteremia and suspected intra-abdominal infection. Figure: splenic lesion in anterior wall of spleen concerning for abscess"

Cardiovascular • Hematological Disorders • Infectious Disease • Inflammation • Thrombosis

Intravenous Immunoglobulin (IVIG) use in HIT and efficacy of early IVIG compared to standard of care treatment. (PubMed, J Thromb Haemost) - "At our institution, IVIG use in HIT was confined to severely ill patients with high thrombotic burden. Early IVIG administration accelerated platelet recovery compared to standard-of-care alone. Prospective multicenter studies are needed to confirm these findings."

Journal • Cardiovascular • Hematological Disorders • Immunology • Thrombocytopenia • Thrombosis

Subcutaneous calcinosis after calcium heparin injection (EADV 2026) - No abstract available

Metabolic Disorders

ANAPHYLAXIS TO INTRAVENOUS UNFRACTIONATED HEPARIN IN PREGNANCY DESPITE PRIOR TOLERANCE OF SUBCUTANEOUS HEPARIN (CHEST 2026) - No abstract available

Allergy • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Safety of Subcutaneous Heparin in Patients Requiring External Ventricular Drains. (PubMed, Neurosurg Pract) - "SQ heparin seems to be safe for chemoprophylactic management of VTE in patients with EVDs."

Journal • Cardiovascular • Hematological Disorders • Venous Thromboembolism

Combined Use of a Factor XIIa Inhibitor with a Polycarboxybetaine Coating Creates Potent Anticoagulation with Preserved Hemostasis during Ambulatory, 24-hour, Rabbit Extracorporeal Life Support. (PubMed, Acta Biomater) - "Systemic anticoagulation, such as intravenous (IV) heparin, is used to mitigate thrombosis but increases the risk of significant, life-threatening bleeding complications...This strategy provided potent protection against clot formation while preserving hemostatic function relative to heparin during 24-hour ECLS in rabbits. These findings demonstrate a promising path toward safer anticoagulation during ECLS."

Journal • Preclinical • Anesthesia • Cardiovascular • Hematological Disorders • Thrombosis

Transabdominal Ultrasound-guided Transjugular Endovascular Mesocaval Shunt Creation in Extrahepatic Portal Vein Obstruction: A Single-center Experience. (PubMed, Interv Radiol (Higashimatsuyama)) - "Anticoagulation was initiated with intravenous heparin and transitioned to direct oral anticoagulants...Transjugular endovascular mesocaval shunt creation using transabdominal ultrasound guidance is feasible, safe, and reproducible in patients with extrahepatic portal vein obstruction who have undergone failed surgical shunting or are unsuitable for portal vein recanalization with transjugular intrahepatic portosystemic shunt. This approach eliminates the need for percutaneous abdominal wall access, computed tomography guidance, or intravascular ultrasound, making it accessible in resource-constrained settings."

Journal • Cardiovascular • Gastroenterology • Hematological Disorders • Hypertension • Infectious Disease • Portal Hypertension • Septic Shock • Transplantation

Radial artery occlusion in transradial coronary catheterization: incidence and prognostic factors (ESC 2026) - "Independent predictors of RAO were as follows: (i) the female gender [aOR = 1.72 (1.05–2.83)], (ii) access site cross-over [aOR = 4.33 (1.02–18.39)], (iii) increased total time of the sheath in the artery [(aOR = 1.01 (1.00–1.02)], (iv) radial artery spasm [aOR = 2.47 (1.40–4.36)], (v) presence of hematoma [aOR = 2.28 (1.28–4.06)], (vi) post-catheterization dabigatran use [aOR = 5.15 (1.29–20.55)], (vii) manual hemostasis [aOR = 1.94 (1.01–3.72)] and (viii) numbness [aOR = 8.25 (1.70–40)]. Contrariwise, two variables were independently associated with increased odds for radial artery patency (RAP): (i) PCI performance [aOR = 0.19 (0.06–0.63)], and (ii) a higher dosage of intravenous heparin per patient weight [aOR = 0.98 (0.96–0.99)], particularly, a dosage of >50 IU/kg [aOR = 0.56 (0.31–1.00)]...The female gender, radial artery trauma and manual hemostasis are the strongest predictors of RAO. Our results could help in the future identification of patients at higher..."

Biomarker • Cardiovascular

Splenic Vein Thrombosis Complicating Hypertriglyceridemia-Induced Acute Pancreatitis in Diabetic Ketoacidosis: A Rare Clinical Tetrad. (PubMed, Cureus) - "Therapeutic intravenous heparin was initiated, followed by transition to oral apixaban. He was discharged in stable condition on basal-bolus insulin, atorvastatin, fenofibrate, and omega-3 acid ethyl esters with multidisciplinary follow-up. This case describes a rare clinical tetrad linking DKA, severe HTG, HTG-AP, and SVT. It highlights the importance of early recognition and prompt multidisciplinary management of both the metabolic and thrombotic complications associated with this uncommon presentation."

Journal • Cardiovascular • Diabetes • Dyslipidemia • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hypertension • Hypertriglyceridemia • Inflammation • Metabolic Disorders • Pain • Pancreatitis • Portal Hypertension • Severe Hypertriglyceridemia • Thrombosis • Type 2 Diabetes Mellitus

Perioperative Management of Severe Heparin-Induced Thrombocytopenia in a Patient Undergoing Double Lung Transplantation for Progressive Idiopathic Pulmonary Fibrosis (ASA 2026) - "To enable perioperative heparin use, she was treated with plasmapheresis, rituximab, and intravenous immunoglobulin. She successfully underwent bilateral lung transplantation on venovenous-arterial extracorporeal membrane therapy with intravenous heparin anticoagulation and epoprostenol, with her postoperative course complicated by thromboses. This case highlights a rare instance of HIT adding considerable perioperative complexity to lung transplantation, requiring multidisciplinary preoperative optimization."

Clinical • Cardiovascular • Hematological Disorders • Idiopathic Pulmonary Fibrosis • Immunology • Obstructive Sleep Apnea • Pulmonary Arterial Hypertension • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Sleep Disorder • Thrombocytopenia • Thrombosis • Transplantation

Effects of cold therapy on ecchymosis and pain after subcutaneous heparin injection: a meta-analysis and systematic review. (PubMed, Front Pain Res (Lausanne)) - "The findings should be interpreted cautiously because of high heterogeneity, outcome-specific risk of bias, and inconsistent reporting of intervention and measurement procedures. https://www.crd.york.ac.uk/PROSPERO/view/CRD420261278725, identifier CRD420261278725."

Journal • Retrospective data • Review • Pain

Alpha-Gal Syndrome in Cardiac Surgery: Clinical Tolerance Despite Serologic Sensitization (ASA 2026) - "After premedication with diphenhydramine and hydrocortisone, he received intravenous porcine heparin (400 units/kg) for cardiopulmonary bypass. Surgery proceeded uneventfully with no signs of anaphylaxis or hypersensitivity. This case highlights that elevated alpha-gal IgE may not consistently predict clinical reactivity and supports individualized perioperative risk assessment."

Clinical • Surgery • Cardiovascular • Immunology

A Rare Case of Limb Loss Following Hemorrhagic Complications of Epidural Injection and Intra-Aortic Balloon Pump Placement (ASA 2026) - "Patient continued to recover in the ICU on IV heparin but had ongoing bleeding from the surgical sites (and ongoing risks from cervical hemorrhage) requiring regular blood transfusions. Patient was eventually discharged and is otherwise neurologically intact."

Clinical • Cardiovascular • Hematological Disorders • Thrombosis

Development and validation of a deep learning model to predict heparin response in critically ill patients with deep vein thrombosis receiving continuous intravenous heparin infusion. (PubMed, Blood Sci) - "Feature importance identified the difference between 45 s and APTT, cumulative heparin dose, and infusion rate as the leading predictors. Collectively, this deep learning model accurately forecasts future APTT values in critically ill patients with DVT receiving intravenous heparin, supporting a shift from reactive to proactive, data-driven heparin management in the ICU with potential benefits for patient safety and treatment efficacy."

Journal • Cardiovascular • Critical care • Hematological Disorders • Thrombosis • Venous Thromboembolism

Acute Paraplegia in the Emergency Department: Acute Leriche Syndrome as a Vascular Mimic of a Spinal Cord Emergency. (PubMed, Cureus) - "The patient was treated with intravenous heparin, followed by catheter-directed thrombolysis and aortic stent placement...This case demonstrates that acute Leriche syndrome may present with acute paraplegia and mimic a spinal cord emergency. It highlights the critical importance of incorporating vascular assessment into the evaluation of non-traumatic acute paraplegia, as timely diagnosis and revascularization may improve neurological outcomes."

Journal • Cardiovascular • Diabetes • Erectile Dysfunction • Metabolic Disorders

EASI-TOC: Endovascular Acute Stroke Intervention - Tandem OCclusion Trial (clinicaltrials.gov) - P=N/A | N=458 | Recruiting | Sponsor: Centre hospitalier de l'Universit de Montral (CHUM) | Trial completion date: Mar 2027 ➔ Oct 2027 | Trial primary completion date: Jun 2026 ➔ May 2027

Trial completion date • Trial primary completion date • Cardiovascular

Targetoid-like necrotic plaque after low-molecular-weight heparin injection. (PubMed, JAAD Case Rep) - No abstract available

Journal • Hematological Disorders • Thrombocytopenia