heparin sodium injection / Generic mfg. - LARVOL DELTA

Portal Vein Thrombosis Due to Concomitant Cytomegalovirus and Epstein-Barr Virus Infection: An Underestimated Complication. (PubMed, Am J Case Rep) - "The patient was shifted to the ICU, and anticoagulation was initiated immediately with unfractionated heparin (intravenous bolus of 80 u/kg followed by 18 u/kg/hr, target aPTT of 1.5-2.3 control)...Treating it as a provoked risk for thromboembolism will aid in its early detection and management. Additionally, by treating it as a triggered risk, unnecessary lifelong anticoagulation can be avoided."

Journal • Cardiovascular • Cytomegalovirus Infection • Epstein-Barr Virus Infections • Fatigue • Hematological Disorders • Infectious Disease • Pain • Rare Diseases • Thrombosis • Venous Thromboembolism

Impact of Ligament of Marshall Resection on Atrial Fibrillation Occurrence in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Controlled Trial (clinicaltrials.gov) - P=N/A | N=220 | Completed | Sponsor: Kasr El Aini Hospital

New trial • Atrial Fibrillation • Cardiovascular

UNILATERAL RENAL ARTERY THROMBOSIS PRESENTING WITH ACUTE KIDNEY INJURY: DIAGNOSTIC AND THERAPEUTIC CHALLENGES (ISN-WCN 2026) - "Continuous intravenous heparin infusion (10,000 units/24 hours) was started for anticoagulation, followed by percutaneous thrombectomy...Maintenance therapy with warfarin and clopidogrel was given to prevent recurrence...Early vascular imaging is crucial in sudden-onset renal failure with nonspecific laboratory findings2. Long-term antithrombotic therapy may prevent recurrence in idiopathic or hypercoagulable conditions2,3.Conclusion Renal artery thrombosis is an uncommon but critical cause of acute kidney injury that demands prompt recognition and swift intervention"

Acute Kidney Injury • Atherosclerosis • Atrial Fibrillation • Cardiovascular • Diabetes • Diabetic Nephropathy • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Renal Disease • Thrombosis

Efficacy of heparin in respiratory support of near-term rabbits with meconium-induced acute lung injury: Linear regression model analyses. (PubMed, PLoS One) - "The comparable efficacy of heparin, alongside the PS and NO, was corroborated in attenuating meconium-mediated, ventilator-induced ALI, which should warrant clinical investigation to validate."

Journal • Preclinical • Acute Lung Injury • Anesthesia • Respiratory Diseases

Heparin for RAO Post-Transradial Angiography in AIS (clinicaltrials.gov) - P3 | N=440 | Completed | Sponsor: Xiang Luo | Recruiting ➔ Completed | Trial completion date: May 2026 ➔ Feb 2026

Trial completion • Trial completion date • Cardiovascular • Ischemic stroke

Efficacy of Apixaban in the Treatment of Portal Vein Thrombosis Occurring More Than One Year After LS (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: Northern Jiangsu People's Hospital | Completed ➔ Recruiting

Enrollment open • Cardiovascular • Hematological Disorders • Hypertension • Immunology • Portal Hypertension • Thrombosis

The unusual outbreak of sepsis in a cancer hospital caused by intrinsically contaminated heparin injection vials (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease • Oncology • Septic Shock

Cerebral Fat Embolism Syndrome With Early Pulmonary Findings on Computed Tomography: A Case Report (SCCM 2026) - "She was started on intravenous heparin for suspected PTE in the intensive care unit (ICU)...Early CFES diagnosis may initiate supportive care and prevent unnecessary interventions, such as prolonged anticoagulation. Further studies should evaluate the role of early pulmonary imaging in CFES."

Case report • Clinical • Cardiovascular • Musculoskeletal Diseases • Orthopedics • Pulmonary Embolism

High on Whippets, Down With Clots: A Rare Case of N2O Thrombosis (SCCM 2026) - "No DVT was found on Doppler.He was initially managed at an outside hospital with tPA (100 mg IV), heparin, fluids, and intubation, but remained in shock...He was extubated within 24 hours, transitioned to apixaban, and started on vitamin B12 and folate...It underscores the need to consider N2O toxicity in similar clinical presentations and demonstrates the importance of early recognition and aggressive intervention. Vitamin supplementation may support recovery, though its role in preventing thrombosis remains unclear."

Clinical • Acute Kidney Injury • Cardiovascular • Hematological Disorders • Metabolic Disorders • Nephrology • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Thrombosis

Acute Liver Failure From Portal Vein Thrombosis in Suspected Catastrophic Antiphospholipid Syndrome (SCCM 2026) - "Despite being on dabigatran, renal dysfunction raised concern for drug accumulation contributing to liver injury. The patient was started on intravenous heparin and supportive care, including vasopressors and continuous renal replacement therapy...Early empiric anticoagulation and multidisciplinary input are critical for suspected CAPS, even before confirmatory testing. The conclusion reflects the authors' interpretation, with assistance from AI tools."

Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Complement-mediated Rare Disorders • Congestive Heart Failure • Coronary Artery Disease • Diabetes • Genetic Disorders • Heart Failure • Hematological Disorders • Hepatology • Hypotension • Immunology • Infectious Disease • Inflammation • Liver Failure • Metabolic Disorders • Nephrology • Renal Disease • Thrombosis

Correlation of Coagulation Parameters in Patients on ECMO: A Retrospective Cohort Study (SCCM 2026) - "This single-center retrospective cohort study demonstrates that ACT and aPTT monitoring methods often agree and are modestly correlated, while ACT and anti-Xa often disagree and are poorly correlated. Clinicians should avoid assumptions that these three coagulation assays are interchangeable, as utilizing ACT over an institution's preferred method of monitoring intravenous heparin can lead to misinformed dosing decisions."

Retrospective data • Cardiovascular • Hematological Disorders • Thrombosis

ALTERNATIVE STRATEGIES FOR TRANSFUSION-FREE EXTRACORPOREAL CARDIOPULMONARY RESUSCITATION SUPPORT AND DECANNULATION: A JEHOVAH'S WITNESS CASE (ACC 2026) - "She underwent stenting to an ostial right coronary artery lesion and started on aspirin and ticagrelor... Bleeding management without transfusion in ECPR is challenging but achievable. This case demonstrates that multimodal ATS can safely guide ECPR and decannulation in patients who decline transfusions, providing a practical framework for managing severe anemia in similar high-risk scenarios."

Clinical • Cardiovascular • Hematological Disorders • Myocardial Infarction • Thrombosis

EARLY POST-OPERATIVE PROPHYLACTIC ANTICOAGULATION AFTER PROSTHETIC HEART VALVE REPLACEMENT (ACC 2026) - "This retrospective analysis aims to describe the safety and efficacy of early prophylactic subcutaneous heparin (UFH) or low-molecular weight heparin (LMWH) post prosthetic valve replacement...Minor outcomes will include time from valve replacement to prophylactic UFH or LMWH initiation, time from valve replacement to warfarin initiation, time from valve replacement to therapeutic international normalized ratio, hospital length of stay, and 30-day mortality... Results of this study will address the use of prophylactic anticoagulation and provide additional insight on anticoagulation management after prosthetic valve surgery."

Cardiovascular • Hematological Disorders • Thrombosis

CRUSHED AT THE CORE: WHEN CANCER CLOSES THE CORONARIES (ACC 2026) - "Despite IV heparin, persistent symptoms after 1 week prompted high-risk PCI... Clinicians should maintain high suspicion for extrinsic coronary compression in patients with mediastinal tumors and ischemic symptoms. When faced with rapidly evolving coronary compromise and limited surgical options, PCI, though unconventional, may represent the only viable path to myocardial salvage."

Atherosclerosis • Breast Cancer • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders • Oncology • Pulmonary Disease • Solid Tumor • Thymoma • Thymus Cancer

ATYPICAL CYSTIC INTRACARDIAC THROMBI: AN UNRECOGNIZED HIGH-RISK MORPHOLOGY (ACC 2026) - "Decision-Making: Intravenous heparin and aggressive diuresis were initiated immediately... This case underscores critical gaps in understanding of cystic intracardiac thrombi and their complications. The atypical cystic morphology created uncertainty regarding embolic potential, which may exceed that of typical solid thrombi. When encountered, clinicians should consider more aggressive strategies, including thrombectomy or prolonged inpatient monitoring."

Addiction (Opioid and Alcohol) • Cardiomyopathy • Cardiovascular • Heart Failure • Pulmonary Disease

PERICARDIAL PRIMARY EFFUSION LYMPHOMA PRESENTING AS ACUTE CORONARY SYNDROME WITH IMMEDIATE STENT THROMBOSIS AND MALIGNANT VENTRICULAR TACHYCARDIA (ACC 2026) - "He was loaded with aspirin and underwent emergent angiography revealing 99% proximal right coronary artery occlusion...Right femoral access was re-established, and he subsequently developed sustained ventricular tachycardia (VT) requiring defibrillation and amiodarone...He received a 2-hour cangrelor infusion, followed by clopidogrel 600mg, and intravenous heparin... Pericardial lymphoma can rarely manifest as ACS with immediate stent thrombosis and ischemia-driven VT. Recognizing malignancy-related hypercoagulability is critical as management may require intensified antithrombotic therapy beyond standard PCI protocols."

Acute Coronary Syndrome • Cardiovascular • Hematological Malignancies • Lymphoma • Monoclonal Gammopathy • Pulmonary Embolism • Respiratory Diseases • Thrombosis • Ventricular Tachycardia

FRAGMENTS OF DANGER: A MYXOMA'S JOURNEY INTO THE CORONARIES (ACC 2026) - "Cardiac myxomas can embolize systemically, but coronary artery embolization is rare. In this case, friable masses in the LAD and RCA likely resulted from tumor fragmentation and resolution with IV heparin supports this thrombotic phenomena. To prevent embolization during surgical excision, careful intraoperative handling, minimal manipulation before aortic cross-clamping, and complete resection with clear margins are essential."

Cardiovascular • Hypertension • Thrombosis

WHEN THE FLOW RUNS LOW: A HIDDEN CAUSE IN LVAD OUTFLOW (ACC 2026) - "CT angiography suggested mural thrombosis of the outflow graft, and intravenous heparin was initiated. Despite therapeutic anticoagulation with warfarin (lower INR goal due to recurrent GI bleeding), review by interventional cardiology and cardiothoracic surgery identified external compression of the outflow graft rather than intraluminal thrombus... External compression of the LVAD outflow graft is rare but important. Percutaneous stenting offers a viable therapeutic option in patients at prohibitive surgical risk."

Cardiomyopathy • Cardiovascular • Gastrointestinal Disorder • Hematological Disorders • Thrombosis

ACUTE SADDLE PULMONARY EMBOLISM PRESENTING WITH BENDOPNEA: A CASE REPORT (ACC 2026) - "Decision-Making: The patient was started on IV heparin and then underwent urgent mechanical thrombectomy following multidisciplinary discussion with pulmonary, cardiology and interventional radiology teams given the high risk nature of the clot with low bleeding risk...He was then transitioned to apixaban and discharged home... This is the first case to our knowledge demonstrating that pulmonary embolism can cause bendopnea. Notably this was in absence of clinical volume overload to suggest elevated left-sided intracardiac pressures and instead presented with right heart strain. Overall, this suggests the possibility of an alternative physiological mechanism for bendopnea, possibly involving the pulmonary arteries or related to the presence of acute right heart strain."

Case report • Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Pulmonary Embolism • Respiratory Diseases

SPONTANEOUS RECTUS SHEATH HEMATOMA AND ACUTE LIMB ISCHEMIA IN AN ELDERLY PATIENT ON APIXABAN: A RARE INTERSECTION OF HEMORRHAGIC AND THROMBOTIC COMPLICATIONS (ACC 2026) - "Case: A 76-year-old man with CAD, PAD, and AF on apixaban and clopidogrel presented with acute abdominal pain and hypotension...IV heparin was started with relief... High-dose andexanet alfa rapidly reverses factor Xa inhibitors but carries significant thrombotic risk. Careful monitoring and individualised dosing are essential to balance hemorrhagic control against thrombosis."

Clinical • Cardiovascular • CNS Disorders • Hematological Disorders • Hypotension • Subarachnoid Hemorrhage • Thrombosis

LATE-ONSET LOEFFLER'S ENDOMYOCARDITIS PRESENTING AS LV THROMBUS AND ATRIAL FIBRILLATION IN A LYMPHOMA SURVIVOR (ACC 2026) - "We report an elderly lymphoma survivor who developed encephalopathy, decompensated heart failure, and a large LV thrombus five years after R-CHOP...He developed AF with RVR (treated acutely with amiodarone)...Given embolic stroke burden, we initiated systemic anticoagulation (IV heparin) and urgent high-dose corticosteroids (prednisone ≈1 mg/kg) to suppress eosinophilic injury... For new LV thrombus with systolic dysfunction and rising eosinophils even years after chemotherapy, demands urgent TTE followed by CMR for tissue characterization to distinguish thrombus from eosinophilic infiltration. Early anticoagulation and prompt immunosuppression (with steroid initiation when safe) are critical to limit embolic complications and irreversible endomyocardial fibrosis; negative marrow/molecular testing supports a secondary HES approach but requires longitudinal surveillance."

Atrial Fibrillation • Cardiomyopathy • Cardiovascular • CNS Disorders • Congestive Heart Failure • Diffuse Large B Cell Lymphoma • Eosinophilia • Fibrosis • Heart Failure • Hematological Disorders • Hematological Malignancies • Hypereosinophilic Syndrome • Immunology • Ischemic stroke • Lymphoma • Pulmonary Disease • Thrombosis • FGFR1 • FIP1L1 • PDGFRA • PDGFRB

INTRAMYOCARDIAL ADIPOSE TISSUE IN HEMORRHAGIC AND NONHEMORRHAGIC INFARCTS (ACC 2026) - "FDG uptake in remote myocardium was suppressed by 48-hour ketogenic diet, 12-hour fasting, and 2000 U heparin injection 15 minutes before FDG administration... We demonstrate for the first time that chronic HEMO+ and HEMO- MIs exhibit similar metabolic phenotype and both ultimately undergo LM, suggesting that LM may be independent from iron-related inflammation."

Cardiovascular • Hematological Disorders • Inflammation • Reperfusion Injury

TOO HIGH, TOO FAST: A CASE REPORT OF IMPROPER GLP-1 DOSE INITIATION LEADING TO STRESS CARDIOMYOPATHY AND CARDIOGENIC SHOCK (ACC 2026) - "Decision-Making: Management included diuretics, intravenous heparin, intra-aortic balloon pump, and antihypertensives... The patient's ejection fraction recovered to 60% prior to discharge. This case highlights the potential for severe GI symptoms from high dose semaglutide to precipitate Takotsubo cardiomyopathy in high-risk individuals and underscores the need for slow dose escalation to mitigate these side effects."

Case report • Clinical • Cardiomyopathy • Cardiovascular • Genetic Disorders • Heart Failure • Hypertension • Inflammation • Obesity • Pulmonary Disease

STROKE DESPITE SURGICAL LEFT ATRIAL APPENDAGE LIGATION: THE HIDDEN RISK OF INCOMPLETE CLOSURE (ACC 2026) - "We began intravenous heparin, bridged to therapeutic enoxaparin and warfarin. Embolic stroke from thrombus within a residual post-ligation LAA was confirmed by TEE and CT. Follow-up includes repeat TEE to confirm thrombus resolution and exclude residual LAA communication, plus ambulatory monitoring for occult AF."

Atherosclerosis • Atrial Fibrillation • Cardiovascular • Hematological Disorders • Ischemic stroke • Thrombosis

PROSTHETIC VALVE THROMBOSIS IN A COMPLEX CONGENITAL HEART DISEASE PATIENT: MULTIMODALITY DIAGNOSIS AND LOW-DOSE, ULTRA-SLOW THROMBOLYTIC THERAPY (ACC 2026) - "Due to elevated surgical risk from multiple prior sternotomies, ultraslow low-dose alteplase infusion (1 mg/h for 25 hours) was administered, followed by intravenous heparin. This case highlights the efficacious use of ultraslow low-dose thrombolysis in managing mechanical aortic PVT in a surgically high-risk patient. Multimodality imaging and Heart Team collaboration, as emphasized in current guidelines, are pivotal for optimizing therapeutic strategies and outcomes."

Clinical • Cardiovascular • Heart Failure • Hematological Disorders • Pulmonary Disease • Thrombosis