XH001
/ NeoCura
- LARVOL DELTA
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October 31, 2025
To evaluate the safety, tolerability, and preliminary efficacy of XH001 injection as adjuvant therapy in patients with high-risk recurrent solid tumors
(ChiCTR)
- P1 | N=48 | Not yet recruiting | Sponsor: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences; Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
New P1 trial • Biliary Cancer • Biliary Tract Cancer • Cholangiocarcinoma • Gallbladder Cancer • Gastric Adenocarcinoma • Gastric Cancer • Hepatocellular Cancer • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor
August 18, 2025
XH001 (New Antigen Tumor Vaccine) Combined With Chemotherapy as Adjuvant Therapy in Pancreatic Cancer
(clinicaltrials.gov)
- P=N/A | N=12 | Not yet recruiting | Sponsor: Peking Union Medical College Hospital
New trial • Oncology • Pancreatic Cancer • Solid Tumor
August 01, 2025
Identifying essential genes in Schaalia odontolytica using a saturated transposon library.
(PubMed, J Bacteriol)
- "The constructed Tn-seq library enabled the identification of putatively essential genes in XH001, revealing growth requirements under laboratory conditions. This library can be leveraged in future studies to elucidate TM7x's dependence on XH001 at the molecular level."
Journal • Dental Disorders • Infectious Disease • Periodontitis
June 06, 2025
Study of XH001(Neoantigen cancer vaccine) in combination with chemtherapy for Adjuvant therapy of pancreatic cancer.
(ChiCTR)
- P=N/A | N=12 | Not yet recruiting | Sponsor: Peking Union Medical College Hospital; Peking Union Medical College Hospital
New trial • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • CA 19-9
April 04, 2025
XH001 Combination With Immunocheckpoint Inhibitor and Chemotherapy for Patients With Resected Pancreatic Cancer
(clinicaltrials.gov)
- P=N/A | N=24 | Recruiting | Sponsor: Wu Wenming | Not yet recruiting ➔ Recruiting | N=12 ➔ 24
Checkpoint inhibition • Enrollment change • Enrollment open • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor • CA 19-9
July 29, 2024
Identifying essential genes in Schaalia odontolytica using a highly-saturated transposon library.
(PubMed, bioRxiv)
- "A highly saturated Tn-seq library was generated with nearly 660,000 unique insertion mutations, averaging one insertion every 2-3 nucleotides. 203 genes, 10.5% of the XH001 genome, were identified as putatively essential."
Journal • Infectious Disease
April 10, 2024
Episymbiotic Saccharibacteria TM7x modulates the susceptibility of its host bacteria to phage infection and promotes their coexistence.
(PubMed, Proc Natl Acad Sci U S A)
- "Here, we showed that during surface-associated growth, a human oral Saccharibacteria isolate (named TM7x) protects its host bacterium, a Schaalia odontolytica strain (named XH001) against lytic phage LC001 predation...Our study highlights the tripartite interaction between the bacterium, episymbiont, and phage. More importantly, we present a mechanism, i.e., episymbiont-mediated modulation of gene expression in host bacteria, which impacts their susceptibility to phage predation and contributes to the formation of "source-sink" dynamics between phage and bacteria in biofilm, promoting their long-term coexistence within the human microbiome."
Journal • Infectious Disease
April 09, 2024
XH001 Combination With Ipilimumab and Chemotherapy for Patients With Resected Pancreatic Cancer
(clinicaltrials.gov)
- P=N/A | N=12 | Not yet recruiting | Sponsor: Wu Wenming
New trial • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor
February 17, 2024
Episymbiotic Saccharibacteria induce intracellular lipid droplet production in their host bacteria.
(PubMed, ISME J)
- "A survival assay demonstrated that the presence of LDs plays a protective role in XH001, enhancing its survival under adverse conditions. In conclusion, our study sheds new light on the intricate interaction between Saccharibacteria and their host bacterium, highlighting the potential benefit conferred by TM7x to its host, and further emphasizing the context-dependent nature of symbiotic relationships."
Journal
February 10, 2024
Complete genome sequence of Schaalia odontolytica isolated from subgingival biofilm.
(PubMed, BMC Genom Data)
- "Additionally, we performed a comparative genome analysis using previously sequenced genomes of strain XH001 and strain FDAARGOS_732, both derived from the human oral cavity...The genome is 2,389,595 bp with a GC content of 66.37%, and contains 2,002 protein-coding genes, 9 rRNAs, and 48 tRNA. Comparative analysis with two previously sequenced strains revealed many strain-specific genes in KHUD_008, primarily related to envelope biogenesis and replication/recombination/repair processes."
Journal • Dental Disorders • Periodontitis
January 09, 2024
Ultrasmall epibiont Nanosynbacter lyticus strain TM7x and host bacteria transcriptional activity after initial host parasitism.
(PubMed, J Oral Microbiol)
- "Oral Saccharibacteria Nanosynbacter lyticus strain TM7× lives as an ultrasmall epibiont on the surface of its host, Schaalia odontolytica strain XH001...TM7× displayed higher expression of type IV pili, consistent with increased attachment to new hosts. As TM7× is a member of the broadly distributed Candidate Phyla Radiation with small genomes lacking numerous biosynthetic pathways, this study provides further insights into how these epibionts interact and modulate their host bacteria."
Journal
July 12, 2023
A Safety and Efficacy Study of XH001 Combined With Sintilimab Injection in Advanced Solid Tumors
(clinicaltrials.gov)
- P=N/A | N=9 | Recruiting | Sponsor: jianming xu
Metastases • New trial • Oncology • Solid Tumor
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