hydrochlorothiazide / Generic mfg. - LARVOL DELTA

Hydrochlorothiazide and chlorthalidone use and glaucoma risk: pharmacovigilance analysis and nationwide cohort study. (PubMed, Front Pharmacol) - "Although the FAERS pharmacovigilance suggested a potential glaucoma risk with hydrochlorothiazide and chlorthalidone, population-based validation found no significant association. Pharmacovigilance signals should be confirmed with population-based data to identify true drug-glaucoma associations."

Adverse events • Journal • Cardiovascular • Glaucoma • Ophthalmology

A RARE CASE OF MYOGLOBIN NEPHROPATHY CAUSED BY PARANEOPLASTIC DERMATOMYOSITIS SECONDARY TO SMOLDERING MULTIPLE MYELOMA (ISN-WCN 2026) - "These findings were suggestive of dermatomyositis.The only comorbidity was hypertension for which he was taking a combination tablet consisting of 10 mg amlodipine, 160 mg valsartan and 12.5 mg hydrochlorothiazide...9 This case serves as a clear example of its utility in early diagnosis.This patient was referred to a haem-oncologist and received 6 cycles of bortezomib/leflunamide and dexamethasone...This prompted further investigation into the type of protein in the urine. This case was referred to a nephrologist and highlights how urine analysis can be the harbinger of diagnosis of a systemic illness and must be done routinely in the form of a simple bedside urine dipstick test and not underestimated"

Clinical • Dermatomyositis • Genito-urinary Cancer • Hematological Malignancies • Hypertension • Immunology • Lymphoma • Monoclonal Gammopathy • Multiple Myeloma • Myositis • Nephrology • Ovarian Cancer • Renal Disease • Smoldering Multiple Myeloma • Solid Tumor • Targeted Protein Degradation • Urothelial Cancer • MB • TRIM33

DISTAL NEPHRON RESPONSE FOLLOWING THIAZIDE TREATMENT IN A RODENT MODEL OF PRESSURE OVERLOAD-INDUCED HEART FAILURE (ISN-WCN 2026) - "TAC mice were then assigned to receive either vehicle or hydrochlorothiazide (HCTZ) in their drinking water for 5 weeks.Results 7 weeks after surgery, TAC induced cardiac hypertrophy in high-salt fed mice, which was attenuated by HCTZ treatment...Consistent with RAAS activation, gene expression of pendrin was also significantly increased by HCTZ treatment. Furthermore, changes in the expression of genes associated with the activation of α-ketoglutarate-OXGR1 pathway, which is implicated in alkalosis-dependent pendrin expression, were observed in the HCTZ-treated group.Conclusion In heart failure, thiazide therapy may induce counter-activation of distal nephron sodium chloride reabsorption mechanisms via RAAS activation and pathways associated with alkalosis, which potentially lead to treatment resistance."

Preclinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Metabolic Disorders • SLC26A4

GENERATION OF AVPR2 MISSENSE MUTATION RAT MODELS FOR CONGENITAL NEPHROGENIC DIABETES INSIPIDUS (ISN-WCN 2026) - "Phenotypes of wild-type and mutant rats was characterized at 8 weeks of age, including assessment of body weight, urine data, response to hydrochlorothiazide (HCTZ), and renal morphology.Results Both D85N and S333del mutant rats were viable after weaning and could be maintained long-term, similar to Avpr2 knockout rats...These gene-edited rat models could be a valuable tool for elucidating the molecular mechanisms and for developing therapeutic strategies for AVPR2-related disorders.I have potential conflict of interest to disclose.The Division of Integrative Renal Replacement Therapy was financially supported by JMS Co. Ltd., Terumo Corporation, and Southern TOHOKU Hospital Group (STHG).I did not use generative AI and AI-assisted technologies in the writing process."

Preclinical • Genetic Disorders • Metabolic Disorders

A RARE CASE OF PSEUDOHYPOALDOSTERONISM TYPE II OR GORDON SYNDROME (ISN-WCN 2026) - "No similar family history.Results He is currently being treated with hydrochlorothiazide, with well controlled blood pressure and normal electrolytes.Conclusion Pseudohypoaldosteronism type II or Gordon's Syndrome is a rare disease, with usually autosomal dominant inheritance, with no specific diagnostic criteria for diagnosis. It should be suspected in adolescent or adult patients with hyperkalemia with normal glomerular filtration, accompanied by hypertension (can be absent), metabolic acidosis, hyperchloremia, low normal plasma renin and relatively normal aldosterone."

Clinical • Cardiovascular • Genetic Disorders • Hypertension • Metabolic Disorders • Rare Diseases • WNK1

THE EFFECTS OF THIAZIDES ON EGFR CHANGES IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE (ISN-WCN 2026) - "This study aimed to investigate the effects of thiazides on renal function decline in patients with advanced CKD.Methods This was a single-center retrospective study of patients diagnosed with CKD G4 (eGFR 15–29 mL/min/1.73 m2) or G5 (eGFR <15 mL/min/1.73 m2) who initiated thiazides (trichloromethiazide, hydrochlorothiazide, or indapamide) from January 2014 to September 2024 in the Department of Nephrology, Kansai Electric Power Hospital in Japan. In this study, thiazides in patients with advanced CKD was associated with a slower decline in eGFR, suggesting their potential usefulness in managing advanced CKD. Furthermore, a reduction in proteinuria was observed in addition to antihypertensive effects, supporting the hypothesis that thiazides may have reno-protective effects by attenuating glomerular overload."

Clinical • Metastases • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Glomerulonephritis • IgA Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • EGFR

A HIDDEN HAZARD OF HEPARIN: LIFE-THREATENING HYPONATREMIA AND HYPERKALEMIA DUE TO TYPE IV RTA (ISN-WCN 2026) - "He subsequently received unfractionated heparin for thromboprophylaxis and dexamethasone for cord compression...Hypertonic saline, sodium zirconium cyclosilicate, and fludrocortisone were administered, and heparin, lisinopril, and hydrochlorothiazide were discontinued, resulting in rapid normalization of serum sodium, potassium, bicarbonate, and blood pressure.Results Download: Download high-res image (159KB)Download: Download full-size imageConclusion Although heparin associated Type 4 RTA is a well-known pharmacologic effect, its clinical impact is often underestimated...This case highlights that even routine heparin prophylaxis can cause severe aldosterone deficiency. Prompt recognition and discontinuation of heparin, along with temporary mineralocorticoid replacement, can be lifesaving."

Cardiovascular • Cognitive Disorders • Endocrine Disorders • Genito-urinary Cancer • Heart Failure • Hypertension • Metabolic Disorders • Nephrology • Prostate Cancer • Renal Disease • Solid Tumor

A RARE CASE OF NEPHROGENIC DIABETES INSIPIDUS IN AN ADULT MALE: A DIAGNOSTIC PROBLEM (ISN-WCN 2026) - "The successful challenge therapy, which involved hydrochlorothiazide, also emphasized that nephrogenic DI therapy is quite straightforward when the clinical suspicion is accurate. Awareness and appropriate clinical judgment can narrow down the differential diagnosis in patients, facilitating a prompt and precise initiation of medication, resulting in a better outcome for the patient."

Clinical • Constipation • Gastroenterology • Gastrointestinal Disorder • Hepatitis B • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Rare Diseases

Adverse events associated with drug-related thiamine deficiency: A pharmacovigilance study. (PubMed, JPEN J Parenter Enteral Nutr) - "This pharmacovigilance analysis identifies safety signals linking specific medications with thiamine deficiency, potentially mediated by mechanisms such as transport inhibition and metabolic interference. These findings highlight the importance of clinical vigilance and the consideration of thiamine monitoring in high-risk patients to mitigate the risk of neurological complications."

Adverse events • Journal • Addiction (Opioid and Alcohol) • CNS Disorders

Uncovering redox-specific biotransformation of organic micropollutants. (PubMed, J Hazard Mater) - "While some OMPs were well-removed (e.g., paracetamol and hydrochlorothiazide) or persistent (e.g., diglyme and bentazon) under all tested conditions, the fate of most OMPs was redox-dependent in both rate and progress along the degradation pathway...Our results provide a more comprehensive view of OMP fate and TP formation across redox conditions. These insights can support the optimization of OMP removal strategies in engineered and natural redox-shifting systems."

Journal

Temporal Risk of Non-Melanoma Skin Cancer with Lisinopril and Hydrochlorothiazide as Monotherapy and in Combination: A Retrospective Cohort Study Using the TriNetX Database (AAD 2026) - "Z-scores between cohorts identified HCTZ alone to carry a significantly greater risk of cSCC at 5 years [RR=3.01 (2.15, 4.213), p<0.0001] when compared to combination LIS+HCTZ. Our study demonstrates that LIS and HCTZ either taken in combination or as monotherapy for HTN increases the risk of NMSC development."

Monotherapy • Retrospective data • Basal Cell Carcinoma • Genetic Disorders • Hypertension • Non-melanoma Skin Cancer • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Skin Cancer

Stratified Temporal Risk of Skin Cancer by Age Associated with Hydrochlorothiazide: A Retrospective Cohort Study Using the TriNetX Database (AAD 2026) - "The association with melanoma in the older aged cohorts and with longer durations of HCTZ usage suggests a role for cumulative actinic damage among other risk factors. We highlight the need for increased dermatological surveillance and counseling among this vulnerable population, especially for those over the age of 50 on sustained HCTZ therapy."

Retrospective data • Basal Cell Carcinoma • Genetic Disorders • Hypertension • Non-melanoma Skin Cancer • Oncology • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Skin Cancer

A Comparison of the Protective effects of Systemic vs Oral Retinoids on Non Melanoma Skin Cancers in Acne Patients: A Retrospective Cohort Study (AAD 2026) - "Two matched cohorts were created: systemic retinoids (alitretinoin, isotretinoin, etretinate, acitretin; n=34,851) and topical retinoids (adapalene, tazarotene, bexarotene, tretinoin; n=34,851). Patients with known NMSC risk factors (chemical exposures, HPV, or use of BRAF inhibitors, cyclosporine, voriconazole, hydrochlorothiazide) were excluded... The enhanced protective effect of systemic retinoids may reflect their deeper influence on keratinocyte turnover and skin cell regeneration compared to topical formulations. Further studies are warranted to clarify the relative efficacy of individual agents and optimize retinoid prophylaxis in high-risk patients."

Retrospective data • Acne Vulgaris • Basal Cell Carcinoma • Genetic Disorders • Kaposi Sarcoma • Non-melanoma Skin Cancer • Sarcoma • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma

Sexual function among controlled and uncontrolled hypertensive females receiving beta-blockers or ACEI/ARB and thiazides: a prospective randomized controlled study. (PubMed, Sci Rep) - "ACEIs/ARBs demonstrated a favorable effect on FSF. Future large-scale cohort studies are warranted to validate these findings as this study was a single center and of small sample size."

Journal • Cardiovascular • Hypertension • Pain • Sexual Disorders

Do Not Dismiss Incidental Hyperkalemia in Childhood: Early Recognition of Pseudohypoaldosteronism Type II. (PubMed, Cureus) - "Treatment with hydrochlorothiazide (HCTZ) resulted in normalization of serum potassium and correction of the metabolic acidosis. Genetic testing revealed a heterozygous KLHL3 variant (c.1501C>T, p.Pro501Ser), confirming the diagnosis of PHAII. This case highlights the importance of not dismissing incidentally detected hyperkalemia in children and illustrates the value of performing a structured evaluation that includes confirming the persistence of hyperkalemia, acid-base assessment, urinary potassium analysis, and family history-taking to facilitate early diagnosis of renal tubular disorders such as PHAII."

Journal • Cardiovascular • Heart Failure • Hypertension • Infectious Disease • Metabolic Disorders

EARLY-ONSET, ASYMPTOMATIC NIFEDIPINE HEPATOTOXICITY: EXPANDING THE SPECTRUM OF CALCIUM CHANNEL BLOCKER LIVER INJURY (ACC 2026) - "He was started on intravenous nicardipine, later transitioned to oral nifedipine 90 mg daily plus losartan...Nifedipine was discontinued, replaced with hydrochlorothiazide, and liver enzymes normalized within 90 days... This case demonstrates that nifedipine can cause early, asymptomatic hepatocellular injury even in young, otherwise healthy individuals. Clinicians should maintain vigilance for unexplained transaminase elevations soon after initiation, and promptly discontinue the drug to prevent progression."

Hepatology • Immunology • Liver Failure

A PRICE TO COIL: SECONDARY HYPERTENSION AFTER BILATERAL ACCESSORY RENAL ARTERY EMBOLIZATION (ACC 2026) - "He was treated with intravenous clevedipine followed by amlodipine and hydrochlorothiazide... Bilateral accessory renal artery coiling during endovascular aneurysm repair can cause loss of renal perfusion and downstream activation of the RAAS leading to abrupt secondary hypertension, even when the main renal arteries and graft remain patent. Careful preoperative assessment and close postoperative monitoring are essential to recognize and manage this complication."

Cardiovascular • CNS Disorders • Hypertension

ARE EDEMA EVENTS IN PRECISION ASSOCIATED WITH AN INCREASED RISK OF HOSPITALIZATION FOR HEART FAILURE? (ACC 2026) - "As a result, some had to switch from loop diuretics or ≥1 diuretic to hydrochlorothiazide (HCTZ; 25 mg/d). HFH in pts receiving aprocitentan was rare and mainly occurred in pts with pre-existing HF and other comorbidities. The protocol-mandated switch to HCTZ from other diuretics most probably contributed to HFH. The incidence of edema events was similar in both HF and non-HF groups, but HFH was higher in the HF cohort, suggesting HFH was not primarily driven by edema observed in PRECISION."

Clinical • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Genetic Disorders • Heart Failure • Hypertension • Metabolic Disorders • Nephrology • Obesity • Renal Disease

POINTER-HF: POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure (clinicaltrials.gov) - P2/3 | N=128 | Not yet recruiting | Sponsor: Hospital de Clinicas de Porto Alegre

New P2/3 trial • Cardiovascular • Congestive Heart Failure • Heart Failure • NPPB

TRIACT: Triple Antihypertensive Medication After Intracerebral Hemorrhage for Blood Pressure Control (clinicaltrials.gov) - P=N/A | N=140 | Recruiting | Sponsor: The University of Hong Kong

New trial • Cerebral Hemorrhage • Hematological Disorders

Pharmacogenetics of RAS-affecting AGT and ACE variants and the efficacy of Valsartan/HCTZ therapy. (PubMed, Sci Rep) - "Considerable inter-individual variability has been observed in the blood pressure response to valsartan/hydrochlorothiazide (Valsartan/HCTZ), and genetic differences within the renin-angiotensin system may contribute to this heterogeneity...A significant AGT rs5050 × ACE I/D interaction revealed the greatest reduction in AC/II (20.6 ± 2.3 mmHg) and the lowest in AA/DD (3.80 ± 2.33 mmHg). These findings highlight meaningful multilocus effects and support the potential for genotype-guided antihypertensive therapy."

Biomarker • Journal • Cardiovascular • Hypertension

Beads of Burden: Severe Hypercalcemia Following Orthopedic Calcium Sulfate Beads Implantation (NKF-SCM 2026) - "METHODS/CASE SUMMARY A 72-year-old man with hypertension on hydrochlorothiazide and GERD on calcium carbonate (Tums) underwent revision right total knee arthroplasty (Day 0)...He received Plasmalyte A (calcium-free) and a single dose of zoledronic acid on Day 5, after which calcium gradually normalized (≈9.8 mg/dL by Day 11) with concurrent improvement in renal function...CONCLUSION This case underscores a rare but clinically important complication of Stimulan calcium-sulfate beads. Perioperative monitoring of serum calcium and renal function, preoperative medication review, judicious bead use, and early recognition allows prompt intervention and reversal."

Acute Kidney Injury • Cardiovascular • Endocrine Disorders • Gastroesophageal Reflux Disease • Hypertension • Immunology • Metabolic Disorders • Monoclonal Gammopathy • Nephrology • Orthopedics • Renal Disease

APOL1-Mediated Kidney Disease Prevention in Blacks (NKF-SCM 2026) - "In African American carriers of the G1 and G2 variant, SSH is not merely a chronic disorder, it is a fatal one. SSH can be prevented or controlled with a low-sodium (1500 mg/day) diet, calcium-channel blockers, hydrochlorothiazide and/or Angiotensin Receptor Blockers (ARBs), thus halting the eventual progression to AMKD kidney failure."

Cardiovascular • Hypertension • Nephrology • Renal Disease

When One Electrolyte Falls, Others Follow: A Case of PPI-Related Hypomagnesemia (NKF-SCM 2026) - "METHODS/CASE SUMMARY A 51-year-old woman with hypertension on hydrochlorothiazide (HCTZ) 25 mg daily and GERD on pantoprazole 40 mg twice daily evaluated for hypomagnesemia and hypokalemia. In this case, HCTZ likely contributed to renal potassium wasting as well but not to magnesium loss as suggested by the low FEMg. CONCLUSION Clinicians should consider PPI-related electrolytes derangements, especially on long-term PPI therapy."

Clinical • Cardiovascular • Endocrine Disorders • Gastroesophageal Reflux Disease • Hypertension

Challenges and Perspectives in Optimising the Treatment of Arterial Hypertension: Role of the Ramipril-Amlodipine-Hydrochlorothiazide Single-Pill Combination. (PubMed, High Blood Press Cardiovasc Prev) - "Strategies to overcome these barriers include clinician education, communication tools, flexible dose options and supportive healthcare policies. Taken together, the evidence supports broader adoption of the ramipril-amlodipine-hydrochlorothiazide SPC as an effective therapeutic approach to contemporary hypertension management."

Journal • Review • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension