hydrochlorothiazide / Generic mfg. - LARVOL DELTA

Blood Pressure Control With Thiazide Diuretics in Peritoneal Dialysis Patients (clinicaltrials.gov) - P4 | N=40 | Recruiting | Sponsor: Chinese University of Hong Kong

New P4 trial • Cardiovascular • Chronic Kidney Disease • Hypertension • Nephrology • Renal Disease

Clinical and genetic features of Gitelman syndrome patients with hyperuricemia. (PubMed, Clin Kidney J) - "In GS patients with or without hyperuricemia, the impairment of NCC function indicated by the value of increase of chloride excretion fraction (△FECl) in the hydrochlorothiazide test was median 0.49% vs 0.82% (P = .10). We focused on the SLC12A3 genotype and 33 SNPs linked to uric acid levels and found no significant genetic differences between patients with or without hyperuricemia. Hyperuricemia is common in patients with GS in China, associated with elevated BMI and potentially more severe NCC dysfunction."

Journal • Gout • Inflammatory Arthritis • Nephrology • Rheumatology • SLC2A3

A Stability Study of Buthiazide, Mebutizide, and Bemethizide in Urinary and Aqueous Matrices. (PubMed, Rapid Commun Mass Spectrom) - "These findings underscore the necessity of carefully controlled storage conditions in routine anti-doping analyses, especially when confirmatory testing of B samples is delayed."

Journal

Impact of Hydrochlorothiazide on Nonmelanoma Skin Cancer: A Distributed Network Analysis of 11 Real-world Databases. (PubMed, Ann Dermatol) - "HCTZ was not associated with the development of NMSC in a Korean hypertensive population, regardless of the duration of drug exposure."

Journal • Real-world evidence • Cardiovascular • Genetic Disorders • Hypertension • Non-melanoma Skin Cancer • Skin Cancer • Solid Tumor

Quantifying the risk of drug-associated skin hyperpigmentation relative to the general population: A national cohort study using TriNetX. (PubMed, JAAD Int) - No abstract available

Journal

Severe Rhabdomyolysis in an Elderly Patient With Diabetes and Vascular Disease: Interplay of Statin Therapy, Sodium-Glucose Cotransporter-2 (SGLT2) Inhibition, and Thiazide-Induced Hypokalemia. (PubMed, Cureus) - "We report a 78-year-old woman with diabetes, hypertension, hyperlipidemia, and carotid artery disease, hypothyroidism, who developed severe rhabdomyolysis, acute kidney injury, and transaminitis while taking simvastatin, hydrochlorothiazide, and empagliflozin. This case underscores the multifactorial etiology of rhabdomyolysis in elderly vascular patients, where dehydration and hypokalemia from thiazides and SGLT2 inhibitors may synergize with statin-induced myotoxicity, complicating evaluation when troponin is elevated without ischemic changes. Clinicians should maintain a high index of suspicion for rhabdomyolysis in patients with new muscle pain, weakness, or fatigue after starting empagliflozin, especially when combined with statins and diuretics, and prioritize early recognition, medication review, and hydration to prevent serious complications."

Journal • Acute Kidney Injury • Cardiovascular • Diabetes • Dyslipidemia • Endocrine Disorders • Fatigue • Hypertension • Metabolic Disorders • Musculoskeletal Pain • Nephrology • Pain • Pulmonary Disease • Renal Disease

Imine Derivatives of Hydrochlorothiazide Bear Potential Diuretic Activity in in vivo Experimental Model by Targeting Renal Outer Medullary Potassium Channel. (PubMed, Curr Med Chem) - "As the derivatives were more active than drugs in some regards; therefore, these derivatives will be beneficial and open new windows for research and additional pharmacological screening could be planned as part of the project's extension."

Journal • Preclinical • Cardiovascular • Hypertension • Nephrology

Hydrochlorothiazide with salt restriction in nonsurgical hypoparathyroidism: a placebo-controlled single-blinded randomized crossover trial assessing efficacy and safety. (PubMed, JBMR Plus) - "These findings indicate that low-dose HCTZ with sodium restriction safely improves calcium homeostasis in nonsurgical hypoparathyroidism-raising serum calcium and reducing calciuria-with good tolerability. Hydrochlorothiazide offers a cost-effective adjunct to standard therapy and warrants further investigation for long-term outcomes."

Clinical • Journal • Endocrine Disorders • Hypoparathyroidism • Immunology

Effects of antihypertensives on the degradation behavior of AZ31 alloy in in-vitro environment. (PubMed, Sci Rep) - "Effects of seven antihypertensives of Losartan Kalicum(LK), Atenolol(ATEN), Nifedipine(NF), Hydrochlorothiazide(HCTZ), Valsartan(VLA), Furosemide(FUR) and Captopril(CAP) have been investigated on the degradation behavior of AZ31 alloy in simulated body fluid (Hank's solution). The surface analysis reveals that the addition of LK, NF and HCTZ can reduce degradation rate by promoting the growth of hydroxyapatite, increasing the protection effect of corrosion film formed. The present results may enhance the corrosion resistance of Mg-based orthopedic implants."

Journal • Preclinical • Orthopedics

In vitro two stage one compartment dumping test data and absorption/formulation PBBM modeling to explain a bioequivalence failure of valsartan formulations. (PubMed, Eur J Pharm Biopharm) - "The study demonstrated that a simple dynamic dissolution methodology can effectively predict in vivo bioequivalence and formulation performance. The application of the "dumping test" provided valuable insights into the dissolution characteristics of different formulations, highlighting its potential as a cost-effective and practical tool for biopredictive studies."

Journal • Preclinical

An exploratory evaluation of the interaction risk between herbal products and pharmaceutical medicines used concurrently for disease management in Blantyre, Malawi. (PubMed, Pharm Biol) - "Participants reported concurrent use of a wide variety of herbal products (e.g., garlic, ginger, okra, lemon, mango, moringa) with prescription medicines (e.g., metformin, insulin, glibenclamide, hydrochlorothiazide, enalapril, amlodipine). This study provides foundational data on herbal-pharmaceutical co-use in Malawi and highlights the need for expanded research, improved documentation of herbal use in healthcare settings, and improved education for patients and providers. Integrating awareness of herbal product use into clinical care is essential, and the methodology and findings may inform future hypothesis-driven studies across Africa and other regions where traditional and modern medicine use overlaps."

Journal • Cardiovascular • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders

The probiotic Limosilactobacillus fermentum CECT5716 enhances the antihypertensive response to hydrochlorothiazide in spontaneously hypertensive rats. (PubMed, Gut Microbes) - "Our findings identify the gut microbiota as a novel therapeutic target to enhance the antihypertensive effects of diuretics. The coadministration of LC40 with HCTZ modulates immune responses, providing a promising strategy to improve hypertension management."

Journal • Preclinical • Cardiovascular • Hypertension • Inflammation • Transplantation

Uncovering Dent Disease in Adulthood: A Case of Incidental Severe Medullary Nephrocalcinosis (KIDNEY WEEK 2025) - "The patient was started on hydrochlorothiazide, advised on dietary modifications, and referred for genetic counseling...Take-away points: 1.Inherited tubulopathies like Dent disease should be considered in adults with unexplained nephrocalcinosis 2.Genetic testing is crucial to confirm diagnosis and inform management. 3.Early diagnosis and supportive care can help slow progression to chronic kidney disease."

Clinical • Acute Kidney Injury • Chronic Kidney Disease • Glomerulonephritis • Immunology • Infectious Disease • Lupus Nephritis • Metabolic Disorders • Nephrology • Pneumonia • Pulmonary Disease • Renal Calculi • Renal Disease • Respiratory Diseases

Rare Case of X-Linked Hereditary Diabetes Insipidus (KIDNEY WEEK 2025) - "The patient experienced symptomatic relief with hydrochlorothiazide...Presence of confounding comorbidities like DM may delay diagnosis. Random Urine studies"

Clinical • Genetic Disorders • Metabolic Disorders • Nephrology • Obesity • Type 2 Diabetes Mellitus

Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Secondary Prevention of Kidney Stones: Randomized, Double-Blind, Crossover Trial (INDAPACHLOR Trial) (KIDNEY WEEK 2025) - P2 | "The NOSTONE trial recently demonstrated that hydrochlorothiazide (HCT) has limited efficacy in preventing recurrence. The study was initially expected to conclude by the end of 2027; however, current recruiting rates indicate it may finish earlier than anticipated. Conclusion No conclusions available — study in progress."

Clinical • Nephrology • Renal Calculi

Humanized Diets Define Optimal Pressure-Lowering Response to Dietary Potassium in Mice (KIDNEY WEEK 2025) - "NCC- (hydrochlorothiazide-sensitive) and ENaC- (benzamil-sensitive) dependent sodium handling was assessed in clearance studies...Conclusion An optimal dietary K level (1.7%) that maximally reduces BP in mice by suppressing NCC activity, limiting aldosterone activation of ENaC, and regulating transport and tubule remodeling pathways in the proximal tubule and CNT was defined. This diet mimics the human DASH diet in K content and further supports its efficacy as a BP-lowering tool."

Preclinical • Hypotension

Empagliflozin Counters Metolazone-Induced Hypomagnesemia and Modifies Renal Ion Transporters and Channels (KIDNEY WEEK 2025) - "Hydrochlorothiazide response test showed EMPA did not reverse MET-induced NCC inhibition, while furosemide response test showed NKCC2 activity did not differ among the treatment groups. However, amiloride response test suggests EMPA may further inhibit ENaC-dependent K + secretion. Abundance of pAQP2 was significantly lower in MET and higher in EMPA mice. Conclusion EMPA could correct drug-induced hypomagnesemia, though it exerts complex effects on renal ion channels and transporters in response to polyuria."

Metabolic Disorders • CALB1

Hypertonic Saline as Adjunct for Diuretic Resistance in Cardiorenal Syndrome (KIDNEY WEEK 2025) - "Case Description A 77-year-old female with a history of chronic heart failure with reduced ejection fraction, type 2 diabetes mellitus, and atrial fibrillation on rivaroxaban presented as a trauma alert after a mechanical fall...Intravenous furosemide and milrinone were initiated, and SNB was employed with the addition of acetazolamide and hydrochlorothiazide...Another less known mechanism is contributing to the restoration of the medullary osmotic gradient, often disrupted in ATN, thereby promoting natriuresis and free water clearance. In conclusion, hypertonic saline represents a viable adjunctive strategy in the management of diuretic-resistant volume overload."

Acute Kidney Injury • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders • Musculoskeletal Diseases • Nephrology • Orthopedics • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Type 2 Diabetes Mellitus

Unmasking of a Heterozygous SLC12A3 Mutation (KIDNEY WEEK 2025) - "The patient had been prescribed amlodipine, and 12.5 mg hydrochlorothiazide (HCTZ) was added, but later changed to 25 mg chlorthalidone (CTD). Finally, glucose intolerance is associated with thiazide diuretics and is attributable, in part, to K depletion. Changes in serum electrolytes (A) and glucose (B) in response to K repletion and insulin, respectively"

Cardiovascular • Diabetes • Dyslipidemia • Heart Failure • Hypertension • Metabolic Disorders • SLC2A3

Predictors of Stone Recurrence in the NOSTONE Trial: Post Hoc Analysis (KIDNEY WEEK 2025) - "Background In the NOSTONE trial, hydrochlorothiazide (HCTZ) did not reduce stone recurrence and lowered urine calcium less than expected...The effect of dietary sodium on urine calcium was attenuated in patients receiving HCTZ compared to patients receiving placebo. Furthermore, both composite and radiologic stone recurrence appear to be independent of dietary sodium intake."

Retrospective data

ALK5 Inhibition Improves Transport and Respiration in Primary Renal Proximal Tubule Cells at One Year in Culture (KIDNEY WEEK 2025) - "Methods Primary human renal proximal tubule cells (Lonza, Basel) were seeded at 10^5 cells per cm^2 on permeable supports and grown in 50:50 DMEM/F12 with ITS, hydrocortisone, T3, and ascorbic acid in humidified 5% CO2/Air...1 week after confluence, media was supplemented with metformin, SB431542, or both...Transport was inhibitable with tenapanor but not furosemide or hydrochlorothiazide...This suggests that prolonged function of a tubule cell bioreactor for cell therapy is feasible. Further investigation of the mechanisms by which ALK5 inhibition improves cell function are warranted."

Renal Disease • TGFB1 • TGFBR1

The Clot That Spoke First: Thrombotic Microangiopathy as an Initial Manifestation of Scleroderma Renal Crisis (KIDNEY WEEK 2025) - "She was on valsartan-hydrochlorothiazide but was off medications for two months after relocating and not yet establishing primary care. Complement activation plays a key role in its pathogenesis. Eculizumab, a C5 inhibitor, blocks early complement activation, serving as a rescue in such cases; while long-term management relies on ACE inhibitor therapy."

Anemia • Cardiovascular • Fibrosis • Gynecology • Hypertension • Immunology • Renal Disease • Scleroderma • Systemic Sclerosis • Thrombocytopenia • Thrombosis • CD34

ACE: Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension (clinicaltrials.gov) - P4 | N=70 | Completed | Sponsor: The University of Texas Health Science Center, Houston | Active, not recruiting ➔ Completed

HEOR • Trial completion • Cardiovascular • Gynecology • Hypertension

Untargeted metabolomics profiling in three cohorts indicates lipid imbalance in individuals with epilepsy (SSIEM 2023) - "Out of 629 known metabolites detected in the PED-C, significant changes (corrected p-value 0.05) were seen in 18, mainly glycerophosphatidylcholines (GPC). In the AD-C, nine out of 327 known metabolites were significantly altered and included mainly triglycerides (TAG). In the ELD-C, only hydrochlorothiazide was significantly altered out of 585 known metabolites."

Clinical • CNS Disorders • Epilepsy • Genetic Disorders • Metabolic Disorders

The cancer risk of hydrochlorothiazide - how can it be prevented? (PubMed, MMW Fortschr Med) - No abstract available

Journal • Review • Oncology