hydrochlorothiazide / Generic mfg. - LARVOL DELTA

Comparison of oral enalapril-hydrochlorothiazide and oral nifedipine in treating postpartum hypertension: An open label randomised controlled trial. (PubMed, Am J Obstet Gynecol MFM) - "Enalapril-hydrochlorothiazide provided greater blood pressure reduction and reduced the need for additional antihypertensive therapy compared with nifedipine in the management of postpartum hypertension."

Journal • Cardiovascular • Hypertension

Secondary and tertiary amino groups in metformin and hydrochlorothiazide within the polypharmacy as cofactors for nitrosoformation, drug-related phototoxicity and subsequent multiple keratinocyte cancer development and progression (EADV 2026) - No abstract available

Oncology

Long-Term Control of Refractory Cardiogenic Pleural Effusion in a Cat Treated with Sacubitril/Valsartan and Hydrochlorothiazide: A Case Report. (PubMed, Animals (Basel)) - "Hydrochlorothiazide is a thiazide diuretic that acts at a more distal segment of the nephron than furosemide...Despite conventional treatment, which included pimobendan, torasemide, and antithrombotic medications, the cat experienced multiple episodes of pleural effusion over the following months, requiring repeated thoracocentesis...Nonetheless, the duration and completeness of the response observed here warrant prospective evaluation of combination of ARNI therapy and hydrochlorothiazide in cats with refractory congestive heart failure. Further studies are needed to assess the safety and effectiveness of this approach in feline cardiomyopathy."

Journal • Pleural effusion • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Respiratory Diseases

Seasonal variation in the office and ambulatory blood pressure control in patients treated with two dual antihypertensive therapies. (PubMed, Hypertens Res) - "The mean changes from baseline to 24-week follow-up tended to be smaller in the benazepril/hydrochlorothiazide than amlodipine/benazepril group in 24-h (mean between-group difference, -2.8 mmHg) and daytime diastolic blood pressure (mean between-group difference, -3.2 mmHg) in patients who commenced treatment in winter, though statistical significance was not achieved (P ≥ 0.07). In conclusion, there was seasonality in the clinic and ambulatory blood pressure-lowering effect of antihypertensive drug combinations, with a marginally significant difference in treatment intensity and blood pressure control between treatment with amlodipine or hydrochlorothiazide in combination with benazepril."

Journal

Severe recurrent hypernatremia and probable lithium-associated nephrogenic diabetes insipidus following pancreatectomy in a patient with schizophrenia: a case report. (PubMed, Front Med (Lausanne)) - "Because urine osmolality and a standardized desmopressin response test were unavailable, NDI could not be biochemically confirmed and central diabetes insipidus could not be definitively excluded...Lithium was discontinued after psychiatric and multidisciplinary consultation, and hydrochlorothiazide was initiated...In patients receiving long-term lithium, postoperative polyuria, recurrent hypernatremia, and low urine specific gravity should prompt consideration of lithium-associated urinary concentrating dysfunction while other causes of water loss are assessed. Careful perioperative medication review, sodium and fluid-balance monitoring, individualized fluid management, and multidisciplinary collaboration are essential."

Journal • CNS Disorders • Metabolic Disorders • Nephrology • Psychiatry • Renal Disease • Schizophrenia • Type 2 Diabetes Mellitus

Integrating Artificial Intelligence with Spectrophotometry: A Novel Python Framework for Automated Green Assessment and Pharmaceutical Analysis. (PubMed, Anal Biochem) - "The platform was applied to eco-friendly spectrophotometric methods for the simultaneous determination of metoprolol (MET) and hydrochlorothiazide (HYD) in binary mixtures and pharmaceutical dosage forms...Importantly, the developed Python code is provided as Supplementary Material, allowing transparent and reproducible implementation and facilitating adaptation to other analytical methodologies. Overall, this work combines automated intelligence-driven sustainability assessment with advanced spectrophotometric analysis, providing a practical and transferable framework for sustainable pharmaceutical analytical chemistry."

Journal

Thiazide Diuretics Are Associated with a Higher Triglyceride-Glucose Index Than Calcium Channel Blockers in Hypertensive Patients. (PubMed, Int J Gen Med) - "A dose-stratified analysis within the diuretic group showed a significant dose-response relationship: higher hydrochlorothiazide (25 vs 12.5 mg/day) and indapamide (2.5 vs 1.25 mg/day) doses were both associated with significantly higher TyG index, fasting glucose, and uric acid levels. RAAS blocker plus thiazide/thiazide-like diuretic regimens were associated with a significantly higher TyG index and a less favorable metabolic profile than RAAS blocker plus CCB regimens, independent of multiple clinical confounders. Metabolic risk profiles should be considered when selecting antihypertensive combination therapy; prospective studies are needed to establish causality."

Journal • Cardiovascular • Diabetes • Hypertension • Metabolic Disorders

A SHAP-Informed Formal Feature Attribution Framework for Drug-Drug Interaction Risk in Large-Scale Claims Data. (PubMed, Clin Transl Sci) - "FFA flagged 115 synergistic pairs and 312 high-confidence triplets (e.g., furosemide + hydrochlorothiazide + lisinopril; digoxin + furosemide + amiodarone, IE = 8.7). Top Intervention Rate drugs included simvastatin, furosemide, and alprazolam. Moderate preventive Z-code monitoring (Q2) was protective (OR = 0.25; 95% CI 0.18-0.34) versus no monitoring, while fragmented high-intensity monitoring (Q4) was not. The framework prioritizes medication combinations for pharmacist review in claims data; it does not replace pharmacokinetic confirmation or prove that changing a drug caused fewer ED visits."

Journal

Contemporary decongestion strategies in acute heart failure: an individual patient data analysis of three randomized controlled trials. (PubMed, Eur J Heart Fail) - "While intensified decongestive strategies in patients hospitalized for ADHF improve diuresis, natriuresis, and reduce LOS, no benefit was observed for post-discharge clinical outcomes. Although a potential reduction in in-hospital mortality was observed, this finding should be considered exploratory and hypothesis-generating."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Comparative Effectiveness of Chlorthalidone Versus Hydrochlorothiazide and Dose-Response of Amiloride on Blood Pressure and Biochemical Parameters. (PubMed, J Am Heart Assoc) - P3 | "Chlorthalidone and hydrochlorothiazide, administered at a 1:2 dosing ratio, show similar effects on BP and laboratory parameters. Amiloride 5 and 10 mg show similar effects on BP and most metabolic parameters, with no clear dose-response relationship, suggesting that any independent BP-lowering effect of amiloride is, at best, weak."

Clinical • HEOR • Journal • Cardiovascular • Hypertension • Hypotension

A DrugâDrug Interaction Gone Pancreatic: Clindamycin and Antiseizure Medication Toxicity (ACG 2026) - "Recent history was notable for treatment of a dental abscess with amoxicillin/clavulanate, transitioned to clindamycin on the day symptoms began. Home medications included lamotrigine, carbamazepine, and hydrochlorothiazide (HCTZ). Given the potential interaction between clindamycin and carbamazepine resulting in elevated carbamazepine exposure and drug-induced pancreatitis, clindamycin and HCTZ were discontinued, and ampicillin/sulbactam was initiated...This case highlights the importance of recognizing drug-drug interactions as an overlooked cause of pancreatitis and carefully evaluating new medications in patients receiving chronic pharmacotherapy to prevent avoidable adverse events. Figure: Figure 1: CT abdomen/pelvis with IV contrast findings of acute pancreatitis with ill-defined hypoenhancing pancreatic parenchyma to level of the body."

CNS Disorders • Dental Disorders • Depression • Epilepsy • Gastroenterology • Gastroesophageal Reflux Disease • Immunology • Neuralgia • Pancreatitis

Metabolic and Inflammatory Adverse Drug Reactions Associated with Amlodipine: A Descriptive and Disproportionality Analysis of EudraVigilance Reports. (PubMed, Pharmaceuticals (Basel)) - " "Hyperglycaemia" could be considered a safety signal for amlodipine, compared to beta-blockers (e.g., bisoprolol-ROR: 2.56), ACE inhibitors (e.g., ramipril-ROR: 2.82), and sartans (e.g., candesartan-ROR: 3.85). "Metabolic syndrome" was reported for amlodipine with a lower probability than for hydrochlorothiazide (ROR: 0.35). Inflammatory signals (e.g., increased C-reactive protein) appeared less frequently for amlodipine than for certain renin-angiotensin-aldosterone system inhibitors (e.g., perindopril-ROR: 0.53)...Reports of inflammation likely reflect patient comorbidities rather than a direct drug effect. These findings demonstrate that post-marketing surveillance remains essential, even when accounting for the methodological limitations of spontaneous reporting."

Adverse drug reaction • Journal • Cardiovascular • Diabetes • Genetic Disorders • Hypertension • Inflammation • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus • CRP

Primary aldosteronism in resistant hypertension unmasked by a thiazide-induced severe hypokalaemia (PubMed, An Sist Sanit Navar) - "We report a 71-year-old man with resistant hypertension and low-normal serum potassium in whom a minimal increase in hydrochlorothiazide dosage (12.5 to 25 mg) precipitated severe hypokalaemia (1.6 mmol/L), metabolic alkalosis, and rhabdomyolysis...This case highlights the importance of recognizing a disproportionate hypokalaemic response to thiazide treatment as a potential indicator of underlying primary aldosteronism. It also underscores the role of family physicians in early detection through appropriate screening."

Journal • Cardiovascular • Endocrine Disorders • Hypertension • Metabolic Disorders

POPS or POP02: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (clinicaltrials.gov) - P=N/A | N=5000 | Recruiting | Sponsor: Duke University | Trial completion date: Jul 2027 ➔ Dec 2026 | Trial primary completion date: Mar 2027 ➔ Nov 2026

Trial completion date • Trial primary completion date • ADHD (Impulsive Aggression) • Asthma • Attention Deficit Hyperactivity Disorder • Bronchopulmonary Dysplasia • Cardiovascular • CNS Disorders • Dermatology • Developmental Disorders • Endocrine Disorders • Genetic Disorders • Gynecology • Heart Failure • Hematological Disorders • Hemophilia • Hypertension • Immunology • Infectious Disease • Insomnia • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Pain • Pneumonia • Psychiatry • Pulmonary Arterial Hypertension • Pulmonary Disease • Rare Diseases • Renal Disease • Respiratory Diseases • Sleep Disorder

Micellar Enhanced Second Derivative Spectrofluorimetric Determination of Hydrochlorothiazide, Amlodipine, and Telmisartan in Fixed Dose Combination and Spiked Human Plasma. (PubMed, Luminescence) - "A very sensitive and eco-friendly second-derivative spectrofluorimetric method was developed for simultaneous analysis of hydrochlorothiazide (HCTZ), amlodipine besylate (AML), and telmisartan (TEL) in pharmaceutical products and human plasma. Assessment of method greenness was conducted using AGREE Prep, MoGAPI, AGSA, SAMI, Ma Tool, CACI, and WECA metrics, all of which indicate superior environmental sustainability. The proposed method is simple, fast, low-cost, ultra-sensitive, and suitable for routine quality control and/or bioanalytical analysis."

Journal • Acute Myelogenous Leukemia

Drug mule, body packer transit time versus obstruction- Does the substance matter? (ASA 2026) - "He remained hypertensive throughout his stay despite nicardipine, clonidine, hydralazine, and hydrochlorothiazide. it was removed with paralysis. It was confirmed to be marijuana wrapped in electrical tape."

Mitral valve posteromedial papillary muscle head rupture presenting after liposomal doxorubicin chemotherapy for metastatic lung liposarcoma: a case report. (PubMed, Eur Heart J Case Rep) - "Her acute heart failure was optimized medically with intravenous loop diuretics, low-dose lisinopril for afterload reduction, and metoprolol succinate, while home amlodipine and hydrochlorothiazide were discontinued. We present this 'two-hit' model as a hypothesis-generating observation, suggesting that chemotherapy-induced structural changes might compound underlying ischaemic or radiation-induced vulnerabilities. As such, advanced imaging modalities may offer value in future efforts to implement risk-adapted surveillance."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Liposarcoma • Oncology • Pulmonary Disease • Sarcoma • Solid Tumor

Atypical endocrine manifestations in Gordon syndrome caused by CUL3 mutation: a case report. (PubMed, Front Med (Lausanne)) - "Treatment with hydrochlorothiazide normalized blood pressure and serum potassium while improving metabolic and hormonal abnormalities. Notably, these improvements reversed upon treatment discontinuation. This case suggests that certain endocrine manifestations in CUL3-related Gordon syndrome may be secondary to chronic electrolyte imbalance rather than direct genetic effects, highlighting the importance of comprehensive endocrine evaluation and sustained thiazide therapy in affected patients."

Journal • Cardiovascular • Hepatology • Hypertension • Metabolic Disorders

Rapid and sensitive multi-residue method for the determination of 235 organic microcontaminants in environmental water samples using direct injection coupled to ultra-high performance liquid chromatography-tandem mass spectrometry. (PubMed, Talanta) - "150 OMCs with sum of concentrations ranging from 17.7 to 239.9 μg/L were detected in WW samples and 0.1 to 1.0 μg/L in DW samples, respectively. All of 12 compounds included in EU Directive 2024/3019 were detected in WW samples with individual concentrations ranging from 46 (metoprolol) to 6667 ng/L (hydrochlorothiazide)."

Journal

Nephrogenic Diabetes Insipidus Presenting with Hypokalemic Paralysis in an Adolescent with Primary Sjögren's Syndrome: A Case Report. (PubMed, Kidney Blood Press Res) - "This case highlights the pathophysiologic cascade of pSS-related dRTA causing secondary NDI and underscores the importance of early recognition and tailored diuretic selection in adolescents."

Journal • Immunology • Metabolic Disorders • Nephrology • Pediatrics • Rare Diseases • Sjogren's Syndrome

Chemogenetic Ca2+ Channel Mitigates Aortic Dissection and Antihypertensive Risk. (PubMed, Hypertension) - "To this therapeutic end, we leveraged a chemogenetic Ca2+-permeable cation channel (pharmacologically selective actuator module 4-serotonin type 3 receptor) exclusively activated by the clinical drug varenicline. The humanized chemogenetic device boosted smooth muscle cell Ca2+ signaling, potentiated the Ca2+-dependent cellular processes, and protected against TAD and the aggravated phenotype induced by hydrochlorothiazide/minoxidil. This study calls for pharmacovigilance of certain antihypertensives in TAD, and suggests that pharmacologically selective actuator module 4-serotonin type 3 receptor, as a viable means of tuning Ca2+ signaling, holds translational potential for TAD therapy."

Journal • Cardiovascular • Critical care • Hypertension

Severe Euvolemic Hyponatremia Consistent With Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) During Localized Herpes Zoster in an Older Adult. (PubMed, Cureus) - "As the patient became symptomatic, and hypertonic saline (with removal of fluid restriction) produced no improvement, a single dose of tolvaptan produced rapid correction of serum sodium and improvement in mentation. The patient was subsequently maintained on sodium chloride tablet supplementation, fluid restriction, and a high-protein diet, with serum sodium improving to 135-136 mEq/L. This case describes severe hypotonic euvolemic hyponatremia meeting biochemical criteria for SIADH in the setting of localized herpes zoster, after consideration of concurrent hydrochlorothiazide exposure and temporally associated oral acyclovir."

Journal • Cardiovascular • Dyslipidemia • Genito-urinary Cancer • Heart Failure • Herpes Zoster • Hypertension • Infectious Disease • Nephrology • Oncology • Pain • Renal Cell Carcinoma • Renal Disease • Solid Tumor • Varicella Zoster

Association of ACE I/D polymorphism with blood pressure response to valsartan-hydrochlorothiazide combination therapy in hypertensive patients from Khyber Pakhtunkhwa, Pakistan. (PubMed, Pharmacogenomics) - "ACE I/D genotype was associated with variation in blood pressure response to fixed-dose Val-HCTZ therapy in this Pakistani cohort, with the most robust finding being poorer response among ID carriers. These findings support further investigation of ACE I/D as a candidate pharmacogenetic marker in genotype-stratified and interventional studies."

Journal • Cardiovascular • Hypertension

Intrathyroidal parathyroid carcinoma in a patient with multiple endocrine neoplasia type 1. (PubMed, JCEM Case Rep) - "After the surgery, calcium dropped to 6.0 mg/dL (SI: 1.5 mmol/L) with PTH of 11 pg/mL (SI: 1.2 pmol/L) requiring oral calcium supplements, calcitriol, and hydrochlorothiazide. Laboratory tests at 12 months on these medications showed calcium of 9.3 mg/dL (SI: 2.3 mmol/L) and PTH 21 pg/mL (SI: 2.2 pmol/L) indicating recovery of parathyroid function without recurrence, and calcitriol was discontinued. This case illustrates that a high index of suspicion for malignancy should be maintained for intrathyroidal parathyroid adenoma in the setting of severe hypercalcemia, especially in MEN1."

Journal • Endocrine Disorders • Metabolic Disorders • Oncology • Solid Tumor • Thyroid Gland Carcinoma

Acute-onset bilateral myopia induced by hydrochlorothiazide. (PubMed, Einstein (Sao Paulo)) - "Sulfonamides are widely prescribed in clinical practice. The symptoms resolved completely after discontinuation of the medication. Although most of the literature highlights this reaction in association with topiramate, it is important to note that any sulfonamide can potentially lead to a similar clinical presentation."

Journal • Ophthalmology