CMX521 / University of North Carolina-Chapel Hill, Jazz - LARVOL DELTA

The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism. (PubMed, J Biol Chem) - "When the coronavirus polymerase is associated with the viral helicase, CMX521 strongly promotes copy-back RNA synthesis suggesting a second inhibitory mechanism for CMX521. Collectively, our findings establish a two-pronged mode of coronavirus polymerase inhibition by CMX521."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism. (PubMed, bioRxiv) - "When the coronavirus polymerase is associated with the viral helicase, CMX521 strongly promotes copy-back RNA synthesis suggesting a second inhibitory mechanism for CMX521. Collectively, our findings establish a two-pronged mode of coronavirus polymerase inhibition by CMX521."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases