ethinyl estradiol/norgestimate / Generic mfg. - LARVOL DELTA

Effects of a Monophasic Hormonal Contraceptive With Norgestimate+Ethinyl Estradiol on Menstrual Bleeding: Protocol and Design of a Multicenter, Prospective, Open-Label, Noncomparative Study in Italy. (PubMed, JMIR Res Protoc) - P4 | "This study into the effects of monophasic NGM/EE 0.25/0.035 mg on menstrual characteristics in healthy Italian women will provide up-to-date data on these effects and includes assessments of a range of other parameters, such as acne severity and patient-reported outcomes, in line with recent international consensus recommendations."

Journal • Observational data • Acne Vulgaris • Gynecology • Pain • Women's Health

Chronic Vaping and Renal Tubular Acidosis: A Case of Worsening Electrolyte Imbalance and Metabolic Acidosis in Chronic Kidney Disease (NKF-SCM 2025) - "Her chronic medications included verapamil, potassium supplements, ethinyl estradiol/norgestimate, cyclobenzaprine, levothyroxine, and pantoprazole. The patient's chronic e-cigarette use, absent from prior records, was revealed only through targeted questioning. Chronic toluene exposure from vaping may exacerbate CKD via distal RTA, worsening metabolic acidosis, hypokalemia, and electrolyte imbalances, complicating management.Conclusion Clinicians should routinely assess e-cigarette use in CKD patients with unexplained metabolic derangements, as chronic toluene exposure from vaping may contribute to RTA and CKD progression, warranting further study."

Clinical • Cardiovascular • Chronic Kidney Disease • Endocrine Disorders • Hypertension • Metabolic Disorders • Nephrology • Rare Diseases • Renal Disease

Exaggerated Increases in the Serum Cortisol Level in a Woman Following Oral Contraceptive Treatment. (PubMed, AACE Clin Case Rep) - "The morning cortisol level had been 10 mcg/dL after administration of 1-mg dexamethasone...She took norgestimate-ethinyl estradiol contraceptive (0.18/0.215/0.25 mg - 35 mcg)...Increases in the serum cortisol-binding proteins are a well-recognized cause for increases in the serum cortisol levels. This case suggests that modern oral contraceptives with low to moderate estrogen activity can cause extreme increases in the serum cortisol levels due to marked increases in the CBG levels."

Journal

The use of a pill containing ethinylestradiol-norgestimate improves female sexuality despite the decrease in circulating androgen: Correspondence. (PubMed, Eur J Contracept Reprod Health Care) - No abstract available

Journal

The use of a pill containing ethinylestradiol-norgestimate improves female sexuality despite the decrease in circulating androgens: a pilot study. (PubMed, Eur J Contracept Reprod Health Care) - "Contraception with EE/NGM was associated with a short term non-deteriorating effect on sexuality despite the evident decrease in androgen levels. Female sexuality during COC use is a complex topic and is not only linked with changes in serum androgen levels."

Journal

Decreased C1INH Function in Hereditary Angioedema Triggered by Combined Oral Contraceptive Use (ACAAI 2023) - "Notably, the patient had started norgestimate-ethinyl estradiol birth control one month prior to symptom onset...However, transient C1-INH dysfunction secondary to estrogen use has rarely been described. Increased awareness of this cause of C1-INH dysfunction is essential given the prevalence of oral contraceptive use in the general population."

Allergy • Cardiovascular • Complement-mediated Rare Disorders • Hereditary Angioedema • Immunology • Long-acting Reversible Contraceptives

Effects of rimegepant 75 mg daily on the pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and norgestimate in healthy female participants. (PubMed, Headache) - "The study identified modest elevations in overall EE and NGMN exposures after multiple doses of rimegepant, but these elevations are unlikely to be clinically relevant in healthy females with migraine."

Journal • PK/PD data • CNS Disorders • Migraine

Metabolic Acidosis in a Patient With Polycystic Ovary Syndrome Taking Oral Contraceptives and Antipsychotics (KIDNEY WEEK 2022) - "Her home medications included lurasidone, sertraline, ethinyl estradiol-norgestimate, metformin, and insulin...Acetaminophen, ethanol, and salicylate levels were negative...She was discharged with OCP containing less estrogen, insulin, statin, omega-3 and fenofibrate...After plasmapharesis and hemodialysis with reduction of triglyceride levels, our patient's HAGMA resolved. There have been a few cases reported of oral contraception-induced hypertriglyceridemia particularly with estrogen, but requires further research."

Clinical • Cardiovascular • CNS Disorders • Depression • Diabetes • Dyslipidemia • Hypertriglyceridemia • Metabolic Disorders • Pain • Polycystic Ovary Syndrome • Psychiatry

Pharmacokinetic and Pharmacodynamic Profiles of Ethinylestradiol/Norgestimate Combination or Norethindrone upon Coadministration with Elagolix 150 mg Once Daily in Healthy Premenopausal Women. (PubMed, Clin Pharmacokinet) - "Coadministration of elagolix 150 mg once daily with oral contraceptives containing EE and norgestimate, or norethindrone, resulted in small pharmacokinetic changes in the oral contraceptive components. Similar or lower FSH, LH, and E2 exposures were observed during coadministration, with ovulatory P concentrations also comparable in both periods. The pharmacodynamic profiles of the oral contraceptives were maintained when coadministered with elagolix."

Clinical • Journal • PK/PD data

A Study to Evaluate Effects of CC-99677 on the Pharmacokinetics of an Oral Contraceptive in Healthy Female Participants (clinicaltrials.gov) - P1; N=28; Completed; Sponsor: Celgene; Recruiting ➔ Completed

Clinical • Trial completion

[VIRTUAL] PULMONARY EMBOLISM ASSOCIATED WITH NITROUS OXIDE ABUSE (CHEST 2021) - "She was on norgestimate-ethinyl estradiol for contraception...She was discharged on Apixaban... VTE should be considered in patients with chronic abuse of N2O in the appropriate context."

Anemia • Anesthesia • Cardiovascular • Hematological Disorders • Leukopenia • Pain • Pulmonary Embolism • Respiratory Diseases • Venous Thromboembolism

[VIRTUAL] Mixed Progestogen Hypersensitivity in a Patient Using a Combined Contraceptive Skin Patch: A Case Report (CDA-I 2020) - "She was treated with IM epinephrine, antihistamines and a course of prednisone...The patient was sent home on norgestimate/Ethinyl estradiol for contraception and rupatadine for dermographism and allergic rhinitis...It has been associated with endogenous as well as exogenous sources of progestogens and can evolve over time. Exogenous progesterone intakes must be considered in the diagnosis."

Clinical • Allergic Rhinitis • Allergy • Asthma • Cardiovascular • Dermatology • Immunology • Rare Diseases • Respiratory Diseases • Seborrheic Dermatitis • Urticaria • KIT

A Study to Evaluate Effects of CC-99677 on the Pharmacokinetics of an Oral Contraceptive in Healthy Female Participants (clinicaltrials.gov) - P1; N=28; Recruiting; Sponsor: Celgene

Clinical • New P1 trial

A Multi-Center, Open-Label, Pharmacokinetic Drug Interaction Study of Erenumab and a Combined Oral Contraceptive in Healthy Females. (PubMed, CNS Drugs) - P1 | "Erenumab did not alter the pharmacokinetics of the active components of an estrogen/progestin combination oral contraceptive. Thus, no change in contraceptive efficacy is expected with erenumab."

Clinical • Journal • PK/PD data • CNS Disorders • Migraine

Epiploic Appendagitis After Rigorous Exercise in a Woman: An Easily Misdiagnosed Cause of Acute Abdomen (ACG 2019) - "Only medication was norgestimate-ethinyl estradiol for contraception...Diagnosis of EA is by imaging via ultrasound or CT scan, and complete resolution typically occurs within two weeks with conservative management. Prompt identification of EA is essential in patients at risk, to avoid unnecessary surgical procedures."

Clinical

The Impact of Hormonal Contraceptives on Breast Cancer Pathology. (PubMed, Horm Cancer) - "Three combination hormonal contraceptive agents (COCs) Lo Ovral (LO), Ortho Novum (ON), and Ortho Tri-Cyclen (OTC) were evaluated as they represented the most commonly used hormonal contraceptives in our cohort. Age at diagnosis, ethnicity, BMI, family history, menstruation status, and duration of use were all independent predictors of different histopathological subtypes. We conclude that patient-specific variables should be considered when deciding on which type of hormonal contraceptive to use to minimize the risk of developing breast cancer or a breast-related pathology."

Journal

"@JNJNews is it true Ortho Tricyclen lo is discontinued?" (@MsTineo)