desferroxamine (DFO) / ZoneOne Pharma - LARVOL DELTA

Recovery of germanium from optical fiber industry wastewater using desferroxamine B. (PubMed, J Hazard Mater) - "Through spectroscopy and density functional theory calculations, the hexadentate complex between hydroxamate groups of DFOB and Ge was identified. When this technology was applied to wastewater from the fiber optics industry, more than 80.0 % of Ge-DFOB was recovered with Ge purity of 84.5 % using reversed-phase high performance liquid chromatography."

Journal

Preoperative PET imaging and fluorescence-guided surgery of human glioblastoma using dual-labeled antibody targeting ETA receptors in a preclinical mouse model: A theranostic approach. (PubMed, Theranostics) - " Monomolecular multimodal imaging platform (MOMIP) - containing both a fluorophore (IRDye800CW) and a chelator for a positron-emitting radiometal (desferroxamine B, DFO) - was conjugated to the axiRA63 antibody targeting ETA receptors, overexpressed on the surface of GBM stem cells... The use of [89Zr]Zr-axiRA63-MOMIP provides an effective theranostic approach to detect and treat GBM by surgery in a preclinical mouse model. Thanks to the high correlation between PET and fluorescence signal allowing patients stratification, this bimodal agent should have a great potential for clinical translation and should present a significant advantage over non-targeted fluorophores already used in the clinic."

Journal • Preclinical • Surgery • Brain Cancer • CNS Tumor • Glioblastoma • Oncology • Solid Tumor

Soy Isoflavones Induce Cell Death by Copper-Mediated Mechanism: Understanding Its Anticancer Properties. (PubMed, Molecules) - "The copper-specific chelator neocuproine decreases the apoptotic potential of isoflavones, whereas the iron and zinc chelators desferroxamine mesylate and histidine do not, confirming the role of copper...Copper levels are widely known to be significantly raised in all malignancies, and we confirm that isoflavones can target endogenous copper, causing prooxidant signaling and, eventually, cell death. These results highlight the importance of copper dynamics within cancer cells and provide new insight into the potential of isoflavones as cancer-fighting nutraceuticals."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • ATP7A

Streptomyces clavuligerus: The Omics Era. (PubMed, J Ind Microbiol Biotechnol) - "Metabolomic studies allowed the detection of new metabolites produced by S. clavuligerus such as naringenin, desferroxamines, several N-acyl tunicamycins, the terpenes carveol and cuminyl alcohol or bafilomycin J. Heterologous expression of S. clavuligerus terpene synthases resulted in the formation of no less than fifteen different terpenes, although none of them was detected in S. clavuligerus culture broth. In summary, application of the Omic tools results in a better understanding of the molecular biology of S. clavuligerus, that allows the use of this strain as an industrial actinobacterial platform and help to improve clavulanic acid production."

Journal • Addiction (Opioid and Alcohol)

[VIRTUAL] Diabetic Ketoacidosis Presenting in Major Thalassemia With Pancreatic Hemosiderosis: A Case Report (ENDO 2021) - "He receives combination of chelators (deferiprone, desferroxamine, deferriprox) with ferritin level 8,387 μg/mL. For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021."

Clinical • Beta-Thalassemia • Cardiovascular • Diabetes • Genetic Disorders • Immunology • Metabolic Disorders • Ventricular Tachycardia • MRI

Isolation and characterization of arsenic-binding siderophores from Rhodococcus erythropolis S43: role of heterobactin B and other heterobactin variants. (PubMed, Appl Microbiol Biotechnol) - "The metabolites produced by S43 in the colorimetric CAS and As-CAS assays, respectively, showed iron- and arsenic-binding properties reaching a chelating activity equivalent to 1.6 mM of desferroxamine B in the supernatant of the culture without arsenite...• Heterobactin B and the compound designated heterobactin A by Carrano are of importance. • In addition, other heterobactins with ornithine in the backbone exist, e.g., the new heterobactin C."

Journal

The Role of Oxidative Stress in Parkinson's Disease. (PubMed, Antioxidants (Basel)) - "Although a number of antioxidants, such as creatine, vitamin E, coenzyme Q10, pioglitazone, melatonin and desferrioxamine, have been tested in clinical trials, none of them have demonstrated conclusive evidence to ameliorate the neurodegeneration in PD patients. Difficulties in clinical studies may be caused by the long-standing progression of neurodegeneration, lack of biomarkers for premotor stage of PD and inadequate drug delivery across blood-brain barrier. Solutions for these challenges will be warranted for future studies with novel antioxidative treatment in PD patients."

Journal • Review • CNS Disorders • Gene Therapies • Immunology • Movement Disorders • Parkinson's Disease

A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation. (PubMed, Neoplasia) - "Compound treatment modulates these interactions and also affects Shelterin complex composition, while conferring cellular protection from cytotoxicity due to bleomycin and desferroxamine. These results demonstrate therapeutic potential of the compound series."

Journal

Brake dust exposure exacerbates inflammation and transiently compromises phagocytosis in macrophages. (PubMed, Metallomics) - "These responses were abrogated by metal chelation using desferroxamine. At minimally cytotoxic doses both DEP and BAD perturbed bacterial clearance and promoted inflammatory responses in U937 cells with similar potency. These data emphasise the requirement to consider contributions of abrasion particles to traffic-related clinical health effects."

Journal • CXCL8 • IL10

PET imaging of the EPR effect in tumor xenografts using small 15 nm diameter polyethylene glycols labeled with zirconium-89. (PubMed, Mol Cancer Ther) - "PEG conjugates of the zirconium ligand desferroxamine B (DFB) of similar size and charge to PLX038 were prepared that contained one or four DFB as well as one that contained three SN-38 moieties and one DFB...Compared to diagnostic liposomes, the PEG nanocarriers have a longer serum half-life, are retained in tumors at higher levels, remain there longer, and afford higher tumor exposure. The small PEG40kDa nanocarriers studied here show properties for passive targeting of tumors that are superior than most nanoparticles and might be effective probes to identify tumors susceptible to a similar size therapeutic nanocarriers such as PLX038."

Journal

Phase I/IIa PET imaging study with zirconium labeled anti-PSMA minibody for urological malignancies. (PubMed, Ann Nucl Med) - "Administration of Zr-Df-IAB2M was well-tolerated and safe in terms of adverse events and radiation exposure and protection. Zr-Df-IAB2M is feasible for usage by long-distance transportation. Further studies are warranted for analysis of its use for tumor lesion detection (UMIN000015356)."

Journal • P1/2 data

Identification of an iron-responsive subtype in two children diagnosed with relapsing-remitting multiple sclerosis using whole exome sequencing. (PubMed, Mol Genet Metab Rep) - "Our findings highlight the potential value of WES to identify heritable risk factors that could affect the reabsorption of transferrin-bound iron in the kidneys causing sustained iron loss, together with inhibition of vitamin B12 absorption and vitamin D reabsorption (CUBN) and iron transport into mitochondria (SLC25A37) as the sole site of heme synthesis. This supports a model for RRMS in children with an apparent iron-deficient biochemical subtype of MS, with oligodendrocyte cell death and impaired myelination possibly caused by deficits of energy- and antioxidant capacity in mitochondria."

Clinical • Journal