FLASH-001 / Flashpoint Therapeutics - LARVOL DELTA

Leveraging large language models (LLM) to guide adjuvant chemotherapy (AC) recommendations in stage III colorectal cancer (CRC). (ASCO-GI 2026) - "HIPAA-compliant Gemini-2.0-Flash-001 and GPT-4o extracted clinical variables (age, neuropathy grade, pathological stage) from EHRs and generated AC recommendations... This exploratory work shows LLM agents can reliably extract variables and generate evidence-based treatment recommendations for stage III CRC. The high rate of expert preference for LLM recommendations in discordant cases is intriguing but limited by small sample size and possible adjudicator bias. Discordant physician recommendations reflect the complexity of decision-making, including patient preferences, performance status, comorbidities, and subtle findings not fully captured in EHRs."

Clinical • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor