Rylomine (morphine) / Pfizer - LARVOL DELTA

Efficacy and feasibility of opioids for burn analgesia: An evidence-based qualitative review of randomized controlled trials. (PubMed, Burns) - "...Intranasal fentanyl (INF) was equivalent to oral morphine in burn wound care both in adult and pediatric patients. OTFC and INF could be considered as viable non-invasive analgesic alternatives to oral opioids for procedural burn pain. However, the level of evidence still seems quite uncertain because of the limited sample size."

Journal • Review • Biosimilar • Pain

Opioids for management of episodic breathlessness or dyspnea in patients with advanced disease. (PubMed) - "Although the pathophysiology and mechanism of action of opioids for management of breathlessness, and specifically EB, are not fully known, there is scientific evidence, and particularly great clinical evidence, of the benefit of this drug class for dyspnea management. It is important to differentiate hospitalized patients from outpatients because venous or subcutaneous access is easier in hospitalized patients, but use of transmucosal fentanyl, especially in faster formulations like intranasal application, opens up new possibilities to manage outpatients due to its fast onset of action. The main problem is the lack of data available and the multitude of unanswered questions about opioid type, administration route, safety, and dose titration."

Journal • Review • Biosimilar • Oncology • Venous Thromboembolism

Manipulation and reduction of paediatric fractures of the distal radius and forearm using intranasal diamorphine and 50% oxygen and nitrous oxide in the emergency department: a 2.5-year study. (PubMed) - Bone Joint J - "Simple easily reducible fractures of the distal radius and forearm in children can be successfully and safely treated in the ED using this approach, thus avoiding theatre admission and costly hospital stay. Cite this article: Bone Joint J 2016;97-B:131-6."

Journal • Retrospective data • Biosimilar

The deadliest drugs in Florida are still opioids, despite a rosy interim report from the state - "'We're seeing the tail of what got started many years ago. There was a massive liberalization of opioid prescribing that had its inception probably in the late '80s, really started to gain momentum in the mid-'90s and went on into the early 2000s. Probably around 2011 you began to see a much bigger public awareness regarding the number of deaths,' Rosenquist says. 'People in 2004 weren't talking about it, but in 2011 they were'...Rosenquist says, just so they wouldn't have to contact the doctor for a refill. These tablets most likely came in the form of hydrocodone or oxycodone, the most popular being Vicodin, OxyContin and Percocet."

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