ONO-8055 / Ono Pharma - LARVOL DELTA

EP2 and EP3 receptors as therapeutic targets for underactive bladder/detrusor underactivity due to diabetic cystopathy in a type 1 diabetic rat model. (PubMed, Low Urin Tract Symptoms) - "The present study was unable to demonstrate that stimulation of EP2 and EP3 receptors caused major improvements in UAB/DU due to DC. However, this equivocal result could arise from inherent limitations of the STZ-induced diabetic rat as a UAB/DU model."

Journal • Preclinical • Diabetes • Metabolic Disorders

Further characterization of a novel EP2 and EP3 receptor dual agonist, ONO-8055, on lower urinary tract function in normal and lumbar canal stenosis rats. (PubMed, Low Urin Tract Symptoms) - "This agonist did not augment bladder contractility or urethral relaxation in normal rats."

Journal • Preclinical