Triesence (triamcinolone acetonide injectable suspension) / Novartis - LARVOL DELTA

Beyond the injection: delivery systems reshaping retinal disease management. (PubMed, Expert Opin Pharmacother) - "Specific innovations discussed include the ranibizumab port delivery system, EYP-1901 (Duravyu, vorolanib implant), KSI-301 (tarcocimab tedromer), KSI-501, OTX-TKI (Axpaxli, axitinib implant), 4D-150, revakinagene taroretcel-lwey (Encelto, NT-501, encapsulated cell therapy), Xipere (triamcinolone acetonide injectable suspension), AU-011 (belzupacap sarotalocan targeted delivery), ABBV-RGX-314, elamipretide, and OCS-01 (high concentration dexamethasone)...Challenges include overcoming the blood-retinal barrier, surgical complications with implantable devices, and ensuring patient adherence. Advances in smart delivery systems, drug formulations, and predictive models, alongside interdisciplinary collaboration, will be crucial in achieving personalized, effective, and sustainable retinal therapies."

Journal • Review • Age-related Macular Degeneration • Diabetic Macular Edema • Diabetic Retinopathy • Gene Therapies • Macular Degeneration • Ophthalmology • Retinal Disorders

Intravitreal low-dose triamcinolone acetonide for nonarteritic anterior ischemic optic neuropathy. (PubMed, Int J Ophthalmol) - "Low-dose IVTA may be an alternative safe treatment option for some NAION patients in the acute stage. However, optic nerve atrophy still existed."

Journal • Cardiovascular • Diabetic Retinopathy • Glaucoma • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Retinal Disorders

Race and Vision Outcomes in Ranibizumab-Treated Participants With Diabetic Macular Edema: A Meta-Analysis. (PubMed, JAMA Ophthalmol) - "Five randomized clinical trials were preselected for analysis, including the RIDE and RISE trials (Ranibizumab Injection in Subjects With Clinically Significant Macular Edema With Center Involvement Secondary to Diabetes Mellitus); Protocol I (Intravitreal Ranibizumab or Triamcinolone Acetonide in Combination With Laser Photocoagulation for Diabetic Macular Edema), Protocol S (Prompt Panretinal Photocoagulation Versus Intravitreal Ranibizumab With Deferred Panretinal Photocoagulation for Proliferative Diabetic Retinopathy), and Protocol T (A Comparative Effectiveness Study of Intravitreal Aflibercept, Bevacizumab and Ranibizumab for Diabetic Macular Edema)...No difference in BCVA was observed in Black vs White participants at 2 years. Smaller enrollment numbers precluded analysis of participants of other races, suggesting lack of robust diversity beyond Black and White participants in these trials."

Clinical • Journal • Retrospective data • Diabetes • Diabetic Macular Edema • Diabetic Retinopathy • Metabolic Disorders • Ophthalmology • Retinal Disorders

Occlusive Retinal Vasculitis After Aflibercept 8mg Injection for Wet Macular Degeneration. (PubMed, Retin Cases Brief Rep) - "ORV is a rare complication of some intravitreal anti-VEGF medications and infectious causes of endophthalmitis. It can be managed with aggressive steroid treatment for an excellent visual outcome in some cases, although the disease may be chronic or recurrent."

Journal • Age-related Macular Degeneration • Inflammation • Macular Degeneration • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders • Uveitis • Vasculitis • Wet Age-related Macular Degeneration

Human Umbilical Cord-Derived Mesenchymal Stem Cells via Suprachoroidal Injection: A Novel Approach for Experimental Uveitis Treatment (ARVO 2025) - "Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Ocular Inflammation • Ophthalmology • Uveitis • IL17A • TNFA

Incidence, Pathogenesis, Risk Factors, and Treatment of Cystoid Macula Oedema Following Cataract Surgery: A Systematic Review. (PubMed, Diagnostics (Basel)) - "Studies evaluating topical NSAIDs, periocular steroids, intravitreal triamcinolone acetonide (TCA), dexamethasone implants (Ozurdex), and intravitreal bevacizumab were included... Topical NSAIDs, particularly ketorolac and diclofenac, showed effectiveness in acute CMO, while their efficacy in chronic cases was variable... Topical NSAIDs, often combined with periocular steroids, serve as first-line therapy, with periocular steroids offering additional efficacy in resistant cases. Further research is needed to establish optimal treatment algorithms and improve outcomes for patients with post-operative CMO."

Journal • Review • Cataract • Macular Edema • Ophthalmology

Dropless vitrectomy surgery for epiretinal membranes; Efficacy and safety compared to standard of care (ARVO 2025) - "Methods A retrospective review was conducted on patients who underwent PPV for ERM removal.Group 1 received an intravitreal injection of Tri-Moxi (0.3mL, delivering 4.5mg triamcinolone acetonide & 0.3mg moxifloxacin) at the conclusion of surgery.Group 2 received a standard postoperative regimen of Tobradex eye drops every 4 hours for 1 week, tapered over 5 additional weeks(6 weeks total)...This method facilitates the direct delivery of concentrated anti-inflammatory and antibacterial agents to the retina and vitreous cavity, where these effects are most beneficial after PPV. In our study, we demonstrated that administering a low dose of intravitreal triamcinolone acetonide directly into the vitreous effectively achieves therapeutic levels for managing postoperative inflammation following PPV for ERM removal."

Clinical • Surgery • Macular Edema • Ocular Infections • Ocular Inflammation • Ophthalmology • Retinal Disorders

Risk of intraocular pressure elevation associated with triamcinolone acetonide administration via different routes in macular edema: a systematic review and network meta-analysis of randomized controlled trials. (PubMed, BMC Ophthalmol) - "For the increased risk of IOP, we recommend that treatment within 4 weeks is safe. Nevertheless, it is advisable to exercise caution when administering IVTA, STiTA, SCTA beyond a duration of 12 weeks, due to the potential risk of IOP elevation. RITA emerged as the safest injection route in the treatment of macular edema in terms of IOP risk. However, more high-quality randomized controlled trials will be necessary to further confirm this."

Clinical • Journal • Retrospective data • Review • Macular Edema • Ophthalmology

Adverse Events Associated with Injection of Suprachoroidal Triamcinolone Acetonide in the Real-World Setting (ARVO 2025) - "Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Adverse events • Clinical • Real-world • Real-world evidence • Cataract • Glaucoma • Macular Edema • Ocular Infections • Ocular Inflammation • Ophthalmology • Uveitis

A case of retinal phlebitis complicated by punctate inner choroidopathy-like lesion (ARVO 2025) - "The patient was started on oral prednisolone (PSL) therapy...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Clinical • Ocular Inflammation • Ophthalmology

Dynamics of Inflammatory Factors in Aqueous Humor During Brolucizumab Treatment for Age-Related Macular Degenerations: A Case Series. (PubMed, Medicina (Kaunas)) - "Vision worsened in one patient who developed IOI after initial IVBr, so IVBr was discontinued and the patient was switched to intravitreal aflibercept with sub-tenon injection of triamcinolone acetonide...In two patients with IOI, not only flares but also IL-8, IP-10, and Flt-3L decreased from 1 to 2 months after IVBr despite continued IVBr. This case series might lead to a better understanding of the pathogenesis of IOI after IVBr."

Journal • Age-related Macular Degeneration • Inflammation • Macular Degeneration • Ophthalmology • Retinal Disorders • Wet Age-related Macular Degeneration • CCL2 • CX3CL1 • CXCL8 • FLT3 • FLT3LG • IL6

Efficacy and Safety of Ophthalmic Steroids in the Management of Polypoidal Choroidal Vasculopathy: A Systematic Review. (PubMed, Clin Ophthalmol) - "Triamcinolone acetonide was administered in seven studies, and dexamethasone in two...The maximum reduction observed in the central foveal thickness and central retinal thickness was -131.4 μm and -261.7 μm, respectively. Ophthalmic steroids may serve as an effective adjunctive treatment for PCV patients, irrespective of anti-VEGF resistance or hemorrhagic involvement, and may be considered as a potential monotherapy in resource-limited settings, with minimal side effects."

Journal • Review • Age-related Macular Degeneration • Cardiovascular • Cataract • Glaucoma • Hematological Disorders • Ophthalmology • Retinal Disorders

From Monotherapy to Combination Strategies: Redefining Treatment Approaches for Multiple-Cause Macular Edema. (PubMed, Clin Ophthalmol) - "Combination therapies, including anti-VEGF drugs with macular laser photocoagulation, triamcinolone acetonide, or dexamethasone intravitreal implant (Ozurdex), have emerged as promising strategies...Future research directions are outlined, emphasizing the importance of large-scale, long-term studies to evaluate the sustained efficacy and safety of combination therapies. The integration of advanced imaging techniques, biomarker analysis, and innovative therapeutic approaches is expected to shape the future landscape of ME management, moving towards more targeted and effective combination therapies."

Journal • Monotherapy • Review • Diabetic Macular Edema • Inflammation • Macular Edema • Ophthalmology • Retinal Disorders • Retinal Vein Occlusion

Potential association of bilateral macular edema with retinal vein occlusion triggered by volatile organic compounds of paint: A case report. (PubMed, Am J Ophthalmol Case Rep) - "He was treated with triamcinolone acetonide and anti-VEGF intravitreal injections, and later with vitrectomy combined with cataract surgery in both eyes due to a persistent bilateral CME...A CME might be exacerbated by the exposure to paint-related VOCs. Our findings suggest that reducing and avoiding the occupational exposure to VOCs and regular measurements of urinary VOC concentration are important for those who work in the printing and painting industries."

Journal • Cataract • Macular Edema • Ophthalmology • Retinal Vein Occlusion

Recurrent uveitic macular edema managed with intravitreal faricimab injection. (PubMed, J Ophthalmic Inflamm Infect) - "The findings of this case hint towards the potential simultaneous effect of angiopoietin-2 blockade along with vascular endothelia growth factor A inhibition by faricimab in managing treatment-resistant UME. Nonetheless, more studies focusing on the role of intravitreal faricimab in UME are required."

Journal • Macular Edema • Ocular Inflammation • Ophthalmology • Retinal Disorders • Vasculitis

Harrow Executes Five-Year Strategic Supply and Development Agreement for TRIESENCE (Businesswire) - "Harrow...announced the execution of a five-year strategic supply and development ('SSD') agreement for TRIESENCE (triamcinolone acetonide injectable suspension) 40 mg/mL, a preservative-free synthetic corticosteroid that is approved by the U.S. Food and Drug Administration (FDA) for visualization during vitrectomy and the treatment of ocular inflammatory conditions that are unresponsive to topical corticosteroids. The SSD agreement is with the current contract manufacturing organization (CMO) producing TRIESENCE, ensuring continuity in quality and leveraging more than 15 years of experience with the TRIESENCE manufacturing process. Harrow also announced that it has begun developing a next-generation version of TRIESENCE and plans to submit a new drug application (NDA) to the FDA before the end of 2027."

Commercial • FDA filing • Ocular Inflammation

Epstein-Barr Virus Associated Frosted Branch Angiitis. (PubMed, Retin Cases Brief Rep) - "Bilateral FBA may present following EBV infection and responds well to corticosteroids and antiviral therapy."

Journal • CNS Disorders • Epstein-Barr Virus Infections • Genetic Disorders • Infectious Disease • Inflammation • Ocular Inflammation • Pain • Retinal Disorders • Vasculitis

Bilateral Foveal Damage Induced by Indirect Picosecond Nd:YAG Laser Exposure: A Case Report. (PubMed, Case Rep Ophthalmol Med) - "Injections of sub-Tenon's triamcinolone acetonide (12 mg/0.3 mL) in the right eye and intravitreal tissue plasminogen activator (30 μg/0.05 mL) in the left eye were administered on the same day... Continuous Nd:YAG laser exposure during cosmetic procedures likely caused the bilateral foveal damage observed in this case. All individuals using lasers must be aware of the importance of protective goggles."

Journal • Aesthetic Medicine • Hematological Disorders • Ophthalmology • Retinal Disorders

Evaluation of the Efficacy and Safety of Preoperative Intravitreal Triamcinolone Acetonide Combined with Internal Limiting Membrane Peeling for the Treatment of Idiopathic Macular Epiretinal Membrane. (PubMed, Semin Ophthalmol) - "Macular morphology and macular integrity improved after vitrectomy combined with ILM peeling surgery. Compared with the no-IVTA group, preoperative intravitreal triamcinolone acetonide can improve best corrected visual acuity and accelerate the absorption of intraretinal fluid in terms of a significant reduction in IRT."

Journal • Macular Edema • Ophthalmology • Retinal Disorders

Intraocular inflammation after intravitreal injection of aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration: a case report. (PubMed, BMC Ophthalmol) - "This case demonstrated a potential dose-dependent inflammatory response following aflibercept 8 mg, which did not occur with aflibercept 2 mg in patients with a history of intraocular inflammation."

Journal • Age-related Macular Degeneration • Diabetes • Inflammation • Macular Degeneration • Metabolic Disorders • Ocular Inflammation • Ophthalmology • Pain • Retinal Disorders • Retinal Vein Occlusion • Vasculitis • Wet Age-related Macular Degeneration

Efficacy of different routes of triamcinolone acetonide administration on macular edema: A systematic review and network meta-analysis. (PubMed, PLoS One) - "SCTA and IVTA were proven to be the best administration routes for improving BCVA and reducing CMT. In addition, STiTA was less advisable than other administration routes of triamcinolone acetonide according to the rankings and SUCRA."

Clinical • Journal • Retrospective data • Review • Macular Edema • Ophthalmology

Coats-Like reaction post-vitreoretinal surgery for PDR managed with laser photocoagulation and adjunctive intravitreal steroids- a case report. (PubMed, BMC Ophthalmol) - "This case highlights the occurrence of a Coats-like response following vitreoretinal surgery for PDR, potentially triggered by retinal ischemia and surgical inflammation. Timely intervention with laser photocoagulation, and adjunctive intravitreal corticosteroids can effectively manage such responses."

Journal • Achromatopsia • Cardiovascular • Cataract • Diabetes • Diabetic Retinopathy • Hypertension • Inflammation • Metabolic Disorders • Ophthalmology • Retinal Disorders • Type 2 Diabetes Mellitus

Transient anterior chamber intraocular lens opacification by triamcinolone acetonide following intravitreal injection. (PubMed, GMS Ophthalmol Cases) - "Conservative management led to spontaneous clearing of intraocular lens (IOL) and resolution of CME in 4 weeks. Opacification of ACIOL following IVTA injection is a rare complication which can be seen in eyes with compromised zonular/capsular bag integrity."

Journal • Cataract • Macular Edema • Ophthalmology

Suprachoroidal injection of triamcinolone acetonide as adjuvant to surgical treatment of epiretinal membrane. (PubMed, Int J Retina Vitreous) - "During vitrectomy for iERM, SChI-TA was more effective than IVTA in reducing CRT and EIFL-T and improving BCVA. SChI-TA was effective in preventing postoperative CME. SChI-TA treatment was safe and reproducible and did not affect postoperative IOP. Trial registration NP6289-June 18th, 2024 (retrospectively registered)."

Journal • CNS Disorders • Depression • Macular Edema • Ophthalmology • Psychiatry • Retinal Disorders

Intravitreal steroid-associated central serous chorioretinopathy. (PubMed, BMJ Case Rep) - "Both cases showed complete resolution of cystoid oedema after intravitreal triamcinolone acetonide injection, but there was a progressive increase in neurosensory detachment (NSD), leading to a suspicion of CSC...The first case was treated with focal laser, and the second one was treated with oral eplerenone...This report adds to the evidence that intravitreal steroids can indeed cause acute CSC. A high index of suspicion for CSC should be maintained in cases where NSD increases following intravitreal steroid administration."

Journal • Diabetic Macular Edema • Macular Edema • Ophthalmology • Retinal Disorders • Retinal Vein Occlusion