ABS-101 / Absci Corp - LARVOL DELTA

ABS-101 (anti-TL1A antibody) (GlobeNewswire) - "Interim data for the Phase 1 clinical trial for ABS-101 demonstrated extended half-life as compared to first-generation anti-TL1A competitor programs, with no apparent impact of ADA on PK, with the overall safety profile being favorable with no serious adverse events reported. With this data, Absci will explore potential partnership and outlicensing opportunities for ABS-101, consistent with the company's business strategy, as well as first-in-class indication expansion opportunities for this target. The company has made the strategic decision not to initiate additional later-stage development trials for ABS-101 internally at this time. Instead, Absci will allocate capital and resources toward expanded and accelerated clinical development of ABS-201 in endometriosis, where there is a high unmet medical need and market opportunity."

Clinical • P1 data • Immunology • Inflammatory Bowel Disease

Absci Announces First Participants Dosed in Phase 1 Clinical Trial of ABS-101, a Potential Best-In-Class anti-TL1A Antibody for the Treatment of Inflammatory Bowel Disease (GlobeNewswire) - "Absci Corporation...announced that the first healthy volunteers have been dosed in a randomized, placebo-controlled Phase 1 study evaluating ABS-101, an investigational anti-TL1A antibody engineered with Absci’s generative AI platform....The study is expected to enroll approximately 40 healthy adult participants. The primary endpoint is safety and tolerability, with PK, PD, and immunogenicity serving as secondary endpoints. The Phase 1 interim data readout is expected in the second half of 2025."

P1 data • Trial status • Inflammatory Bowel Disease

Absci Reports Business Updates and Third Quarter 2024 Financial and Operating Results (GlobeNewswire) - "ABS-101 (potential best-in-class anti-TL1A antibody):...Absci continues to advance ABS-101 through IND-enabling studies, plans to initiate Phase 1 clinical studies for ABS-101 in the first half of 2025, and continues to expect an interim data readout in the second half of 2025....Research and development expenses were $18.0 million for the three months ended September 30, 2024 compared to $11.0 million for the three months ended September 30, 2023. This increase was primarily driven by increased lab operations, including direct costs associated with IND-enabling studies for ABS-101, and an increase in stock compensation expense."

New P1 trial • P1 data • Immunology • Inflammatory Bowel Disease

Absci Reports Business Updates and First Quarter 2024 Financial and Operating Results (GlobeNewswire) - "Absci plans to share additional preclinical data, including data from non-human primate studies, for this program in the next few months. Absci expects to initiate Phase 1 clinical studies for ABS-101 in early 2025, with an interim data readout expected in the second half of 2025."

New P1 trial • P1 data • Preclinical • Immunology • Inflammatory Bowel Disease