oxycodone/acetaminophen / Generic mfg. - LARVOL DELTA

Prospective, Randomized, Controlled Trial of an Opioid-Sparing Protocol Versus Standard Opioid-Based Protocol Following Open Reduction Internal Fixation of Distal Radius Fractures (AAOS 2026) - "We hypothesized that a post-operative opioid-sparing (OS) pain medication regimen would yield similar patient reported pain scores to a standard opioid-based (OB) pain regimen after surgical fixation of distal radius fractures while reducing opioid pills and oral morphine equivalents (OME) consumed...Patients presenting with closed distal radius fractures meeting criteria for open reduction internal fixation with a volar locking plate in an outpatient setting were invited to participate in the study and were randomized to either a traditional opioid-based (acetaminophen and oxycodone) or opioid-sparing (acetaminophen, gabapentin, celecoxib) post-operative pain control regimen... This study shows a 50% decrease in opioid pills consumed after fixation of distal radius fractures in the opioid-sparing pain management group. Significantly more of the opioid-sparing cohort had discontinued opioid pain medications by two-weeks post-operatively. There were no significant..."

Clinical • Musculoskeletal Diseases • Orthopedics

Prospective, Randomized, Controlled Trial of an Opioid-Sparing Protocol Versus Standard Opioid-Based Protocol Following Open Reduction Internal Fixation of Distal Radius Fractures (AAOS 2026) - "We hypothesized that a post-operative opioid-sparing (OS) pain medication regimen would yield similar patient reported pain scores to a standard opioid-based (OB) pain regimen after surgical fixation of distal radius fractures while reducing opioid pills and oral morphine equivalents (OME) consumed...Patients presenting with closed distal radius fractures meeting criteria for open reduction internal fixation with a volar locking plate in an outpatient setting were invited to participate in the study and were randomized to either a traditional opioid-based (acetaminophen and oxycodone) or opioid-sparing (acetaminophen, gabapentin, celecoxib) post-operative pain control regimen... This study shows a 50% decrease in opioid pills consumed after fixation of distal radius fractures in the opioid-sparing pain management group. Significantly more of the opioid-sparing cohort had discontinued opioid pain medications by two-weeks post-operatively. There were no significant..."

Clinical • Musculoskeletal Diseases • Orthopedics

Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy (clinicaltrials.gov) - P2/3 | N=100 | Suspended | Sponsor: Wake Forest University Health Sciences | Recruiting ➔ Suspended

Trial suspension • Genito-urinary Cancer • Oncology • Pain • Prostate Cancer • Solid Tumor

Radiographic Manifestations of Intravenous Administration of Oxycodone-acetaminophen Mimicking Septic Pulmonary Emboli (ATS 2026) - No abstract available

Cardiovascular • Pulmonary Embolism

Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (clinicaltrials.gov) - P4 | N=120 | Recruiting | Sponsor: Medical University of Silesia | Not yet recruiting ➔ Recruiting | Trial completion date: Feb 2026 ➔ Jun 2026 | Trial primary completion date: Feb 2026 ➔ Jun 2026

Enrollment open • Trial completion date • Trial primary completion date • Anesthesia • Orthopedics • Pain

FENTANYL'S YOUNGEST VICTIMS: HOSPITAL ENCOUNTER OUTCOMES RELATED TO FENTANYL USE IN PATIENTS 18 AND UNDER (WRMC 2026) - "The rise in pediatric substance use underscores the urgent need for healthcare providers to better recognize, refer, and treat these cases. Emergency department presentations involving fentanyl-laced pills, including counterfeit Percocet and Xanax, are a significant part of this emerging crisis. Increasing public access to naloxone is a crucial step in preventing these opioid overdoses from becoming fatal."

Clinical • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Mood Disorders • Respiratory Diseases

Opioid Prescribing Patterns of Board-Certified Emergency Physicians Compared With Other Physicians Practicing Emergency Medicine Among Medicare Part-D Beneficiaries Between 2018 and 2020 in the United States. (PubMed, J Am Coll Emerg Physicians Open) - "The average total day supply (TDS) of opioids per beneficiary for the 4 most common opioids (acetaminophen/codeine, hydrocodone/acetaminophen, oxycodone/acetaminophen, tramadol) was estimated using generalized linear models with Poisson distribution, log-link, and individual clustering and compared by board certification in EM status. Board certification in EM was associated with lower opioid prescribing rates. The average TDS of opioids per Medicare beneficiary was lower for board-certified EM physicians compared to non-EM board-certified physicians staffing EDs between 2018 and 2020."

Journal • Medicare • Reimbursement • US reimbursement • Pain

Application of Time-Point Matching Preventive Analgesia Based on Pain Trajectories in Patients Undergoing Pulmonary Tuberculosis Surgery (ChiCTR) - P=N/A | N=86 | Not yet recruiting | Sponsor: Chengdu Public Health Clinical Medical Center; Chengdu Public Health Clinical Medical Center

New trial • Infectious Disease • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

PANDA: Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial (clinicaltrials.gov) - P2 | N=287 | Completed | Sponsor: Washington University School of Medicine | Recruiting ➔ Completed | Trial completion date: Jun 2025 ➔ Sep 2025 | Trial primary completion date: Jan 2025 ➔ Jul 2025

Head-to-Head • Trial completion • Trial completion date • Trial primary completion date • Gynecology

Association between oxycodone-acetaminophen use and acute kidney injury in patients with lower extremity fractures: A retrospective cohort study. (PubMed, Medicine (Baltimore)) - "The use of oxycodone-acetaminophen within 48 hours of hospitalization may increase the risk of AKI in patients with lower extremity fractures. However, further randomized controlled trials are needed to elucidate this relationship."

Journal • Observational data • Retrospective data • Acute Kidney Injury • Critical care • Musculoskeletal Diseases • Nephrology • Orthopedics • Renal Disease

The effect of dexmedetomidine nasal spray combined with thoracic paravertebral nerve block on sleep and pain in patients with herpes zoster neuralgia (ChiCTR) - P4 | N=70 | Recruiting | Sponsor: Jiangsu Provincial People's Hospital; Jiangsu Provincial People's Hospital

New P4 trial • Herpes Zoster • Neuralgia • Pain • Varicella Zoster

Longitudinal Pain Medication Use Among US Older Adults After a Hip Fracture. (PubMed, J Am Med Dir Assoc) - "Most older adults received pain medication after hip fracture, and multimodal opioid-containing regimens were most common. Most individuals who received a gabapentinoid immediately after SNF admission were co-prescribed an opioid. These findings suggest an urgent need for closer medication management in SNFs to ensure adequate pain control after hip fracture while minimizing potentially harmful analgesic combinations."

Journal • Musculoskeletal Diseases • Orthopedics • Pain

Opioid Utilization in Post-Tonsillectomy Pediatric Patients (AAO-HNSF 2025) - "Patients were prescribed ibuprofen and acetaminophen with oxycodone for breakthrough pain... Our findings indicate some demographic factors may affect oxycodone use post-tonsillectomy. Moreover, many caregivers lack information on safe opioid disposal. Tonsillitis was associated with greater oxycodone usage."

Clinical • Infectious Disease • Otorhinolaryngology • Pediatrics

Identification of N-pyrrolidino protonitazene in suspect tablets encountered at an international mail facility. (PubMed, J Forensic Sci) - "One of the United States Food and Drug Administration's (FDA) National Forensic Chemistry Center (NFCC) international mail facility (IMF) satellite laboratories received suspect light blue, round tablets debossed with "PERCOCET 5" on one side and half score on the other side...This finding is alarming considering that this compound reportedly has 25 times the potency of fentanyl...Since first being identified in these tablets, N-pyrrolidino protonitazene has been encountered with increasing regularity by this laboratory in other tablets with different colors, shapes, and markings. This compound has also been identified in tablets containing other drug substances."

Journal

Does Liposomal Bupivacaine Reduce Postoperative Opioid Use in Tissue Expander Based Breast Reconstruction? (PSTM 2025) - "Opioid prescriptions were confirmed through the New York Prescription Monitoring Program (PMD) and converted into morphine equivalent doses (MED) for comparison...Patients prescribed multiple opioid types (e.g., Percocet + Tramadol or Percocet + Oxycodone) had higher MED and total opioid prescriptions than those prescribed a single opioid type (p<0.05), emphasizing the impact of combination opioid therapy on overall consumption... The use of Exparel regional blocks significantly reduces postoperative opioid consumption and total opioid prescriptions following tissue expander-based breast reconstruction compared to Marcaine. This is likely due to Exparel's extended analgesic effect during the critical early postoperative period, when pain is most severe. These findings align with previous studies demonstrating the efficacy of Exparel in reducing opioid use across various surgical procedures."

Addiction (Opioid and Alcohol) • Anesthesia • Constipation • Gastroenterology • Gastrointestinal Disorder

Comment on: Evaluation of the analgesic effect of a combination of oral acetaminophen and oxycodone after extracorporeal shock wave lithotripsy (SWL). (PubMed, Urologia) - No abstract available

Journal • Pain

Assessing Clinician Compliance with The Office of the Inspector General (OIG) Recommended Follow-Up for Long-Term Opioid Therapy (PAINWeek 2025) - "The most common opioid initiated for long-term opioid therapy was tramadol (36.4%), followed by hydrocodone/acetaminophen (19.3%), oxycodone (18.6%), and buprenorphine (16.4%). A total of 159 patients were initially identified for review based on meeting enrollment criteria for chronic opioid therapy between July 1, 2022 to July 1, 2024. Of those patients, 5 were excluded due to off-label opioid use disorder treatment or death prior to the end of the 90-day follow-up period. Additionally, 14 patients were excluded as the prescription for the long-term opioid therapy originated from a community care provider and therefore risk mitigation strategies were not required by a VA provider."

Clinical • Compliance • Back Pain • CNS Disorders • Musculoskeletal Pain • Pain • Substance Abuse

No-PAIN: NSAID Use After Robotic Partial Nephrectomy (clinicaltrials.gov) - P2 | N=110 | Recruiting | Sponsor: University of Miami | Trial completion date: Sep 2025 ➔ Sep 2026 | Trial primary completion date: Sep 2025 ➔ Sep 2026

Trial completion date • Trial primary completion date • Genito-urinary Cancer • Kidney Cancer • Oncology • Pain • Renal Cell Carcinoma • Solid Tumor

Prescription Trends by Orthopedic Surgery Provider: Review of the Medicare Part D Prescribers - by Provider and Drug, 2013-2021. (PubMed, Orthopedics) - "In line with national guidelines, claims for NSAIDs are increasing and claims for opioid pain medications and AOMs are decreasing. Claims for outpatient antibiotics are increasing, which is of significant concern, given renewed focus on antibiotic stewardship."

Journal • Medicare • Reimbursement • Review • US reimbursement • Orthopedics • Pain

Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone (clinicaltrials.gov) - P2 | N=121 | Recruiting | Sponsor: Stanford University | Trial completion date: Aug 2026 ➔ Aug 2027 | Trial primary completion date: Feb 2026 ➔ Feb 2027

Trial completion date • Trial primary completion date • Immunology • Osteoarthritis • Pain • Rheumatology

Outcomes After Implementation of an Enhanced Recovery Protocol for Minimally Invasive Repair of Pectus Excavatum. (PubMed, Am Surg) - "Use of narcotic patient-controlled analgesia (PCA) was nearly halved after ERAS implementation (50.0% vs. 97.2%), and total oxycodone, Percocet, and Dilaudid dosages were significantly reduced. Implementation of an ERAS protocol was associated with significant reductions in overall hospital length of stay, ICU utilization, and inpatient opioid consumption following Nuss repair of pectus excavatum. These changes in post-op management are expected to reduce costs and promote earlier return to school and activities."

Journal • Critical care • Pain • Pediatrics

Trial to Assess the Efficacy and Safety During Convective Radiofrequency Water Vapor Thermal Therapy (REZUM) for Benign Prostate Hyperplasia (clinicaltrials.gov) - P3 | N=48 | Not yet recruiting | Sponsor: University of Manitoba

Head-to-Head • New P3 trial • Anesthesia • Benign Prostatic Hyperplasia

Outpatient hybrid intracavitary-interstitial brachytherapy for cervical cancer with minimal sedation in a freestanding setting. (PubMed, Gynecol Oncol Rep) - "The patients were treated using minimal sedation (oral lorazepam and oxycodone/acetaminophen). Combining intracavitary and interstitial implants using a hybrid applicator appears to be feasible, efficient and safe in an outpatient freestanding clinic. Further studies are warranted."

Journal • Anesthesia • Cervical Cancer • Oncology • Solid Tumor

Therapeutic Efficacy of Oxycodone/Acetaminophen Combined with Bisphosphonates in Bone Metastasis-Induced Cancer Pain and Its Modulation of Pain-Related Mediators (ChiCTR) - P4 | N=60 | Not yet recruiting | Sponsor: Quzhou People Hospital; Quzhou People Hospital

New P4 trial • Oncology • Pain • Solid Tumor

A RARE CASE OF ACUTE ON CHRONIC PAIN IN SETTING OF LUMBAR SPINAL STENOSIS AND MULTIPLE SCLEROSIS (ASRA-SPRING 2025) - "Here, we present a case of lumbar spinal stenosis and associated radiculopathy in a patient with MS causing diagnostic difficulty CASE PRESENTATION A 47-year-old female with history of multiple sclerosis (diagnosed in 2003) on Ozanimod, L5-S1 spinal stenosis on cyclobenzaprine, tizanidine, and gabapentin, prior radiculopathy and myofascial pain - having received multiple trigger point injections with lidocaine over bilateral cervicothoracic paraspinals and prior TFESI (Transforaminal Lumbar Epidural Steroid Injections) in 2015, presented to the emergency department in 2024 with shooting pain starting at her right hip progressing down the back of her leg with associated numbness on the right ankle and foot...She was started on a multimodal pain regimen including oxycodone 5 mg, acetaminophen 975 mg, ibuprofen 800 mg, lidocaine patch, gabapentin 600 mg, cyclobenzaprine 10 mg, duloxetine 30 mg and hydromorphone for breakthrough pain...This case highlights the importance of..."

Clinical • CNS Disorders • Inflammation • Multiple Sclerosis • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain