d3-testosterone (AVA-291) / Aviva Biopharm - LARVOL DELTA

Effects of AVA-291 (d3-testosterone) versus testosterone on MCF-7 estrogen receptor positive breast cancer cells - lack of aromatization to estradiol leads to a highly differentiated cellular proliferation profile (AACR 2026) - "We demonstrate that T has a proliferative effect on the ER+ BC cell line MCF-7 and that AVA-291, a non-aromatizing form of T, did not stimulate cell proliferation at similar concentrations. These findings confirm prior literature reports on this effect by T and the purported underlying mechanism of androgen aromatization by MCF-7 ER+ BC cells. These results suggest that AVA-291 may be a useful alternative to T in clinical situations where the aromatization of T limits its therapeutic potential, such as hormone replacement therapy in postmenopausal women."

Breast Cancer • Estrogen Receptor Positive Breast Cancer • Hormone Receptor Breast Cancer • Oncology • Solid Tumor • AR • ER