cephalexin / Generic mfg. - LARVOL DELTA

Performance of the Self-Controlled Case Series With Active Comparators for Drug Safety Signal Detection Using the Clinical Practice Research Datalink (CPRD). (PubMed, Pharmacoepidemiol Drug Saf) - "Using a carefully designed reference set of drug-outcome pairs well suited to the study design, the SCCS performed moderately well for signal detection in CPRD. Whilst active comparators effectively reduced confounding by indication, they also reduced the number of correctly identified positive controls, due to a reduction in power. We showed some evidence that SCCS is able to highlight SDRs before they were present on labels."

Journal

Photodynamic Inactivation Enhances Antibiotic Efficacy Without Affecting Drug Stability: Insights into Photosensitizer-Antibiotic Combination Therapies. (PubMed, Int J Mol Sci) - "In this study, the tetracationic 5,10,15,20-tetra(4-N,N,N-trimethylammoniophenyl)porphyrin (TMAP4+) was evaluated in combination with ATBs: ampicillin (AMP) and rifampicin (RIF) against Staphylococcus aureus and cephalexin (CFX) against Escherichia coli. Growth curve analyses corroborated these results, showing delayed bacterial growth and decreased maximal optical densities in the combined treatments compared to single agents. Overall, these findings demonstrate that the photodynamic process can potentiate the antimicrobial effect of conventional ATBs without compromising their stability, supporting the potential of PS-ATB combination therapies as a valuable approach to improve antibacterial efficacy and mitigate ATB resistance."

Journal

Reactive oxygen species-sensitive release of cephalexin from hyaluronic acid-g-cephalexin dimer copolymer for treatment of inflammation and infection of oral soft tissue cells. (PubMed, Sci Rep) - "HAgCPX nanoparticles showed antimicrobial activity in vitro against various oral microbials as well as free CPX. We suggested that HAgCPX nanoparticles are promising candidate for ROS-specific and CD44 receptor-mediated delivery of drugs against inflammatory of oral soft tissue cells."

Journal • Infectious Disease • Inflammation • CD44

Cephalexin-Induced Hemolytic Anemia and Renal Failure: A Case Report and Review of the Literature. (PubMed, Cureus) - "This case highlights the importance of considering this rare adverse reaction to cephalexin when a patient presents with findings suggestive of intrarenal acute kidney injury. Early recognition can expedite the diagnostic workup and treatment, potentially improving outcomes."

Journal • Acute Kidney Injury • Anemia • Hematological Disorders • Infectious Disease • Nephrology • Renal Disease • HP

Reduction of surgical-site infections and improvement of scar parameters with a uniform fractional ultra-pulse CO₂ laser protocol in cosmetic surgery: a five-center retrospective cohort. (PubMed, Front Med (Lausanne)) - "A multicenter retrospective cohort enrolled 562 adults undergoing elective rhinoplasty, liposuction, breast augmentation, facelift, abdominoplasty, or Botox...All patients followed a five-day antibiotic regimen (oral cefalexin + topical mupirocin)...Standardized fractional ultra-pulse CO₂ laser therapy reduces SSIs, improves scar outcomes, and enhances patient satisfaction in cosmetic surgery. These findings support wider adoption of laser protocols, warranting further prospective, pathogen-specific research."

Journal • Retrospective data • Aesthetic Medicine • Cardiovascular • Fibrosis • Infectious Disease

Unraveling the potential of metal-organic frameworks for antibiotic remediation: From molecular interactions to real-world challenges. (PubMed, Chemosphere) - "Zr-based MOFs such as PCN-777 and MOF-525 exhibit exceptional adsorption capacities, 442.48 mg/g for cephalexin and up to 860 mg/g for tetracycline, surpassing conventional adsorbents like activated carbon. Key challenges, including hydrolytic instability, metal ion leaching, performance reduction in complex matrices, regeneration inefficiencies, and the limited representativeness of single-compound studies in predicting field-scale behavior, are critically evaluated. By linking mechanistic understanding with operational challenges, this work provides a targeted roadmap for developing water-stable, regenerable MOFs capable of delivering scalable and sustainable antibiotic remediation in diverse and challenging wastewater environments."

Journal • Real-world evidence • Review

Trends in Community Antibiotic Dispensing for Children and Young People in Aotearoa New Zealand, 2010-2019: Implications for Antimicrobial Stewardship. (PubMed, J Paediatr Child Health) - "These findings suggest an overall improvement in prescribing practices, likely due to the adoption of antimicrobial stewardship programmes. Further study is under way to understand the reasons for and any risks associated with, high community rates of cefalexin dispensing."

Journal

Collaboration to harmonize antimicrobial registry measures (CHARM) database analysis of antibiotic prescribing in urgent and non-urgent care: a retrospective study on demographic factors. (PubMed, Antimicrob Steward Healthc Epidemiol) - "Amoxicillin was the most prescribed antibiotic in urgent care (17.4% vs 11.4%, p < .001), while cephalexin led in non-urgent care (13.5% vs 11.5%, p < .001). Comparatively, a larger proportion of urgent care visits were for patients under the age of 18 and for patients with URTIs. Meanwhile, a greater proportion of non-urgent care encounters were for patients over the age of 60 years old and patients with unspecified UTI."

Journal • Retrospective data • Infectious Disease • Nephrology • Otorhinolaryngology • Respiratory Diseases

The Role of Chitosan-Based Materials in Interactions with Antibiotics: An Overview of In Vitro and In Silico Studies. (PubMed, Int J Mol Sci) - "Since covering all the antibiotics that can be found in the environment would be an overwhelming task, we concentrated our efforts on describing the studies related to the removal of tetracycline, ciprofloxacin, cephalexin, and azithromycin, which are perhaps the most ubiquitous ones. In addition, we also review in silico studies that have been carried out to obtain molecular-level insights into the interactions between chitosan-based adsorbents and the four mentioned antibiotics. Particular emphasis is placed on our recent computational work regarding the adsorption of tetracycline by various chitosan-based materials."

Journal • Preclinical • Review

Practice Patterns in the Management of Preseptal and Orbital Cellulitis: A National Survey. (PubMed, Hosp Pediatr) - "There is limited consensus on diagnostic tests, subspeciality consultation, and empirical antibiotic therapy for preseptal and orbital cellulitis. This survey provides insight into health system-level usage that highlights the need to develop a clinical practice guideline to help standardize management."

Journal • Dermatology • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Pediatrics • CRP

Influence of mixing time and agitation speed on partitioning and mass transfer coefficient of cephalexin in aqueous two-phase systems. (PubMed, Sci Rep) - "The finding shows an enhanced mixing speed and longer mixing durations improved both partitioning and mass transfer, with mass transfer coefficients determined as 0.093 min⁻¹ and 0.0898 min⁻¹ for the respective systems at the optimum conditions; a correlation relating mixing speed to the mass transfer coefficient is also proposed. Consequently, the results emphasize that mixing conditions substantially influence ATPS mass transfer kinetics and highlight the importance of kinetic considerations alongside equilibrium properties."

Journal

Some Virulence-Associated Genes of Proteus Isolates Could Predict Antibiotic Susceptibility and Even Infection Source. (PubMed, Int J Microbiol) - "Maximum frequency of resistance was detected against trimethoprim-sulfamethoxazole combination in P. mirabilis isolates and against cefalexin in P. vulgaris isolates...Amikacin, tobramycin, and meropenem were introduced as the most effective antibiotics against Proteus isolates. Our finding primarily introduced some VAGs as biomarkers for predicting antibiotic susceptibility and also in order to differentiate Proteus isolates. However, it has to be confirmed through complementary studies later."

Journal • Infectious Disease

Laxative-induced contact burns from accidental ingestion of senna in a 2-year-old female. (PubMed, JPGN Rep) - "In the emergency department, the blisters were treated by unroofing, topical mupirocin application, a petrolatum dressing, and a 5-day course of oral cephalexin. Inquiries about sennoside use should be made when perineal burns are observed in pre-continent children to prevent misdiagnosis of child abuse. Preventive measures, including caregiver education, child-resistant packaging, and safe medication storage, are essential."

Journal • Constipation • Dermatology • Gastroenterology • Gastrointestinal Disorder • Pain • Pediatrics • Thermal Injury

The impact of day care attendance on antibiotic use among children aged 0-12 years: A population-based register study. (PubMed, PLoS One) - "Four most commonly prescribed antibiotics were amoxicillin, azithromycin, cefalexin, and amoxicillin with beta-lactamase inhibitor. Regardless of the number siblings, the number of cumulative antibiotic purchases remained lowest in the group of children with the longest home care period, and the results remained robust after controlling for the mother's age and education, and immigrant background. These findings contribute to a broader understanding of how early childhood care arrangements may be associated with long-term patterns of antibiotic use, with potential relevance for public health planning and antimicrobial stewardship."

Journal • Infectious Disease

Performance of the Self-Controlled Case Series With Active Comparators for Drug Safety Signal Detection Using Merative MarketScan Research Databases. (PubMed, Pharmacoepidemiol Drug Saf) - "MarketScan databases are potentially suitable for drug safety signal detection due to their large size and information contained. Using a carefully designed reference set of drug-outcome pairs well suited to the study design, the SCCS, while imperfect, performed comparably to optimal settings identified in previously published studies. Active comparators did not enhance overall performance but showed improved specificity by better controlling confounding by indication at the cost of reduced sensitivity."

Journal

A comprehensive descriptive, predictive, and prescriptive analysis of antibiotic products' demand pre-, amid, and post-COVID-19 in Iran. (PubMed, Sci Rep) - "The proposed data analytical approach is employed to analyze the consumption rate of the 73 popular antibiotic products belonging to the top-11 list of antibiotics in Iran, including Amoxicillin, Co-amoxiclav, Azithromycin, Cefalexin, Cefixime, Ciprofloxacin, Clindamycin, Doxycycline, Levofloxacin, Metronidazole, and Penicillin. The results showed the considerable impacts of COVID-19 on the consumption trend of Amoxicillin and Azithromycin, a decline in Penicillin parental consumption in 2021 due to COVID-19 vaccination, and a higher share of parental Levofloxacin during COVID-19. In addition, several prescriptive analyses are proposed."

Journal • Infectious Disease • Novel Coronavirus Disease

Traceability and Characteristic Investigation of Burkholderia Gladioli Bloodstream Infection in Patients with Hematologic Malignancies (ASH 2023) - "Antibiotic susceptibility tests revealed that the clinical strains were susceptible to cefazoxime, ciprofloxacin, levofloxacin, trimethoprim/sulfamethoxazole, cefalexin, cefoperazone/sulbactam, meropenem, imipenem, piperacillin/tazobactam, amikacin, tobramycin, minocycline hydrochloride, tigecycline and resistant to polymyxinB, ampicillin, cefazolin, cefuroxime, aztreonam, and cefoxitin. Foodborne B. gladioli strains in this study exhibited low toxicity and high thermal stability and caused opportunistic bloodstream infections of hematologic malignant patients in immunodeficient states, which deserves our attention. Its special biological characteristic might be attributed to whole and partial loss of toxigenic gene clusters. Clinical B gladioli strains are resistant to polymyxinB, but the standard B gladioli strain and lethal B gladioli strain are susceptible to it, indicating acquired resistance during colonization and empirical antibiotic therapy."

Clinical • Cystic Fibrosis • Febrile Neutropenia • Genetic Disorders • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Neutropenia • Oncology • Primary Immunodeficiency • Respiratory Diseases

Female Hemophilia in a Set of Triplets (ASH 2023) - "She had staphylococcal scalded skin syndrome and was treated with vancomycin and cephalexin. We presented three infant-triplets-with factor VIII deficiency; infant #1 and infant #2 have severe HA. Infant #3 is an asymptomatic carrier. They all have the same mutation as their asymptomatic carrier mother."

Dermatology • Genetic Disorders • Hematological Disorders • Hemophilia • Hemophilia A • Infectious Disease • Rare Diseases • Steven-Johnson Syndrome • Turners Syndrome

Salmonellosis Outbreak in a Rottweiler Kennel Associated with Raw Meat-Based Diets. (PubMed, Animals (Basel)) - "The isolate was susceptible to some antimicrobial agents but resistant to cephalexin, aminoglycosides, lincosamides, macrolides, and fusidic acid, and showed intermediate susceptibility to polymyxin B. Following discontinuation of raw meat feeding, targeted antimicrobial therapy, and environmental disinfection, all dogs recovered, and subsequent tests for Salmonella spp., were negative...The findings emphasise the importance of feed safety, biosecurity, and traceability of feed sources in kennels, as well as the potential zoonotic risk associated with raw feeding practices. The diagnostic and therapeutic measures implemented in this case provide an effective model for managing similar epidemiological events within the One Health framework."

Journal • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Psychiatry

Green synthesis of CuO nanoparticles using thyme extract and their application as cephalexin carriers against Klebsiella pneumoniae. (PubMed, Nanoscale Adv) - "Moreover, the cephalexin-copper oxide nanocomposite achieved complete bacterial inhibition at an optimal concentration of 30 mg ml-1, while biofilm formation inhibition tests identified 20 mg ml-1 as the optimal concentration for suppression of pulmonary biofilm generation by Klebsiella pneumoniae. These findings underscore the potential of the cephalexin-CuO nanocomposite as a promising candidate for the development of innovative antibacterial and antioxidant solutions."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Evaluating antimicrobial prescriptions in primary health care across an entire Brazilian city through the analysis of electronic medical records: where public health and data science converge. (PubMed, BMC Med Inform Decis Mak) - "Implementing a system that can extract data directly from electronic records and automatically present it in a logical and relevant way to health professionals-including policymakers and administrators-would enable the identification of potential problems, the planning of interventions to improve antimicrobial use, and the monitoring of their impact. Our findings highlight opportunities to improve antimicrobial prescribing through data-driven tracking, analysis, and feedback mechanisms."

Journal • Dental Disorders • Infectious Disease • Nephrology • Periodontitis • Respiratory Diseases • Urology

A Rare Case of Mycobacterium abscessus Peritoneal Dialysis-Associated Peritonitis (KIDNEY WEEK 2025) - "The patient was initially treated with oral antibiotics, and shortly after, with vancomycin through her PD catheter and Keflex...The patient began hemodialysis (HD) thrice weekly and was initiated on an antibiotic regimen of 500 mg azithromycin daily, 300 mg omadacycline daily, 500 mg IV imipenem every 12 hours, and amikacin...The described treatment plan for M. abscessus PD-associated peritonitis highlights the importance of culture-directed antibiotic therapy, particularly that of an amikacin-led regimen. This case additionally emphasizes the need for multiple modalities of dialysis, as removal of the contaminated catheter and proper recovery of the wound site prompted a switch to HD."

Clinical • Asthma • Chronic Kidney Disease • Constipation • Diabetic Nephropathy • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Nephrology • Nontuberculous Mycobacterial Disease • Renal Cell Carcinoma • Renal Disease • Respiratory Diseases

Poststreptococcal Crescentic Glomerulonephritis in a Kidney Transplant Recipient (KTR) (KIDNEY WEEK 2025) - "He was treated with cephalexin and had stable allograft function at the time (baseline sCr 1.8-2mg/dL)...He needed 2 sessions of hemodialysis, methylprednisolone pulse followed by a prednisone taper over 12 weeks, & an extended antibiotic course for 8 weeks...Our patient had a RPGN with crescents involving 50% of the glomeruli which prompted steroid therapy. Despite an initial need for dialysis, he eventually recovered kidney function, which highlights the importance of early histological diagnosis & aggressive management, including steroids, when crescents are present, & infection is controlled."

Clinical • Cardiovascular • Dermatology • Glomerulonephritis • Hypertension • IgA Nephropathy • Infectious Disease • Lupus Nephritis • Nephrology • Transplantation

Nutcracker Syndrome in an 11-Year-Old Girl with ADPKD (KIDNEY WEEK 2025) - "Urinalysis (UA) showed “large amounts of blood and some tissue” for which she was prescribed Cefdinir, and a renal US revealed new renal cysts and enlargement of previous cysts...She was again diagnosed with a UTI and discharged on Cephalexin...In this case, flank pain and hematuria were initially suspected to be caused by an enlarging, infected, or hemorrhagic cyst. Treatment of NCS in patients with ADPKD should involve an individualized approach and may require a lower threshold for more aggressive management, such as endovascular stenting or surgical intervention, as well as closer monitoring to preserve kidney function."

Autosomal Dominant Polycystic Kidney Disease • Genetic Disorders • Hematological Disorders • Nephrology • Pediatrics • Polycystic Kidney Disease • Renal Disease

A Cytokine Storm in Fungal Infection: Disseminated Histoplasmosis-Induced Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Recipient (KIDNEY WEEK 2025) - "Before admission, she had multiple ED visits for intermittent fevers, abdominal pain, and weakness and was treated empirically with IV antibiotics followed by oral Keflex with no benefit...The patient was started on itraconazole and anakinra...Secondary HLH has a very poor prognosis and an extremely high fatality rate. Early diagnosis with multidisciplinary care involving infectious disease and hematology services can potentially lead to improved outcomes."

Clinical • Cytokine storm • Bone Marrow Transplantation • Cerebral Hemorrhage • Glomerulonephritis • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Rare Diseases • Renal Disease • Subarachnoid Hemorrhage • Transplantation • IL2