EP004
/ Endpoint Health
- LARVOL DELTA
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January 26, 2024
Tissue Factor and Protease-Activated Receptor 2 associated genes are upregulated in patients with Inflammatory Bowel Disease
(ECCO-IBD 2024)
- "To address this safety concern, EP004, a human IgG1 monoclonal antibody, targets the extracellular domain of human TF, inhibiting PAR2-induced inflammatory signaling while not altering coagulation activity...Profiling Gene Expression Induced by Protease-Activated Receptor 2 (PAR2) Activation in Human Kidney Cells. PLOS ONE 5(11): e13809."
Clinical • Crohn's disease • Immunology • Inflammation • Inflammatory Bowel Disease • CXCL8 • CXCR1
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