Capoxigem (apricoxib) / Adastra Pharma - LARVOL DELTA

Strain-dependent susceptibility to prion infection encoded by Arg171 and Lys176 sheep-PrP polymorphic variants. (PubMed, J Infect Dis) - "These results indicate that the R171 and K176 polymorphic variants of the ovine PrP sequence restrict the propagation of prions in a strain-dependent manner and are useful tools for prion strain discrimination."

Journal • CNS Disorders • Infectious Disease

TPT2001: Discover an Addition to the Myelofibrosis Treatment Landscape (EHA 2025) - "Sponsored by GSK. This educational activity is supported by an unrestricted educational grant from GSK and organized by Bluprint Oncology."

Myelofibrosis

Revolutionizing localized prostate cancer treatment: Stereotactic radiotherapy "Moroccan experience". (PubMed, Arch Ital Urol Androl) - "The results of our study are consistent with the existing literature and support the safety and effectiveness of SBRT as a treatment option for localized prostate cancer (CaP). In the United States, both ASTRO and the NCCN recognize SBRT as a valid treatment option for localized CaP. Ongoing phase III trials are being conducted to further substantiate these long-term results and to establish SBRT as the future standard of care for localized CaP."

Journal • Gastrointestinal Disorder • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • Urethral Cancer • Urology

TG01 IND application filed in China by Circio’s partner IOVaxis Therapeutics (Circio Press Release) - "Circio Holding ASA...announces that partner IOVaxis Therapeutics of Nantong, China, has filed the updated TG01 investigational new drug (IND) application with the Chinese National Medical Products Administration (NMPA), with an expected review period of sixty days. IOVaxis has an exclusive option agreement to license mutant RAS cancer vaccines TG01 and TG02 for China, Hong Kong, Macau, and Singapore...Within two weeks of TG01 IND approval by the NMPA, IOVaxis may exercise its exclusive license option and trigger a USD 3m milestone payment to Circio....'Once we have the IND approval, we intend to initiate a phase 1 study in pancreatic cancer as soon as possible, and then rapidly expand to other KRAS indications and combinations'."

Licensing / partnership • New P1 trial • Gastrointestinal Cancer • Oncology • Pancreatic Cancer • Solid Tumor

The TG01 Study With TG01/QS-21 Vaccine in Patients With High-risk Smouldering Multiple Myeloma and Multiple Myeloma (clinicaltrials.gov) - P1/2 | N=20 | Recruiting | Sponsor: Oslo University Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Hematological Malignancies • Multiple Myeloma • Oncology • IFNG • KRAS • NRAS • RAS • TNFA

Chest Wall toxicity after lung SBRT treatments and influential parameters. (ESTRO 2023) - "In agreement with UK Consortium and AAPM TG101, BED calculation has considered dose to volume constrains as shown in table II and III...Structured information might be the standard way of reporting for efficient data mining. Further studies may include a radiomic analysis to evaluate bone density and its clinical relevance with rib failure."

Musculoskeletal Diseases • Orthopedics • Osteoporosis • Pain • Rheumatology

The TG01 Study With TG01/QS-21 Vaccine in Patients With High-risk Smouldering Multiple Myeloma and Multiple Myeloma (clinicaltrials.gov) - P1/2 | N=20 | Not yet recruiting | Sponsor: Oslo University Hospital

New P1/2 trial • Hematological Malignancies • Multiple Myeloma • Oncology • KRAS • NRAS • RAS

"@circio_asa #ASCO23 poster #PancreaticCancer #balstilimab #TG01 https://t.co/4FRYimg5wv" (@Aol123455)

Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor

TG01/GM-CSF and adjuvant gemcitabine in patients with resected RAS-mutant adenocarcinoma of the pancreas (ESMO 2017) - P1/2; "The regimen was generally well tolerated although some late, manageable allergic reactions were seen. OS and DFS was encouraging in view of published reports. TG01/GM-CSF generated early immune responses in 89% of patients with R0/R1 resected pancreatic cancer."

Clinical • Pancreatic Cancer

Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model. (PubMed, Acta Neuropathol Commun) - "Brain homogenates from spontaneously diseased transgenic mice were inoculated in several models to assess their transmissibility and characterize the prion strain generated: TgShI112 (ovine I112 ARQ PrP), Tg338 (ovine VRQ PrP), Tg501 (ovine ARQ PrP), Tg340 (human M129 PrP), Tg361 (human V129 PrP), TgVole (bank vole I109 PrP), bank vole (I109I PrP), and sheep (AHQ/ARR and AHQ/AHQ churra-tensina breeds). Our analysis of the results of these bioassays concludes that the strain generated in this model is indistinguishable to that causing atypical scrapie (Nor98). Thus, we present the first faithful model for a bona fide, transmissible, ovine, atypical scrapie prion disease."

Journal • Preclinical • CNS Disorders

Evaluation of Apricoxib (Selective Cyclooxygenase 2 Inhibition) in Modulating T Regulatory Cells of Patients With Early Stage Non-small Cell Lung Cancer (clinicaltrials.gov) - P=N/A; N=1; Terminated; Sponsor: Jonsson Comprehensive Cancer Center; N=40 ➔ 1

Clinical • Enrollment change • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • Thoracic Cancer

A phase I/II trial of TG01/GM-CSF and gemcitabine as adjuvant therapy for treating patients with resected RAS-mutant adenocarcinoma of the pancreas. (ASCO 2017) - P1/2; "TG01/GM-CSF generated early immune responses in 84% of patients with R0/R1 resected pancreatic cancer. The regimen was generally well tolerated although some late, manageable allergic reactions were seen. OS was encouraging in view of published reports."

Clinical • P1/2 data • Biosimilar • Immunology • Pancreatic Cancer

Extracting Organ-Specific Radiobiological Model Parameters of Abdominal Organs from Clinical Outcome Data for Biological Radiation Treatment Planning (ASTRO 2022) - "Materials/ Available clinical studies from the literature reporting dose volume constraints for abdominal organs, e.g., duodenum, stomach, small bowel, and rectum, along with the compiled data in available sources such as TG101, QUANTEC, HyTEC, national and institutional trial protocols were analyzed... We developed a robust method to successfully extract abdominal organ-specific radiobiological parameters from clinical data. These parameters can be used to convert OAR dose constraints from different RT fractionations/techniques for biologically optimized RT planning"

Clinical • Clinical data • Oncology • Vaginal Cancer

Identification and Characterization of a Multifunctional Biocontrol Agent, Streptomyces griseorubiginosus LJS06, Against Cucumber Anthracnose. (PubMed, Front Microbiol) - "Four bacterial strains, namely TG01, TG02, LJS06, and LJS08, were found to effectively reduce the mycelial growth of Colletotrichum orbiculare COC3 on PDA media. In addition, the spraying and drenching of diluted SL06 before inoculation consistently and significantly (p < 0.05) reduced anthracnose severity. These results jointly suggest that S. griseorubiginosus LJS06 can aid in the management of cucumber anthracnose by directly inhibiting conidial function and priming the plant defense system."

Journal

Utility of ctDNA to Manage Adjuvant Therapy in CRC Based on Results of the GALAXY Study - Episode 9: Ongoing Trials and Future Directions in CRC (Cancer Network) - "Drs. Cohen and...close by outlining ongoing clinical trials in CRC and hopes for the future of care."

Video

Overexpression of Oil Palm Early Nodulin 93 Protein Gene (EgENOD93) Enhances In Vitro Shoot Regeneration in Arabidopsis thaliana. (PubMed, Mol Biotechnol) - "Experiments using leaf explants revealed higher numbers of regenerated shoots at day 27 in all the homozygous transgenic Arabidopsis cultures (Tg01, Tg02 and Tg03) compared to controls. This together with the previous results observed in oil palm and Medicago truncatula suggests that ENOD93 plays a key role in the induction of somatic embryogenesis. A similarity to early nodulation-like ontogeny is possible."

Journal • Preclinical

LITE SABR M1: Planning design and dosimetric endpoints for a phase I trial of lattice SBRT. (PubMed, Radiother Oncol) - P=N/A | "Lattice SBRT planning techniques produce consistent and efficient treatment plans. Refined techniques described here further improve the quality of the planning technique."

Journal • P1 data • Oncology

[VIRTUAL] Dosimetric Comparison of Single-Isocenter and Multiple-Isocenter Techniques for Two-Lesion Lung SBRT Using the RefleXion High-Speed Ring-Gantry System (ASTRO 2021) - "Treatment doses were in accordance with AAPM TG101 criteria (50Gy in 5 fractions) and planned such that 95% of the planning target volume (PTV) would receive at least 95% of the prescription dose... This study shows that a single-isocenter technique for the scenario of two lung lesions is dosimetrically feasible and clinically efficient with the RefleXion X1 in SBRT mode. Single-isocenter treatment delivery techniques may be a desirable option for efficient radio-ablative therapies directed at multiple metastatic targets."

Oncology

Dosimetric Comparison of Single-Isocenter and Multiple-Isocenter Techniques for Two-Lesion Lung SBRT Using the RefleXion High-Speed Ring-Gantry System. (PubMed, Int J Radiat Oncol Biol Phys) - "This study shows that a single-isocenter technique for the scenario of two lung lesions is dosimetrically feasible and clinically efficient with the RefleXion X1 in SBRT mode. Single-isocenter treatment delivery techniques may be a desirable option for efficient radio-ablative therapies directed at multiple metastatic targets."

Journal • Oncology

Identification of potential candidate genes for lip and oral cavity cancer using network analysis. (PubMed, Genomics Inform) - "VEGFA, IL6, MAPK3, INS, TNF, MAPK8, MMP9, CXCL8, EGF, and PTGS2 were recognized as network hub genes using the maximum clique centrality algorithm available in cytoHubba, and nine potential drug candidates (ranibizumab, siltuximab, sulindac, pomalidomide, dexrazoxane, endostatin, pamidronic acid, cetuximab, and apricoxib) for lip and oral cavity cancer were identified from the DGIdb database. Gene enrichment analysis was also performed to identify the gene ontology categorization of cellular components, biological processes, molecular functions, and biological pathways. The genes identified in this study could furnish a new understanding of the underlying molecular mechanisms of carcinogenesis and provide more reliable biomarkers for early diagnosis, prognostication, and treatment of lip and oral cavity cancer."

Journal • Lip Cancer • Oncology • Oral Cancer • CXCL8 • IL6 • MAPK3 • MAPK8 • MMP9 • PTGS2

MicroRNA Alterations in a Tg501 Mouse Model of Prion Disease. (PubMed, Biomolecules) - "Minimal changes observed before the disease onset suggests that most miRNA alterations observed here are driven by advanced prion-associated pathology, possibly limiting their use as diagnostic markers. However, the results encourage further mechanistic studies on miRNA-regulated pathways involved in these neurodegenerative conditions."

Journal • Preclinical • CNS Disorders • Immunology • MIR144 • MIR146A • MIR223 • PCR

Learning Deficits Accompanied by Microglial Proliferation After the Long-Term Post-Injection of Alzheimer's Disease Brain Extract in Mouse Brains. (PubMed, J Alzheimers Dis) - "These results potentially implicate tau propagation in functional decline and indicate that long-term changes in non-mutated tau mice may reflect human pathological conditions."

Journal • Alzheimer's Disease • CNS Disorders

Expanding Immunoscore clinical utility on 3000+ stage III colon cancer patients (GlobeNewswire) - "The objectives of the new Immunoscore® study announced today are to consolidate results obtained in the Immunoscore-IDEA France study for its predictive and prognostic performance in additional independent series. Moreover, the study will investigate Immunoscore® performance in CAPOX treated patients, in order to assist oncologists to select optimal adjuvant chemotherapy regimen for individual patients. The study will be conducted in 3000 patients receiving either FOLFOX or CAPOX chemotherapy."

Diagnostic • Colon Cancer • Gastrointestinal Cancer • Oncology

Distribution of Zinc in Mycelial Cells and Antioxidant and Anti-Inflammatory Activities of Mycelia Zinc Polysaccharides from Thelephora ganbajun TG-01. (PubMed, Oxid Med Cell Longev) - "By establishing zebrafish models, we found that MZPS-2 can significantly scavenge free radicals, reduce the generation of reactive oxygen species caused by inflammation, and inhibit the recruitment of neutrophils toward the injury site. Therefore, MZPS-2 exhibited antioxidant and anti-inflammatory effects and can be used as a zinc supplement with specific biological activities to alleviate zinc deficiency complications, such as chronic oxidative stress or inflammation."

Journal • Immunology

Apricot-P: A randomized placebo-controlled phase II study of COX-2 inhibitor apricoxib or placebo in combination with gemcitabine and erlotinib in advanced or metastatic adenocarcinoma of the pancreas. (2012 Gastrointestinal Cancers Symposium) - P2, N=109; NCT00709826; The apricoxib containing arm had increased GI toxicity including GI hemorrhage; Although the primary endpoint was not met, overall survival in patients with a PGEM response to COX-2 inhibition favored addition of apricoxib

P2 data • Oncology • Pancreatic Cancer