mosedipimod (EC-18) / Enzychem Lifesci - LARVOL DELTA

Development of a senescence-related lncRNA signature in endometrial cancer based on multiple machine learning models. (PubMed, Front Genet) - "Paclitaxel, gemcitabine, and cisplatin (all p < 0.05) may be more useful in EC patients with high expression of targeted srlncRNAs in the GDSC database. The EC-18 PDO was more resistant to three drugs, which aligned with clinical observation. The srlncRNA signature (AL121906.2, AP002761.4, BX322234.1, LINC00662, LINC00908, VIM-AS1, and ZNF236-DT) could guide prognosis prediction and treatment choices for EC patients."

IO biomarker • Journal • Endometrial Cancer • Oncology • Solid Tumor • VIM-AS1 • ZKSCAN1 • ZNF23

Virulence patterns of Colletotrichum truncatum isolates causing soybean anthracnose disease and identification of resistance sources. (PubMed, BMC Plant Biol) - "In the current study, a total of sixty isolates of C. truncatum were tested for their virulence against three soybean genotypes viz., EC 18,596, JS 20-34, and JS 95 - 60...The remaining 49 genotypes were included in cluster VIIb. Diverse resistant genotypes will further be utilized in breeding for anthracnose resistant varieties."

Journal

Detection of local ventilation defects using xenon-enhanced dynamic dual-energy CT (ERS 2025) - "Methods Six anesthetised New Zealand rabbits [2.6 ± 0.2 (SD) kg] were mechanically ventilated (EC 18-272-15)...During bronchoconstriction, sV in VDF areas was 0.30 ± 0.13, compared to 0.44 ± 0.08 outside the VDF areas, p=0.021. Conclusion This study shows the potential of Xe-DECT for quantitative studies of local ventilation defects in healthy and pathologic in vivo rabbit lungs."

Anesthesia

A Two-Stage Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Ec-18 in Altering the Severity and Course of Oral Mucositis Secondary to Chemoradiation Therapy for Squamous Cell Cancers of the Head and Neck. (PubMed, Cancers (Basel)) - "EC-18 administered orally may be a safe and effective CRT-associated SOM intervention in patients with HNC."

Clinical • Journal • P2 data • Head and Neck Cancer • Mucositis • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • Stomatitis

EC-18 Abnormal Involuntary Movement: AIM ~Focusing on Videos~ (JSNE 2025) - "In the EEG of acute impairment of consciousness and acute symptomatic seizures, differences in the degree of neuronal and astrocyte damage, and the juxtaposition of cerebral ischemia and metabolic disorders are more complicated by differences in pathophysiology compared to chronic intractable epilepsy. The purpose of this course is to 1) clarify the differences in the characteristics and interpretation of EEG between chronic epilepsy and critical care, 2) to be able to appropriately reflect the results of EEG interpretation in general clinical practice in diagnosis and treatment according to the etiological etiology, and 3) to deepen understanding by presenting the actual reading of both types mainly in the form of case studies."

Cardiovascular • CNS Disorders • Dystonia • Epilepsy • Metabolic Disorders • Movement Disorders

Experiences in setting up a transitional care process in patients with differences in sex development and congenital adrenal hyperplasia in a tertiary care centre of a low-middle-income country (ESPE-ESE 2025) - "The process is also hindered by logistical issues with rescheduling and coordination of joint care meetings in low resource settings, and absence of specialized services and medicine in local hospitals. However, ways of overcoming the challenges identified are important for successful transition which is crucial for optimizing long-term patient care."

Clinical • Congenital Adrenal Hyperplasia • Endocrine Disorders • Mood Disorders • Pediatrics • Psychiatry

Subcutaneous inoculation of Escherichia coli in broiler chickens causes cellulitis and elicits innate and specific immune responses. (PubMed, BMC Vet Res) - "Inoculation of E. coli caused cellulitis and prompted a rapid activation/redistribution of circulating monocytes followed by antibody production. The responses were most pronounced in chickens inoculated with E. coli strain ECB11, presumably because of a higher virulence."

Journal • Dermatology • MRC1

Enzychem Life Sciences, 'EC-18' reveals anticancer efficacy in non-small cell lung cancer animal model [Google translation] (Hankyung) - "Global new drug development company Enzychem Lifesciences...announced on the 28th that a paper was published in 'Biomedicine & Pharmacotherapy' (Impact Factor: 6.9), an internationally renowned academic journal (SCI) in the top 10% in the pharmacology and pharmaceutical field, after discovering anticancer efficacy in a non-clinical study of an animal model of non-small cell lung cancer (NSCLC). According to the research paper, EC-18 reduced tumor size and improved the survival rate of mice by suppressing excessive neutrophil infiltration in a mouse model transplanted with LLC-1 cells, a non-small cell lung cancer cell line. In addition, the combined administration of EC-18 and a PD-1 immune checkpoint inhibitor (aPD-1) showed a synergistic effect of anticancer treatment by regulating the T cell population in the tumor microenvironment (TME)."

Preclinical • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

To Determine the Dose-dependent Efficacy and Safety of EC-18 in Patients With Moderate or Severe Atopic Dermatitis (clinicaltrials.gov) - P2 | N=150 | Not yet recruiting | Sponsor: Enzychem Lifesciences Corporation

New P2 trial • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • IL17A • IL6

Effect of Different Yeasts on the Higher Alcohol Content of Mulberry Wine. (PubMed, Foods) - "The total higher alcohol content in fermented mulberry wine was 298 mg/L, which was 41.9% lower than that of fermented mulberry wine with yeast EC118...Considering the correlation values among increased alcohol, decreased sugar, and related amino acids, the very slight difference suggests that both sugar anabolism and amino acid catabolism pathways have an equivalent impact on the synthesis of higher alcohols during the fermentation of mulberry wine. These results provide a theoretical basis for reducing the content of higher alcohols in mulberry wines, given the history and foundation for producing mulberry wine."

Journal

Comparative Analysis of Wild-type and Triple Gene-knockout Pig Red Blood Cell Transfusions in Non-human Primates: Therapeutic Efficacy and Immunological Responses (FOCIS 2024) - "WT and TKO pRBC transfusions initially improved hematologic parameters, but rapid pRBC clearance followed. TKO pRBCs had less impact on liver function than WT. Despite initial benefits, strong antibody responses and potential adverse reactions highlight risks in xenotransfusion."

Clinical • Immunology

Single-cell Transcriptomics Analysis Reveals a Bidirectional Cross-talk Between Pulmonary Fibroblasts and Immune Cells in Distal Pulmonary Arteries of Hypoxia-exposed PH Calves (ATS 2024) - " we found that control dPAs contain vascular wall cells (fibroblasts 30%, SMC 26%, and EC 18%) and immune cells (9% macrophages, 3% T cells, 3% mast cells, 2% neutrophil and 1% each of DC and NK cells)... we found that bovine CO dPAs contain similar cell types to these reported in human CO dPAs (Crnkovic et al, 2022, JCI insight). In addition, SMC and fibs are the only cell types that are found to exhibit significant gene expression changes in both human and bovine PH. A dominant or unique role of fibroblast subclusters in inflammation and fibrosis further support a critical role of fibroblasts in PH."

Immune cell • Cardiovascular • Fibrosis • Hypertension • Immunology • Inflammation • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • CCL2 • CCR2 • CSF1 • IL1B • IL1R1 • IL6 • TNFA

Protocol for cost-effectiveness analysis of a randomised trial of mHealth coaching (Bump2Baby and Me) compared with usual care for healthy gestational weight gain and postnatal outcomes in at-risk women and their offspring in the UK, Australia, Ireland and Spain. (PubMed, BMJ Open) - "The National Maternity Hospital Human Research and Ethics Committee was the primary approval site (EC18.2020) with approvals from University College Dublin HREC-Sciences (LS-E-20-150-OReilly), Junta de Andalucia CEIM/CEI Provincial de Granada (2087-M1-22), Monash Health HREC (RES-20-0000-892A) and National Health Service Health Research Authority and Health and Care Research Wales (HCRW) (21/WA/0022). The results from the analysis will be disseminated in scientific papers, through conference presentations and through different channels for communication within the project. ACTRN12620001240932."

Clinical protocol • Cost effectiveness • HEOR • Journal • Diabetes • Gestational Diabetes • Metabolic Disorders • Obesity

A high-throughput UPLC-MS-MS Bio-analytical method for the analysis of veterinary pharmaceutical residues in Chicken Tissues, Application of efficient-valid-green (EVG) Framework as a Competence Tool. (PubMed, J Chromatogr A) - "A UPLC-MS-MS method was developed using Poroshell 120 ECC18 and a mobile phase composed of acetonitrile and distilled water, containing 0.1 % formic acid, in the ratio of (85:15 v/v) at a flow rate of 0.6 mL/min...The method was applied to decide the time required for poultry products to be safe for human use after administration of the studied drugs. It was found that, after the administration of the last dose, minimally 7 days are required till the levels of the drugs drop to the maximum residue limit determined by the FDA/WHO in animal tissues."

Journal • Immunology

Indole-3-Carbinol Promotes Apoptosis and Inhibits the Metastasis of Esophageal Squamous Cell Carcinoma by Downregulating the Wnt/β-Catenin Signaling Pathway. (PubMed, Nutr Cancer) - "MTT and flow cytometry were used to assess cell viability and apoptosis in EC18 and TE1 cells, while wound healing and transwell assays were used to investigate cell migration and invasion in vitro...I3C promoted ESCC apoptosis and inhibited cell migration and invasion by downregulating β-catenin, c-myc, and cyclin D1 in vitro and decreased the tumor growth in vivo; this process was reversed by LiCl treatment. In summary, I3C inhibits ESCC malignant behavior by suppressing the Wnt/β-catenin signaling pathway, thus deeming it a promising drug for ESCC treatment."

Journal • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Oncology • Squamous Cell Carcinoma • CCND1 • MYC

BREAKING BARRIERS: NEED FOR MULTIDISCIPLINARY CARE CENTERS TO ADDRESS CHALLENGES FACED BY CHILDREN WITH DIFFERENCES IN SEX DEVELOPMENT (ICE-EDEC 2024) - "This study aimed to review data from a university clinic-based electronic-patient registry, to identifying the medical, psycho-socio-cultural challenges encountered by children with DSD, and evaluate of the potential advantages of an MCC as a centralized, specialized service hub designed to facilitate and promote improved health outcomes Data from an electronic patient-registry of young people with DSD managed between 1999-2022, at the University of Colombo Professorial Unit-Pediatric Endocrinology clinic, Lady Ridgeway Hospital for children were analyzed with ethical approval (EC-18-092). This study included 119 patients with DSD (mean age:13 years, range: 2-24 years) from Sri Lanka... Children with Disorders of Sex Development (DSD) encounter substantial challenges. Establishing a dedicated Multidisciplinary Care Center (MCC) could serve as an effective approach to address these challenges comprehensively. Such a center could offer transitional care services, crucial..."

Clinical • CNS Disorders • Genetic Disorders • Pediatrics • Turners Syndrome

Initial investigation on the feasibility of porcine red blood cells from genetically modified pigs as a human red blood cell alternative for transfusion (IPITA-IXA-CTRMS 2023) - "22-CM-EC-18... The elimination of porcine carbohydrate antigens in TKO or QKO pigs resulted in a marked enhancement of pRBC compatibility with human serum compared to ABO-incompatible hRBCs and WT pRBCs. The improved compatibility was comparable to that of type O hRBCs. However, DKO/hCD55KI/hCD39KI pRBCs exhibited lower compatibility and higher classical pathway complement activation than TKO pRBCs."

Preclinical • Hematological Disorders • Infectious Disease

ENGICEM Life Sciences opens expanded central research center [Google translation] (Pharm News) - "According to ENGICEM Life Sciences, the central research center conducts basic research, translational research, and applied research on new drug candidates, including 'EC-18', an immunomodulatory platform substance....Through this, ENGICEM Life Sciences plans to further accelerate global licensing of EC-18, a global new drug candidate."

Commercial • Oncology

Influence of the HCN4 channels on pain processing in the ZNS - genetic knockout vs. pharmacological inhibition (IASP-GPC 2023) - "In an epilepsy animal model, a lower epilepsy susceptibility to the EC18 could be proven using electrocorticography with targeted HCN4 blockade [3]...Conclusion While the pharmacological blockage of the HCN4 channel, and thus the lack of rhythmogenic activity, as expected, a reduction in the Bold parameters was determined, Bold volume and amplitude were 45 ° C and 50 ° C in the cortical regions of genetic Ko significantly increased. An explanation for this thermal phenotype of the HCN4-KO mice may be that the genetic tissue-specific knockout in the brain in the developing organism leads to ontogenetically to compensation or overcompensation phenomena, which, however, does not necessarily reflect the primarily physiological function of the channel."

CNS Disorders • Epilepsy • Pain

Management of Severe Chemotherapy-induced Neutropenia in Advanced Breast Cancer (clinicaltrials.gov) - P1/2 | N=28 | Completed | Sponsor: Enzychem Lifesciences Corporation | Unknown status ➔ Completed | Phase classification: P2 ➔ P1/2 | N=12 ➔ 28

Enrollment change • Metastases • Phase classification • Trial completion • Breast Cancer • Chemotherapy-Induced Neutropenia • Febrile Neutropenia • Hematological Disorders • Neutropenia • Oncology • Solid Tumor

EC-18 for Oral Mucositis in Patients With Concomitant Chemoirradiation (clinicaltrials.gov) - P2 | N=105 | Completed | Sponsor: Enzychem Lifesciences Corporation | Active, not recruiting ➔ Completed

Trial completion • Dental Disorders • Mucositis • Oncology • Oral Cancer • Stomatitis

Adjustable continence therapy (proACT) for the treatment of male stress urinary incontinence post-prostatectomy: a systematic review and meta-analysis (2023 update). (PubMed, World J Urol) - "Implantation of proACT adjustable balloons is a minimally invasive technique that provides medium outcomes (53%) with a strict definition of dryness (0-1 PPD) and important complication rate (31.2%). Past of irradiation is a negative predictive factor for incontinence."

Journal • Retrospective data • Review • Urinary Incontinence • Urology

Offline analysis of secondary formation markers in ambient organic aerosols by liquid chromatography coupled with time-of-flight mass spectrometry. (PubMed, J Chromatogr A) - "After testing three analytical columns, the best separation of the compounds of interest was achieved on a Poroshell 120 ECC18 column (4.6 × 50 mm, 2.7 µm) thermostated at 35 °C, operating in gradient elution mode with 0.1% acetic acid in water and acetonitrile at a 0.8 mL min flow rate...The developed method was shown to be reliable for the quantification of the targeted compounds in real atmospheric aerosol samples. The accuracy in the molecular mass determination of less than 5 ppm and the acquisition in the full scan mode were shown to bring additional insights into the organic constituents in atmospheric aerosols."

Journal

The study of structure and effects of two new proanthocyanidins from Anogeissus pendula leaves on rumen enzyme activities. (PubMed, Front Vet Sci) - "The ruminal glutamic pyruvic transaminase activity was significantly inhibited (p < 0.01) from EC 12.59-16.29 mg/mL, and R-cellulase inhibition was recorded with EC 18.20-21.98 mg/mL by compounds 1 and 2, respectively. Protease activity decreased with increasing incubation time and concentration of both compounds. The novel proanthocyanidins have potential roles in improving feed conversion ratios and in drug development."

Journal

Simultaneous determination of ten neonicotinoid insecticides and a metabolite in human whole blood by QuEChERS coupled with UPLC-Q Exactive orbitrap high-resolution mass spectrometry. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "The separation was performed on an Agilent EC18 column with the gradient elution with 0.1% formic acid in water and acetonitrile as the mobile phase...The method was furthermore applied to a real case of neonicotinoid insecticide poisoning to demonstrate its feasibility. The proposed method is suitable for the rapid screening of neonicotinoid insecticides in poisoned human blood in the field of forensic science, as well as monitoring of neonicotinoid insecticide residues in humans in the field of environmental safety, compensating for a lack of studies on neonicotinoid insecticide determination in biological samples."

Journal