metronidazole oral / Generic mfg. - LARVOL DELTA

METABOLIC ACTIVITY OF CERVICAL IMMUNE CELLS DECREASES AFTER SUCCESSFUL TREATMENT OF BACTERIAL VAGINOSIS (WRMC 2026) - "Cervical biopsy samples were collected from women before vs after successful treatment of BV with a standard course of oral metronidazole... This increase in puromycin incorporation indicates increased translation and activation of CD4+ and CD8+ in the presence of BV. Despite limited sample size, consistent increases in CD4+ and CD8+ cell metabolism during BV infection indicates that BV metabolically influences cervical immune cells and this effect can be reversed by successful BV treatment. This finding suggests a unique mechanism by which BV may increase HIV susceptibility and may inform novel therapeutics for BV."

Immune cell • Cervical Cancer • Gynecology • Human Immunodeficiency Virus • Infectious Disease • Vaginitis • CD4 • CD8

Letter to the Editor: Topical versus oral metronidazole for post-haemorrhoidectomy pain: A systematic review and meta-analysis of randomized controlled trials. (PubMed, Colorectal Dis) - No abstract available

Journal • Retrospective data • Pain

CONCURRENT CLOSTRIDIUM DIFFICILE COLITIS AND CYTOMEGALOVIRUS INFECTION AS A CAUSE OF PERSISTENT DIARRHEA AFTER AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR NON-HODGKIN LYMPHOMA FOLLOWING BENDAMUSTINE-BASED CONDITIONING. (PubMed, Acta Clin Croat) - "After treatment with oral metronidazole, vancomycin and fidaxomicin, diarrhea persisted despite undetectable C. difficile toxin, with elevation of hepatic enzymes. Eventually, CMV infection was diagnosed by real-time polymerase chain reaction and treated with ganciclovir and valganciclovir...Bendamustine-induced colitis and prior rituximab treatment may have been additional risk factors in this patient. Therefore, more comprehensive workup of diarrhea is needed in ASCT recipients treated with these agents."

Journal • Bone Marrow Transplantation • Cytomegalovirus Infection • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology • Transplantation

Bioavailability of oral metronidazole: promotion of oral vs IV initiative (ESCMID Global 2026) - No abstract available

Anaerobic pericarditis due to Clostridium ramosum: First known case report. (PubMed, IDCases) - "He was treated with intravenous ampicillin-sulbactam followed by oral metronidazole, with resolution of the effusion and no recurrence on follow-up. Importantly, routine anaerobic cultures of pericardial fluid should be considered to avoid missed diagnoses. Recognition of rare anaerobic pathogens in pericardial infections expands the understanding of their pathogenic potential and informs future diagnostic and therapeutic approaches."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders • Depression • Dyslipidemia • Hematological Disorders • Hypertension • Infectious Disease • Psychiatry • Septic Shock

REaCT-NSQIP: Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery (clinicaltrials.gov) - P4 | N=630 | Active, not recruiting | Sponsor: Ottawa Hospital Research Institute | Recruiting ➔ Active, not recruiting

Enrollment closed

Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies (clinicaltrials.gov) - P=N/A | N=166 | Completed | Sponsor: HaEmek Medical Center, Israel | N=750 ➔ 166 | Trial completion date: Aug 2025 ➔ Dec 2025 | Recruiting ➔ Completed

Enrollment change • Trial completion • Trial completion date

From the Ear to the Brain: Otitis Externa Complicated by Coalescent Mastoiditis Leading to Temporal Lobe Abscess and Wernicke's Aphasia. (PubMed, Cureus) - "Given the small size of the abscess and absence of mass effect, she was managed nonoperatively with intravenous cefepime and vancomycin and oral metronidazole, alongside intensive glycemic optimization. She completed a six-week antimicrobial regimen and achieved full neurological recovery with near-complete radiographic resolution. This case highlights that inadequately treated otitis externa may serve as a suspected otogenic source of intracranial abscess in patients with uncontrolled diabetes and emphasizes the importance of early MRI evaluation when neurologic symptoms arise, even when CT imaging and laboratory findings are initially reassuring."

Journal • Cardiovascular • CNS Disorders • Dermatology • Diabetes • Infectious Disease • Metabolic Disorders • Otorhinolaryngology • Type 2 Diabetes Mellitus

Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-responders (clinicaltrials.gov) - P2 | N=15 | Active, not recruiting | Sponsor: M.D. Anderson Cancer Center | Trial completion date: Dec 2025 ➔ Dec 2027 | Trial primary completion date: Dec 2025 ➔ Dec 2027

dMMR • Trial completion date • Trial primary completion date • Colorectal Adenocarcinoma • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Small Intestinal Carcinoma • Solid Tumor • Transplantation • CEACAM5 • MLH1 • MSH2 • MSH6 • MSI

Physicochemical, compressional, mechanical, and dissolution properties of metronidazole tablets prepared with cocoa pod gum. (PubMed, Polim Med) - "Cocoa pod gum exhibits promising binder properties comparable to XNG and may serve as a cost-effective, sustainable and biocompatible alternative to conventional excipients in tablet formulations."

Journal

Revisiting the Disulfiram-Like Reaction Between Alcohol and Oral Metronidazole. (PubMed, Sex Transm Dis) - "While all four case reports and one older clinical trial reported a potential link between some oral 5-nitroimidazoles and DLR, 3 clinical trials, one cross-sectional chart review, and 2 experimental animal studies did not. Thus, the available evidence does not strongly support a clinically significant interaction between alcohol and oral MTZ, calling into question the need for strict alcohol abstinence during treatment."

Journal • Cardiovascular

Topical versus oral metronidazole for post-haemorrhoidectomy pain: A systematic review and meta-analysis of randomized controlled trials. (PubMed, Colorectal Dis) - "Topical and oral metronidazole showed similar short-term analgesic efficacy after haemorrhoidectomy."

Clinical • Journal • Retrospective data • Review • Pain

Study of Metronidazole Delayed-Release Capsules in Comparison With Immediate-Release Tablets (Flagyl) for Safety and Pharmacokinetics (clinicaltrials.gov) - P1 | N=18 | Completed | Sponsor: Gateway Pharmaceutical LLC

New P1 trial • Infectious Disease

Title of the Protocol: Combined Use of Vaginal Clindamycin Cream and Oral Metronidazole Versus Oral Metronidazole (clinicaltrials.gov) - P=N/A | N=100 | Completed | Sponsor: Ain Shams Maternity Hospital

New trial • Vaginitis

Metronidazole as Preoperative Therapy in CRC / FusoMetro-001 (clinicaltrials.gov) - P2 | N=40 | Recruiting | Sponsor: Oncology Institute of Southern Switzerland | Trial completion date: Dec 2024 ➔ Dec 2026 | Trial primary completion date: Dec 2024 ➔ Dec 2026

Trial completion date • Trial primary completion date • Colorectal Cancer • Oncology • Solid Tumor

Vaginitis: Diagnosis and Treatment. (PubMed, Am Fam Physician) - "Bacterial vaginosis is treated with oral or intravaginal metronidazole or intravaginal clindamycin...Trichomoniasis is treated with oral metronidazole or tinidazole. When treating trichomoniasis, testing for reinfection, as well as other sexually transmitted infections, is recommended. Treatments for noninfectious vaginitis include vaginal lubricants and moisturizers, topical hormones, and topical steroids, depending on the cause."

Journal • Review • Candidiasis • Dermatology • Gynecology • Infectious Disease • Inflammation • Pruritus • Vaginitis

REaCT-NSQIP: Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery (clinicaltrials.gov) - P4 | N=630 | Recruiting | Sponsor: Ottawa Hospital Research Institute | Trial completion date: Dec 2026 ➔ Jul 2026 | Trial primary completion date: Sep 2025 ➔ May 2026

Trial completion date • Trial primary completion date

Male Partner Treatment and the Potential Sexual Transmission of Bacterial Vaginosis: Considerations for Patient Counseling and Clinical Application in the United States. (PubMed, Am J Obstet Gynecol) - "However, for the first time, an open-label, randomized controlled trial in Australia showed a decrease in BV recurrences in women whose male partners were treated with a combination of oral metronidazole and topical clindamycin cream over 12 weeks. This has resulted in increasing questions from patients regarding both MPT and the sexual transmissibility of BV. Here, we review evidence regarding the sexual transmission of BV, discuss complexities with potential implementation of MPT, and provide a framework from which to counsel patients."

Journal • Gynecology • Vaginitis

UNPACKING THE TEMPORAL RELATIONSHIP: G. VAGINALIS CLADES AND INCIDENT HIGH-RISK HPV INFECTION (IPVC 2025) - "When stratified by treatment, Clade 3 demonstrated a statistically significant interaction between HrHPV incidence and women receiving oral metronidazole (interaction p = 0.015)... This analysis suggests a potential treatment-dependent relationship between Clade 3 and HrHPV incidence. Treatment of BV appears to reduce HrHPV incidence in women with G.vag Clade 3. Further research is needed to clarify the clinical significance between G.vag clades and acquisition and/or clearance of HPV and to inform targeted STI prevention strategies."

Human Papillomavirus Infection • Infectious Disease • Vaginitis

A prospective, multicenter, randomized, double-blind, controlled phase III clinical study on the efficacy and safety of XLF055 combined with metronidazole in the prevention of recurrence of bacterial vaginosis (BV) (ChiCTR) - P3 | N=440 | Not yet recruiting | Sponsor: Peking University First Hospital; Peking University First Hospital

New P3 trial • Vaginitis

An Unexpected Infection: Diagnosing a Liver Abscess in a Young, Healthy Adult (ACG 2025) - "Patient was started started on Zosyn and underwent IR-guided drainage with cultures positive for E. coli. Antibiotics were deescalated to Flagyl and TMP/SMX...While this patient's colonoscopy was grossly normal, he was taking omeprazole outpatient...Figure B: Abdominal CT scan showing hepatic abscess. Abdominal MRI scan of hepatic abscess"

Clinical • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammatory Bowel Disease • Pneumonia • ALK

Streptococcus constellatus Pyogenic Liver Abscess Resembling a Neoplastic Lesion: A Case Review (ACG 2025) - "Antibiotic therapy was narrowed to Rocephin and Flagyl. B. Axial MRCP portrayed a well-defined, segment 4, 14.4 x 9.8 x 15.9 cm T2 hyperintense liver lesion, with restricted diffusion, suggestive of malignancy."

Clinical • Review • Addiction (Opioid and Alcohol) • Cardiovascular • Diabetes • Fatigue • Gastrointestinal Cancer • Gastrointestinal Disorder • Hepatology • Infectious Disease • Metabolic Disorders • Pancreatitis

Unmasking a Hidden Parasite: Colonic Necrosis and Liver Abscess From Entamoeba histolytica (ACG 2025) - "Intravenous Unasyn and Flagyl were initiated, and a CT-guided drain was placed into the peri-colonic abscess...Figure B: RBC's ingested within the E. histolytica involving necrosis.Figure C: Zoomed out histology slide of the necrosis. Figure D: Gangrenous transmural necrosis with E. histolytica"

Cardiovascular • Developmental Disorders • Gastrointestinal Disorder • Hepatology • Hypertension • Infectious Disease • Septic Shock

When Suspicion Outpaces Confirmation: A Case of Suspected Invasive Entamoeba Histolytica (ACG 2025) - "He was started on flagyl and ceftriaxone, and a PICC line was placed for prolonged antibiotic treatment. histolytica antigen is often negative in extraintestinal disease despite colonic involvement, as fewer trophozoites are shed into the colon as the infection progresses to the liver, lowering antigen sensitivity. Even in low-prevalence areas like the U.S., a broad differential is crucial in patients with intermittent fevers and liver lesions.Figure: Patchy areas of ulceration seen in the cecumFigure: Liver mass seen on CT of the abdomen and pelvis"

Clinical • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hepatology • Hypertension • Immunology • Infectious Disease

Epiglottitis of an Unusual Etiology (ACG 2025) - "The patient was started empirically on IV Acyclovir, Fluconazole, Ceftriaxone, and Flagyl...Antibiotics were discontinued and he was discharged home on Valtrex...It has also been estimated that roughly 70% of patients affected with Herpes Zoster laryngitis are concurrently immunocompromised [2]. There have been reported findings of biopsy proven VZV epiglottitis in the order of single digits making this an exceedingly rare diagnostic finding especially in an immunocompetent host.Figure: Esophageal Herpetic Plaques"

Gastrointestinal Disorder • Herpes Zoster • Infectious Disease • Influenza • Otorhinolaryngology • Respiratory Diseases • Varicella Zoster