buspirone/melatonin (BCI-952) / BrainCells - LARVOL DELTA

Augmentation Therapy With Serotonin 5-HT1A Receptor Partial Agonists on Cognitive Function in Depressive Disorders: A Systematic Review of Randomized Controlled Studies. (PubMed, Neuropsychopharmacol Rep) - "Further studies with novel 5-HT1A receptor agonists are warranted to examine their potentially more robust benefits on cognitive performance in subjects suffering from mood deficits."

Journal • Review • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia

Buspirone and Melatonin for Depression Following Traumatic Brain Injury (clinicaltrials.gov) - P4 | N=10 | Recruiting | Sponsor: Massachusetts General Hospital | Not yet recruiting ➔ Recruiting | Trial completion date: Jul 2022 ➔ Jul 2026 | Trial primary completion date: Jul 2021 ➔ Jul 2026

Enrollment open • Trial completion date • Trial primary completion date • CNS Disorders • Depression • Psychiatry • Vascular Neurology

Medroxyprogesterone for Refractory Agitation in TBI and Parkinson’s Disease (APA 2022) - "Throughout hospitalization, control of seizures proved difficult and the patient underwent trials of Leviteracetam, Phenytoin, Clobazam and was ultimately maintained on Valproic acid 250 mg BID (weaned due to hyperammonemia and thrombocytopenia), Lacosamide 200 mg/300 mg, Lamotrigine 200 mg/100 mg, Clobazam 5 mg nightly. Psychiatric course of treatment included adequate trials of Quetiapine, Olanzapine, Buspirone, Melatonin, Valproic Acid, Trazodone, and varying levels of benzodiazepines...Due to severity of his Parkinson''s, Neurology was reluctant to make changes to Carbidopa-Levodopa 25-100 mg four times daily due to the overall motor benefit he experienced...As in the prior case, he was started on medroxyprogesterone IM 150 mg weekly and found benefit at 300 mg weekly, which allowed for discharge to memory care unit. While dopamine and D2-like receptor families have been associated with impulsive personality traits, these cases illustrate the potential for..."

CNS Disorders • Cognitive Disorders • Epilepsy • Hematological Disorders • Movement Disorders • Parkinson's Disease • Psychiatry • Subarachnoid Hemorrhage • Thrombocytopenia • Vascular Neurology

Buspirone and Melatonin for Depression Following Traumatic Brain Injury (clinicaltrials.gov) - P4; N=10; Not yet recruiting; Sponsor: Massachusetts General Hospital

New P4 trial • CNS Disorders • Depression • Mood Disorders • Vascular Neurology

Buspirone: Back to the Future. (PubMed) - J Psychosoc Nurs Ment Health Serv - "Buspirone and melatonin may synergistically promote neurogenesis, supporting the potential use of this combination for treating depression and cognitive impairment. [Journal of Psychosocial Nursing and Mental Health Services, 53(11), 21-24.]."

Journal • Alzheimer's Disease • Biosimilar • Depression

The psychopharmacology of autism spectrum disorder and Rett syndrome. (PubMed, Handb Clin Neurol) - "Experimental drug treatments for ASD include oxytocin and vasopressin, bumetanide, sulforaphane, nutritional supplements, memantine, and d-cycloserine. Work performed on syndromic forms, represents an important source of information for experimental therapies of ASD and knowledge of the unique mechanisms underlying autism in each individual patient may in the future pave the path to personalized drug treatments."

Journal • Attention Deficit Hyperactivity Disorder • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Epilepsy • Genetic Disorders • Mood Disorders • Psychiatry • Psychomotor Agitation