Sendai virus vector based Sars-Cov2 vaccine for SARS-CoV-2 vaccine / I’rom Group, Fudan University - LARVOL DELTA

Association of Early Inflammation with Age and Asymptomatic Disease in COVID-19. (PubMed, J Inflamm Res) - "Early inflammatory response potentially plays a critical role for host-defense in COVID-19. The impaired early inflammatory response was associated with older age while a robust early inflammation was associated with asymptomatic disease."

Journal • Immunology • Infectious Disease • Inflammation • Novel Coronavirus Disease • Respiratory Diseases • CD8 • IL10 • IL2

A Rapid and Efficient Screening System for Neutralizing Antibodies and Its Application for SARS-CoV-2. (PubMed, Front Immunol) - "At least 20% of these NAbs exhibited advanced neutralizing potency and high affinity, with the top two NAbs showing half-maximal inhibitory concentration (IC) to block authentic SARS-CoV-2 at 9.88 and 11.13 ng/ml, respectively. Altogether, our study provides an effective methodology with high applicable value for discovering potential preventative and therapeutic NAbs for the emerging infectious diseases."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Drug Repurposing of Itraconazole and Estradiol Benzoate against COVID-19 by Blocking SARS-CoV-2 Spike Protein-Mediated Membrane Fusion. (PubMed, Adv Ther (Weinh)) - "Further studies shed light on the mechanism that ITZ and EB can interact with the heptad repeat 1 (HR1) region of the spike protein, to present anti-SARS-CoV-2 infections in vitro, indicating they are novel potential therapeutic remedies for COVID-19 treatment. Furthermore, ITZ shows broad-spectrum activity targeting 6-HB in the S2 subunit of SARS-CoV and MERS-CoV S protein, inspiring that ITZ have the potential for development as a pan-coronavirus fusion inhibitor."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A Novel Prediction Model for Long-Term SARS-CoV-2 RNA Shedding in Non-Severe Adult Hospitalized Patients with COVID-19: A Retrospective Cohort Study. (PubMed, Infect Dis Ther) - "Using the CCCCA score, clinicians can identify patients with long-term SARS-CoV-2 RNA shedding."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • CD4 • CRP

Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease. (PubMed, Biosci Trends) - "Eighty-five COVID-19 patients were enrolled for detection of SARS-CoV-2 viral antigens, including 57 anti-SARS-CoV-2 antibody negative cases and 28 antibody positive cases. Furthermore, positive antigen detection indicated disease progression, nine cases with positive antigen (9/30, 30.0%), in contrast to two cases (2/27, 7.40%) (p = 0.0444) with negative antigen, which progressed into severe disease. Thus, the viral antigens were persistent in early stages of infection when virus was in highly replicating status, and viral antigen detection promises to rapidly screen positive patients in the early stage of SARS-CoV-2 infection."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

[VIRTUAL] Kidney Injury in ICU Adults with Severe COVID-19 (KIDNEY WEEK 2020) - "Background: The SARS-CoV-2 infected humans through the angiotensin converting enzyme (ACE-2) receptor... Kidney injury including abnormal urine routine and increased serum creatinine presented in almost all severe Covid-19 patients. AKI event could predict poor prognosis with severe Covid-19. We should increase awareness of kidney injury in patients with severe COVID-19."

Clinical • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Renal Disease

[VIRTUAL] Effect of Early Initiation of Blood Purification in ICU Adults with Severe COVID-19 (KIDNEY WEEK 2020) - "Background: Cytokine storm induced by SARS-CoV-2 was considered as one of the main mechanisms of multiple organs dysfunction in Covid-19... Early initiation of blood purification could probably reduce the mortality of severe Covid-19. It was implied that it could delay occurs and reduce degrees of target organs injuries by cutting the peak load of cytokine storm. Further research in basic and clinical were needed to clarify the mechanism of blood purification in cytokine storm-related diseases."

Clinical • Infectious Disease • Novel Coronavirus Disease