nOPV1
/ PATH, Batavia Biosci
- LARVOL DELTA
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August 17, 2025
Safety and immunogenicity of novel live attenuated type 1 and type 3 oral poliomyelitis vaccines in healthy adults in the USA: a first-in-human, observer-masked, multicentre, phase 1 randomised controlled trial.
(PubMed, Lancet Infect Dis)
- P1 | "nOPV1 and nOPV3 were well tolerated and showed similar immunogenicity and shedding profiles to mOPV1 and mOPV3, respectively, supporting progression of these vaccine candidates to phase 2 studies."
Journal • P1 data • Fatigue • Infectious Disease • Musculoskeletal Pain • Pain
June 03, 2025
Study of Trivalent and Bivalent (Types 1 & 2) Novel Oral Poliomyelitis Vaccines
(clinicaltrials.gov)
- P1/2 | N=2400 | Recruiting | Sponsor: PATH | Not yet recruiting ➔ Recruiting
Enrollment open • Infectious Disease
March 26, 2025
SCOPE: Study of Co-administered (Types 1 & 2) Novel Oral Poliomyelitis Vaccines Evaluation
(clinicaltrials.gov)
- P2 | N=675 | Not yet recruiting | Sponsor: PATH
New P2 trial • Infectious Disease
August 01, 2024
Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh
(clinicaltrials.gov)
- P2 | N=2012 | Recruiting | Sponsor: PATH | Trial completion date: Feb 2025 ➔ May 2026 | Trial primary completion date: Feb 2025 ➔ May 2026
Trial completion date • Trial primary completion date • Infectious Disease
April 05, 2024
Study of Trivalent and Bivalent (Types 1 & 2) Novel Oral Poliomyelitis Vaccines
(clinicaltrials.gov)
- P1/2 | N=2400 | Not yet recruiting | Sponsor: PATH | Trial completion date: Dec 2025 ➔ Dec 2027 | Initiation date: Dec 2023 ➔ Mar 2025 | Trial primary completion date: Dec 2025 ➔ Dec 2027
Trial completion date • Trial initiation date • Trial primary completion date • Infectious Disease
February 22, 2024
Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh
(clinicaltrials.gov)
- P2 | N=1683 | Recruiting | Sponsor: PATH | Trial completion date: Jun 2024 ➔ Feb 2025 | Trial primary completion date: Jun 2024 ➔ Feb 2025
Trial completion date • Trial primary completion date • Infectious Disease
November 26, 2023
Improvement of the qmosRT-PCR Assay and Its Application for the Detection and Quantitation of the Three Serotypes of the Novel Oral Polio Vaccine in Stool Samples.
(PubMed, Vaccines (Basel))
- "In addition, the lowest viral concentration that the assay was able to detect in stool samples was 17 CCID/mL for nOPV1 and nOPV2 viruses and 6 CCID/mL for nOPV3. The qmosRT-PCR was specific and sensitive for the simultaneous identification and quantification of all three nOPV viruses. It can be used as an identity test during the nOPV manufacturing process and in evaluation of virus excretion in nOPV clinical trials."
Journal
November 19, 2023
Study of Trivalent and Bivalent (Types 1 & 2) Novel Oral Poliomyelitis Vaccines
(clinicaltrials.gov)
- P1/2 | N=2400 | Not yet recruiting | Sponsor: PATH
New P1/2 trial • Infectious Disease
May 31, 2023
Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh
(clinicaltrials.gov)
- P2 | N=1683 | Recruiting | Sponsor: PATH | Enrolling by invitation ➔ Recruiting
Enrollment status • Infectious Disease
May 12, 2023
Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh
(clinicaltrials.gov)
- P2 | N=1683 | Enrolling by invitation | Sponsor: PATH | Not yet recruiting ➔ Enrolling by invitation
Enrollment open • Infectious Disease
March 01, 2023
Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines
(clinicaltrials.gov)
- P1 | N=205 | Completed | Sponsor: PATH | Active, not recruiting ➔ Completed
Trial completion • Infectious Disease
December 09, 2022
Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh
(clinicaltrials.gov)
- P2 | N=1683 | Not yet recruiting | Sponsor: PATH
New P2 trial • Infectious Disease
August 12, 2022
Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines
(clinicaltrials.gov)
- P1 | N=230 | Active, not recruiting | Sponsor: PATH | Recruiting ➔ Active, not recruiting
Enrollment closed • Infectious Disease
February 08, 2022
Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines
(clinicaltrials.gov)
- P1 | N=230 | Recruiting | Sponsor: PATH | Trial completion date: Aug 2022 ➔ Jan 2023 | Trial primary completion date: Aug 2022 ➔ Jan 2023
Trial completion date • Trial primary completion date • Infectious Disease
August 30, 2021
Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines
(clinicaltrials.gov)
- P1; N=230; Recruiting; Sponsor: PATH; Trial primary completion date: Apr 2022 ➔ Aug 2022
Clinical • Trial primary completion date • Infectious Disease
April 06, 2021
Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines
(clinicaltrials.gov)
- P1; N=230; Recruiting; Sponsor: PATH; Not yet recruiting ➔ Recruiting
Enrollment open • Infectious Disease
March 09, 2021
Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines
(clinicaltrials.gov)
- P1; N=230; Not yet recruiting; Sponsor: PATH; Initiation date: Jan 2021 ➔ Apr 2021
Clinical • Trial initiation date • CNS Disorders • Infectious Disease
November 30, 2020
Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines
(clinicaltrials.gov)
- P1; N=230; Not yet recruiting; Sponsor: PATH; Trial completion date: Dec 2021 ➔ Aug 2022; Trial primary completion date: Dec 2021 ➔ Apr 2022
Clinical • Trial completion date • Trial primary completion date • CNS Disorders • Infectious Disease
August 27, 2020
Study of Novel Types 1 and 3 Oral Poliomyelitis Vaccines
(clinicaltrials.gov)
- P1; N=230; Not yet recruiting; Sponsor: PATH
New P1 trial • CNS Disorders • Infectious Disease
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