induced pluripotent stem cells / Paragon Biosciences - LARVOL DELTA

Vascular Smooth Muscle Cell Derived from IPS Cell of Moyamoya Disease - Comparative Characterization with Endothelial Cell Transcriptome. (PubMed, J Stroke Cerebrovasc Dis) - "This is the first study that established VSMCs from NCSCs using MMD patient-derived iPSCs and demonstrated similar biological function and transcriptome profile of iPSC-derived VMSCs in MMD patients and HC subjects under naïve single culture condition. Comparative transcriptome features between iPSC-derived VSMCs and ECs, displaying distinct transcriptome in the ECs, suggested that pathological traits can be driven by naïve ECs predominantly and VSMCs may require specific environmental factors in MMD, which provides novel insight into the pathophysiology of MMD. Our iPSC derived VSMC model can contribute to further investigations of diagnostic and therapeutic target of MMD in addition to the current iPSC derived EC model."

Journal • Cardiovascular • CNS Disorders • CD31 • CD34

Clinicopathologic Correlations of Retinal Membranes Associated With Intravitreal 'Stem Cell' Injections. (PubMed, Ophthalmic Surg Lasers Imaging Retina) - "...The authors speculate that the "stem cells" may cause RDs by differentiation into myofibroblasts that cause tractional membranes, though further studies are warranted. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:125-131.]."

Clinical • Journal

Stem cell transplants could significantly improve Parkinson’s treatment, study suggests (Parkinson's News Today) - "Using stem cells made in the lab for transplants would allow the production of enough cells to cover the current demand, ensure the number and type of transplanted cells are always the same, that they produce the desired amounts of dopamine...New types of transplants focusing on non-motor symptoms could be developed if the initial trials with dopamine-producing cells are successful."

Review