NSG-33 / Gloriana Therap, Sanofi - LARVOL DELTA

Potential emerging roles of the novel adipokines adipolin/CTRP12 and meteorin-like/METRNL in obesity-osteoarthritis interplay. (PubMed, Cytokine) - "Metrnl, and to a lesser extent adipolin seem to be interrelated with OA. Different in-context regulatory mechanisms for metrnl production from various tissues are strongly suggested. Importantly, the findings of the current study shed lights on metrnl as a potential novel mediator and therapeutic target to consider in obesity-OA interplay."

Journal • Dyslipidemia • Genetic Disorders • Immunology • Metabolic Disorders • Obesity • Osteoarthritis • Pain • Rheumatology • MMP13

[VIRTUAL] Meteorin-like Glial Cell Differentiation Regulator is a Novel Protein Biomarker of Cardiovascular Outcomes in Patients With Diabetes and Vascular Disease: A TECOS Substudy (AHA 2020) - " Using the Olink aptamer-based platform, we performed proteomic profiling (>700 proteins) on 440 paired cases and matched controls from placebo-assigned participants in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS). Three novel protein biomarkers, in particular METRNL (a circulating adipokine that regulates insulin-sensitivity), may identify diabetic patients at high risk for subsequent HF and MACE. Additional studies are needed to replicate these findings and uncover the biologic mechanism linking adipokine signaling and heart failure."

Biomarker • Clinical • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Diabetes • Dyslipidemia • Heart Failure • Metabolic Disorders • Type 2 Diabetes Mellitus • NOTCH3 • ROR1

Administration of metrnl delays the onset of diabetes in non-obese diabetic mice. (PubMed, Endocr J) - "Meteorin-like protein (metrnl) is a secreted protein homologous to the neurotrophin metrn and it is induced after exercise in the skeletal muscle...Histology of pancreas showed a decreased infiltration of leukocytes, which was in association with augmentation of regulatory T cells, suppression of autoreactive T cells and altered cytokine secretion. To sum up, the present study showed that intravenous administration of metrnl ameliorated islet lymphocyte infiltration and modulated immune cell responses, raising the possibility that it might be beneficial in improving islet function clinically."

Journal • Diabetes • Immunology • Metabolic Disorders • Obesity • Type 1 Diabetes Mellitus

Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway. (PubMed, Redox Biol) - "Collectively, cardiac-derived METRNL activates SIRT1 via cAMP/PKA signaling axis in an autocrine manner, which ultimately improves DOX-elicited oxidative stress, apoptosis and cardiac dysfunction. Targeting METRNL may provide a novel therapeutic strategy for the prevention of DOX-associated cardiotoxicity."

Journal • Breast Cancer • Immunology • Inflammation • Oncology • Solid Tumor

Comment on: Effect of sleeve gastrectomy on the expression of Meteorin-like (METRNL) and irisin (FNDC5) in muscle and brown adipose tissue and its impact on (UCPs) in diet-induced obesity rats. (PubMed, Surg Obes Relat Dis) - No abstract available

Journal • Genetic Disorders • Obesity

Correlation of serum meteorin-like concentrations with diabetic nephropathy. (PubMed, Diabetes Res Clin Pract) - "Serum Metrnl concentrations are inversely correlated with renal function and DN."

Journal • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Effect of sleeve gastrectomy on the expression of meteorin-like (METRNL) and Irisin (FNDC5) in muscle and brown adipose tissue and its impact on uncoupling proteins in diet-induced obesity rats. (PubMed, Surg Obes Relat Dis) - "Sleeve gastrectomy induces weight loss through complex mechanisms that may include browning of fat."

Journal • Genetic Disorders • Obesity

Effects of electrical stimulation-induced resistance exercise training on white and brown adipose tissues and plasma meteorin-like concentration in rats. (PubMed, Physiol Rep) - "These results suggest that plasma Metrnl is associated with PGC-1α and mitochondrial biogenesis in BAT. This study describes a potential role of RT in preventing metabolic diseases via altering WAT and BAT and increasing plasma Mertnl concentrations."

Journal • Preclinical • Metabolic Disorders

Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism. (PubMed, Nat Metab) - "Perturbations in this pathway inhibit efficacy of Metrnl in the regenerative process. Together, these studies identify Metrnl as an important regulator of muscle regeneration and a potential therapeutic target to enhance tissue repair."

Journal

Circulating levels of Meteorin-like protein in polycystic ovary syndrome: A case-control study. (PubMed, PLoS One) - "These findings revealed a possible role of Metrnl in the pathogenesis of PCOS and RPL. Nevertheless, there is a necessity for future studies to prove this concept."

Clinical • Journal • Metabolic Disorders • Polycystic Ovary Syndrome

Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin. (PubMed, Cells) - "Additionally, a strong positive association was observed between METRNL and irisin. Further studies are necessary to examine the role of these proteins in T2D and obesity, against their ethnic background and to understand the mechanistic significance of their possible interplay."

Biomarker • Journal • Genetic Disorders • Immunology • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus

Serum Metrnl is associated with the presence and severity of coronary artery disease. (PubMed, J Cell Mol Med) - "Meteorin-like (Metrnl) is a novel adipokine that is highly expressed in white adipose tissue...Furthermore, decreased Metrnl level was negatively correlated with the severity of CAD quantified by the Gensini score. This first case-control study shows significant associations of serum Metrnl with the presence and severity of CAD, suggesting Metrnl might be a new promising therapeutic target for CAD."

Journal • Atherosclerosis • Cardiovascular • Coronary Artery Disease

Meteorin-Like (METRNL) Attenuates Myocardial Ischemia/Reperfusion Injury-Induced Cardiomyocytes Apoptosis by Alleviating Endoplasmic Reticulum Stress via Activation of AMPK-PAK2 Signaling in H9C2 Cells. (PubMed, Med Sci Monit) - "CONCLUSIONS METRNL attenuates MI/R injury-induced cardiomyocytes apoptosis by alleviating endoplasmic reticulum stress via activation of AMPK-PAK2 signaling in H9C2 cells. Our findings support that METRNL might be a promising target for treatment of myocardial ischemia in the future."

Journal • Cardiovascular • Coronary Artery Disease • Gene Therapies • Immunology • Ischemic stroke • Myocardial Ischemia • Reperfusion Injury • PCR

Low Serum Levels of Meteorin-like/Subfatin: An Indicator of Diabetes Mellitus and Insulin Resistance? (PubMed, Endokrynol Pol) - "Serum levels of subfatin show a gradual decrease from healthy individuals to more advanced stages of diabetes, suggesting that it can serve as a useful marker in the prediabetic period in individuals with risk factors for diabetes."

Journal • Diabetes • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus

Association of Meteorin-Like Hormone with insulin resistance and body composition in healthy Iranian adults. (PubMed, Diabetes Metab Syndr) - "Baseline plasma Metrnl is correlated with regular physical activity and insulin sensitivity, but not with body composition parameters. Metrnl may be one possible mediator of the beneficial effects of PA on insulin sensitivity in healthy humans. Hence, increasing awareness of the benefits of physical activity and incorporating physical activity into lifestyle are of great importance for people with non-communicable diseases."

Clinical • Journal

Meteorin-like Levels in Individuals With Periodontitis (clinicaltrials.gov) - P; N=75; Recruiting; Sponsor: Istanbul Saglik Bilimleri University

Clinical • New trial • Dental Disorders • Periodontitis • IL10 • VEGFA

The novel cytokine Metrnl/IL-41 is elevated in psoriatic arthritis synovium and induced at the enthesis. (PubMed, Clin Immunol) - "Meteorin-like(IL-41), is a novel cytokine that is thought to be immunoregulatory and is highly expressed in psoriatic skin...In conclusion, IL-41 is expressed in PsA synovium and is present and inducible at the enthesis. Its functional effect in psoriatic inflammation remains to be fully elucidated."

Journal

Aerobic Exercise Increases Meteorin-Like Protein in Muscle and Adipose Tissue of Chronic High-Fat Diet-Induced Obese Mice. (PubMed, Biomed Res Int) - "Moreover, regular exercise increased acyl-CoA oxidase 1 (ACOX-1) and monoglyceride lipase (MGL) expression in adipose tissue (p < 0.05) and significantly decreased abdominal fat mass (p < 0.05). This study suggests that exercise-induced muscle Metrnl effectively reduces fat accumulation through the increase of Metrnl in adipose tissue, which may be a therapeutic target for chronic obesity."

Journal • Preclinical • Biosimilar • Metabolic Disorders • Obesity

Antihyperalgesic effects of Meteorin in the rat chronic constriction injury model: a replication study. (PubMed, Pain) - "Systemic administration of recombinant mouse Meteorin (0.5 and 1.8 mg/kg, s.c.) at days 10, 12, 14, 17, and 19 after CCI produced a prolonged reversal of neuropathic hypersensitivity with efficacy comparable with that obtained with gabapentin (100 mg/kg, orally). Despite some protocol deviations (eg, nociceptive endpoint, animal vendor, testing laboratory, investigator, etc.) being incurred, these did not affect study outcome. By paying careful attention to key facets of study design, using bioactive material, and confirming drug exposure, the current data have replicated the salient findings of the previous study, promoting confidence in further advancement of this novel molecule as a potential therapy for neuropathic pain."

Journal • Preclinical

Looking on the "brite" side exercise-induced browning of white adipose tissue. (PubMed, Pflugers Arch) - "The role of various endocrine factors, including catecholamines, interleukin-6, irisin, and meteorin-like in addition to local re-esterification-mediated mechanisms in inducing the browning of WAT will be discussed. The physiological importance of browning will be discussed, as will discrepancies in the literature between human and rodent studies."

Journal • Review

The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2. (PubMed, FEBS J) - "An intraperitoneal injection of recombinant metrnl improved glucose tolerance in mice with high-fat-diet-induced obesity or type 2 diabetes, but not in AMPK β1β2 muscle-specific null mice. Metrnl improves glucose metabolism via AMPKα2 and is a promising therapeutic candidate for glucose-related diseases such as type 2 diabetes."

Journal • Preclinical

ANNALS EXPRESS: Correlation of serum meteorin-Like concentration with the presence and severity of obstructive sleep apnea syndrome. (PubMed, Ann Clin Biochem) - "Serum Metrnl concentration is inversely correlated with the presence and severity of OSAS. Key words: meteorin-like; obstructive sleep apnea syndrome; inflammation."

Journal

Administration of Meteorine-Like Protein Ameliorates Hepatic Steatosis in Diet Induced Obese Mice (ISC 2020) - "Abstract embargoed at this time."

Preclinical

Is Metrnl an Adipokine İnvolved in the Anti-inflammatory Response to Acute Exacerbations of COPD? (PubMed, Lung) - "The high Metrnl level in COPD exacerbations and active smoking may be important in balancing the inflammatory response. However, plasma Metrnl levels were found to be lower in COPD patients with comorbidities."

Journal

Can novel adipokines, asprosin and meteorin-like, be biomarkers for malignant mesothelioma? (PubMed, Biotech Histochem) - "ASP and METRNL immunoreactivity was more prominent in the MM specimens than the RMH specimens. Therefore, ASP and METRNL potentially could be used as markers for differentiating MM from benign diseases."

Biomarker • Journal