mebendazole / Generic mfg. - LARVOL DELTA

Developing epigenetic synergistic drug combinations with albendazole in paediatric acute myeloid leukaemia (ASH 2025) - "Similar anthelmintic agents, mebendazole (MBZ) and parbendazole (PBZ), have been reported to have effects on epigenetic regulators that alter C-MYB degradation (Walf-Vorderwülbecke et al...These epigenetic hits represent various target families such as HDAC inhibitors (vorinostat, panobinostat, and CUDC-101), BET inhibitors (OTX-015, PFI-1, and (-)-JQ), aurora kinase inhibitors (MK-8745 and JNJ-7706621), and DNA synthesis inhibitors (cytarabine)...HDAC inhibitors (vorinostat), BET inhibitors (OTX-015) and histone methyltransferase (MS023) were among the most represented epigenetic target families, indicating potential mechanism of action of the novel ABZ+epigenetic combination. The novel drug candidate ABZ was found to have remarkable anti-leukaemia efficacy in murine and human models of childhood AML in vitro and in vivo while having negligible effects in normal cells. Current work is focused on evaluating ABZ+epigenetic synergistic combinations that will be taken..."

Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Pediatrics • HOXA9 • IL1B • MEIS1

Loa loa Encephalopathy Following Treatment With Benzimidazole Derivatives: A Systematic Review. (PubMed, Open Forum Infect Dis) - "Benzimidazole derivatives albendazole and mebendazole are recommended as alternative treatments due to their perceived safety in hypermicrofilaremic patients. Due to the limited global use of prolonged benzimidazole regimens for loiasis, the number of encephalopathy cases identified raises significant safety concerns, challenging the rationale of their use. Further research on mechanisms and safer alternative regimens is urgently needed."

Journal • CNS Disorders

Activity of antifilarial drugs on microfilaremia in the treatment of loiasis: a systematic review. (PubMed, Parasit Vectors) - "Antifilarial drug efficacy against L. loa microfilaremia varies by dosage and treatment duration, with IVM and DEC demonstrating rapid, high efficacy but presenting safety concerns for hypermicrofilaremic individuals. ALB and MBZ show efficacy with extended treatment but are slower acting. Further research is needed to optimize treatment regimens and assess clinical outcomes beyond microfilaremia reduction."

Journal • Review

Misinformation about breast cancer treatment on social media: Implications for engagement with patients and social media (SABCS 2025) - "Background: Despite lack of clinical trial data supporting drug efficacy or safety, many patients request alternative treatments, such as ivermectin, fenbendazole, mebendazole, and methylene blue, over standard treatments... Although it represents a minority of SM content surrounding breast cancer, content promoting and endorsing alternative treatments for breast cancer reached an estimated >55M people. Most content promotes treatments that are (1) not guideline concordant and/or endorsed by oncology experts, and (2) have no supporting scientific evidence of safety or efficacy for breast cancer. Our data suggest the bulk of content promoting such treatments may be from automated accounts or "bots." Given the wide-reaching impact of these SM posts, these findings highlight a need for information about evidence-based treatments in SM discussions, a need to equip breast cancer advocates and oncology providers to have such discussions with breast cancer..."

Clinical • Breast Cancer • Oncology • Solid Tumor

Ecotoxicological risk and environmental assessment of mebendazole: A comprehensive study using freshwater snails as non-target species. (PubMed, J Hazard Mater) - "Integrating transcriptomic analysis, qPCR, enzymatic profiling, histopathology, and molecular docking revealed that mebendazole interacts with the colchicine-binding site of tubulin, disrupting microtubule polymerization in hepatopancreas and kidneys and inducing organelle vacuolization and structural disintegration. Field validation at 0.25-0.50 mg/L resulted in high mortality of freshwater snails, highlighting the ecological hazards associated with mebendazole exposure. These findings provide critical evidence of mebendazole's ecological risks to non-target species, highlighting the urgency for dose optimization frameworks and ecosystem-level risk assessments to balance veterinary drug efficacy with environmental sustainability and biodiversity preservation in aquaculture systems."

Journal • Infectious Disease • Metabolic Disorders

Lactylation-Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22-Mediated Dephosphorylation of NLRP3. (PubMed, Adv Sci (Weinh)) - "Furthermore, mebendazole, a small-molecule drug targeting YTHDC1, significantly alleviates MASLD. In conclusion, YTHDC1 mitigates MASLD by inhibiting the PTPN22-mediated dephosphorylation and activation of NLRP3, offering new insights into therapeutic strategies for MASLD."

Journal • Hepatology • Inflammation • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Targeted Protein Degradation • AARS1 • IL18 • IL1B • LDHA • NLRP3 • PTPN2 • PTPN22 • YTHDC1

Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated With Mebendazole Use. (PubMed, Basic Clin Pharmacol Toxicol) - No abstract available

Journal • Steven-Johnson Syndrome

Rapid-Kinetics Degron Benchmarking Reveals Off-Target Activities and Mixed Agonism-Antagonism of MYB Inhibitors (ASH 2023) - "In parallel, we performed SLAM-seq in AML cells treated with six agents reported as MYB inhibitors: MYBMIM, celastrol, naphthol AS-E phosphate, mebendazole, plumbagin and all-trans retinoic acid (ATRA). For comparison, we treated MV411 cells with the BET bromodomain inhibitor JQ1, which has been reported to indirectly inhibit MYB by interfering with its expression and function...Our work will serve as a proof-of-principle demonstration of the use of rapid kinetic resolution of TF degron models for a more precise characterization of the target specificity and efficacy of TF-directed inhibitors. Benchmarking of TF modulators against degron models in nascent transcriptomics assays should be considered as an important criterion in their functional characterization."

Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • Targeted Protein Degradation

Novel Agents with Efficacy Against Cellular Models of Familial Platelet Disorder with Myeloid Malignancy (FPD-MM) Associated with Germline Mutant RUNX1 (ASH 2023) - "LINCS1000-CMap analysis, conducted with the RNA-Seq signature induced by lethal RUNX1 knockdown in AML cells with mutant (mt) RUNX1, was reported by us to reveal homoharringtonine (HHT or omacetaxine) and the anthelmintic fenbendazole (analog of mebendazole) as the top expression mimickers (EMs). These preclinical findings highlight the molecular features associated with progression of RUNX1-FPD to FPD-MM, including the newly established GMR-AML1 cell line. They also demonstrate that HHT or MB are effective against cellular models of FPD-MM versus RUNX1-FPD."

Clinical • IO biomarker • Acute Myelogenous Leukemia • Graft versus Host Disease • Hematological Malignancies • Immunology • Oncology • BCL2 • BCOR • CCND2 • CD123 • CD33 • CD34 • CDK6 • IL3RA • KIT • KRAS • MCL1 • MECOM • MYC • PHF6 • PTPN11 • RRM2 • RUNX1 • TET2 • WT1

EB1-Regulated Microtubule Dynamics Drive Cyst Formation in ADPKD (KIDNEY WEEK 2025) - "Importantly, treatment with mebendazole attenuates cyst growth and improves renal function in the Pkd1 knockout mouse model. These results highlight a novel role for microtubules in polycystic kidney disease and suggest that mebendazole may be a promising therapeutic candidate."

Autosomal Dominant Polycystic Kidney Disease • Genetic Disorders • Nephrology • Polycystic Kidney Disease • Renal Disease • GSK3B • Microtubule Associated Protein RP/EB Family Member 1 • PKD1 • PRKD1

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model. (PubMed, Oncol Rep) - "Patient‑derived tumor cells from acute myeloid leukemia (AML) and ovarian, colorectal and renal cancer were exposed to Mbz alone and, for solid tumors and the CT26 cell line, in combination with irinotecan, cisplatin or gemcitabine (patient cells only). Flow cytometry of the resected mouse tumors indicated that Mbz promoted macrophage polarization from the M2 to M1 phenotype, suggesting that immune modulation may contribute to its anticancer effect. Mbz has features making it a candidate for repositioning into an anticancer drug and part of its effect may be mediated by macrophage modulation."

Journal • Preclinical • Acute Myelogenous Leukemia • Colon Cancer • Colorectal Cancer • Hematological Malignancies • Immune Modulation • Immunology • Kidney Cancer • Leukemia • Oncology • Renal Cell Carcinoma • Solid Tumor

Analysis of discrepancy in SNEDDS performance for a "brick dust" mebendazole between in and vitro and in-vivo estimation. (PubMed, Eur J Pharm Biopharm) - "The SGIE-EMCP method, reflecting both GI-transit and subsequent absorption processes, indicated the highest precipitation of MBZ and MBZ transfer to the CHCl3 phase less than the EMCP method. The SGIE-EMCP method also indicated that 2 % HPMCP-50 SNEDDS transferred MBZ to the CHCl3 phase significantly larger than SNEDDS without the polymer, which coincided with the in-vivo tendency."

Journal • Preclinical • Gastrointestinal Disorder

Evaluation of Benzimidazole Resistance in Equine Cyathostomins in the Kermanshah Province of Iran Using Coprological Analysis and Allele-Specific PCR. (PubMed, Iran J Parasitol) - "There was a 96.1%-98.3% (90% CI) reduction in faecal egg counts following mebendazole treatment and a 96.6% - 98.7% (90% CI) reduction in faecal egg counts following fenbendazole treatment...Benzimidazole resistance in equine small strongyles has been reported globally, and the results of the present study were unexpected. The probable reasons for the slow development of BZ-resistance are climatic conditions in the country that have significant negative effects on the ability of free stages of the resistant strongyle nematode to survive and develop."

Journal

A Squirmy Surprise: Enterobiasis vermicularis Treatment in Pregnancy (ACG 2025) - "Pyrantel pamoate is preferred to albendazole and mebendazole due to poor systemic absorption limiting fetal exposure. In order to prevent reinfection, hygienic measures should be implemented to include washing bedsheets, fingernail clipping and, frequent handwashing. Due to the endemic nature of pinworms and their potential complications, physicians need greater awareness and understanding on treatment in pregnancy.Figure: Pinworm in rectumFigure: Pinworm in sigmoid colon"

Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pruritus

Endoscopy in the Diagnosis of Anemia (ACG 2025) - "The treatment of choice for hookworm infection is albendazole (400mg) or mebendazole (500mg) administered orally for 3 days for maximum effectiveness, with iron and nutritional support. This case demonstrates the necessity to suspect hookworm infection in IDA patients even when stool tests are negative and shows how prevention efforts fail to address zoonotic transmission. The control of soil-transmitted helminthiasis requires regular deworming programs together with veterinary interventions in areas where the disease is endemic and to prevent its long term morbidity calls for public health strategies that combine education with sanitation improvements and multisectoral collaboration.Figure: Parasitic worm located in the descending part of the second part of duodenum.Figure: Parasitic worms located in the ampullary region of the second part of duodenum."

Anemia • Anorexia • Eosinophilia • Fatigue • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Pulmonary Disease

Pinworm Found During Screening Colonoscopy (ACG 2025) - "The main medications used are albendazole, mebendazole, or pyrantel pamoate. The are no estimates of the prevalence of pinworms found during routine colonoscopy.Figure: Figure 1. Small worms in the cecum near the appendiceal orifice."

Colorectal Cancer • Infectious Disease • Pruritus • Solid Tumor

From Burden to Control; Assessing the outcomes of MDA programme for schistosomiasis and soil transmitted Heliminthiasis in Abuja, Nigeria (ASTMH 2025) - "Consequently, mass drug administration (MDA) with praziquantel and mebendazole began in 2015, targeting school-age children (SAC, 5-14 years). Five years of integrated MDA have nearly eliminated STH as a public health problem among SAC in the FCT, but SCH transmission persists. To eliminate SCH, the programme should: intensify praziquantel coverage, particularly in persistent hotspots, strengthen WASH infrastructure, and expand behaviour change education. Continuous surveillance will be crucial for tracking trends and guiding adaptive strategies."

Infectious Disease

Polyparasitism among school aged children living near source and irrigated rice fields in Ankililoaka in the subarid south-western part of Madagascar in 2023 (ASTMH 2025) - "All STH infections were treated with albendazole 500 mg. All malaria cases were treated with artesunate + amodiaquine...Given the increasing rainfall following the cyclones in early 2025, we believe that an integrated intervention is needed. Malaria chemoprevention using ACTs and repeated mass drug administration of praziquantel and mebendazole expanded to the adults (not limited to children) would be the better strategy to fight these parasitic diseases in the area."

Clinical • Anemia • Hematological Disorders • Infectious Disease • Malaria

Case Series of Autochthonous Ascariasis in Manitoba, Canada (ASTMH 2025) - "All cases were treated with mebendazole with good result...Our case highlights the need for Canadian medical practitioners to be aware of ascariasis especially with any pig exposure. From a One Health perspective, future prevention and control measures should not only focus on humans, but also in infected pigs."

Clinical • Infectious Disease

A single presumptive deworming may not suffice to reduce the burden of intestinal parasitic infections during pregnancy in rural Amhara Ethiopia (ASTMH 2025) - "The burden of intestinal parasite infection among third-trimester pregnant women in rural Amhara, Ethiopia remained high after a single presumptive treatment with 500 mg mebendazole in the second trimester and protozoal infections were most prevalent. Presumably a single dose was inadequate to treat the existing pathogens, and/or rates of reinfection were high."

Anemia • Hematological Disorders • Infectious Disease

Pericardial Hydatid Cyst in a Patient With Multisensory Impairments: Case Report and Review. (PubMed, Clin Case Rep) - "Management planning depends on the symptoms, involvement, and anatomical features of the HC. Some cases have reported total management with medical management with Albendazole or Mebendazole, while for the vast majority of cases, surgical intervention is needed."

Journal • Infectious Disease

Use of mebendazole (anthelmintic) for recurrent uncomplicated urinary tract infections in a healthy female: A case report. (PubMed, Qatar Med J) - "The patient received multiple courses of culture-guided antibiotics, including ertapenem, for over a period of two years. This case raises the question of whether empirical treatment with mebendazole should be considered for recurrent uncomplicated UTIs in sexually active, healthy females - alongside standard antibiotic therapy. Identifying pinworm infection in healthy adult females with rUTIs could provide valuable insights, particularly if an association between the two is confirmed."

Journal • Infectious Disease • Nephrology

"Diagnostic challenges, atypical presentations, and therapeutic implications in ectopic Enterobius vermicularis infections: a global systematic review.". (PubMed, Diagn Microbiol Infect Dis) - "Ectopic E. vermicularis infection can affect diverse organs and present with non-specific symptoms, frequently causing delays in diagnosis and unnecessary invasive procedures. Increased awareness among clinicians, alongside the use of adjunct non-invasive and molecular diagnostic methods, is crucial for early detection, complication prevention, and minimizing surgical interventions."

Journal • Review • Gastrointestinal Disorder • Gynecology • Infectious Disease • Pain

Preliminary Assessment of Repurposed Mebendazole Nano-Systems for Passive Targeting and Potential Treatment of Bone Metastasis. (PubMed, Pharm Dev Technol) - "In conclusion, these comprehensive findings strongly support the clinical relevance of NC4 in treating bone metastasis. Its ability to passively target the drug, inhibit tumor growth, alleviate pain, and exhibit favorable biomarker profiles and safety make it a promising candidate for improving the management and outcomes of patients with bone metastasis."

Journal • Oncology • Osteosarcoma • Pain • Solid Tumor

Development of an Ultrasensitive Monoclonal Antibody-Based Time-Resolved Fluorescence Immunochromatographic Assay for Mebendazole Detection. (PubMed, J Agric Food Chem) - "Results correlated strongly with LC-MS/MS (R2 > 0.97). This TRFIA provides a highly sensitive, reliable, and cost-effective platform for on-site screening of MBZ residues in animal-derived foods."

Journal