mebendazole / Generic mfg. - LARVOL DELTA

ER-Localized Deadenylase PNLDC1 Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of TUBB4B. (PubMed, Exploration (Beijing)) - "Importantly, we demonstrate that the TUBB4B inhibitor, mebendazole, effectively suppresses the enhanced proliferation in lower-expression PNLDC1 models, including cell, mouse xenografts, and patient-derived tumor-like cell clusters, positioning it as a promising therapeutic agent. These findings establish PNLDC1 as a valuable biomarker and therapeutic target, paving the way for developing novel CRC treatments."

Journal • Colorectal Cancer • Oncology • Solid Tumor

Effects of Mebendazole and Flutamide Combination in Prostate Cancer Cell Lines: a Comprehensive in Vitro Analysis. (PubMed, Cell Physiol Biochem) - "Mebendazole in combination with flutamide reduced dose of flutamide and increased the sensitivity of prostate cancer cells to treatment. Therefore, this combination may represent a promising in vitro strategy that warrants further mechanistic and in vivo investigation."

IO biomarker • Journal • Preclinical • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • BAX • BCL2 • CDH1 • CDH2 • HIF1A • KLK3 • TUBB1 • TUBB3 • VEGFC

A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer. (PubMed, Sci Rep) - "Individualized dose adjusted mebendazole is safe and well tolerated in patients with advanced cancer but all patients experienced rapid progressive disease. New approaches such as prodrug development and combination with other anticancer drugs seem needed for further exploration of mebendazole as an anticancer drug."

Clinical • Journal • P2a data • Gastrointestinal Cancer • Gastrointestinal Disorder • Infectious Disease • Oncology • Solid Tumor

Repurposing niclosamide ethanolamine for alveolar echinococcosis reveals a disconnect between in vitro efficacy and in vivo outcome in the intraperitoneal infection model. (PubMed, PLoS Negl Trop Dis) - "Although niclosamide and NEN demonstrated potent activity against E. multilocularis in vitro, this efficacy did not translate in the mouse model. The lack of in vivo activity could be attributed to several factors such as infection model, limited drug uptake by the parasite in the animal, or the rapid metabolization of the compound. Future studies should explore novel niclosamide derivatives and formulations to enhance efficacy against AE in vivo."

Journal • Preclinical • Infectious Disease • Oncology

When âAlternativeâ Becomes Harmful: Liver Injury Triggered by Off-Label Ivermectin and Mebendazole in Cancer Self-Treatment (ACG 2026) - "After previously declining conventional therapy, she began anastrozole in August 2025 and subsequently added metformin, ivermectin, and mebendazole as alternative treatment. Early recognition and withdrawal of the offending medications is critical to mitigating further injury, avoiding unnecessary interventions, and facilitating recovery. This case highlights the importance of thorough medication history and the need to consider uncommon drug related etiologies."

Breast Cancer • Dyslipidemia • Hepatology • Liver Failure • Oncology • Solid Tumor

Novel Agents with Efficacy Against Cellular Models of Familial Platelet Disorder with Myeloid Malignancy (FPD-MM) Associated with Germline Mutant RUNX1 (ASH 2023) - "LINCS1000-CMap analysis, conducted with the RNA-Seq signature induced by lethal RUNX1 knockdown in AML cells with mutant (mt) RUNX1, was reported by us to reveal homoharringtonine (HHT or omacetaxine) and the anthelmintic fenbendazole (analog of mebendazole) as the top expression mimickers (EMs). These preclinical findings highlight the molecular features associated with progression of RUNX1-FPD to FPD-MM, including the newly established GMR-AML1 cell line. They also demonstrate that HHT or MB are effective against cellular models of FPD-MM versus RUNX1-FPD."

Clinical • IO biomarker • Acute Myelogenous Leukemia • Graft versus Host Disease • Hematological Malignancies • Immunology • Oncology • BCL2 • BCOR • CCND2 • CD123 • CD33 • CD34 • CDK6 • IL3RA • KIT • KRAS • MCL1 • MECOM • MYC • PHF6 • PTPN11 • RRM2 • RUNX1 • TET2 • WT1

Novel agents with efficacy against germline mutant RUNX1 familial platelet disorder with myeloid malignancy (FPD-MM) (AACR 2024) - "LINCS1000-CMap analysis, of the RUNX1 knockdown RNA-Seq signature revealed homoharringtonine (HHT or omacetaxine) and the anthelmintic fenbendazole (analog of mebendazole (MB)) as the top expression mimickers. Finally, in the GMR-AML1 cell xenograft, treatment with omacetaxine or MB significantly reduced AML burden and improved overall survival of NSG mice. These preclinical findings highlight the molecular features associated with progression of RUNX1-FPD to FPD-MM and highlight HHT or MB as effective against cellular models of FPD-MM."

Clinical • IO biomarker • Acute Myelogenous Leukemia • Hematological Malignancies • Oncology • BCL2 • CD123 • CD33 • CDK6 • IL3RA • KIT • MCL1 • MECOM • MYC • RUNX1

Clinical Practices in the Diagnosis and Treatment of Enterobiasis: A Retrospective Analysis. (PubMed, Am J Trop Med Hyg) - "The most common initial treatment of enterobiasis was albendazole (73.6%) followed by mebendazole (15.0%), pyrantel (10.9%), and ivermectin (0.5%)...This study suggests that there are knowledge gaps in the optimal diagnostic approach to enterobiasis as well as the role of adjunctive measures to prevent a cycle of continuous reinfection, such as empiric retreatment, empiric treatment of household members, and counseling on decontamination measures. Additionally, the prominence of albendazole use relative to pyrantel pamoate represents an opportunity for cost-conscious care."

Journal • Retrospective data • Infectious Disease

TREMO-Pemba: Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections (clinicaltrials.gov) - P3 | N=315 | Active, not recruiting | Sponsor: Swiss Tropical & Public Health Institute | Enrolling by invitation ➔ Active, not recruiting

Enrollment closed • Infectious Disease

Chest pain and eosinophilia in a middle-aged female caused by hookworm infection: a case report. (PubMed, Rev Inst Med Trop Sao Paulo) - "Treatment of oral mebendazole (400 mg twice daily) for three days resulted in complete resolution of symptoms, normalization of eosinophil count, and clearance of parasites on follow-up. This case highlights hookworm infection as a potential cause of eosinophilia and chest pain in endemic regions."

Journal • Eosinophilia • Hematological Disorders • Infectious Disease • Pain

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas (clinicaltrials.gov) - P1/2 | N=10 | Active, not recruiting | Sponsor: Julie Krystal | Completed ➔ Active, not recruiting | N=36 ➔ 10 | Trial completion date: Apr 2024 ➔ Dec 2027 | Trial primary completion date: Apr 2024 ➔ Mar 2027

Enrollment change • Enrollment closed • Trial completion date • Trial primary completion date • Astrocytoma • Brain Cancer • Diffuse Intrinsic Pontine Glioma • Glioblastoma • Glioma • Gliosarcoma • Low Grade Glioma • Oncology • Pediatrics • Pilocytic Astrocytoma • Pleomorphic Xanthoastrocytoma • Sarcoma • Solid Tumor

Enterobius vermicularis as a Mimic of Acute Appendicitis: A Case Report and Updated Systematic Review. (PubMed, Cureus) - "Symptoms resolved following surgery and mebendazole treatment...Recognition of enterobiasis may guide anthelmintic therapy and consideration of household treatment; however, a causal relationship between EV and systemic hypersensitivity features cannot be established from a single case. Importantly, clinical deterioration should continue to prompt urgent surgical assessment."

Journal • Cardiovascular • Dermatology • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Musculoskeletal Pain • Pain • Pruritus • Urticaria • CRP

Prevalence, risk factor, control and dwelling of Ascaridia galli in the gut of chickens. (PubMed, Trop Biomed) - "The A. galli infection are very common, and cause intestine damage. The mebendazole and its derivative decrease egg shedding significantly, Husbandry, management and treatment should be enhanced for effective control strategies."

Journal • Infectious Disease • Inflammation

Inflammation-triggered nanodrug delivery microneedles targeting pathogenic COX2+ endothelial cell-mediated glycocalyx degradation to ameliorate psoriasis. (PubMed, Biomaterials) - "The ROS-COX2-MMP9 axis can be effectively suppressed by mebendazole, an FDA-approved anthelmintic drug...This approach markedly enhances glycocalyx coverage from 11.91 ± 4.09% to 87.5 ± 8.7% and significantly reduces immune cell infiltration. Collectively, this work establishes a vascular-targeted therapeutic paradigm centered on endothelial glycocalyx repair and achieves precise and effective intervention in inflammatory diseases."

Journal • Dermatology • Immunology • Inflammation • Psoriasis • MMP9 • PACERR • PTGS2

Metabolic cell competition in the glioblastoma tumour microenvironment: glucose, glutamine, and lactate as determinants of immune exclusion and targets for pharmacological reprogramming. (PubMed, Front Oncol) - "Glioblastoma (GBM) remains the most lethal primary brain tumour, with median overall survival of 14 to 16 months despite maximal safe surgical resection, concurrent chemoradiotherapy, and adjuvant temozolomide...Disrupting glucose and glutamine metabolism through glutamine antagonism (DON and prodrugs JHU083/JHU395), dichloroacetate (DCA)-mediated PDK inhibition, intravenous pharmacological ascorbate-mediated GAPDH inactivation and HIF-1alpha destabilisation, systemic glucose restriction (SGLT2 inhibitors), sodium phenylbutyrate-mediated glutamine depletion, and monocarboxylate transporter inhibition can invert this competitive hierarchy, reprogramming the immunosuppressive myeloid compartment while preserving T cell fitness; mebendazole is additionally reviewed as a multi-target anti-parasitic repurposing candidate with demonstrated GBM preclinical survival benefit...GBM cells and immunosuppressive myeloid cells are proposed to constitute a substrate-dependent..."

Journal • Review • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • GAPDH • HIF1A • NLRP3

Sigmoid volvulus and incidental enterobiasis in a young adult: a case report. (PubMed, Front Surg) - "Endoscopic detorsion was achieved successfully with placement of a rectal decompression tube; during colonoscopy, a single adult gravid Enterobius vermicularis was retrieved and confirmed parasitologically (characteristic ova demonstrated within the gravid female), prompting consultation with an infectious diseases team and a course of mebendazole...A two-stage strategy of colonoscopic detorsion followed by definitive laparoscopic sigmoidectomy is feasible and effective in hemodynamically stable patients without ischemia. The clinical relevance of the coexisting enterobiasis remains hypothesis-generating and should not be overstated."

Journal • Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pain

Treatment outcomes and factors associated with recovery among children aged 6-59 months with severe acute malnutrition admitted to therapeutic feeding units in Central Tanzania: a longitudinal descriptive study. (PubMed, BMJ Open) - "Recovery rate among children with severe acute malnutrition was influenced by place of residence, breastfeeding status, caregiver occupation and the use of mebendazole and folic acid supplementation. However, mortality remained a concern, highlighting the need for improved management of severe acute malnutrition in therapeutic feeding units. Further research is needed to explore additional factors affecting recovery and treatment outcomes."

Journal

Cancer Therapy Using Antiparasitic Medications Guided by Acupuncture Meridian Assessment: A Case Series of Six Patients. (PubMed, Integr Med (Encinitas)) - "Treatment protocols included combinations of ivermectin, mebendazole, praziquantel, niclosamide, and antifungals, selected based on AMA readings...AMA-guided antiparasitic therapy showed promising outcomes in this small case series. These preliminary results warrant further study to evaluate the efficacy and safety of this integrative approach."

Journal • Brain Cancer • Breast Cancer • Genito-urinary Cancer • Glioblastoma • Hematological Malignancies • Infectious Disease • Lung Cancer • Multiple Myeloma • Oncology • Prostate Cancer • Solid Tumor

Efficacy, safety, and acceptability of a child-friendly, chewable formulation of oxantel pamoate versus mebendazole for Trichuris spp infections in children aged 2-12 years in Tanzania: a randomised, single-blind, phase 2 trial. (PubMed, Lancet Infect Dis) - P2 | "Our study did not provide sufficient evidence of superiority in terms of cure rate for single-dose oxantel pamoate over single-dose mebendazole. However, the superiority in egg reduction rates seems to corroborate the higher efficacy observed in previous phase 2 studies and supports phase 3 development towards regulatory approval."

Journal • P2 data • Infectious Disease • Pain

MISSION: Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations (clinicaltrials.gov) - P=N/A | N=5760 | Recruiting | Sponsor: Uwemedimo Friday Ekpo

New trial • Infectious Disease • Ophthalmology

Intestinal Capillariasis in a South Indian Farmer: A Report of a Rare Case From a Tertiary Care Hospital. (PubMed, Cureus) - "The patient received oral mebendazole at a dose of 200 mg twice daily for 20 days, together with adequate hydration, dietary advice, and nutritional supplementation...This case emphasises that intestinal capillariasis should be considered as a possible diagnosis in patients with long-standing diarrhoea, weight loss, and eosinophilia, even in areas where the disease is not commonly reported. Early stool examination, careful dietary history, and timely anti-helminthic therapy can prevent prolonged morbidity and possible complications."

Journal • Eosinophilia • Hematological Disorders • Infectious Disease • Pain

Implications of global health funding patterns for implementation of a novel soil-transmitted helminth and lymphatic filariasis medicine: Ivermectin/albendazole fixed-dose combination. (PubMed, PLoS Negl Trop Dis) - "Introduction of the FDC in the absence of donation schemes poses significant financing and supply challenges, especially for LICs and LMICs where essential medicine availability is already limited. However, it also presents an opportunity to reset NTD access models by embedding sustainable financing strategies, such as pooled procurement, tiered pricing, and primary health care integration, from the outset. Early planning with manufacturers, donors, and governments will be essential to ensure equitable access and country ownership of this novel treatment."

Journal • Review

Paracapillaria philippinensis Infection in India: A Report of Four Cases. (PubMed, Am J Trop Med Hyg) - "Three patients responded well to albendazole; mebendazole was prescribed to the other patient, who was subsequently lost to follow-up. In the present report, the authors suggest considering Paracapillaria infection as a differential diagnosis for chronic diarrhea with an unclear etiology and aim to raise awareness among healthcare providers working in regions where Paracapillaria infections are infrequently reported."

Journal • Infectious Disease • Pain

Mebendazole Shows Antiproliferative and Antimigratory Effects in Paediatric Low-Grade Glioma Models. (PubMed, Oncol Res) - "Objectives: Advances in molecular profiling of pediatric low-grade glioma have enabled targeted therapies to emerge as effective and better-tolerated alternatives to conventional chemotherapy, increasingly used in progressive or recurrent disease and may reduce long-term treatment toxicity. These findings indicate that MBZ exerts potent antiproliferative and anti-migratory activity in pediatric glioma cell lines, supporting its potential as a repositioned therapeutic drug. However, no additional benefit was observed when combined with vinblastine, underscoring the importance of exploring MBZ as a single-agent strategy in future translational studies."

Journal • Brain Cancer • Glioma • Low Grade Glioma • Oncology • Pediatrics • Solid Tumor

Pediatric Anal Pruritus and Misdiagnosis: Dipylidium caninum in a Spanish Child with a Review of Reported Human Cases. (PubMed, Am J Trop Med Hyg) - "We present the case of a 3-year-old Spanish boy with intense anal itching, treated twice with mebendazole for presumed pinworm infection without improvement...Treatment with paromomycin sulfate resulted in complete cure. This case highlights the importance of recognizing the characteristic morphology of D. caninum to avoid misdiagnosis and inappropriate therapy."

Journal • Anorexia • Dermatology • Infectious Disease • Pediatrics • Pruritus