mebendazole / Generic mfg. - LARVOL DELTA

A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer. (PubMed, Sci Rep) - "Individualized dose adjusted mebendazole is safe and well tolerated in patients with advanced cancer but all patients experienced rapid progressive disease. New approaches such as prodrug development and combination with other anticancer drugs seem needed for further exploration of mebendazole as an anticancer drug."

Clinical • Journal • P2a data • Gastrointestinal Cancer • Gastrointestinal Disorder • Infectious Disease • Oncology • Solid Tumor

Repurposing flufenamic acid as a putative PmrB-directed adjuvant to restore colistin activity in Klebsiella pneumoniae. (PubMed, Microbiol Spectr) - "High-throughput virtual screening of DrugBank using integrated ligand- and structure-based approaches shortlisted five approved drugs (mebendazole, flurbiprofen, tirbanibulin, flufenamic acid, and netarsudil) for experimental evaluation. Mechanistically, our findings are consistent with modulation of the PmrB/PmrA resistance pathway, supporting bacterial histidine-kinase signaling as a promising direction for antibiotic adjuvant development. Overall, this study highlights a practical and scalable framework for discovering resistance-targeted adjuvants to help protect last-resort antibiotics and improve treatment options for difficult-to-treat infections."

Journal • Infectious Disease • Pneumonia

Mebendazole-Treated Human Monocyte-Derived Dendritic Cells Represent Promoted Immunogenic Phenotype with Augmented Expression of Inflammatory Markers. (PubMed, Adv Pharm Bull) - "MBZ holds significant potential for reshaping immunotherapy by exerting a profound impact on dendritic cells. By comprehending the intricate interaction between MBZ and dendritic cell function, innovative interventions can be developed."

IO biomarker • Journal • Oncology • CD86 • IL10 • IL18 • IL1B • ITGAX • TNFA

Comparison of Efficacy of Albendazole, Mebendazole and Pyrantel Pamoate in Achieving Remission and Preventing Recurrence of Enterobius vermicularis Infestation in Children: A Randomised Controlled Trial. (PubMed, Indian Pediatr) - "Albendazole, mebendazole and pyrantel pamoate had similar efficacy in inducing remission, while mebendazole was better than the other two agents in preventing recurrences."

Journal

107: Controversial Therapies in Oncology: Evidence, Ethics, and Effective Communications Surrounding Ivermectin, Fenbendazole, and Mebendazole (HOPA 2026) - "Participants will also explore communication strategies that support respectful, patient-centered dialogue—balancing scientific integrity with empathy and trust-building. By the end of the session, attendees will be better equipped to evaluate the risks and benefits of these therapies and guide oncology patients through informed decision-making UAN: 0465-0000-26-023-L99-P Knowledge or Application Based: Application Learning Objectives: Describe misinformation related to the use of controversial therapies in oncology, including repurposed drugs such as ivermectin, fenbendazole, and mebendazoleEvaluate the current evidence regarding efficacy and clinical relevance of selected controversial therapiesIdentify potential risks and ethical concerns related to the use of non-evidence-based treatments in oncology careApply effective, patient-centered communication strategies to discuss controversial therapies while promoting informed, evidence-based decision making"

Oncology

Risk factors, pathologies and control of gut-dwelling roundworms in chickens. (PubMed, Helminthologia) - "Anthelmintic trials demonstrated that both Mebendazole and its derivative significantly reduced the eggs per gram (EPG) of faecal samples of roundworm, with the derivative being more effective. Nematode infections cause significant health problems and economic losses in poultry; therefore, improved management, sanitation, and regular deworming practices are essential to effectively control parasitic infections in domestic chickens."

Journal • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Inflammation • Inflammatory Bowel Disease

Glycyl-l-histidyl-l-lysine as a novel co-former in co-amorphous systems: Enhanced aqueous solubility and physical stability. (PubMed, Eur J Pharm Sci) - "Basic mebendazole, neutral tadalafil and acidic indomethacin were selected as the model drugs. Notably, salt formation and hydrogen bonding were associated with the observed improvements in dissolution performance and physical stability. In conclusion, GHK represents a promising co-former, expanding the design space for co-amorphous systems."

Journal

Evaluation of the Efficacy of Anthelmintic Drugs Against Trichinella spiralis Larvae. (PubMed, Antibiotics (Basel)) - "Background: Albendazole, mebendazole, and ivermectin are effective against adult Trichinella spiralis but show limited efficacy against encapsulated muscle stage larvae... Seven antiparasitic drugs, albendazole (ABZ), miltefosine (MLT), ivermectin (IVM), tribendimidine (TBD), praziquantel (PZQ), artesunate (ART), and mefloquine (MEQ), were evaluated for in vitro activity against T. spiralis muscle larvae...In vivo, TBD treatment significantly reduced larval burdens in diaphragm and gastrocnemius muscles and was associated with reduced collagen capsule thickness, inflammation, and fibrosis compared with ABZ-treated controls. This study validated an assay for quantitative evaluation of T. spiralis muscle larvae and demonstrates robust in vitro and in vivo activity of TBD against this stage."

Journal • Fibrosis • Immunology • Inflammation

Mebendazole impairs the expression and function of enzymes in nucleotide metabolism pathways, leading to Selective Cytotoxicity, Cell Cycle Arrest, and Damage to Cell Morphology in Gastric Cancer. (PubMed, Chem Biol Interact) - "Our findings suggest that MBZ modulates nucleotide synthesis pathways, contributing to its selective antiproliferative effects in GC cells. This study highlights potential new pharmacological targets for drug repurposing and further investigation into the broader therapeutic applications of MBZ."

Journal • Gastric Cancer • Gene Therapies • Oncology • Solid Tumor • HPRT1 • PRPS1 • TYMS

Treatment and Prevention of Severe Anemia in Pregnant Zanzibari Women (clinicaltrials.gov) - P3 | N=2500 | Completed | Sponsor: Cornell University | Active, not recruiting ➔ Completed

Trial completion • Anemia • Hematological Disorders

Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus. (PubMed, Sci Rep) - No abstract available

Journal • Preclinical • Immunology • Inflammatory Arthritis • Lupus • Systemic Lupus Erythematosus

Inhibition of Antioxidant Genes Expression in Echinococcus Granulosus by Baicalein: Implications for Novel Antiparasitic Strategies. (PubMed, Acta Parasitol) - "The results of the study showed that BC had a significant protoscolicicidal effect on E. granulosus PTS, which increased parasite death by reducing the expression of antioxidant genes, indicating a direct effect on their defense system and metabolic pathways. Also, BC had a favorable selective effect on HepG2 cancer cells and showed less toxicity than normal THLE-2 cells, which confirms its high selectivity index. Future studies can focus on developing novel drug delivery formulations and investigating signaling pathways related to oxidative stress and apoptosis in parasites to optimize the antiparasitic and anticancer effects of BC."

Journal • Liver Cancer • Oncology • Solid Tumor

Possible Efficacy and Safety of Mebendazole in Patients With Ulcerative Colitis Treated With Mesalamine (clinicaltrials.gov) - P=N/A | N=46 | Recruiting | Sponsor: Tanta University | Not yet recruiting ➔ Recruiting | Trial completion date: May 2025 ➔ May 2026 | Trial primary completion date: Apr 2025 ➔ Apr 2026

Enrollment open • Trial completion date • Trial primary completion date • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis • ICAM1

Mebendazole inhibits PELI3-mediated ubiquitination of TRADD in non-small cell lung cancer cells. (PubMed, Front Oncol) - "Mebendazole inhibited the viability of HCC827 and A549 cells with diminished expression of PELI3 and increased expression of TRADD. PELI3 can function as an E3 ubiquitin ligase to ubiquitinate TRADD, and Mebendazole might be a promising drug to affect PELI3 expression in NSCLC."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • TNFA • TRADD

TREMO-Pemba: Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections (clinicaltrials.gov) - P3 | N=315 | Enrolling by invitation | Sponsor: Swiss Tropical & Public Health Institute | Not yet recruiting ➔ Enrolling by invitation | Trial completion date: Apr 2026 ➔ Jul 2026

Enrollment open • Trial completion date • Infectious Disease

TREMO-Siargao: Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections (clinicaltrials.gov) - P3 | N=315 | Not yet recruiting | Sponsor: Swiss Tropical & Public Health Institute | Trial completion date: Sep 2026 ➔ Dec 2026 | Initiation date: Jan 2026 ➔ Apr 2026 | Trial primary completion date: Jun 2026 ➔ Sep 2026

Trial completion date • Trial initiation date • Trial primary completion date • Infectious Disease

Girdin silencing enhances mebendazole-mediated anticancer activity: a combinatorial therapeutic strategy for ovarian cancer. (PubMed, Med Oncol) - "Docking studies confirmed stable MBZ binding to Girdin's catalytic domain, supported by favorable binding energies and molecular interactions. This is the first study to demonstrate that MBZ's anticancer efficacy is significantly enhanced by Girdin silencing, implicating the modulation of critical oncogenic pathways."

Journal • Gynecologic Cancers • Oncology • Ovarian Cancer • Solid Tumor

Phase 1 study of mebendazole therapy for refractory/progressive or recurrent pediatric brain tumors. (PubMed, Neurooncol Pract) - "MBZ is safe and tolerable in treating refractory or progressive pediatric brain tumors, with doses up to 2500 mg/m2/day. There was limited evidence of single-agent efficacy."

Journal • P1 data • Anorexia • Astrocytoma • Brain Cancer • Diffuse Intrinsic Pontine Glioma • Diffuse Midline Glioma • Ependymoma • Glioblastoma • Glioma • High Grade Glioma • Medulloblastoma • Oncology • Pediatrics • Solid Tumor

Niche Restriction and Host Gut Bacterial Sensitivity in Intestinal Nematodes of the African Nightcrawler. (PubMed, Zool Stud) - "Control experiments indicate that both intestinal nematodes are sensitive to environmental residues of the anthelmintic mebendazole...These findings underscore the strong correlation between T. endoscolicum infection dynamics and the host's bacterial abundance, aligning with previous research on the potential relationship between pinworms, host digestion, and the resident bacterial population. Given that African nightcrawler is a widely used compost earthworm, the influence of intestinal nematodes, along with varying prevalence under different farming conditions, may significantly affect the efficiency of earthworm composting-an aspect that has been relatively underexplored in the composting industry."

Journal • Infectious Disease

Activity of antifilarial drugs on microfilaremia in the treatment of loiasis: a systematic review. (PubMed, Parasit Vectors) - "Antifilarial drug efficacy against L. loa microfilaremia varies by dosage and treatment duration, with IVM and DEC demonstrating rapid, high efficacy but presenting safety concerns for hypermicrofilaremic individuals. ALB and MBZ show efficacy with extended treatment but are slower acting. Further research is needed to optimize treatment regimens and assess clinical outcomes beyond microfilaremia reduction."

Journal • Review

Disruption of epidermal growth factor receptor signaling and cytoskeletal dynamics by mebendazole and gefitinib synergistically impairs paracrine cytokine signaling in non-small cell lung cancer and triple-negative breast cancer Cell lines. (PubMed, PLoS One) - "The combination of mebendazole and gefitinib effectively suppresses tumor cell viability and modulates key pathways involved in cancer progression. By targeting cytoskeletal integrity and EGFR signaling, it may disrupt cytokine and tumor-microenvironment interactions, supporting further exploration as a strategy to overcome resistance in lung and breast cancers."

Journal • Preclinical • Breast Cancer • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • EGFR • IFNG • IL1B • IL6 • MMP2 • STAT4 • TNFA

Misinformation about breast cancer treatment on social media: Implications for engagement with patients and social media (SABCS 2025) - "Background: Despite lack of clinical trial data supporting drug efficacy or safety, many patients request alternative treatments, such as ivermectin, fenbendazole, mebendazole, and methylene blue, over standard treatments... Although it represents a minority of SM content surrounding breast cancer, content promoting and endorsing alternative treatments for breast cancer reached an estimated >55M people. Most content promotes treatments that are (1) not guideline concordant and/or endorsed by oncology experts, and (2) have no supporting scientific evidence of safety or efficacy for breast cancer. Our data suggest the bulk of content promoting such treatments may be from automated accounts or "bots." Given the wide-reaching impact of these SM posts, these findings highlight a need for information about evidence-based treatments in SM discussions, a need to equip breast cancer advocates and oncology providers to have such discussions with breast cancer..."

Clinical • Breast Cancer • Oncology • Solid Tumor

Developing epigenetic synergistic drug combinations with albendazole in paediatric acute myeloid leukaemia (ASH 2025) - "Similar anthelmintic agents, mebendazole (MBZ) and parbendazole (PBZ), have been reported to have effects on epigenetic regulators that alter C-MYB degradation (Walf-Vorderwülbecke et al...These epigenetic hits represent various target families such as HDAC inhibitors (vorinostat, panobinostat, and CUDC-101), BET inhibitors (OTX-015, PFI-1, and (-)-JQ), aurora kinase inhibitors (MK-8745 and JNJ-7706621), and DNA synthesis inhibitors (cytarabine)...HDAC inhibitors (vorinostat), BET inhibitors (OTX-015) and histone methyltransferase (MS023) were among the most represented epigenetic target families, indicating potential mechanism of action of the novel ABZ+epigenetic combination. The novel drug candidate ABZ was found to have remarkable anti-leukaemia efficacy in murine and human models of childhood AML in vitro and in vivo while having negligible effects in normal cells. Current work is focused on evaluating ABZ+epigenetic synergistic combinations that will be taken..."

Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Pediatrics • HOXA9 • IL1B • MEIS1

Loa loa Encephalopathy Following Treatment With Benzimidazole Derivatives: A Systematic Review. (PubMed, Open Forum Infect Dis) - "Benzimidazole derivatives albendazole and mebendazole are recommended as alternative treatments due to their perceived safety in hypermicrofilaremic patients. Due to the limited global use of prolonged benzimidazole regimens for loiasis, the number of encephalopathy cases identified raises significant safety concerns, challenging the rationale of their use. Further research on mechanisms and safer alternative regimens is urgently needed."

Journal • CNS Disorders

Ecotoxicological risk and environmental assessment of mebendazole: A comprehensive study using freshwater snails as non-target species. (PubMed, J Hazard Mater) - "Integrating transcriptomic analysis, qPCR, enzymatic profiling, histopathology, and molecular docking revealed that mebendazole interacts with the colchicine-binding site of tubulin, disrupting microtubule polymerization in hepatopancreas and kidneys and inducing organelle vacuolization and structural disintegration. Field validation at 0.25-0.50 mg/L resulted in high mortality of freshwater snails, highlighting the ecological hazards associated with mebendazole exposure. These findings provide critical evidence of mebendazole's ecological risks to non-target species, highlighting the urgency for dose optimization frameworks and ecosystem-level risk assessments to balance veterinary drug efficacy with environmental sustainability and biodiversity preservation in aquaculture systems."

Journal • Infectious Disease • Metabolic Disorders