isoxsuprine / Generic mfg. - LARVOL DELTA

Screening of neurotransmitter receptor modulators reveals novel inhibitors of influenza virus replication. (PubMed, Front Cell Infect Microbiol) - "Three representative compounds (isoxsuprine, ciproxifan, and rotigotine) inhibited H1N1 replication in a dose-dependent manner in multiple cell lines, and were effective against H1N1, oseltamivir-resistant H1N1, H3N2, and influenza B strains. In a mouse model of lethal influenza, isoxsuprine significantly decreased lung viral titers, mitigated pulmonary inflammation, and enhanced survival rates. These findings highlight neurotransmitter receptors as potential targets for developing novel anti-influenza agents, providing a foundation for further optimization of the identified compounds as potential therapeutic agents."

Journal • Preclinical • Acute Respiratory Distress Syndrome • Infectious Disease • Inflammation • Influenza • Novel Coronavirus Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Investigation of the clinical effects of isoxsuprine hydrochloride administered before cesarean section in sheep on mother and newborn. (PubMed, Res Vet Sci) - "From these groups, a total of four groups were formed: Group I (n = 10), which received 5 mL saline solution 45 min before the cesarean operation; Group II (n = 10), which received 0.6 mg/kg IP 45 min before the cesarean operation; Group III (n = 10), which received 16 mg dexamethasone 24 h before the cesarean operation; and Group IV (n = 10), which received 16 mg dexamethasone 24 h before and 0.6 mg/kg IP 45 min before the cesarean operation. Furthermore, antioxidant capacities (TAS) were higher, and oxidative stress levels (TOS, OSI) were lower in lambs from the isoxsuprine-treated groups (p < 0.001). In conclusion, isoxsuprine administration improved maternal and fetal circulation, enhancing blood flow and positively affecting offspring viability."

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Tailored Fibrils Approach via Ag(I).Peptidomimetic-Based Interface Design: Efficient Encapsulation of Diverse Active Pharmaceutical Ingredients in Wastewater Remediation during Effluent Treatment Plant (ETP) Processing. (PubMed, Langmuir) - "We further investigated the removal of various commonly prescribed drugs, including antibiotics such as β-lactam (amoxicillin), fluoroquinolone (ciprofloxacin), aminoglycoside (neomycin), and tetracycline; antiparasitic agents with antiprotozoal properties (praziquantel and metronidazole); nonsteroidal anti-inflammatory drugs (NSAIDs) such as phenylbutazone and ketoprofen; the vasodilator isoxsuprine; amphiphilic antidepressants (amitriptyline); and the antiviral drug amantadine. Finally, the encapsulation of APIs was evaluated using Ag(I) metal ion-driven ANS-3 based self-assembled nanofibrous material. This research contributes to the development of innovative physicochemical wastewater treatment strategies for environmental remediation and validates the importance of rational design in encapsulation-based wastewater remediation technologies."

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Contrack: A High-Throughput Contractility Screening Platform for 3D Human Cardiac Microtissues (AHA 2024) - "Reduced cardioid contractility was found with treatments of doxorubicin and verapamil. Interestingly, we found isoxsuprine significantly increased cardioid contractility... Contrack allows for streamlined analysis that meets the increasing demand for cost-efficient, large-scale functional validation in the study of cardiovascular disease. It provides a powerful translational platform for investigation of disease mechanisms and drug discovery relevant to heart failure and cardiomyopathy."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure

Development of a New Isoxsuprine Hydrochloride-Based Hydroxylated Compound with Potent Antioxidant and Anti-Inflammatory Activities. (PubMed, J Microbiol Biotechnol) - "This study illustrates that PDMA is an effective strategy for screening known natural and chemical compounds and for generating new bioactive compounds through biotransformation. Our newly produced compound has potential future applications in pharmacology and biotechnology."

Journal • Inflammation • IL1B • IL6 • PTGS2 • Tyrosinase

Spontaneous Wing Tip Edema in Captive Birds of Prey: Review of 41 Cases in the United Kingdom (2004-2022). (PubMed, J Avian Med Surg) - "End-stage disease, represented by primary flight feather loss and metacarpal ischemic (dry) gangrene, and enalapril use were associated with poor patient outcomes. Presentation within 24 hours of disease onset, isoxsuprine use, and physiotherapy were associated with improved patient outcomes. This study showed that WTE is an infrequently encountered but clinically significant condition in captive raptors and is associated with an overall high morbidity and moderate mortality risk."

Journal • Retrospective data • Review

Effects of topical isoxsuprine ointment on imiquimod-induced psoriasiform skin inflammation in mice. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "In contrast, the other markers (TNF-α, IL6, and IL10) showed significant differences between clobetasol and isoxsuprine groups. Isoxsuprine ointment showed comparable efficacy to clobetasol ointment in treating imiquimod-induced psoriasiform skin inflammation in mice models, probably due to its possible effect of anti-inflammatory and immunomodulatory activities."

Journal • Preclinical • Dermatitis • Dermatology • Immunology • Inflammation • Psoriasis • IL10 • IL17A • IL23A • IL6 • TNFA

Failure of isoxsuprine HCl to increase sheep fertility after cervical versus laparoscopic AI using chilled semen at different durations. (PubMed, Anim Sci J) - "In addition, fertility was affected by the storage duration of the semen; laparoscopic AI was more successful than cervical AI in terms of fertility; if cervical AI is performed, the duration between semen collection and AI should be less than 8 h after chilling the semen at 4°C, and if laparoscopic AI is performed, the time between semen collection and insemination can be up to 24 h after chilling the semen at 4°C. Longer storage periods should be studied."

Clinical • Journal

Safety and Tolerability of ISX (Isoxsuprine HCL) in MS Relapses (clinicaltrials.gov) - P1/2 | N=2 | Completed | Sponsor: University of New Mexico | Trial completion date: Jul 2021 ➔ Jul 2023 | Trial primary completion date: Jul 2021 ➔ Jul 2023

Trial completion date • Trial primary completion date • CNS Disorders • Multiple Sclerosis

Formulation and Therapeutic Evaluation of Isoxsuprine-Loaded Nanoparticles against Diabetes-Associated Stroke. (PubMed, Pharmaceutics) - "Furthermore, the in vivo studies verified the improved neurological behavior and decreased dead shrunken neurons and vascular congestion of the rats treated with the optimized ILEP formulation, demonstrating its anti-stroke activity. In conclusion, our study found that treatment with an optimized ILEP formulation prevented the initiation and severity of stroke, especially in diabetic patients."

Journal • Cardiovascular • Diabetes • Ischemic stroke • Metabolic Disorders

Vaginal Drain to Prevent Ascending Infection in Preterm Premature Rupture of Membranes: A Novel Method. (PubMed, Cureus) - "By using a vaginal drain for P(P)ROM, ascending infection can be prevented, leaks can be stopped in 40% of women, and can buy time for ANS to act."

Journal • Acute Respiratory Distress Syndrome • Infectious Disease • Obstetrics

Effects of tocolytic drugs (isoxsuprine hydrochloride) during the implantation period in pregnant sheep. (PubMed, Pol J Vet Sci) - "Blood progesterone, cortisol and calcium concentration were determined. As a result, it was determined that the single application of isoxsuprine hydrochloride (3 ml) in the implantation period did not have a positive or negative effect on reproductive parameters, and did not change the blood progesterone, calcium and cortisol concentration in ewes."

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Plant leads for mitigation of Oral Submucous Fibrosis: Current scenario and future prospect. (PubMed, Oral Dis) - "We concluded that plant drugs like lycopene, curcumin, Aloe vera, colchicine, and Glycyrrhiza glabra, were found effective against OSMF in various in-vitro and/or clinical studies and are being used by modern and traditional practitioners."

Journal • Review • Fibrosis • Immune Modulation • Immunology • Inflammation • IFNG

Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A comparative study. (PubMed, J Family Med Prim Care) - "The overall success rate was better in group B (86.8%) compared to group A (80%). Nifedipine was slightly more effective in arresting preterm labor with fewer side effects, compared to isoxsuprine."

Journal • Acute Respiratory Distress Syndrome • Cardiovascular • Pain • Respiratory Diseases

Analysis of β-agonists in Different Biological Matrices By Liquid Chromatography-tandem Mass Spectrometry. (PubMed, J Vet Res) - "Validation results met the requirement of the confirmation criteria according to European Commission Decision 2002/657/EC in terms of apparent recoveries (93.2-112.0%), repeatability (3.1-7.1%) and intra-laboratory reproducibility (4.1-8.2%). The method can be successfully applied in the detection and determination of clenbuterol, salbutamol, mabuterol, mapenterol, terbutaline, brombuterol, zilpaterol, isoxsuprine and ractopamine in feed, drinking water, urine, muscle, lung and liver matrices."

Journal

Safety and Tolerability of ISX (Isoxsuprine HCL) in MS Relapses (clinicaltrials.gov) - P1/2 | N=2 | Completed | Sponsor: University of New Mexico | Recruiting ➔ Completed | N=20 ➔ 2 | Trial completion date: Dec 2020 ➔ Jul 2021 | Trial primary completion date: Jun 2020 ➔ Jul 2021

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • CNS Disorders • Multiple Sclerosis

Interventions for treating leg ulcers in people with sickle cell disease. (PubMed, Cochrane Database Syst Rev) - "Given the very low quality of the evidence identified in this updated Cochrane Review we are uncertain whether any of the assessed pharmaceutical interventions reduce ulcer size or result in leg ulcer closure in treated participants compared to controls. However, this intervention was assessed as having a high risk of bias due to inadequacies in the single trial report. Other included studies were also assessed as having an unclear or high risk of bias. The harm profile of the all interventions remains inconclusive."

Journal • Review • Cystic Fibrosis • Fibrosis • Genetic Disorders • Hematological Disorders • Immunology • Pulmonary Disease • Respiratory Diseases • Sickle Cell Disease

Topical Isoxsuprine in experimentally induced hypertrophic scar in rabbits. (PubMed, J Popul Ther Clin Pharmacol) - "Regarding histopathological scores of inflammation, the scar height, and scar index, the scores were highest in was highest in group 2 (hypertrophic scar without treatment), followed by group 3 (hypertrophic scar treated with triamcinolone acetonide gel) and group 4 (hypertrophic scar treated with isoxsuprine gel) - no significant difference between them since p > 0.05, with the exception of index of scar, and then by group 1 (healthy control group). It was concluded that isouxoprine in a topical formulation greatly reduced inflammation and scar formation in deep wounds in a manner comparable to that seen with triamcinolone."

Journal • Preclinical • Fibrosis • Immunology • Inflammation • TGFB1

Commonly used agent for acute pain management of sickle cell anemia in Saudi Emergency Department: A narrative review. (PubMed, Saudi Pharm J) - "We found that continuous administration of IV morphine accompanied by oral analgesics including NSAIDs and acetaminophen is the most commonly used practice for treating SCD patients presenting with a vaso-occlusive pain crisis. Possible effectiveness of tinzaparin, isoxsuprine, and pethidine as therapeutic options may be considered. However, there was no recommendation for a certain agent to be prescribed. We recommend conducting further clinical randomized-controlled trials."

Journal • Review • Anemia • Genetic Disorders • Hematological Disorders • Pain • Sickle Cell Disease

Activation of β2-adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells. (PubMed, Cancer Sci) - "In addition, inhibition of cell migration upon the treatment with isoxsuprine was reverted by a non-selective β-AR antagonist, propranolol, and CRISPR/Cas9 system-mediated deletion of β2-AR gene, suggesting that the effects exerted by isoxsuprine involve the signals mediated by β2-AR. In addition, in subcutaneous xenograft model of oral cancer cells, the administration of isoxsuprine effectively suppressed primary tumor growth suggesting β2-AR signals to be a promising cancer therapeutic target for treatment of OSCC."

Journal • Head and Neck Cancer • Oncology • Oral Cancer • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

Efficacy of hyaluronidase combined with corticosteroids in treatment of oral submucous fibrosis: a meta-analysis of randomised controlled clinical trials. (PubMed, J Oral Pathol Med) - "According to this meta-analysis, weak evidence indicates that hyaluronidase combined with corticosteroids has no additional clinical benefit over control drugs (lycopene, pentoxifylline, aloe vera, dexamethasone, Turmix and isoxsuprine) in improving maximum mouth opening and alleviating the burning sensation in patients with OSF. Therefore, more high-quality, multi-centre randomized controlled trials with larger samples are needed to further assess the efficacy of hyaluronidase combined with corticosteroids in the treatment of OSF."

Journal • Retrospective data • Fibrosis • Immunology

The determination of β-agonist residues in bovine tissues using liquid chromatography tandem mass spectrometry. (PubMed, Biomed Chromatogr) - "We aimed to develop a rapid, simple, and reproducible method based on liquid chromatography/tandem mass spectrometry (LC-MS/MS) to analyze β-agonist residues (clenbuterol, zilpaterol, ractopamine, and isoxsuprine) in bovine tissues...This method was used to detect four β-agonists in 100 bovine muscle, 100 liver, and 100 kidney tissues from a slaughterhouse. No residue was found above the maximum residue limit level."

Journal

Safety and Tolerability of ISX (Isoxsuprine HCL) in MS Relapses (clinicaltrials.gov) - P1/2; N=20; Recruiting; Sponsor: University of New Mexico; Trial completion date: Apr 2020 ➔ Dec 2020; Trial primary completion date: Nov 2019 ➔ Jun 2020

Clinical • Trial completion date • Trial primary completion date • CNS Disorders • Multiple Sclerosis

Catalytic activity and structural changes of catalase in the presence of Levothyroxine and Isoxsuprine hydrochloride. (PubMed, Int J Biol Macromol) - "The results of the molecular docking investigations confirmed the experimental data and showed that the main binding forces in the LEV-BLC and ISO-BLC systems were hydrogen bond and hydrophobic force. The best binding site of both drugs on BLC is located at a cavity among the wrapping domain, N-Terminal arm, and β-barrel."

Journal • CAT

Comparing the predictability of different chemometric models over UV-spectral data of isoxsuprine and its toxic photothermal degradation products. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "On the other hand, the application of GA prior to model implementation affected the number of latent variables the prediction ability of both PLS and ANN models. The validated models were successfully applied as stability indicating assay methods for the selective determination of ISX and its photothermal degradation products in ISX raw material and market formulations."

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